Our findings are particularly interesting given that our study was specifically designed to examine the neural alterations related to addiction amongst a population of alcohol and cannabis users. This is in contrast to studies that examine alcohol/cannabis use compared to nonuser controls. By using a control group that consisted of substance users, this study effectively probed the neural activity related to pathologic use, as opposed to any use. Thus, our study design should have been particularly sensitive to addiction-related aberrations, which may drive compulsive substance use. Identification of such networks is crucial in understanding substance use disorders and may be helpful in guiding targeted therapies in the future. Alternatively however, our findings could have also reflected circuits and oscillatory responses that are altered with substantial use of the substance, since use that is more chronic often co-occurs with more severe use disorder. This would have suggested frequency-specific alterations related to consumption of large quantities of the substance. To address this, we performed follow-up regression analyses that included number of use disorder symptoms, as well as measures of the frequency of
