All twins completed diagnostic telephone interviews between 1992–1994 (Cohort I) or 1997–2002 (Cohort II). Twins in the current study were selected based on lifetime history of alcohol use disorder (AUD). Pairs where at least one twin had biological children ages 7– 24 and one twin met DSM-IV criteria for AUD [operationalized for this study as alcohol dependence (AD) in male twins and either AD or alcohol abuse (AB) in female twins] were recruited for participation in one of two children of twins studies with coordinated assessment: Mothers And Their Children (MATCH) and Parental Alcoholism & Child Environmental Risk (PACER). A random sample of control pairs, where at least one twin had biological children ages 7– 24, but neither twin met criteria for AUD, was also recruited.
