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Chunk #0 — Introduction

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Topological organization of functional brain networks in healthy children: differences in relation to age, sex, and intelligence.
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Recent developments in generating a network map of the human brain, known as the human connectome, provide new insights into the organization of the brain's structural connections and their role in shaping functional dynamics [1], [2]. The features of the structural and functional networks in the human brain have been well defined, such as small-world topology, highly connected hubs, and modularity [3], [4], [5]. Great efforts in the study of the human connectome have greatly expanded our knowledge of the topological principles of brain network organization in the healthy, developing, aging, and diseased brains [6], [7]. Developmental changes in the functional brain networks include two general principles: 1) regional interactions change from being predominately anatomically local in children to interactions spanning longer cortical distances in young adults and 2) this developmental change in functional connectivity occurs via mechanisms of segregation of local regions and integration of distant regions into disparate subnetworks [8].