Some genetic analyses of sweetener consumption by mice yielded evidence that it is influenced by a single locus, named Sac (saccharin preference),[102,106,110,122] whereas other experiments indicated that more than one gene is involved.[107,110,111,123,124] The apparent discrepancy in whether the single-gene or the multi-gene model better describes genetic variation in sweetener preferences is likely due to use of different progenitor strains and types of mapping panels, different sweetener solutions tested, and different quantitative analyses used in these studies.
