specific pathogenic processes, some caution is required before making strong statements about the replication status of individual SNPs. Other studies have reached a similar conclusion that for SCZ, many SNPs with small effects may be involved and these SNPs replicate as a group.21,45 Our article adds to these studies. The facts that we used a family-based replication (thereby minimizing the probability that population substructure accounts for the replication) and tested a much smaller set of SNPs pinpoints more precisely the genes that are likely involved.
