The observed hyperconnectivity across prefrontal regions in AUD is an important finding, given the prominent role of ACC and PFC in human cognition [86,87,88,89] as well as in the development of AUD [4,90,91,92,93]. Therefore, it is highly likely that altered FC within prefrontal DMN nodes may be a manifestation of these structural/functional impairments of frontal lobe regions in AUD. Previous findings from the literature also suggest that prefrontal hyperconnectivity in AUD may have resulted in increased impulsivity and a lack of inhibitory control in these subjects, as there is an association between prefrontal hyperconnectivity and externalizing traits, such as impulsivity, aggression, psychopathy, [94,95,96] and ADHD [97,98]. Therefore, the observed hyperconnectivity across the prefrontal regions may indicate a state of neural hyper-excitability in individuals with AUD [99]. In the same groups of subjects, we have recently reported that the AUD group had smaller volumes in frontal cortices (left pars orbitalis, right medial orbitofrontal, right caudal middle frontal regions) as well as in bilateral hippocampi [6], further confirming possible aberrations frontal networks exhibited by AUD patients. Furthermore, the increased impulsivity and visual
