We next analyzed genotypes as predictors of transcription (i.e., a GWAS for each transcript) for 2,494 twins, using a REML (restricted maximum likelihood) model accounting for twin status and covariates. eQTLs within ± 1 Mb of a gene were classified “local” and all others as distant, with separate false discovery rate (FDR) control. Genes with at least one local eQTL (q < 0.01) had significantly higher expression levels and heritability (P < 10−200 for both).
