a result of a series of requests for applications (RFAs) to support the establishment and work of a coordinating center (CC), genotyping centers (GCs) and study investigators (SI). The goals of the consortium are to (i) identify genetic variants associated with complex diseases and traits in initial genome-wide discovery studies; (ii) identify variations in gene-trait associations related to environmental exposures; and (iii) ensure the rapid sharing of data to the general scientific community.