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Chunk #0 — Introduction

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Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS.
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Obsessive-compulsive disorder (OCD) is a psychiatric condition characterized by persistent, intrusive, senseless thoughts and urges (obsessions) and repetitive, intentional behaviors (compulsions). Affected individuals tend to recognize that their thoughts and behaviors are excessive and unreasonable, and often struggle to resist them. The lifetime prevalence of OCD is estimated to be between 1–3%, based on national and international population-based surveys 1, 2. Patients experience a chronic or episodic course with exacerbations that can substantially impair social, occupational, and academic functioning; according to the World Health Organization, OCD is among the most disabling medical conditions worldwide 3.