To explain emotional dysfunction, theorists have made reference to participation of multiple regions of the brain (Gainotti 2001) (eg, see Table 1 and Figure 1). In alcoholics, there is growing evidence for involvement of many of the regions responsible for emotional functioning (Bowirrat and Oscar-Berman 2005). We begin by examining cortical and white-matter changes, followed by changes in the limbic system and the cerebellum.
