Genome-wide SNP heritability and correlation estimates were obtained using association summary statistics and linkage disequilibrium (LD) information through LD Score (LDSC) regression analyses38,39. These analyses were restricted to HapMap3 SNPs with minor allele frequency above 5% in European populations of 1000 Genomes. Association summary statistics used for these analyses were based on lung cancer histological/smoking types (lung cancer overall, adenocarcinoma, squamous cell, small cell, ever smokers and never smokers) and smoking behavior parameters (cigarettes per day (CPD), smoking status (ever vs never smokers), and smoking cessation (current vs former smokers) from TRICL-ILCCO OncoArray consortium and Tobacco And Genetics consortium (https://www.med.unc.edu/pgc/downloads)40.
