Sample size requirements for matched case-control studies of gene-environment interaction.
paper
Cited
Public
Unavailable
- Authors
- Gauderman, W James
- Year
- 2002
- Journal
- Statistics in medicine
- PMID
- 11782049
- DOI
- 10.1002/sim.973
Consideration of gene-environment (GxE) interaction is becoming increasingly important in the design of new epidemiologic studies. We present a method for computing required sample size or power to detect GxE interaction in the context of three specific designs: the standard matched case-control; the case-sibling, and the case-parent designs. The method is based on computation of the expected value of the likelihood ratio test statistic, assuming that the data will be analysed using conditional logistic regression. Comparisons of required sample sizes indicate that the family-based designs (case-sibling and case-parent) generally require fewer matched sets than the case-control design to achieve the same power for detecting a GxE interaction. The case-sibling design is most efficient when studying a dominant gene, while the case-parent design is preferred for a recessive gene. Methods are also presented for computing sample size when matched sets are obtained from a stratified population, for example, when the population consists of multiple ethnic groups. A software program that implements the method is freely available, and may be downloaded from the website http://hydra.usc.edu/gxe.
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| Association of the LRRK2 genetic polymorphisms with leprosy in Han Chinese from Southwest China. | Wang D et al. | β | 2015 | β |
| Brain derived neurotrophic factor gene (BDNF) and personality traits: the modifying effect of season of birth and sex. | Kazantseva A et al. | β | 2015 | β |
| Candidate gene-environment interaction research: reflections and recommendations. | Dick DM et al. | β | 2015 | β |
| Clock gene variants differentiate mood disorders. | Dmitrzak-Weglarz MP et al. | β | 2015 | β |
| Common variants of NFE2L2 gene predisposes to acute respiratory distress syndrome in patients with severe sepsis. | Acosta-Herrera M et al. | β | 2015 | β |
| Common variants of OPA1 conferring genetic susceptibility to leprosy in Han Chinese from Southwest China. | Xiang YL et al. | β | 2015 | β |
| Common variants of the PINK1 and PARL genes do not confer genetic susceptibility to schizophrenia in Han Chinese. | Li X et al. | β | 2015 | β |
| Do nuclear-encoded core subunits of mitochondrial complex I confer genetic susceptibility to schizophrenia in Han Chinese populations? | Li X et al. | β | 2015 | β |
| Evaluating historical candidate genes for schizophrenia. | Farrell MS et al. | β | 2015 | β |
| Failing beta-cell adaptation in South Asian families with a high risk of type 2 diabetes. | Jainandunsing S et al. | β | 2015 | β |
| Gene and stress history interplay in emergence of PTSD-like features. | Chakraborty N et al. | β | 2015 | β |
| Genetic determinants for gestational diabetes mellitus and related metabolic traits in Mexican women. | Huerta-Chagoya A et al. | β | 2015 | β |
| Genetic polymorphisms in the prostaglandin pathway genes and risk of head and neck cancer. | Lee WT et al. | β | 2015 | β |
| Genetic polymorphisms of serum amyloid A1 and coronary artery disease risk. | Xie X et al. | β | 2015 | β |
| Genetic Variation in miR-146a Is Not Associated with Susceptibility to IgA Nephropathy in Adults from a Chinese Han Population. | Yang B et al. | β | 2015 | β |
| IL5RA polymorphisms, smoking and eczema in Japanese women: the Kyushu Okinawa Maternal and Child Health Study. | Miyake Y et al. | β | 2015 | β |
| Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism. | Germain M et al. | β | 2015 | β |
| Mitochondrial DNA haplogroup B5 confers genetic susceptibility to Alzheimer's disease in Han Chinese. | Bi R et al. | β | 2015 | β |
| Polymorphisms within the human leucocyte antigen-E gene and their associations with susceptibility to rheumatoid arthritis as well as clinical outcome of anti-tumour necrosis factor therapy. | Iwaszko M et al. | β | 2015 | β |
| Possible association between DBH 19 bp insertion/deletion polymorphism and clinical symptoms in schizophrenia with tardive dyskinesia. | Hui L et al. | β | 2015 | β |
| Recurrent Coding Sequence Variation Explains Only A Small Fraction of the Genetic Architecture of Colorectal Cancer. | Timofeeva MN et al. | β | 2015 | β |
| The Effects of BDNF Val66Met Gene Polymorphism on Serum BDNF and Cognitive Function in Methamphetamine-Dependent Patients and Normal Controls: A Case-Control Study. | Su H et al. | β | 2015 | β |
| Variation within three apoptosis associated genes as potential risk factors for Achilles tendinopathy in a British based case-control cohort. | Rickaby R et al. | β | 2015 | β |
| 8q24 risk alleles and prostate cancer in African-Barbadian men. | Cropp CD et al. | β | 2014 | β |
| ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology. | Nelson PT et al. | β | 2014 | β |
| Alcohol consumption during pregnancy and birth outcomes: the Kyushu Okinawa Maternal and Child Health Study. | Miyake Y et al. | β | 2014 | β |
| A matrilineal genetic legacy from the last glacial maximum confers susceptibility to schizophrenia in Han Chinese. | Zhang W et al. | β | 2014 | β |
| An interaction between a FNDC5 variant and obesity modulates glucose metabolism in a Chinese Han population. | Tang S et al. | β | 2014 | β |
| A Polymorphism in the IL-5 Gene is Associated with Inhibitor Development in Severe Hemophilia A Patients. | FidancΔ± ID et al. | β | 2014 | β |
| Association between 17q12-21 variants and asthma in Japanese women: rs11650680 polymorphism as potential genetic marker for asthma. | Miyake Y et al. | β | 2014 | β |
| Association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and first-episode patients with schizophrenia in a Chinese Han population. | Hui L et al. | β | 2014 | β |
| Association of NOS3 gene variants and clinical contributors of hypoxic-ischemic encephalopathy. | KuzmaniΔ Ε amija R et al. | β | 2014 | β |
| Association study of MICA gene polymorphisms with rheumatoid arthritis susceptibility in south Tunisian population. | Achour Y et al. | β | 2014 | β |
| Autoimmune diseases association study with the KIAA1109-IL2-IL21 region in a Tunisian population. | Bouzid D et al. | β | 2014 | β |
| Calcium intake is associated with decreased prevalence of periodontal disease in young Japanese women. | Tanaka K et al. | β | 2014 | β |
| Case-control study of rhinoconjunctivitis associated with IL5RA polymorphisms in Japanese women: the Kyushu Okinawa Maternal and Child Health Study. | Miyake Y et al. | β | 2014 | β |
| CUBN and NEBL common variants in the chromosome 10p13 linkage region are associated with multibacillary leprosy in Vietnam. | Grant AV et al. | β | 2014 | β |
| Detecting rare haplotype-environment interaction with logistic Bayesian LASSO. | Biswas S et al. | β | 2014 | β |
| Education influences the association between genetic variants and refractive error: a meta-analysis of five Singapore studies. | Fan Q et al. | β | 2014 | β |
| Factors associated with oxidative stress and cancer risk in the Breast and Prostate Cancer Cohort Consortium. | Blein S et al. | β | 2014 | β |
| Further evidence for genetic association of CACNA1C and schizophrenia: new risk loci in a Han Chinese population and a meta-analysis. | Zheng F et al. | β | 2014 | β |
| Genetic susceptibility to accelerated cognitive decline in the US Health and Retirement Study. | Zhang C et al. | β | 2014 | β |
| Genome-wide association study of bipolar disorder in Canadian and UK populations corroborates disease loci including SYNE1 and CSMD1. | Xu W et al. | β | 2014 | β |
| Joint testing of genotypic and gene-environment interaction identified novel association for BMP4 with non-syndromic CL/P in an Asian population using data from an International Cleft Consortium. | Chen Q et al. | β | 2014 | β |
| No association between genetic variants of the LRRK2 gene and schizophrenia in Han Chinese. | Li X et al. | β | 2014 | β |
| No association of the LRRK2 genetic variants with Alzheimer's disease in Han Chinese individuals. | Bi R et al. | β | 2014 | β |
| Posterior tibial tendinopathy: what are the risk factors? | Beeson P | β | 2014 | β |
| Promoter variant rs2301228 on the neural cell adhesion molecule 1 gene confers risk of schizophrenia in Han Chinese. | Zhang W et al. | β | 2014 | β |
| Relationship between IL1 gene polymorphisms and periodontal disease in Japanese women. | Tanaka K et al. | β | 2014 | β |
| Statistical power and significance testing in large-scale genetic studies. | Sham PC et al. | β | 2014 | β |
| The OSR1 rs12329305 polymorphism contributes to the development of congenital malformations in cases of stillborn/neonatal death. | LoziΔ B et al. | β | 2014 | β |
| Variants within the COMP and THBS2 genes are not associated with Achilles tendinopathy in a case-control study of South African and Australian populations. | Saunders CJ et al. | β | 2014 | β |
| A genome-wide association study of central corneal thickness in Latinos. | Gao X et al. | β | 2013 | β |
| A genome-wide association study to identify genetic susceptibility loci that modify ductal and lobular postmenopausal breast cancer risk associated with menopausal hormone therapy use: a two-stage design with replication. | Hein R et al. | β | 2013 | β |
| Association between DBH 19 bp insertion/deletion polymorphism and cognition in first-episode schizophrenic patients. | Hui L et al. | β | 2013 | β |
| Association of kinase insert domain-containing receptor (KDR) gene polymorphisms with idiopathic recurrent spontaneous abortion in Korean women. | Rah H et al. | β | 2013 | β |
| Association of miR-146aC>G, miR-196a2T>C, and miR-499A>G polymorphisms with risk of premature ovarian failure in Korean women. | Rah H et al. | β | 2013 | β |
| Associations between genetic variants in the IRGM gene and inflammatory bowel diseases in the Korean population. | Moon CM et al. | β | 2013 | β |
| Associations of the PTEN -9C>G polymorphism with insulin sensitivity and central obesity in Chinese. | Yang Q et al. | β | 2013 | β |
| Association study of MICA-TM polymorphism with inflammatory bowel disease in the South Tunisian population. | Kamoun A et al. | β | 2013 | β |
| Autoinflammatory gene polymorphisms and susceptibility to UK juvenile idiopathic arthritis. | Hinks A et al. | β | 2013 | β |
| Case-control study of eczema in relation to IL4RΞ± genetic polymorphisms in Japanese women: The Kyushu Okinawa Maternal and Child Health Study. | Miyake Y et al. | β | 2013 | β |
| CD36 gene variants and their association with type 2 diabetes in an Indian population. | Gautam S et al. | β | 2013 | β |
| Complement receptor 1 coding variant p.Ser1610Thr in Alzheimer's disease and related endophenotypes. | Van Cauwenberghe C et al. | β | 2013 | β |
| DNA polymorphism in the FKBP5 gene affects impulsivity in intertemporal choice. | Kawamura Y et al. | β | 2013 | β |
| Fetal polymorphisms at the ABCB1-transporter gene locus are associated with susceptibility to non-syndromic oral cleft malformations. | Omoumi A et al. | β | 2013 | β |
| Gene-environment interactions in cancer epidemiology: a National Cancer Institute Think Tank report. | Hutter CM et al. | β | 2013 | β |
| Genetic analysis of adiponectin variation and its association with type 2 diabetes in African Americans. | Sandy An S et al. | β | 2013 | β |
| Genetic analysis of recently identified osteoporosis susceptibility genes in southern Chinese. | Xiao SM et al. | β | 2013 | β |
| Genetic polymorphisms of the CASP8 gene promoter may not be associated with colorectal cancer in Han Chinese from southwest China. | Xiao MS et al. | β | 2013 | β |
| Genetic susceptibility loci, environmental exposures, and Parkinson's disease: a case-control study of gene-environment interactions. | Chung SJ et al. | β | 2013 | β |
| Genetic variants of complement genes ficolin-2, mannose-binding lectin and complement factor H are associated with leprosy in Han Chinese from Southwest China. | Zhang DF et al. | β | 2013 | β |
| Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci. | Weissglas-Volkov D et al. | β | 2013 | β |
| Glutamatergic GRIN2B and polyaminergic ODC1 genes in suicide attempts: associations and gene-environment interactions with childhood/adolescent physical assault. | Sokolowski M et al. | β | 2013 | β |
| IL3 SNP rs40401 variant is a risk factor for rhinoconjunctivitis in Japanese women: the Kyushu Okinawa maternal and child health study. | Miyake Y et al. | β | 2013 | β |
| Influence of ABCB1 genetic variants in breast cancer treatment outcomes. | Chaturvedi P et al. | β | 2013 | β |
| Influence of serotonin transporter promoter variation on the effects of separation from parent/partner on depression. | FandiΓ±o-Losada A et al. | β | 2013 | β |
| IΞΊBKΞ² and NFΞΊB1, NSAID use and risk of colorectal cancer in the Colon Cancer Family Registry. | Seufert BL et al. | β | 2013 | β |
| Lack of relationship between birth conditions and allergic disorders in Japanese children aged 3 years. | Miyake Y et al. | β | 2013 | β |
| Pharmacogenetic influence of GST polymorphisms on anthracycline-based chemotherapy responses and toxicity in breast cancer patients: a multi-analytical approach. | Tulsyan S et al. | β | 2013 | β |
| Socioeconomic status and risk of dental caries in Japanese preschool children: the Osaka Maternal and child health study. | Tanaka K et al. | β | 2013 | β |
| Susceptibility genes for lung function: from adulthood to school age. | Brehm JM et al. | β | 2013 | β |
| Using a Bayesian hierarchical model for identifying single nucleotide polymorphisms associated with childhood acute lymphoblastic leukemia risk in case-parent triads. | Cao Y et al. | β | 2013 | β |
| VDR gene polymorphisms, interaction with smoking and risk of periodontal disease in Japanese women: the Kyushu Okinawa maternal and child health study. | Tanaka K et al. | β | 2013 | β |
| Absence of association between length variation of an intronic region in the NFATC1 gene and congenital heart defects in a Han Chinese population. | Liu H et al. | β | 2012 | β |
| A case-only study of gene-environment interaction between genetic susceptibility variants in NOD2 and cigarette smoking in Crohn's disease aetiology. | Helbig KL et al. | β | 2012 | β |
| A common genetic variant of FCN3/CD164L2 is associated with essential hypertension in a Chinese population. | Lu J et al. | β | 2012 | β |
| A family-based association study of DIO2 and children mental retardation in the Qinba region of China. | Zhang K et al. | β | 2012 | β |
| Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variation. | Proitsi P et al. | β | 2012 | β |
| Association of cystic fibrosis transmembrane conductance regulator gene variants with acute lung injury in African American children with pneumonia*. | Baughn JM et al. | β | 2012 | β |
| Association of functional dopamine-beta-hydroxylase (DBH) 19 bp insertion/deletion polymorphism with smoking severity in male schizophrenic smokers. | Zhang XY et al. | β | 2012 | β |
| Association of serotonin and dopamine gene pathways with behavioral subphenotypes in dementia. | Proitsi P et al. | β | 2012 | β |
| A two-stage strategy to accommodate general patterns of confounding in the design of observational studies. | Haneuse S et al. | β | 2012 | β |
| Best friends and alcohol use in adolescence: the role of the dopamine D4 receptor gene. | van der Zwaluw CS et al. | β | 2012 | β |
| Characterization of genome-wide association-identified variants for atrial fibrillation in African Americans. | Delaney JT et al. | β | 2012 | β |
| Common variants of the liver fatty acid binding protein gene influence the risk of type 2 diabetes and insulin resistance in Spanish population. | Mansego ML et al. | β | 2012 | β |
| Crohn's disease susceptibility genes are associated with leprosy in the Vietnamese population. | Grant AV et al. | β | 2012 | β |
| Design and analysis issues in gene and environment studies. | Liu CY et al. | β | 2012 | β |
| Functional polymorphisms in IL13 are protective against high Schistosoma mansoni infection intensity in a Brazilian population. | Grant AV et al. | β | 2012 | β |
| Genetic variants of the MRC1 gene and the IFNG gene are associated with leprosy in Han Chinese from Southwest China. | Wang D et al. | β | 2012 | β |
| Hypothesis-driven candidate genes for schizophrenia compared to genome-wide association results. | Collins AL et al. | β | 2012 | β |
| Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls. | Timofeeva MN et al. | β | 2012 | β |
| Interaction between serotonin transporter polymorphism (5-HTTLPR) and stressful life events in adolescents' trajectories of anxious/depressed symptoms. | Petersen IT et al. | β | 2012 | β |
| Invited commentary: GE-Whiz! Ratcheting gene-environment studies up to the whole genome and the whole exposome. | Thomas DC et al. | β | 2012 | β |
| Limited evidence for parent-of-origin effects in inflammatory bowel disease associated loci. | Fransen K et al. | β | 2012 | β |
| Matrix metalloproteinase-9 genetic polymorphisms and the risk for advanced pelvic organ prolapse. | Wu JM et al. | β | 2012 | β |
| Multiple genes in the 15q13-q14 chromosomal region are associated with schizophrenia. | Stephens SH et al. | β | 2012 | β |
| Multiple loci associated with renal function in African Americans. | Shriner D et al. | β | 2012 | β |
| No association of ALOX5AP polymorphisms with risk of MRI-defined brain infarcts. | Barral S et al. | β | 2012 | β |
| No evidence that major mtDNA European haplogroups confer risk to schizophrenia. | Mosquera-Miguel A et al. | β | 2012 | β |
| Polymorphism Thr160Thr in SRD5A1, involved in the progesterone metabolism, modifies postmenopausal breast cancer risk associated with menopausal hormone therapy. | Hein R et al. | β | 2012 | β |
| Sample Size and Power Calculations for Additive Interactions. | VanderWeele TJ | β | 2012 | β |
| SNCA polymorphisms, smoking, and sporadic Parkinson's disease in Japanese. | Miyake Y et al. | β | 2012 | β |
| The association of attempted suicide with genetic variants in the SLC6A4 and TPH genes depends on the definition of suicidal behavior: a systematic review and meta-analysis. | Clayden RC et al. | β | 2012 | β |
| The dopamine b-hydroxylase 19 bp insertion/deletion polymorphism was associated with first-episode but not medicated chronic schizophrenia. | Hui L et al. | β | 2012 | β |
| The role of lysyl oxidase-like 1 DNA copy number variants in exfoliation glaucoma. | Liu Y et al. | β | 2012 | β |
| Towards Deeper Research and Better Policy for Healthy Aging --Using the Unique Data of Chinese Longitudinal Healthy Longevity Survey. | Zeng Y | β | 2012 | β |
| A comprehensive association analysis of homocysteine metabolic pathway genes in Singaporean Chinese with ischemic stroke. | Low HQ et al. | β | 2011 | β |
| A follow-up study for left ventricular mass on chromosome 12p11 identifies potential candidate genes. | Della-Morte D et al. | β | 2011 | β |
| A genome-wide screen of gene-gene interactions for rheumatoid arthritis susceptibility. | Liu C et al. | β | 2011 | β |
| Alcohol consumption, alcohol dehydrogenase 1C (ADH1C) genotype, and risk of colorectal cancer in the Netherlands Cohort Study on diet and cancer. | Bongaerts BW et al. | β | 2011 | β |
| Analysis of FTO gene variants with obesity and glucose homeostasis measures in the multiethnic Insulin Resistance Atherosclerosis Study cohort. | Wing MR et al. | β | 2011 | β |
| An association analysis at 2q36 reveals a new candidate susceptibility gene for juvenile absence epilepsy and/or absence seizures associated with generalized tonic-clonic seizures. | YalΓ§in O et al. | β | 2011 | β |
| An Interdisciplinary Approach to Studying Gene-Environment Interactions: From Twin Studies to Gene Identification and Back. | Dick DM | β | 2011 | β |
| Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma. | Wu IC et al. | β | 2011 | β |
| Association between the SERPING1 gene and age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese. | Nakata I et al. | β | 2011 | β |
| Association of CHRNA4 polymorphisms with smoking behavior in two populations. | Han S et al. | β | 2011 | β |
| Association of common variants in the human eyes shut ortholog (EYS) with statin-induced myopathy: evidence for additional functions of EYS. | Isackson PJ et al. | β | 2011 | β |
| Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD. | BΓΆger CA et al. | β | 2011 | β |
| Association of NOS3 tag polymorphisms with hypoxic-ischemic encephalopathy. | KuzmaniΔ Samija R et al. | β | 2011 | β |
| Clinical and genetic correlates of suicidal ideation during antidepressant treatment in a depressed outpatient sample. | Perroud N et al. | β | 2011 | β |
| Common genetic variation within IGFI, IGFII, IGFBP-1, and IGFBP-3 and endometrial cancer risk. | McGrath M et al. | β | 2011 | β |
| Defining the power limits of genome-wide association scan meta-analyses. | Chapman K et al. | β | 2011 | β |
| Fine mapping the KLK3 locus on chromosome 19q13.33 associated with prostate cancer susceptibility and PSA levels. | Parikh H et al. | β | 2011 | β |
| Gene-environment interaction in psychological traits and disorders. | Dick DM | β | 2011 | β |
| Genetic association and gene-environment interaction: a new method for overcoming the lack of exposure information in controls. | Kazma R et al. | β | 2011 | β |
| Genetic polymorphisms in 15q25 and 19q13 loci, cotinine levels, and risk of lung cancer in EPIC. | Timofeeva MN et al. | β | 2011 | β |
| Genomics in the post-GWAS era. | Juran BD et al. | β | 2011 | β |
| IL13 genetic polymorphisms, smoking, and eczema in women: a case-control study in Japan. | Miyake Y et al. | β | 2011 | β |
| Interactions between genetic polymorphisms in the apoptotic pathway and environmental factors on esophageal adenocarcinoma risk. | Wu IC et al. | β | 2011 | β |
| Joint ancestry and association testing in admixed individuals. | Shriner D et al. | β | 2011 | β |
| N-acetyltransferase 2 polymorphisms, tobacco smoking, and breast cancer risk in the breast and prostate cancer cohort consortium. | Cox DG et al. | β | 2011 | β |
| Prolactin as a biomarker for treatment response and tardive dyskinesia in schizophrenia subjects: old thoughts revisited from a genetic perspective. | Souza RP et al. | β | 2011 | β |
| Quality control procedures for genome-wide association studies. | Turner S et al. | β | 2011 | β |
| Reassessing the role of mitochondrial DNA mutations in autism spectrum disorder. | Γlvarez-Iglesias V et al. | β | 2011 | β |
| Sample size requirements to detect gene-environment interactions in genome-wide association studies. | Murcray CE et al. | β | 2011 | β |
| Stress-induced and cue-induced craving for alcohol in heavy drinkers: Preliminary evidence of genetic moderation by the OPRM1 and CRH-BP genes. | Ray LA | β | 2011 | β |
| Strong association of the APOA5-1131T>C gene variant and early-onset acute myocardial infarction. | De Caterina R et al. | β | 2011 | β |
| The ENPP1 K121Q polymorphism is not associated with type 2 diabetes and related metabolic traits in an Iranian population. | Saberi H et al. | β | 2011 | β |
| The functional ACTN3 577X variant increases the risk of falling in older females: results from two large independent cohort studies. | Judson RN et al. | β | 2011 | β |
| The galanin receptor 1 gene associates with tobacco craving in smokers seeking cessation treatment. | Lori A et al. | β | 2011 | β |
| The role of vitamin D receptor gene polymorphisms in the bone mineral density of Greek postmenopausal women with low calcium intake. | Stathopoulou MG et al. | β | 2011 | β |
| To stratify or not to stratify: power considerations for population-based genome-wide association studies of quantitative traits. | Behrens G et al. | β | 2011 | β |
| A candidate gene study of Tardive dyskinesia in the CATIE schizophrenia trial. | Tsai HT et al. | β | 2010 | β |
| A haplotype of glycogen synthase kinase 3Ξ² is associated with early onset of unipolar major depression. | Saus E et al. | β | 2010 | β |
| A novel approach to simulate gene-environment interactions in complex diseases. | Amato R et al. | β | 2010 | β |
| Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF{kappa}B signalling pathways. | Potter C et al. | β | 2010 | β |
| Association between the oxytocin receptor gene and amygdalar volume in healthy adults. | Inoue H et al. | β | 2010 | β |
| Association of FTO variants with BMI and fat mass in the self-contained population of Sorbs in Germany. | TΓΆnjes A et al. | β | 2010 | β |
| Association study of the GSK-3B gene with tardive dyskinesia in European Caucasians. | Souza RP et al. | β | 2010 | β |
| ATHENA: A knowledge-based hybrid backpropagation-grammatical evolution neural network algorithm for discovering epistasis among quantitative trait Loci. | Turner SD et al. | β | 2010 | β |
| Case-control studies of gene-environment interaction: Bayesian design and analysis. | Mukherjee B et al. | β | 2010 | β |
| Components of the transforming growth factor-beta family and the pathogenesis of human Achilles tendon pathology--a genetic association study. | Posthumus M et al. | β | 2010 | β |
| Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder. | Soria V et al. | β | 2010 | β |
| Disease-associated alleles in genome-wide association studies are enriched for derived low frequency alleles relative to HapMap and neutral expectations. | Lachance J | β | 2010 | β |
| Do 5HTTLPR and stress interact in risk for depression and suicidality? Item response analyses of a large sample. | Coventry WL et al. | β | 2010 | β |
| DRD4 and DAT1 in ADHD: Functional neurobiology to pharmacogenetics. | Turic D et al. | β | 2010 | β |
| Effect of dopamine D3 receptor gene polymorphisms and clozapine treatment response: exploratory analysis of nine polymorphisms and meta-analysis of the Ser9Gly variant. | Hwang R et al. | β | 2010 | β |
| Effect of including environmental data in investigations of gene-disease associations in the presence of qualitative interactions. | Williamson E et al. | β | 2010 | β |
| Efficient genome-wide association testing of gene-environment interaction in case-parent trios. | Gauderman WJ et al. | β | 2010 | β |
| Gene--environment-wide association studies: emerging approaches. | Thomas D | β | 2010 | β |
| Gene-gene and gene-environment interactions on IgE production in prenatal stage. | Yang KD et al. | β | 2010 | β |
| Genetic polymorphisms and human sensitivity to opioid analgesics. | Nishizawa D et al. | β | 2010 | β |
| Genetic polymorphisms of MPO, GSTT1, GSTM1, GSTP1, EPHX1 and NQO1 as risk factors of early-onset lung cancer. | Timofeeva M et al. | β | 2010 | β |
| Genetic variants and abnormal processing of pre-miR-182, a circadian clock modulator, in major depression patients with late insomnia. | Saus E et al. | β | 2010 | β |
| Glial cell line-derived neurotrophic factor receptor alpha 2 (GFRA2) gene is associated with tardive dyskinesia. | Souza RP et al. | β | 2010 | β |
| Low-density lipoprotein receptor-related protein 5 polymorphisms are associated with bone mineral density in Greek postmenopausal women: an interaction with calcium intake. | Stathopoulou MG et al. | β | 2010 | β |
| Methods for investigating gene-environment interactions in candidate pathway and genome-wide association studies. | Thomas D | β | 2010 | β |
| Neuropeptide Y (NPY) gene: Impact on emotional processing and treatment response in anxious depression. | Domschke K et al. | β | 2010 | β |
| Phosphodiesterase 4B genetic variants are not associated with antipsychotic-induced tardive dyskinesia. | Souza RP et al. | β | 2010 | β |
| Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma. | Gao PS et al. | β | 2010 | β |
| Resequencing and association analysis of arylalkylamine N-acetyltransferase (AANAT) gene and its contribution to major depression susceptibility. | Soria V et al. | β | 2010 | β |
| Resequencing of nicotinic acetylcholine receptor genes and association of common and rare variants with the FagerstrΓΆm test for nicotine dependence. | Wessel J et al. | β | 2010 | β |
| Role of genetic variation in the cannabinoid type 1 receptor gene (CNR1) in the pathophysiology of human obesity. | Schleinitz D et al. | β | 2010 | β |
| Testing haplotype-environment interactions using case-parent triads. | Shi M et al. | β | 2010 | β |
| The association between oxytocin receptor gene (OXTR) polymorphisms and affective temperaments, as measured by TEMPS-A. | Kawamura Y et al. | β | 2010 | β |
| The chromosome 16q region associated with ankylosing spondylitis includes the candidate gene tumour necrosis factor receptor type 1-associated death domain (TRADD). | Pointon JJ et al. | β | 2010 | β |
| A case-control and a family-based association study revealing an association between CYP2E1 polymorphisms and nasopharyngeal carcinoma risk in Cantonese. | Jia WH et al. | β | 2009 | β |
| Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study. | Wing MR et al. | β | 2009 | β |
| Association of glutathione-S-transferase omega haplotypes with susceptibility to chronic obstructive pulmonary disease. | Yanbaeva DG et al. | β | 2009 | β |
| Association of interleukin 23 receptor variants with psoriatic arthritis. | Rahman P et al. | β | 2009 | β |
| Association of rheumatoid factor and anti-cyclic citrullinated peptide positivity, but not carriage of shared epitope or PTPN22 susceptibility variants, with anti-tumour necrosis factor response in rheumatoid arthritis. | Potter C et al. | β | 2009 | β |
| Association of the 5'-upstream regulatory region of the alpha7 nicotinic acetylcholine receptor subunit gene (CHRNA7) with schizophrenia. | Stephens SH et al. | β | 2009 | β |
| Associations among GABRG1, level of response to alcohol, and drinking behaviors. | Ray LA et al. | β | 2009 | β |
| Association study and mutational screening of SYNGR1 as a candidate susceptibility gene for schizophrenia. | Iatropoulos P et al. | β | 2009 | β |
| Coding variant Met72Thr in the PEDF gene and risk of neovascular age-related macular degeneration and polypoidal choroidal vasculopathy. | Bessho H et al. | β | 2009 | β |
| CYP450 polymorphisms as risk factors for early-onset lung cancer: gender-specific differences. | Timofeeva MN et al. | β | 2009 | β |
| Gene-environment interactions and alcohol use and dependence: current status and future challenges. | van der Zwaluw CS et al. | β | 2009 | β |
| Genetic variation in GPR133 is associated with height: genome wide association study in the self-contained population of Sorbs. | TΓΆnjes A et al. | β | 2009 | β |
| Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo. | Sullivan PF et al. | β | 2009 | β |
| Germ-line DNA polymorphisms and susceptibility to differentiated thyroid cancer. | Adjadj E et al. | β | 2009 | β |
| Identification and association analysis of single nucleotide polymorphisms in the human noggin (NOG) gene and osteoporosis phenotypes. | Moffett SP et al. | β | 2009 | β |
| Investigating the role of mitochondrial haplogroups in genetic predisposition to meningococcal disease. | Salas A et al. | β | 2009 | β |
| Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients. | Bowes JD et al. | β | 2009 | β |
| Methodological Issues in Multistage Genome-wide Association Studies. | Thomas DC et al. | β | 2009 | β |
| Mutual information for testing gene-environment interaction. | Wu X et al. | β | 2009 | β |
| Novel sequence variations in the brain-derived neurotrophic factor gene and association with major depression and antidepressant treatment response. | Licinio J et al. | β | 2009 | β |
| Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults. | Brito EC et al. | β | 2009 | β |
| Role of in silico tools in gene discovery. | Yu B | β | 2009 | β |
| SOD2 gene polymorphisms in neovascular age-related macular degeneration and polypoidal choroidal vasculopathy. | Kondo N et al. | β | 2009 | β |
| The impact of gene-environment dependence and misclassification in genetic association studies incorporating gene-environment interactions. | LindstrΓΆm S et al. | β | 2009 | β |
| The mitochondrial A10398G polymorphism, interaction with alcohol consumption, and breast cancer risk. | Pezzotti A et al. | β | 2009 | β |
| Two-stage analysis for gene-environment interaction utilizing both case-only and family-based analysis. | Chen YH et al. | β | 2009 | β |
| Using cases and parents to study multiplicative gene-by-environment interaction. | Kistner EO et al. | β | 2009 | β |
| A brain-derived neurotrophic factor (BDNF) haplotype is associated with antidepressant treatment outcome in mood disorders. | GratacΓ²s M et al. | β | 2008 | β |
| ARLTS1 germline variants and the risk for breast, prostate, and colorectal cancer. | Siltanen S et al. | β | 2008 | β |
| Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies. | Lewis JP et al. | β | 2008 | β |
| Association analysis of IL-12B and IL-23R polymorphisms in myocardial infarction. | Mangino M et al. | β | 2008 | β |
| Association of KLOTHO gene polymorphisms with knee osteoarthritis in Greek population. | Tsezou A et al. | β | 2008 | β |
| Environmental tobacco smoke and interleukin 4 polymorphism (C-589T) gene: environment interaction increases risk of wheezing in African-American infants. | Smith AM et al. | β | 2008 | β |
| ESR1 and EGF genetic variation in relation to breast cancer risk and survival. | EinarsdΓ³ttir K et al. | β | 2008 | β |
| Estimating interaction between genetic and environmental risk factors: efficiency of sampling designs within a cohort. | Bureau A et al. | β | 2008 | β |
| Evaluating the association of FAAH common gene variation with childhood, adult severe obesity and type 2 diabetes in the French population. | Durand E et al. | β | 2008 | β |
| Family-based methods for linkage and association analysis. | Laird NM et al. | β | 2008 | β |
| Gene-environment interactions for complex traits: definitions, methodological requirements and challenges. | Dempfle A et al. | β | 2008 | β |
| Genes and Environmental Exposures in Veterans with Amyotrophic Lateral Sclerosis: the GENEVA study. Rationale, study design and demographic characteristics. | Schmidt S et al. | β | 2008 | β |
| Genomewide association for schizophrenia in the CATIE study: results of stage 1. | Sullivan PF et al. | β | 2008 | β |
| Haplotypes of the estrogen receptor beta gene and breast cancer risk. | Breast and Prostate Cancer Cohort Consortium et al. | β | 2008 | β |
| HHEX gene polymorphisms are associated with type 2 diabetes in the Dutch Breda cohort. | van Vliet-Ostaptchouk JV et al. | β | 2008 | β |
| IGF-I and IGF-II genetic variation and breast cancer risk in Chinese women: results from the Shanghai Breast Cancer Study. | Deming SL et al. | β | 2008 | β |
| Lack of association of two common polymorphisms on 9p21 with risk of coronary heart disease and myocardial infarction; results from a prospective cohort study. | Dehghan A et al. | β | 2008 | β |
| Novel breast cancer risk alleles and endometrial cancer risk. | McGrath M et al. | β | 2008 | β |
| One-carbon metabolism-related gene polymorphisms and risk of breast cancer. | Suzuki T et al. | β | 2008 | β |
| Polymorphisms in nucleotide excision repair genes, smoking and intake of fruit and vegetables in relation to lung cancer. | Raaschou-Nielsen O et al. | β | 2008 | β |
| Preeclampsia risk and angiotensinogen polymorphisms M235T and AGT -217 in African American and Caucasian women. | Jenkins LD et al. | β | 2008 | β |
| Sample size and optimal design for logistic regression with binary interaction. | Demidenko E | β | 2008 | β |
| Sample size requirements for indirect association studies of gene-environment interactions (G x E). | Hein R et al. | β | 2008 | β |
| SUMO4 gene polymorphisms in Chinese Han patients with Behcet's disease. | Hou S et al. | β | 2008 | β |
| The growth differentiation factor 5 (GDF5) core promoter polymorphism is not associated with knee osteoarthritis in the Greek population. | Tsezou A et al. | β | 2008 | β |
| What can genome-wide association studies tell us about the genetics of common disease? | Iles MM | β | 2008 | β |
| 1484insG polymorphism of the PTPN1 gene is associated with insulin resistance in an Iranian population. | Meshkani R et al. | β | 2007 | β |
| A genetic association study of 5-HTT LPR and GNbeta3 C825T polymorphisms with irritable bowel syndrome. | Saito YA et al. | β | 2007 | β |
| An SNP in the 5'-UTR of GDF5 is associated with osteoarthritis susceptibility in Europeans and with in vivo differences in allelic expression in articular cartilage. | Southam L et al. | β | 2007 | β |
| Dense SNP association study for bipolar I disorder on chromosome 18p11 suggests two loci with excess paternal transmission. | Mulle JG et al. | β | 2007 | β |
| ENPP1 K121Q polymorphism and obesity, hyperglycaemia and type 2 diabetes in the prospective DESIR Study. | Meyre D et al. | β | 2007 | β |
| Exploiting gene-environment interaction to detect genetic associations. | Kraft P et al. | β | 2007 | β |
| Family-based association study of serotonergic candidate genes and attention-deficit/hyperactivity disorder in a German sample. | Heiser P et al. | β | 2007 | β |
| Gene-environment interaction in allergic disease: more questions, more answers? | Koppelman GH | β | 2007 | β |
| Gene-environment studies: any advantage over environmental studies? | Bermejo JL et al. | β | 2007 | β |
| Genetic association analysis of RHOB and TXNDC3 in osteoarthritis. | Loughlin J et al. | β | 2007 | β |
| Genetic polymorphisms and esophageal cancer risk. | Hiyama T et al. | β | 2007 | β |
| Inherited thrombophilia and stratification of ischaemic stroke risk among users of oral contraceptives. | Pezzini A et al. | β | 2007 | β |
| LGALS2 functional variant rs7291467 is not associated with susceptibility to myocardial infarction in Caucasians. | Mangino M et al. | β | 2007 | β |
| MIC1 and IL1RN genetic variation and advanced prostate cancer risk. | Cheng I et al. | β | 2007 | β |
| No evidence of association between genetic variants of the PDCD1 ligands and SLE. | Abelson AK et al. | β | 2007 | β |
| Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 (PPARgamma-2) gene is associated with greater insulin sensitivity and decreased risk of type 2 diabetes in an Iranian population. | Meshkani R et al. | β | 2007 | β |
| Serotonin Receptor 2A (HTR2A) Gene Polymorphisms Are Associated with Blood Pressure, Central Adiposity, and the Metabolic Syndrome. | Halder I et al. | β | 2007 | β |
| Spurious genetic associations. | Sullivan PF | β | 2007 | β |
| Study design options in evaluating gene-environment interactions: practical considerations for a planned case-control study of pediatric leukemia. | Goodman M et al. | β | 2007 | β |
| SULT1A1 genotype and susceptibility to colorectal cancer. | Lilla C et al. | β | 2007 | β |
| TGFB1 and TGFBR1 polymorphisms and breast cancer risk in the Nurses' Health Study. | Cox DG et al. | β | 2007 | β |
| The impact of genotype misclassification errors on the power to detect a gene-environment interaction using cox proportional hazards modeling. | Tung L et al. | β | 2007 | β |
| The p53 Arg72Pro and MDM2 -309 polymorphisms and risk of breast cancer in the nurses' health studies. | Cox DG et al. | β | 2007 | β |
| Xenobiotic metabolizing enzyme gene polymorphisms predict response to lung volume reduction surgery. | Hersh CP et al. | β | 2007 | β |
| Analysis of variations in the NAPG gene on chromosome 18p11 in bipolar disorder. | Weller AE et al. | β | 2006 | β |
| Analysis of variations in the tryptophan hydroxylase-2 (TPH2) gene in cocaine dependence. | Dahl JP et al. | β | 2006 | β |
| Association study of IL10, IL1beta, and IL1RN and schizophrenia using tag SNPs from a comprehensive database: suggestive association with rs16944 at IL1beta. | Shirts BH et al. | β | 2006 | β |
| Case-control genetic association studies in gastrointestinal disease: review and recommendations. | Saito YA et al. | β | 2006 | β |
| Comprehensive analysis of the ATM, CHEK2 and ERBB2 genes in relation to breast tumour characteristics and survival: a population-based case-control and follow-up study. | EinarsdΓ³ttir K et al. | β | 2006 | β |
| Frizzled-related protein variants are risk factors for hip osteoarthritis. | Lane NE et al. | β | 2006 | β |
| Genes, environment and the value of prospective cohort studies. | Manolio TA et al. | β | 2006 | β |
| Genetic linkage and association analysis of COPD-related traits on chromosome 8p. | Hersh CP et al. | β | 2006 | β |
| Genetics of Kidneys in Diabetes (GoKinD) study: a genetics collection available for identifying genetic susceptibility factors for diabetic nephropathy in type 1 diabetes. | Mueller PW et al. | β | 2006 | β |
| Gene x Gene interaction between MnSOD and GPX-1 and breast cancer risk: a nested case-control study. | Cox DG et al. | β | 2006 | β |
| Hypertension, obesity and GNB 3 gene variants. | Danoviz ME et al. | β | 2006 | β |
| Is there a folate-related gene-environment interaction in the etiology of childhood acute lymphoblastic leukemia? | Milne E et al. | β | 2006 | β |
| NOS2A and the modulating effect of cigarette smoking in Parkinson's disease. | Hancock DB et al. | β | 2006 | β |
| Parental smoking and the risk of childhood leukemia. | Chang JS et al. | β | 2006 | β |
| SNP-SNP interactions in breast cancer susceptibility. | Onay VU et al. | β | 2006 | β |
| The CALM1 core promoter polymorphism is not associated with hip osteoarthritis in a United Kingdom Caucasian population. | Loughlin J et al. | β | 2006 | β |
| The COL5A1 gene and Achilles tendon pathology. | Mokone GG et al. | β | 2006 | β |
| Analysis of vascular endothelial growth factor (VEGF) functional variants in rheumatoid arthritis. | Rueda B et al. | β | 2005 | β |
| Association analysis of CHMP1.5 genetic variation and bipolar disorder. | McNabb LD et al. | β | 2005 | β |
| Association of a polymorphism in the Homer1 gene with cocaine dependence in an African American population. | Dahl JP et al. | β | 2005 | β |
| Complex HTR2C linkage disequilibrium and promoter associations with body mass index and serum leptin. | McCarthy S et al. | β | 2005 | β |
| CTLA4/CT60 polymorphism is not relevant in susceptibility to autoimmune inflammatory intestinal disorders. | Rueda B et al. | β | 2005 | β |
| Design of case-controls studies with unscreened controls. | Moskvina V et al. | β | 2005 | β |
| Exploiting gene-environment independence in family-based case-control studies: increased power for detecting associations, interactions and joint effects. | Chatterjee N et al. | β | 2005 | β |
| Family-based case-control study of cigarette smoking and Parkinson disease. | Scott WK et al. | β | 2005 | β |
| Gene-environment interactions in human diseases. | Hunter DJ | β | 2005 | β |
| Genetic association studies. | Cordell HJ et al. | β | 2005 | β |
| Increased power to detect gene-environment interaction using siblings controls. | Andrieu N et al. | β | 2005 | β |
| Integrating epidemiology and genetic association: the challenge of gene-environment interaction. | Kraft P et al. | β | 2005 | β |
| Investigating the aspartic acid (D) repeat of asporin as a risk factor for osteoarthritis in a UK Caucasian population. | Mustafa Z et al. | β | 2005 | β |
| Lack of evidence for genetic association to RUNX1 binding site at PSORS2 in different German psoriasis cohorts. | HΓΌffmeier U et al. | β | 2005 | β |
| Novel exonic mu-opioid receptor gene (OPRM1) polymorphisms not associated with opioid dependence. | Smith RJ et al. | β | 2005 | β |
| Oral clefts, maternal smoking, and TGFA: a meta-analysis of gene-environment interaction. | Zeiger JS et al. | β | 2005 | β |
| Pharmacotherapy and pharmacogenetics of nicotine dependence. | Berrettini WH et al. | β | 2005 | β |
| Statistical design and analysis of pharmacogenetic trials. | Kelly PJ et al. | β | 2005 | β |
| The epidemiologic approach to pharmacogenomics. | Little J et al. | β | 2005 | β |
| The inherent complexities of gene-environment interactions. | Grigorenko EL | β | 2005 | β |
| Trick or treat: the effect of placebo on the power of pharmacogenetic association studies. | Singer C et al. | β | 2005 | β |
| Will the real disease gene please stand up? | Shephard N et al. | β | 2005 | β |
| A survey of current software for genetic power calculations. | Knight J | β | 2004 | β |
| Bayesian trio models for association in the presence of genotyping errors. | Bernardinelli L et al. | β | 2004 | β |
| Genetic dissection methods: designs used for tests of gene-environment interaction. | Liu X et al. | β | 2004 | β |
| Genetic polymorphisms of DNA repair and xenobiotic-metabolizing enzymes: effects on levels of sister chromatid exchanges and chromosomal aberrations. | Tuimala J et al. | β | 2004 | β |
| Sequential tests for gene-environment interactions in matched case-control studies. | Tweel Iv et al. | β | 2004 | β |
| The ACE gene and endurance performance during the South African Ironman Triathlons. | Collins M et al. | β | 2004 | β |
| The case-combined-control design was efficient in detecting gene-environment interactions. | Andrieu N et al. | β | 2004 | β |
| Toll-like receptor polymorphisms and allergic disease: interpreting the evidence from genetic studies. | Yang IA et al. | β | 2004 | β |
| Candidate gene association analysis for a quantitative trait, using parent-offspring trios. | Gauderman WJ | β | 2003 | β |
| The role of genetic factors in occupational asthma. | Mapp CE | β | 2003 | β |
| Codon 311 (Cys --> Ser) polymorphism of paraoxonase-2 gene is associated with apolipoprotein E4 allele in both Alzheimer's and vascular dementias. | Janka Z et al. | β | 2002 | β |
| The postmortem sociomedical interview: uncertainty in confirming infectious disease risks of young tattooed donors. | Scardino MK et al. | β | 2002 | β |