Specifically in the COGA European American (EA) sample, we tested for the following phenotypes: alcohol diagnosis (AD_DX), alcohol symptoms count (AD_SX), and maximum drinks in 24 hour (MAX24), using mRNA (591 SNPs) and miRNA(68 SNPs) eQTL sets. Correction for multiple testing was assessed using the Simes test; Simes is modification of Bonferroni test and performs better for small number of multiple tests [107]. MAX24 phenotype didn’t show significance in any set based analysis. None of the three phenotypes show set-based signal with miRNA set, most likely due to lack of power. Additional pertinent information for the enriched eQTLs, such as chromosome position and minor allele frequency is provided in S12 Table.
