least pronounced in seeds near SMA, and occurs latest and most markedly in ventral seeds typically associated with the DMN. This trend likely stems from several sources. Synaptic pruning takes place throughout the first twenty years of life (Huttenlocher, 1979), and could contribute to reduced local rs-fcMRI correlation. Conversely, myelination throughout childhood and adolescence could facilitate increased long-range rs-fcMRI correlations (Brody et al., 1987; Paus et al., 2001). Computational and empirical studies have demonstrated significant correlations between structural and functional connectivity (Hagmann et al.; Honey et al., 2007), giving support to such ideas, though they have also demonstrated that present estimates of structural connectivity leave much of the variance in rs-fcMRI signal unaccounted for (Honey et al., 2009).
