Event-related brain potentials are different in individuals at high and low risk for developing alcoholism.
paper
Cited
Public
Unavailable
- Authors
- Elmasian, R; Neville, H; Woods, D; Schuckit, M; Bloom, F
- Year
- 1982
- Journal
- Proceedings of the National Academy of Sciences of the United States of America
- PMID
- 6961459
- DOI
- 10.1073/pnas.79.24.7900
- PMCID
- PMC347457
Event-related brain potentials (ERPs) from normal drinkers with and without a family history of alcoholism were compared. Three separate groups of 10 subjects each (5 with and 5 without a family history of alcoholism) ingested either a placebo or ethanol at 0.56 or 0.94 g/kg. In each comparison, ERP components elicited in conjunction with subjects' decisions about task-relevant stimuli were of significantly reduced amplitude in individuals with a family history of alcoholism. Additionally, both the latency of the positive component and reaction times to correctly detected targets were significantly later in individuals with a positive history of alcoholism than in those without such a history. These group differences were apparent both with and without a challenge of alcohol. The data suggest that brain functions are different in individuals at high and low risk for the development of alcoholism (i.e., those with and without a family history of alcoholism, respectively).
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