The Roscommon Family Study. IV. Affective illness, anxiety disorders, and alcoholism in relatives.
paper
Cited
Public
Unavailable
- Authors
- Kendler, K S; McGuire, M; Gruenberg, A M; O'Hare, A; Spellman, M; Walsh, D
- Year
- 1993
- Journal
- Archives of general psychiatry
- PMID
- 8250681
- DOI
- 10.1001/archpsyc.1993.01820240036005
OBJECTIVES: This report seeks to evaluate the specificity of the familial liability to schizophrenia by examining in the relatives of the various proband groups the risk for affective illness (AI), anxiety disorders, and alcoholism. DESIGN: A case-controlled epidemiologic family study using DSM-III-R criteria. PARTICIPANTS: Three hundred eighty-four index probands from a psychiatric case register, 150 unselected control probands from an electoral register and 2043 of their living and traceable relatives, of whom 1753 were personally interviewed. RESULTS: In personally interviewed relatives of schizophrenic probands, the lifetime risk for all AI (24.9% +/- 3.8%) or just bipolar AI (1.2% +/- 0.7%) was very similar to that found in interviewed relatives of controls (22.8% +/- 4.0% and 1.4% +/- 0.7%, respectively). However, the risk for all AI (49.7% +/- 12.9%) or bipolar AI (4.8% +/- 3.2%) was substantially increased in relatives of schizoaffective probands. A substantially higher proportion of relatives of schizophrenic vs control probands who had AI demonstrated psychotic--and specially mood-incongruent psychotic--symptoms when affectively ill. Neither the risk for anxiety disorders nor that for alcoholism was increased in relatives of schizophrenic vs control probands. CONCLUSIONS: The familial liability to schizophrenia possesses some specificity and does not substantially increase the risk to AI, anxiety disorders, or alcoholism. Even when narrowly defined, schizoaffective disorder has a substantial familial link to classic AI. The familial liability to schizophrenia predisposes to psychosis, and especially mood-incongruent psychosis, when affectively ill. Finally, these results do not support the hypothesis that, from a familial perspective, schizophrenia and AI are on a single etiologic continuum.
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| The Manic Idea Creator? A Review and Meta-Analysis of the Relationship between Bipolar Disorder and Creative Cognitive Potential. | Forthmann B et al. | — | 2023 | → |
| Evaluating the role of common risk variation in the recurrence risk of schizophrenia in multiplex schizophrenia families. | Ahangari M et al. | — | 2022 | → |
| Examining the source of increased bipolar disorder and major depressive disorder common risk variation burden in multiplex schizophrenia families. | Ahangari M et al. | — | 2022 | → |
| The patterns of family genetic risk scores for eleven major psychiatric and substance use disorders in a Swedish national sample. | Kendler KS et al. | — | 2021 | → |
| An Extended Swedish National Adoption Study of Bipolar Disorder Illness and Cross-Generational Familial Association With Schizophrenia and Major Depression. | Kendler KS et al. | — | 2020 | → |
| Psychological factors of sibling caregivers of patients with severe mental disorders: an observational study. | Pierazzuoli F et al. | — | 2020 | → |
| Comparative familial aggregation of bipolar disorder in patients with bipolar I and bipolar II disorders. | Parker GB et al. | — | 2018 | → |
| Association between substance use disorder and polygenic liability to schizophrenia | Hartz SM et al. | — | 2017 | — |
| Association Between Substance Use Disorder and Polygenic Liability to Schizophrenia. | Hartz SM et al. | — | 2017 | → |
| Familial Aggregation and Heritability of Schizophrenia and Co-aggregation of Psychiatric Illnesses in Affected Families. | Chou IJ et al. | — | 2017 | → |
| Positive Traits in the Bipolar Spectrum: The Space between Madness and Genius. | Greenwood TA | — | 2017 | → |
| Tract-based analysis of white matter integrity in psychotic and nonpsychotic bipolar disorder. | Ji A et al. | — | 2017 | → |
| Associations between Polygenic Risk for Psychiatric Disorders and Substance Involvement. | Carey CE et al. | — | 2016 | → |
| Association Study of Gene Polymorphisms in GABA, Serotonin, Dopamine, and Alcohol Metabolism Pathways with Alcohol Dependence in Taiwanese Han Men. | Wu LS et al. | — | 2016 | → |
| Examining the Psychosis Continuum. | DeRosse P et al. | — | 2015 | → |
| The impact of clinical heterogeneity in schizophrenia on genomic analyses. | Liang SG et al. | — | 2015 | → |
| Genetic relationships between schizophrenia, bipolar disorder, and schizoaffective disorder. | Cardno AG et al. | — | 2014 | → |
| Genomic insights into the overlap between psychiatric disorders: implications for research and clinical practice. | Doherty JL et al. | — | 2014 | → |
| Health-related quality of life in alcohol dependence: a systematic literature review with a specific focus on the role of depression and other psychopathology. | Levola J et al. | — | 2014 | → |
| Independence of familial transmission of mania and depression: results of the NIMH family study of affective spectrum disorders. | Merikangas KR et al. | — | 2014 | → |
| POSITIVE AND NEGATIVE SUBCLINICAL SYMPTOMS AND MCCB PERFORMANCE IN NON-PSYCHIATRIC CONTROLS. | Korponay C et al. | — | 2014 | → |
| Specificity of psychosis, mania and major depression in a contemporary family study. | Vandeleur CL et al. | — | 2014 | → |
| At risk for schizophrenic or affective psychoses? A meta-analysis of DSM/ICD diagnostic outcomes in individuals at high clinical risk. | Fusar-Poli P et al. | — | 2013 | → |
| The reality monitoring deficit as a common neuropsychological correlate of schizophrenic and affective psychosis. | Radaelli D et al. | — | 2013 | → |
| Comparing the prodrome of schizophrenia-spectrum psychoses and affective disorders with and without psychotic features. | Schultze-Lutter F et al. | — | 2012 | → |
| Genome-wide association of mood-incongruent psychotic bipolar disorder. | Goes FS et al. | — | 2012 | → |
| Molecular genetics of the psychosis phenotype. | DeRosse P et al. | — | 2012 | → |
| TPH2 gene polymorphisms and major depression--a meta-analysis. | Gao J et al. | — | 2012 | → |
| Creativity and psychopathology: a shared vulnerability model. | Carson SH | — | 2011 | → |
| Depression and heavy drinking occasions: a cross-sectional general population study. | Levola J et al. | — | 2011 | → |
| Schizophrenia in the internalizing-externalizing framework: a third dimension? | Kotov R et al. | — | 2011 | → |
| Twelve-month follow-up of family communication and psychopathology in children and adolescents with a first psychotic episode (CAFEPS study). | Otero S et al. | — | 2011 | → |
| Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study. | Lichtenstein P et al. | — | 2009 | → |
| Family-based association study of Neuregulin 1 with psychotic bipolar disorder. | Goes FS et al. | — | 2009 | → |
| Prevalence of psychotic and non-psychotic disorders in relatives of patients with a first episode psychosis. | Faridi K et al. | — | 2009 | → |
| Validity of the prodromal risk syndrome for first psychosis: findings from the North American Prodrome Longitudinal Study. | Woods SW et al. | — | 2009 | → |
| Allelic association of G72/G30 with schizophrenia and bipolar disorder: a comprehensive meta-analysis. | Shi J et al. | — | 2008 | → |
| A review on cognitive impairments in depressive and anxiety disorders with a focus on young adults. | Castaneda AE et al. | — | 2008 | → |
| Schizoaffective disorder: diagnostic issues and future recommendations. | Malhi GS et al. | — | 2008 | → |
| The genetics of psychotic bipolar disorder. | Goes FS et al. | — | 2008 | → |
| Mood-incongruent psychotic features in bipolar disorder: familial aggregation and suggestive linkage to 2p11-q14 and 13q21-33. | Goes FS et al. | — | 2007 | → |
| The genetic deconstruction of psychosis. | Owen MJ et al. | — | 2007 | → |
| Carving chaos: genetics and the classification of mood and psychotic syndromes. | Potash JB | — | 2006 | → |
| Genomewide linkage scan of 409 European-ancestry and African American families with schizophrenia: suggestive evidence of linkage at 8p23.3-p21.2 and 11p13.1-q14.1 in the combined sample. | Suarez BK et al. | — | 2006 | → |
| Schizoaffective disorders are psychotic mood disorders; there are no schizoaffective disorders. | Lake CR et al. | — | 2006 | → |
| Schizophrenia and bipolar disorder: differences and overlaps. | Maier W et al. | — | 2006 | → |
| The heritability of melatonin secretion and sensitivity to bright nocturnal light in twins. | Hallam KT et al. | — | 2006 | → |
| The vulnerability to alcohol and substance abuse in individuals diagnosed with schizophrenia. | Krystal JH et al. | — | 2006 | → |
| Anxiety and schizophrenia: the interaction of subtypes of anxiety and psychotic symptoms. | Huppert JD et al. | — | 2005 | → |
| Genetic models of schizophrenia and bipolar disorder: overlapping inheritance or discrete genotypes? | Maier W et al. | — | 2005 | → |
| Genetic tests of biologic systems in affective disorders. | Hattori E et al. | — | 2005 | → |
| An overview of the genetics of psychotic mood disorders. | Tsuang MT et al. | — | 2004 | → |
| Bipolar disorder and schizophrenia: convergent molecular data. | Berrettini W | — | 2004 | → |
| Psychotic bipolar disorders: dimensionally similar to or categorically different from schizophrenia? | Ketter TA et al. | — | 2004 | → |
| Why genetic investigation of psychiatric disorders is so difficult. | Bearden CE et al. | — | 2004 | → |
| Bipolar disorder and schizophrenia: not so distant relatives? | Berrettini W | — | 2003 | → |
| Boundaries of schizophrenia. | Adler CM et al. | — | 2003 | → |
| Common genetic risk factors for psychiatric and simatic disorders. | Bondy B | — | 2003 | → |
| Evidence for shared susceptibility in bipolar disorder and schizophrenia. | Berrettini W | — | 2003 | → |
| Familial aggregation of psychotic symptoms in a replication set of 69 bipolar disorder pedigrees. | Potash JB et al. | — | 2003 | → |
| Heterogeneity and the genetics of bipolar disorder. | Faraone SV et al. | — | 2003 | → |
| Initial genome-wide scan for linkage with schizophrenia in the Japanese Schizophrenia Sib-Pair Linkage Group (JSSLG) families. | Japanese Schizophrenia Sib-Pair Linkage Group | — | 2003 | → |
| Genome-wide scans of three independent sets of 90 Irish multiplex schizophrenia families and follow-up of selected regions in all families provides evidence for multiple susceptibility genes. | Straub RE et al. | — | 2002 | → |
| Hierarchy and heritability: the role of diagnosis and modeling in psychiatric genetics. | Kendler KS | — | 2002 | → |
| Is there a familial overlap between schizophrenia and bipolar disorder? | Somnath CP et al. | — | 2002 | → |
| Self-experienced vulnerability, prodromal symptoms and coping strategies preceding schizophrenic and depressive relapses. | Bechdolf A et al. | — | 2002 | → |
| The dichotomy of schizophrenia and affective disorders in extended pedigrees. | Maier W et al. | — | 2002 | → |
| Analysis of epistasis in linked regions in the Irish study of high-density schizophrenia families. | Sullivan PF et al. | — | 2001 | → |
| Multilevel Modeling of Cognitive Function in Schizophrenic Patients and Their First Degree Relatives. | Rabe-Hesketh S et al. | — | 2001 | → |
| The common genetic liability between schizophrenia and bipolar disorder: a review. | Bramon E et al. | — | 2001 | → |
| The familial aggregation of psychotic symptoms in bipolar disorder pedigrees. | Potash JB et al. | — | 2001 | → |
| The "prodromal" patient: both symptomatic and at-risk. | Woods SW et al. | — | 2001 | → |
| Family characteristics of deficit and nondeficit schizophrenia in the Roscommon Family Study. | Kirkpatrick B et al. | — | 2000 | → |
| Lifetime prevalence of mood and anxiety disorders in twin pairs discordant for schizophrenia. | Lyons MJ et al. | — | 2000 | → |
| Sex-based linkage analysis of alcoholism. | Paterson AD et al. | — | 1999 | → |
| A schizophrenia locus may be located in region 10p15-p11. | Straub RE et al. | — | 1998 | → |
| Slow-wave sleep and ventricular size: a comparative study in schizophrenia and major depression. | Lauer CJ et al. | — | 1998 | → |
| The new epidemiology of schizophrenia. | Jones P et al. | — | 1998 | → |
| Bipolar disorder: from families to genes. | Alda M | — | 1997 | → |
| The molecular genetics of schizophrenia: an update. | Mowry BJ et al. | — | 1997 | → |
| The New York High-Risk Project. Prevalence and comorbidity of axis I disorders in offspring of schizophrenic parents at 25-year follow-up. | Erlenmeyer-Kimling L et al. | — | 1997 | → |
| Evidence of a locus for schizophrenia and related disorders on the short arm of chromosome 5 in a large pedigree. | Silverman JM et al. | — | 1996 | → |
| Familial-genetic and reproductive epidemiology of schizophrenia in rural Ireland: age at onset, familial morbid risk and parental fertility. | Waddington JL et al. | — | 1996 | → |
| Irish study on high-density schizophrenia families: field methods and power to detect linkage. | Kendler KS et al. | — | 1996 | → |
| Schizophrenia. | Cannon M et al. | — | 1996 | → |
| Schizophrenia and affective disorder--distinct entities or continuum?: an analysis based on a prospective 6-year follow-up. | Winokur G et al. | — | 1996 | → |
| The risk for psychiatric illness in siblings of schizophrenics: the impact of psychotic and non-psychotic affective illness and alcoholism in parents. | Kendler KS et al. | — | 1996 | → |
| A case of bipolar disorder with balanced chromosomal translocation. | Kunugi H et al. | — | 1995 | → |
| A simple genetic basis for a complex psychological trait in laboratory mice. | Flint J et al. | — | 1995 | → |
| Evaluating the spectrum concept of schizophrenia in the Roscommon Family Study. | Kendler KS et al. | — | 1995 | → |
| Gender and schizophrenia. Results of an epidemiologically-based family study. | Kendler KS et al. | — | 1995 | → |
| Schizoaffective psychoses: genetical clues to classification. | Bertelsen A et al. | — | 1995 | → |
| The New York High-Risk Project. Psychoses and cluster A personality disorders in offspring of schizophrenic parents at 23 years of follow-up. | Erlenmeyer-Kimling L et al. | — | 1995 | → |
| Genetic epidemiology of psychiatric disorders. | Maier W | — | 1993 | → |