We noted a weaker cis-eQTL for rs10784774 with YEATS4 expression in both cell types (pmonocyte=1.26×10−13, pB-cell=1.55×10−7). Although YEATS4 is a transcription factor23 and therefore could potentially account for the observed trans-eQTL, the exclusivity of the trans-eQTL to monocytes would argue against this. Furthermore, correlation analyses between monocyte YEATS4, CREB1 and LYZ expression and that of other probes demonstrates the strongest coefficient of correlation to expression of LYZ and CREB1 for all trans associated genes to this locus (Supplementary Table 5).
