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Chunk #40 — Discussion

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A polymorphism in GABRA2 is associated with the medial frontal response to alcohol cues in an fMRI study.
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to stimulus salience. On the other hand, GABRA2 variation could affect broader parameters, such as personality and behavioral inhibition (Dick et al., 2006; Lind et al., 2008), particularly if the GABRA2 association with alcohol disorders is more prominent in polysubstance abuse (Agrawal et al., 2006), mediated by anxiety (Enoch et al., 2006), or associated with a more generalized addiction potential (Philibert et al., 2009).