Co-association between Transcription FactorsPanel A shows significant co-associations of TF pairs using the GSC statistic across the entire genome in K562 cells. The colour strength represents the extent of association (red (strongest) through orange to yellow (weakest)), whereas the depth of colour represents the fit to the GSC20 model (white meaning that the statistical model is not appropriate) as indicated by the key. The majority of TFs have a non-random association to other TFs, and these associations are dependent on the genomic context, meaning that once the genome is separated into promoter proximal and distal regions, the overall levels of co-association decrease, but more specific relationships are uncovered. Panel B illustrates three classes of behaviour. The first column shows a set of associations whose strength is independent of location in promoter and distal regions while the second shows a set of TFs which have stronger associations in promoter-proximal regions. Both these examples are from data in K562 cells and are highlighted on the genome wide coassociation matrix (panel A) by the labelled boxes A and B, respectively. The third column shows a set of TFs that show stronger association in distal regions (in the H1 hESC cell line).
