The remaining novel associations on 3q25, 8q, 11p11, 17q21 and 19q13.3 were more complex. The index variants on chromosome 8q22.1 were not localized to any genes, and it is unclear from the credible set analyses what the causal variants may be at these loci. The credible SNP sets for the 3q25.33, 11p11.2, 17q21.31 and 19q13.3 regions contained over 50 SNPs each, which spanned several genes. For example, the index SNP on chromosome 17q21.31 was an intronic SNP in MAPT, which encodes the tau protein and has been robustly associated with Parkinson’s disease (30, 31) (Supplementary Table 14) and other neurodegenerative tauopathies (32), and more recently with neuroticism (33). However, we note that the region of association on chromosome 17q21.31 spans the corticotrophin receptor gene (CRHR1), which has been associated with alcohol use in animals and humans (34). Thus, due to the extended complex LD in this region, we are unable to determine the likely causal variant. Similarly, the index SNP (rs2293576) at chromosome 11p11.2 is a synonymous SNP of the zinc transporter gene SLC39A13; however, this region includes 54 associated
