In this respect, assumptions about what should count as legitimate risks for genome research also come up in deciding how to frame the genomic research agenda. Should genomics be concerned with social and cultural beliefs that might be challenged by scientific findings, or let the “chips fall where they may” in terms of the social sequelae of genomic variation research for group identity claims, values, and social coherence? Here, examinations of the risks to cultural beliefs constitutive of our social fabric were discussed in the context of microbiome research [G-5, Frank], ancestry studies [D-8, Ossorio], and population structure and reputation [G-4].