Post-mortem human brains from the NIMH Brain Tissue Collection in the Clinical Brain Disorders Branch (NIMH, CBDB) were obtained at autopsy. Additional brain tissue samples were provided by the NICHD Brain and Tissue Bank for Developmental Disorders (http://www.BTBank.org). Clinical characterization, diagnoses and macro- and microscopic neuropathological examinations, toxicological analysis, RNA extraction and quality control measures were performed using a standardized paradigm. Subjects with evidence of neuropathology, drug use, alcohol abuse, or psychiatric illness were excluded. Subject demographics and sample details are contained in Supplementary Table 7.
