In a GWAS of recurrent, early-onset MDD, three SNPs located in the FHIT gene were among the strongest associations in the overall and sex-stratified analyses (8) although none was genome-wide significant. Genetic variants located in FHIT have been reported in genetic studies of anxiety,(42) autism (43), mental stress (44), comorbid depressive syndromes and alcohol dependence (45), citalopram-induced side effects (46) and in a latent class analysis of MDD symptoms (7), but none met genome-wide significance.
