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Chunk #2 — Introduction

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Long-term suppression of forebrain neurogenesis and loss of neuronal progenitor cells following prolonged alcohol dependence in rats.
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the forebrain subventricular zone (SVZ). Both in rodents and humans, cells that originate from progenitors in the SVZ migrate to become GABAergic and dopaminergic neurons in the olfactory bulb, where they contribute to learning, associating, and discriminating odours (Curtis et al. 2007; Wilson et al. 2004). Impaired olfactory discrimination has been found in human alcoholics (Rupp et al. 2003), but long-term effects of chronic alcohol on neurogenesis in the SVZ have to our knowledge not been reported previously.