Path analysis of P300 amplitude of individuals from families at high and low risk for developing alcoholism.
- Authors
- Hill, S Y; Yuan, H; Locke, J
- Year
- 1999
- Journal
- Biological psychiatry
- PMID
- 10023513
- DOI
- 10.1016/s0006-3223(97)00525-8
BACKGROUND: A substantial amount of evidence exists suggesting that P300 amplitude in childhood is a risk marker for later development of alcohol dependence. There is evidence that P300 amplitude is heritable. The goal of the present study was to determine if patterns of transmission differed in families who were either at high or low risk for developing alcohol dependence. METHODS: Auditory P300 was recorded from 536 individuals spanning three generations. The path analytic TAU model was used to investigate the familial transmission of P300 amplitude in the two independent samples of families. RESULTS: Transmission of P300 in high-risk families most likely followed a polygenic model of inheritance with significant parent-to-offspring transmission. Parent-to-offspring transmission was significantly greater in high-risk than low-risk families. Total phenotypic variance due to transmissible factors was greater in low-risk families than in high-risk families, however. A somewhat unexpected finding was the substantial correlation between mates for P300 amplitude in both high- and low-risk families. CONCLUSIONS: P300 is transmissible in families. Differences exist in the pattern of transmission for P300 in families at high and low risk for alcoholism.
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| Neurocognitive deficits in male alcoholics: an ERP/sLORETA analysis of the N2 component in an equal probability Go/NoGo task. | 2012 | 22024409 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Density and Dichotomous Family History Measures of Alcohol Use Disorder as Predictors of Behavioral and Neural Phenotypes: A Comparative Study Across Gender and Race/Ethnicity. | Pandey G et al. | — | 2020 | → |
| Psychological and Neurobiological Precursors of Alcohol Use Disorders in High Risk Youth. | Hill SY et al. | — | 2015 | → |
| Early-onset alcohol dependence increases the acoustic startle reflex. | Schellekens AF et al. | — | 2012 | → |
| Neurocognitive deficits in male alcoholics: an ERP/sLORETA analysis of the N2 component in an equal probability Go/NoGo task. | Pandey AK et al. | — | 2012 | → |
| Auditory P300 and N100 components as intermediate phenotypes for psychotic disorder: familial liability and reliability. | Simons CJ et al. | — | 2011 | → |
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| Childhood risk factors for young adult substance dependence outcome in offspring from multiplex alcohol dependence families: a prospective study. | Hill SY et al. | — | 2009 | → |
| Latent deleterious effects of binge drinking over a short period of time revealed only by electrophysiological measures. | Maurage P et al. | — | 2009 | → |
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