Chunk #9 — METHODS — Univariable Mendelian randomization

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Extending the MR-Egger method for multivariable Mendelian randomization to correct for both measured and unmeasured pleiotropy.

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The MR‐Egger estimate is obtained using the same regression model as Equation 2, but allowing the intercept to be estimated9: (4)β^Yj=θ0UE+θUEβ^Xj+ϵUEj,weights=se(β^Yj)−2.