Pharmacological analysis of the heterogeneous discriminative stimulus effects of ethanol in rats using a three-choice ethanol-dizocilpine-water discrimination.
- Authors
- Bowen, C A; Grant, K A
- Year
- 1998
- Journal
- Psychopharmacology
- PMID
- 9768546
- DOI
- 10.1007/s002130050693
The present study used a three-choice operant drug discrimination procedure to determine if NMDA-mediated discriminative stimulus effects could be separated from other stimulus effects of 2.0 g/kg ethanol. Adult male Long-Evans rats (n = 7) were trained to discriminate dizocilpine (0.17 mg/kg; i.g.) from ethanol (2.0 g/kg; i.g.) from water (4.7 ml; i.g.) using food reinforcement. Substitution tests were conducted following administration of the GABA(A) positive modulators allopregnanolone (5.6-30.0 mg/kg; i.p.), diazepam (0.3-10.0 mg/kg; i.p.) and pentobarbital (1.0-21.0 mg/kg; i.p.), the non-competitive NMDA antagonist phencyclidine (0.3-10.0 mg/kg; i.p.), the 5-HT1 agonists TFMPP (0.3-5.6 mg/kg; i.p.) and RU 24969 (0.3-3.0 mg/kg; i.p.), and isopropanol (0.10-1.25 g/kg; i.p.). Allopregnanolone, diazepam and pentobarbital substituted completely (>80%) for ethanol. Isopropanol partially (77%) substituted for ethanol. Phencyclidine substituted completely for dizocilpine. RU 24969 and TFMPP did not completely substitute for either training drug, although RU 24969 partially (62%) substituted for ethanol. Successful training of this three-choice discrimination indicates that the discriminative stimulus effects of 0.17 mg/kg dizocilpine were separable from those of 2.0 g/kg ethanol. The finding that attenuation of NMDA-mediated effects of ethanol occurred without altering significantly GABA(A)- and 5-HT1-mediated effects suggests that the NMDA component may be independent of other discriminative stimulus effects of 2.0 g/kg ethanol.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Genetic vulnerability and susceptibility to substance dependence. | 2011 | 21338875 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| The persistent effects of exposure to a predator odor stressor on sensitivity to alcohol. | Tyler RE et al. | — | 2025 | → |
| mGlu<sub>2</sub> and mGlu<sub>3</sub> receptor negative allosteric modulators attenuate the interoceptive effects of alcohol in male and female rats. | Tyler RE et al. | — | 2024 | → |
| mGlu<sub>2</sub>and mGlu<sub>3</sub>receptor negative allosteric modulators attenuate the interoceptive effects of alcohol in male and female rats | Tyler RE et al. | — | 2022 | — |
| Genetic vulnerability and susceptibility to substance dependence. | Bierut LJ | — | 2011 | → |
| Effects of drugs and drug combinations in pigeons trained to discriminate among pentobarbital, dizocilpine, a combination of these drugs, and saline. | McMillan DE et al. | — | 2009 | → |
| Differentiating the discriminative stimulus effects of gamma-hydroxybutyrate and ethanol in a three-choice drug discrimination procedure in rats. | Baker LE et al. | — | 2008 | → |
| GABA(A) and opioid receptors of the central nucleus of the amygdala selectively regulate ethanol-maintained behaviors. | Foster KL et al. | — | 2004 | → |
| The GABA(A) receptor alpha1 subtype in the ventral pallidum regulates alcohol-seeking behaviors. | Harvey SC et al. | — | 2002 | → |
| Discrimination of pentobarbital doses and drug mixtures under fixed-ratio and fixed-interval reinforcement schedules. | McMillan DE et al. | — | 2001 | → |
| Four-choice drug discrimination in pigeons. | Li M et al. | — | 2001 | → |
| Generalisation of ethanol with drug mixtures containing a positive modulator of the GABA(A) receptor and an NMDA antagonist. | Stolerman IP et al. | — | 2001 | → |
| Influence of training history on ethanol discrimination in rats. | Stolerman IP et al. | — | 2000 | → |
| Increased specificity of ethanol's discriminative stimulus effects in an ethanol-pentobarbital-water discrimination in rats. | Bowen CA et al. | — | 1999 | → |
| Neurosteroids mediate pharmacological effects of ethanol: a new mechanism of ethanol action? | Morrow AL et al. | — | 1999 | → |
| Strategies for understanding the pharmacological effects of ethanol with drug discrimination procedures. | Grant KA | — | 1999 | → |