to the highest AUC. An AUC of 0.75 is generally regarded as the minimum useful level for screening subjects already considered at risk, whereas AUC of 0.99 is sufficient for screening the population at large [31]. For these two diseases the latter cannot be achieved from genetic data alone, so Table 4 gives minimum sample sizes for AUC of 0.75 and for 90%, 95% and 99% of the maximum possible AUC given the heritability.
