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Chunk #13 — Methods — Multiple test correction

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Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD.
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Across the four target loci, multiple traits (4), the multiple models (additive and additive+heterozygote deviation), and the 2-SNP joint analyses (3 loci), our study was designed to perform fewer than 80 tests. A conservative Bonferroni correction would result in an uncorrected p-value threshold of 6.25×10−4 corresponding to an experiment-wide alpha of 0.05. The results tables report uncorrected p-values which we compared to this threshold to determine statistical significance.