The TDT and other family-based tests for linkage disequilibrium and association.
paper
Cited
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- Authors
- Spielman, R S; Ewens, W J
- Year
- 1996
- Journal
- American journal of human genetics
- PMID
- 8900224
- PMCID
- PMC1914831
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| Lack of association between variations in the melanocortin 5 receptor gene and bipolar disorder. | Lohoff FW et al. | — | 2005 | → |
| Linkage disequilibrium and association studies in higher plants: present status and future prospects. | Gupta PK et al. | — | 2005 | → |
| No association between common variations in the human alpha 2 subunit gene (ATP1A2) of the sodium-potassium-transporting ATPase and idiopathic generalized epilepsy. | Lohoff FW et al. | — | 2005 | → |
| No association between common variations in the neuronal nicotinic acetylcholine receptor alpha2 subunit gene (CHRNA2) and bipolar I disorder. | Lohoff FW et al. | — | 2005 | → |
| Nonreplication in genetic studies of complex diseases--lessons learned from studies of osteoporosis and tentative remedies. | Shen H et al. | — | 2005 | → |
| Paraoxonase gene variants are associated with autism in North America, but not in Italy: possible regional specificity in gene-environment interactions. | D'Amelio M et al. | — | 2005 | → |
| Protein tyrosine phosphatase gene PTPN22 polymorphism in psoriasis: lack of evidence for association. | Nistor I et al. | — | 2005 | → |
| Rheumatoid arthritis seropositive for the rheumatoid factor is linked to the protein tyrosine phosphatase nonreceptor 22-620W allele. | Dieudé P et al. | — | 2005 | → |
| Statistical distribution of blood serotonin as a predictor of early autistic brain abnormalities. | Janusonis S | — | 2005 | → |
| Tapasin gene polymorphism in systemic onset juvenile rheumatoid arthritis: a family-based case-control study. | Bukulmez H et al. | — | 2005 | → |
| The methionine allele of the COMT polymorphism impairs prefrontal cognition in children and adolescents with ADHD. | Bellgrove MA et al. | — | 2005 | → |
| The molecular-genetic basis of functional hyperandrogenism and the polycystic ovary syndrome. | Escobar-Morreale HF et al. | — | 2005 | → |
| Uteroglobin-related protein 1(UGRP1) gene polymorphisms and atopic asthma in the Indian population. | Batra J et al. | — | 2005 | → |
| Variants in estrogen-biosynthesis genes CYP17 and CYP19 and breast cancer risk: a family-based genetic association study. | Ahsan H et al. | — | 2005 | → |
| Vitamin D receptor gene polymorphisms are linked to and associated with adult height. | Xiong DH et al. | — | 2005 | → |
| What is known about autism: genes, brain, and behavior. | Santangelo SL et al. | — | 2005 | → |
| A case-control and family-based association study of the 5-HTTLPR in pediatric-onset depressive disorders. | Nobile M et al. | — | 2004 | → |
| A family-based genetic association study of variants in estrogen-metabolism genes COMT and CYP1B1 and breast cancer risk. | Ahsan H et al. | — | 2004 | → |
| A powerful strategy to account for multiple testing in the context of haplotype analysis. | Becker T et al. | — | 2004 | → |
| Association analysis of cystatin A and zinc finger protein 148, two genes located at the psoriasis susceptibility locus PSORS5. | Samuelsson L et al. | — | 2004 | → |
| Association between 10 microsatellite markers and nonsyndromic cleft lip palate in the Chilean population. | Blanco R et al. | — | 2004 | → |
| Association of genetic loci: replication or not, that is the question. | Ott J | — | 2004 | → |
| Association of tryptophan 2,3 dioxygenase gene polymorphism with autism. | Nabi R et al. | — | 2004 | → |
| A transmission disequilibrium test for general pedigrees that is robust to the presence of random genotyping errors and any number of untyped parents. | Gordon D et al. | — | 2004 | → |
| Combining the transmission disequilibrium test and case-control methodology using generalized logistic regression. | Nagelkerke NJ et al. | — | 2004 | → |
| Complexities in psychiatric genetics. | Sanders AR et al. | — | 2004 | → |
| Enhanced APOE2 transmission rates in families with autistic probands. | Persico AM et al. | — | 2004 | → |
| Evidence that the risk of spina bifida is influenced by genetic variation at the NOS3 locus. | Brown KS et al. | — | 2004 | → |
| False positive rates in association studies as a function of degree of stratification. | Koller DL et al. | — | 2004 | → |
| Family-based association studies between 5-HT5A receptor gene and schizophrenia. | Dubertret C et al. | — | 2004 | → |
| Family-based association study between autism and glutamate receptor 6 gene in Chinese Han trios. | Shuang M et al. | — | 2004 | → |
| Family-based association study of the serotonin-6 receptor gene (C267T polymorphism) in schizophrenia. | Dubertret C et al. | — | 2004 | → |
| Frequency and transmission of glutamate receptors GRIK2 and GRIK3 polymorphisms in patients with obsessive compulsive disorder. | Delorme R et al. | — | 2004 | → |
| Genetic determinants of the inflammatory response. | Imahara SD et al. | — | 2004 | → |
| Genetic epidemiology: some special contributions of birth cohorts. | Pembrey M | — | 2004 | → |
| Genetics and drug use as a complex phenotype. | Lessov CN et al. | — | 2004 | → |
| Genetics of ovarian disorders: polycystic ovary syndrome. | Franks S et al. | — | 2004 | → |
| Genetics of Parkinson disease. | Pankratz N et al. | — | 2004 | → |
| HLA and hypocomplementemia: the disadvantage of carrying the HLA-B35 and the silent alleles of the C4 complement component. | Zorzetto M et al. | — | 2004 | → |
| Identification of five chromosomal regions involved in predisposition to melanoma by genome-wide scan in the MeLiM swine model. | Geffrotin C et al. | — | 2004 | → |
| Lack of association between VNTR polymorphism of dopamine transporter gene (SLC6A3) and schizophrenia in a Brazilian sample. | Cordeiro Q et al. | — | 2004 | → |
| Lack of evidence for association between serotonin transporter gene (5-HTTLPR) and obsessive-compulsive disorder by case control and family association study in humans. | Chabane N et al. | — | 2004 | → |
| Linkage of the dopamine receptor D1 gene to attention-deficit/hyperactivity disorder. | Misener VL et al. | — | 2004 | → |
| Linkage studies of schizophrenia. | Riley B | — | 2004 | → |
| Localizing a putative mutation as the major contributor to the development of sporadic Hirschsprung disease to the RET genomic sequence between the promoter region and exon 2. | Burzynski GM et al. | — | 2004 | → |
| Mapping disease-susceptibility genes in admixed populations using interval principal component tests. | Lee WC et al. | — | 2004 | → |
| Maternal transmission disequilibrium of the glutamate receptor GRIK2 in schizophrenia. | Bah J et al. | — | 2004 | → |
| Multiple marker analysis at the promoter region of the DRD4 gene and ADHD: evidence of linkage and association with the SNP -616. | Lowe N et al. | — | 2004 | → |
| New approach to association testing in case-parent designs under informative parental missingness. | Chen YH | — | 2004 | → |
| Polymorphisms in xenobiotic metabolism genes and autism. | Serajee FJ et al. | — | 2004 | → |
| Robust transmission/disequilibrium test for incomplete family genotypes. | Sebastiani P et al. | — | 2004 | → |
| The genes for schizophrenia: finally a breakthrough? | Shirts BH et al. | — | 2004 | → |
| The microsatellite alleles on chromosome 1 associated with essential hypertension and blood pressure levels. | Nakayama T et al. | — | 2004 | → |
| The potential role of genes in nonalcoholic fatty liver disease. | Day CP | — | 2004 | → |
| The University of California, San Francisco Family Alcoholism Study. I. Design, methods, and demographics. | Vieten C et al. | — | 2004 | → |
| Transmission disequilibrium test (TDT) for case-control studies. | Ruiz-Narváez EA et al. | — | 2004 | → |
| Transmission of parentally shared human leukocyte antigen alleles and the risk of preterm delivery. | Li DK et al. | — | 2004 | → |
| Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations. | Edenberg HJ et al. | — | 2004 | → |
| von Willebrand's disease and psychotic disorders: co-segregation and genetic associations. | Lee YS et al. | — | 2004 | → |
| Accounting for linkage in family-based tests of association with missing parental genotypes. | Martin ER et al. | — | 2003 | → |
| Admixture mapping using interval transmission/disequilibrium tests. | Lee WC et al. | — | 2003 | → |
| A general class of association tests for family-based data using weight functions. | Liu X et al. | — | 2003 | → |
| A genome-wide scan for loci predisposing to non-syndromic cleft lip with or without cleft palate in two large Syrian families. | Wyszynski DF et al. | — | 2003 | → |
| Alpha-adducin gene polymorphism is associated with essential hypertension in Chinese: a case-control and family-based study. | Ju Z et al. | — | 2003 | → |
| An update on the genetics of Gilles de la Tourette syndrome. | Pauls DL | — | 2003 | → |
| Association analysis of monoamine oxidase A and attention deficit hyperactivity disorder. | Lawson DC et al. | — | 2003 | → |
| Association of GABA(A) receptors and alcohol dependence and the effects of genetic imprinting. | Song J et al. | — | 2003 | → |
| Association of INPP1, PIK3CG, and TSC2 gene variants with autistic disorder: implications for phosphatidylinositol signalling in autism. | Serajee FJ et al. | — | 2003 | → |
| Association studies for asthma and atopic diseases: a comprehensive review of the literature. | Hoffjan S et al. | — | 2003 | → |
| Candidate gene analysis of the human metabotropic glutamate receptor type 4 (GRM4) in patients with juvenile myoclonic epilepsy. | Izzi C et al. | — | 2003 | → |
| CARD15 gene mutations in sarcoidosis. | Schürmann M et al. | — | 2003 | → |
| Detecting genotype combinations that increase risk for disease: maternal-fetal genotype incompatibility test. | Sinsheimer JS et al. | — | 2003 | → |
| Disease associations and family-based tests. | Ewens WJ et al. | — | 2003 | → |
| Does accounting for gene-environment (GxE) interaction increase the power to detect the effect of a gene in a multifactorial disease? | Selinger-Leneman H et al. | — | 2003 | → |
| Effects of dopamine transporter and receptor polymorphisms on smoking cessation in a bupropion clinical trial. | Lerman C et al. | — | 2003 | → |
| Elucidating the role of genetic factors in smoking behavior and nicotine dependence. | Lerman C et al. | — | 2003 | → |
| Estimation and testing of parent-of-origin effects for quantitative traits. | Whittaker JC et al. | — | 2003 | → |
| Family-based and case-control association studies of catechol-O-methyltransferase in attention deficit hyperactivity disorder suggest genetic sexual dimorphism. | Qian Q et al. | — | 2003 | → |
| From genomics to proteomics: new directions in molecular neuropsychiatry. | Eisener AF et al. | — | 2003 | → |
| Genes of the LMP/TAP cluster are associated with the human autoimmune disease vitiligo. | Casp CB et al. | — | 2003 | → |
| Genetic approaches to stature, pubertal timing, and other complex traits. | Palmert MR et al. | — | 2003 | → |
| Genetic association tests for family data with missing parental genotypes: a comparison. | Whittemore AS et al. | — | 2003 | → |
| Genetic linkage and association studies in bipolar affective disorder: a time for optimism. | Schulze TG et al. | — | 2003 | → |
| Genotype-based association test for general pedigrees: the genotype-PDT. | Martin ER et al. | — | 2003 | → |
| Hierarchical modeling of linkage disequilibrium: genetic structure and spatial relations. | Conti DV et al. | — | 2003 | → |
| Nonparametric disequilibrium mapping of functional sites using haplotypes of multiple tightly linked single-nucleotide polymorphism markers. | Cheng R et al. | — | 2003 | → |
| Parathyroid hormone gene with bone phenotypes in Chinese. | Zhou XG et al. | — | 2003 | → |
| Pedigree disequilibrium tests for multilocus haplotypes. | Dudbridge F | — | 2003 | → |
| Psychopathology in the postgenomic era. | Plomin R et al. | — | 2003 | → |
| Sequence variation in the promoter region of the cholinergic receptor muscarinic 3 gene and asthma and atopy. | Donfack J et al. | — | 2003 | → |
| Sum statistics for the joint detection of multiple disease loci in case-control association studies with SNP markers. | Wille A et al. | — | 2003 | → |
| Teratogenic alleles and neurodevelopmental disorders. | Johnson WG | — | 2003 | → |
| The metabotropic glutamate receptor 8 gene at 7q31: partial duplication and possible association with autism. | Serajee FJ et al. | — | 2003 | → |
| Analysis of ten candidate genes in autism by association and linkage. | Philippe A et al. | — | 2002 | → |
| Association between a GABRB3 polymorphism and autism. | Buxbaum JD et al. | — | 2002 | → |
| Association between anorexia nervosa and the hsKCa3 gene: a family-based and case control study. | Koronyo-Hamaoui M et al. | — | 2002 | → |
| Association of the 867Asp variant of the human anion exchanger 3 gene with common subtypes of idiopathic generalized epilepsy. | Sander T et al. | — | 2002 | → |
| A unified framework for transmission-disequilibrium test analysis of discrete and continuous traits. | Liu Y et al. | — | 2002 | → |
| Combined segregation and linkage analysis of HLA markers in familial psoriasis. | Guo SW et al. | — | 2002 | → |
| Essential hypertension and beta2-adrenergic receptor gene: linkage and association analysis. | Tomaszewski M et al. | — | 2002 | → |
| Evidence that BCL3 plays a role in the etiology of nonsyndromic oral clefts in Brazilian families. | Gaspar DA et al. | — | 2002 | → |
| For further investigations in IgA nephropathy the approach from phenotype to genotype is welcome. | Schena FP | — | 2002 | → |
| Gelatinase B, PECAM-1 and MCP-3 gene polymorphisms in Belgian multiple sclerosis. | Nelissen I et al. | — | 2002 | → |
| Genetic analysis in human hypertension. | Kato N | — | 2002 | → |
| Genetic analysis of the (CTG)n NOTCH4 polymorphism in 65 multiplex bipolar pedigrees. | Swift-Scanlan T et al. | — | 2002 | → |
| Genetic association mapping at the crossroads: which test and why? Overview and practical guidelines. | Schulze TG et al. | — | 2002 | → |
| Genetic association of the catalase gene (CAT) with vitiligo susceptibility. | Casp CB et al. | — | 2002 | → |
| Genetics of osteoporosis. | Peacock M et al. | — | 2002 | → |
| Genetic strategies to detect genes involved in alcoholism and alcohol-related traits. | Dick DM et al. | — | 2002 | → |
| Genome screening for susceptibility loci in systemic lupus erythematosus. | Shirai T et al. | — | 2002 | → |
| Haplotype block structure and its applications to association studies: power and study designs. | Zhang K et al. | — | 2002 | → |
| HLA in coeliac disease families: a novel test of risk modification by the 'other' haplotype when at least one DQA1*05-DQB1*02 haplotype is carried. | Louka AS et al. | — | 2002 | → |
| Human genetic variation and mental disorders. | Arias B et al. | — | 2002 | → |
| Identification of a psoriasis susceptibility candidate gene by linkage disequilibrium mapping with a localized single nucleotide polymorphism map. | Hewett D et al. | — | 2002 | → |
| Joint linkage and linkage disequilibrium mapping of quantitative trait loci in natural populations. | Wu R et al. | — | 2002 | → |
| Linkage analysis of twelve candidate gene loci regulating water and sodium metabolism and membrane ion transport in essential hypertension. | Chu SL et al. | — | 2002 | → |
| Linkage and association of the glutamate receptor 6 gene with autism. | Jamain S et al. | — | 2002 | → |
| Maternal genetic effects, exerted by genes involved in homocysteine remethylation, influence the risk of spina bifida. | Doolin MT et al. | — | 2002 | → |
| Methodological aspects of investigating gene-nutrient interactions. | Bonaïti-Pellié C | — | 2002 | → |
| Multiple sclerosis in the tropics: genetic association to STR's loci spanning the HLA and TNF. | Palacio LG et al. | — | 2002 | → |
| Mutation screening and association of human retinoid X receptor gamma variation with lipid levels in familial type 2 diabetes. | Wang H et al. | — | 2002 | → |
| Mutation screening and transmission disequilibrium study of ATP10C in autism. | Kim SJ et al. | — | 2002 | → |
| Polymorphisms in the TNF region confer susceptibility to UVB-induced impairment of contact hypersensitivity induction in mice and humans. | Niizeki H et al. | — | 2002 | → |
| "Power comparisons for genotypic vs. allelic TDT methods with >2 alleles". | Fallin D et al. | — | 2002 | → |
| Properties of the transmission-disequilibrium test in the presence of inbreeding. | Génin E et al. | — | 2002 | → |
| Role of genetics in osteoporosis. | Recker RR et al. | — | 2002 | → |
| Serotonin transporter gene promoter variants do not explain the hyperserotoninemia in autistic children. | Persico AM et al. | — | 2002 | → |
| Studies with His475Tyr glutamate carboxipeptidase II polymorphism and neural tube defects. | Vieira AR et al. | — | 2002 | → |
| Tests of linkage and/or association of genes for vitamin D receptor, osteocalcin, and parathyroid hormone with bone mineral density. | Deng HW et al. | — | 2002 | → |
| The changing face of epidemiology in the genomics era. | Millikan R | — | 2002 | → |
| The genetic basis for psychiatric illness in man. | Tandon K et al. | — | 2002 | → |
| The genetics of autoimmune polyendocrine syndrome type II. | Robles DT et al. | — | 2002 | → |
| TNF-alpha, IL1-beta, and immunoglobulin (GM and KM) gene polymorphisms in sarcoidosis. | Pandey JP et al. | — | 2002 | → |
| Transmission disequilibrium testing of arginine vasopressin receptor 1A (AVPR1A) polymorphisms in autism. | Kim SJ et al. | — | 2002 | → |
| A case-control study of nonsyndromic oral clefts in Maryland. | Beaty TH et al. | — | 2001 | → |
| A family-based strategy to identify genes for diabetic nephropathy. | Covic AM et al. | — | 2001 | → |
| A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. | Ogura Y et al. | — | 2001 | → |
| Approaches to gene mapping in complex disorders and their application in child psychiatry and psychology. | Asherson PJ et al. | — | 2001 | → |
| Association analysis of HLA-class II and class III gene polymorphisms in the susceptibility to mediterranean visceral leishmaniasis. | Meddeb-Garnaoui A et al. | — | 2001 | → |
| Association and excess of transmission of a DRD2 haplotype in a sample of French schizophrenic patients. | Dubertret C et al. | — | 2001 | → |
| Association of the interleukin 1 receptor antagonist gene with ulcerative colitis in Northern European Caucasians. | Carter MJ et al. | — | 2001 | → |
| Association studies of bipolar disorder. | Craddock N et al. | — | 2001 | → |
| Association study designs for complex diseases. | Cardon LR et al. | — | 2001 | → |
| Candidate gene case-control association studies: advantages and potential pitfalls. | Daly AK et al. | — | 2001 | → |
| Candidate gene studies of bipolar disorder. | Jones I et al. | — | 2001 | → |
| Case control and family-based studies of tryptophan hydroxylase gene A218C polymorphism and suicidality in adolescents. | Zalsman G et al. | — | 2001 | → |
| Case-control studies of association in structured or admixed populations. | Pritchard JK et al. | — | 2001 | → |
| Comparison of novel and existing methods for detection of linkage disequilibrium using parent-child trios in the GAW12 genetic isolate simulated data. | Bailey-Wilson JE et al. | — | 2001 | → |
| Detection of human genetic linkage: foundations. | Thompson E | — | 2001 | → |
| Effect of polygenes on Xiong's transmission disequilibrium test of a QTL in nuclear families with multiple children. | Deng HW et al. | — | 2001 | → |
| Evidence for linkage disequilibrium between the dopamine transporter and bipolar disorder. | Greenwood TA et al. | — | 2001 | → |
| Family-based association studies of monoaminergic gene polymorphisms among North Indians with schizophrenia. | Semwal P et al. | — | 2001 | → |
| Family-based association study of serotonin transporter promoter in suicidal adolescents: no association with suicidality but possible role in violence traits. | Zalsman G et al. | — | 2001 | → |
| Family-based transmission disequilibrium test (TDT) and case-control association studies reveal surfactant protein A (SP-A) susceptibility alleles for respiratory distress syndrome (RDS) and possible race differences. | Floros J et al. | — | 2001 | → |
| Family study of non-responsiveness to hepatitis B vaccine confirms the importance of HLA class III C4A locus. | De Silvestri A et al. | — | 2001 | → |
| Further evidence for linkage of Gilles de la Tourette syndrome (GTS) susceptibility loci on chromosomes 2p11, 8q22 and 11q23-24 in South African Afrikaners. | Simonic I et al. | — | 2001 | → |
| Further refinement of the MYP2 locus for autosomal dominant high myopia by linkage disequilibrium analysis. | Young TL et al. | — | 2001 | → |
| Genetic association analysis of behavioral inhibition using candidate loci from mouse models. | Smoller JW et al. | — | 2001 | → |
| Genetic determinants of ethanol-induced liver damage. | Monzoni A et al. | — | 2001 | → |
| Genetics of affective disorders. | Johansson C et al. | — | 2001 | → |
| Genetics of autism. | Cook EH | — | 2001 | → |
| Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease. | Rioux JD et al. | — | 2001 | → |
| Genome scan for linkage to asthma using a linkage disequilibrium-lod score test. | Jiang Y et al. | — | 2001 | → |
| Genomic organization of the SLC1A1/EAAC1 gene and mutation screening in early-onset obsessive-compulsive disorder. | Veenstra-VanderWeele J et al. | — | 2001 | → |
| Haplotyping and estimation of haplotype frequencies for closely linked biallelic multilocus genetic phenotypes including nuclear family information. | Rohde K et al. | — | 2001 | → |
| Introduction: association and transmission/disequilibrium test analyses of discrete traits in the GAW12 simulated data. | Bailey-Wilson JE | — | 2001 | → |
| [Introduction to genetic psychiatry: progress in uncovering genetic susceptibility to psychiatric disorders]. | Roy MA et al. | — | 2001 | → |
| Investigation of a candidate gene, environment, and G x E interaction using case-control and case-parent study designs. | Norris JM et al. | — | 2001 | → |
| Linkage and association of HLA class II genes with vitiligo in a Dutch population. | Zamani M et al. | — | 2001 | → |
| Linkage of HLA to myasthenia gravis and genetic heterogeneity depending on anti-titin antibodies. | Giraud M et al. | — | 2001 | → |
| Linkage of hypertension to chromosome 2q14-q23 in Chinese families. | Zhu DL et al. | — | 2001 | → |
| Linkage studies between attention-deficit hyperactivity disorder and the monoamine oxidase genes. | Jiang S et al. | — | 2001 | → |
| Markers close to the dopamine D5 receptor gene (DRD5) show significant association with schizophrenia but not bipolar disorder. | Muir WJ et al. | — | 2001 | → |
| MC1R genotype modifies risk of melanoma in families segregating CDKN2A mutations. | Box NF et al. | — | 2001 | → |
| Molecular mechanisms of human hypertension. | Lifton RP et al. | — | 2001 | → |
| Multipoint linkage-disequilibrium-mapping approach based on the case-parent trio design. | Liang KY et al. | — | 2001 | → |
| Neural networks and disease association studies. | Ott J | — | 2001 | → |
| No association between the 4g/5G polymorphism of the plasminogen activator inhibitor-1 gene promoter and autistic disorder. | Persico AM et al. | — | 2001 | → |
| Possible relationship between the van der Woude syndrome (vWS) locus and nonsyndromic cleft lip with or without cleft palate (NSCL/P). | Houdayer C et al. | — | 2001 | → |
| Reelin gene alleles and haplotypes as a factor predisposing to autistic disorder. | Persico AM et al. | — | 2001 | → |
| Role of the serotonin transporter gene in the behavioral expression of autism. | Tordjman S et al. | — | 2001 | → |
| Sex, genes and blood pressure. | Ellis JA et al. | — | 2001 | → |
| Testing for colon neoplasia susceptibility variants at the human COX2 locus. | Wiesner GL et al. | — | 2001 | → |
| The genetics of complex autoimmune diseases: non-MHC susceptibility genes. | Wandstrat A et al. | — | 2001 | → |
| The genetics of Tourette syndrome. | Pauls DL | — | 2001 | → |
| The natural history of primary biliary cirrhosis: of genes and cooperation. | Gershwin ME | — | 2001 | → |
| The tissue transglutaminase gene is not a primary factor predisposing to celiac disease. | van Belzen MJ et al. | — | 2001 | → |
| The use of common genetic polymorphisms to enhance the epidemiologic study of environmental carcinogens. | Rothman N et al. | — | 2001 | → |
| Trimming, weighting, and grouping SNPs in human case-control association studies. | Hoh J et al. | — | 2001 | → |
| Two newly identified SNPs in the APO AI-CIII intergenic region are strongly associated with familial combined hyperlipidaemia. | Groenendijk M et al. | — | 2001 | → |
| Using complex plant pedigrees to map valuable genes. | Jannink J et al. | — | 2001 | → |
| Wingless-type frizzled protein receptor signaling and its putative role in human colon cancer. | Uthoff SM et al. | — | 2001 | → |
| Adenosine deaminase alleles and autistic disorder: case-control and family-based association studies. | Persico AM et al. | — | 2000 | → |
| A Monte Carlo procedure for two-stage tests with correlated data. | Martin ER et al. | — | 2000 | → |
| Analysis of linkage disequilibrium in gamma-aminobutyric acid receptor subunit genes in autistic disorder. | Martin ER et al. | — | 2000 | → |
| An analytic solution to single nucleotide polymorphism error-detection rates in nuclear families: implications for study design. | Gordon D et al. | — | 2000 | → |
| Angiotensin I-converting enzyme gene insertion/deletion and angiotensinogen M235T polymorphisms: risk of chronic renal failure. End-Stage Renal Disease Study Group. | Gumprecht J et al. | — | 2000 | → |
| A novel variant of the MHC-linked hsp70, hsp70-hom, is associated with rheumatoid arthritis. | Jenkins SC et al. | — | 2000 | → |
| Antisociality, substance dependence, and the DRD5 gene: a preliminary study. | Vanyukov MM et al. | — | 2000 | → |
| A search for susceptibility loci for anorexia nervosa: methods and sample description. | Kaye WH et al. | — | 2000 | → |
| A second-generation genomewide screen for asthma-susceptibility alleles in a founder population. | Ober C et al. | — | 2000 | → |
| Assessment of the non-HLA-DR-DQ contribution to IDDM1 in British Caucasian families: analysis of LMP7 polymorphisms. | McTernan CL et al. | — | 2000 | → |
| Association between the alpha-adducin gene and hypertension in the HyperGEN Study. | Province MA et al. | — | 2000 | → |
| Association between the Glu298Asp polymorphism in the endothelial constitutive nitric oxide synthase gene and brain infarction. The GENIC Investigators. | Elbaz A et al. | — | 2000 | → |
| A test for linkage and association in general pedigrees: the pedigree disequilibrium test. | Martin ER et al. | — | 2000 | → |
| beta(2)-adrenergic receptor Arg16/Arg16 genotype is associated with reduced lung function, but not with asthma, in the Hutterites. | Summerhill E et al. | — | 2000 | → |
| Celiac disease and TNF promoter polymorphisms. | de la Concha EG et al. | — | 2000 | → |
| Circumventing multiple testing: a multilocus Monte Carlo approach to testing for association. | McIntyre LM et al. | — | 2000 | → |
| Comparison of tests for association and linkage in incomplete families. | Cervino AC et al. | — | 2000 | → |
| CTLA-4 gene polymorphism confers susceptibility to primary biliary cirrhosis. | Agarwal K et al. | — | 2000 | → |
| Deciphering diabetic nephropathy: progress using genetic strategies. | Adler SG et al. | — | 2000 | → |
| Detection of disease genes by use of family data. II. Application to nuclear families. | Tu IP et al. | — | 2000 | → |
| Detection of disease genes by use of family data. I. Likelihood-based theory. | Whittemore AS et al. | — | 2000 | → |
| Evaluation of IBD candidate genes and the case of NRAMP2. | Brant SR | — | 2000 | → |
| Exploiting excess sharing: a more powerful test of linkage for affected sib pairs than the transmission/disequilibrium test. | Wicks J | — | 2000 | → |
| Family-based association studies. | Zhao H | — | 2000 | → |
| Genetics of body-weight regulation. | Barsh GS et al. | — | 2000 | → |
| Genetic studies of autism: from the 1970s into the millennium. | Rutter M | — | 2000 | → |
| Genetic studies of substance abuse. | Vanyukov MM et al. | — | 2000 | → |
| Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci. | Rioux JD et al. | — | 2000 | → |
| HLA-DRB1*01 alleles are associated with sensitization to cockroach allergens. | Donfack J et al. | — | 2000 | → |
| HLA-DRB1*04 and susceptibility to type 1 diabetes mellitus in a German/Belgian family and German case-control study. The Belgian Diabetes Registry. | Donner H et al. | — | 2000 | → |
| Identifying autism susceptibility genes. | Maestrini E et al. | — | 2000 | → |
| Interleukin 1 receptor antagonist (IL-1ra) in multiple sclerosis. | Feakes R et al. | — | 2000 | → |
| Lack of association between serotonin transporter gene promoter variants and autistic disorder in two ethnically distinct samples. | Persico AM et al. | — | 2000 | → |
| Linkage disequilibrium analysis of biallelic DNA markers, human quantitative trait loci, and threshold-defined case and control subjects. | Schork NJ et al. | — | 2000 | → |
| Linkage disequilibrium and the search for complex disease genes. | Jorde LB | — | 2000 | → |
| Localization of psoriasis-susceptibility locus PSORS1 to a 60-kb interval telomeric to HLA-C. | Nair RP et al. | — | 2000 | → |
| Molecular heterosis: a review. | Comings DE et al. | — | 2000 | → |
| Mutation screening of the chromosome 8q24.3-human activity-regulated cytoskeleton-associated gene (ARC) in idiopathic generalized epilepsy. | Haug K et al. | — | 2000 | → |
| Pharmacogenetics and the serotonin system: initial studies and future directions. | Veenstra-VanderWeele J et al. | — | 2000 | → |
| Pharmacogenetics. Promise and potential in child and adolescent psychiatry. | Anderson GM et al. | — | 2000 | → |
| Pharmacogenomics and addiction to opiates. | Lichtermann D et al. | — | 2000 | → |
| Polymorphisms of the IL-4, TNF-alpha, and Fcepsilon RIbeta genes and the risk of allergic disorders in at-risk infants. | Zhu S et al. | — | 2000 | → |
| Pooled genotyping of microsatellite markers in parent-offspring trios. | Kirov G et al. | — | 2000 | → |
| Relationship between case-control studies and the transmission/disequilibrium test. | Mitchell LE | — | 2000 | → |
| Removing the sampling restrictions from family-based tests of association for a quantitative-trait locus. | Monks SA et al. | — | 2000 | → |
| RET genotypes comprising specific haplotypes of polymorphic variants predispose to isolated Hirschsprung disease. | Borrego S et al. | — | 2000 | → |
| Searching for a locus for schizophrenia within chromosome Xp11. | Wei J et al. | — | 2000 | → |
| Serotonin transporter gene and schizophrenia: evidence for association/linkage disequilibrium in families with affected siblings. | Hranilovic D et al. | — | 2000 | → |
| S gene (Corneodesmosin) diversity and its relationship to psoriasis; high content of cSNP in the HLA-linked S gene. | Enerbäck C et al. | — | 2000 | → |
| Some properties of a variance components model for fine-mapping quantitative trait loci. | Cardon LR et al. | — | 2000 | → |
| Statistical approaches to gene mapping. | Ott J et al. | — | 2000 | → |
| The NOTCH4 locus is associated with susceptibility to schizophrenia. | Wei J et al. | — | 2000 | → |
| The use of case-parent triads to study joint effects of genotype and exposure. | Umbach DM et al. | — | 2000 | → |
| Transmission/disequilibrium tests using multiple tightly linked markers. | Zhao H et al. | — | 2000 | → |
| Ultradian rapid cycling in prepubertal and early adolescent bipolarity is not in transmission disequilibrium with val/met COMT alleles. | Geller B et al. | — | 2000 | → |
| Unbiased application of the transmission/disequilibrium test to multilocus haplotypes. | Dudbridge F et al. | — | 2000 | → |
| Use of classification trees for association studies. | Zhang H et al. | — | 2000 | → |
| Variation in the interleukin 4-receptor alpha gene confers susceptibility to asthma and atopy in ethnically diverse populations. | Ober C et al. | — | 2000 | → |
| A fifth locus for Bardet-Biedl syndrome maps to chromosome 2q31. | Young TL et al. | — | 1999 | → |
| Allowing for missing parents in genetic studies of case-parent triads. | Weinberg CR | — | 1999 | → |
| A logistic regression extension of the transmission disequilibrium test for continuous traits: application to linkage disequilibrium between alcoholism and the candidate genes DRD2 and ADH3. | Waldman ID et al. | — | 1999 | → |
| Applicability of the case-parent design in the etiological research of Type 1 diabetes in Chile and other genetically mixed populations. | Santos JL et al. | — | 1999 | → |
| A program for the monte carlo evaluation of significance of the extended transmission/disequilibrium test. | Zhao JH et al. | — | 1999 | → |
| A screen of candidates from peaks of linkage: evidence for the involvement of myeloperoxidase in multiple sclerosis. | Chataway J et al. | — | 1999 | → |
| A test of transmission/disequilibrium for quantitative traits in pedigree data, by multiple regression. | George V et al. | — | 1999 | → |
| Basic concepts in the study of diseases with complex genetics. | Burmeister M | — | 1999 | → |
| Benefits and pitfalls encountered in psychiatric genetic association studies. | Malhotra AK et al. | — | 1999 | → |
| Characterization of the major susceptibility region for psoriasis at chromosome 6p21.3. | Balendran N et al. | — | 1999 | → |
| Cladistic association analysis of Y chromosome effects on alcohol dependence and related personality traits. | Kittles RA et al. | — | 1999 | → |
| Comparison of linkage-disequilibrium methods for localization of genes influencing quantitative traits in humans. | Page GP et al. | — | 1999 | → |
| Do schizophrenia and affective disorder share susceptibility genes? | Wildenauer DB et al. | — | 1999 | → |
| Exploring genetic analysis of complex traits through the paradigm of alcohol dependence: summary of GAW11 contributions. | Almasy L et al. | — | 1999 | → |
| Exploring the dense mapping of a region of potential linkage in complex disease: an example in multiple sclerosis. | Feakes R et al. | — | 1999 | → |
| Finite-sample properties of family-based association tests. | Whittaker JC et al. | — | 1999 | → |
| Gene mapping by linkage and association analysis. | March RE | — | 1999 | → |
| Genetic linkage of IgA deficiency to the major histocompatibility complex: evidence for allele segregation distortion, parent-of-origin penetrance differences, and the role of anti-IgA antibodies in disease predisposition. | Vorechovský I et al. | — | 1999 | → |
| Genetic mapping of complex traits. | Olson JM et al. | — | 1999 | → |
| Genetic susceptibility and ischaemic stroke. | Elbaz A et al. | — | 1999 | → |
| Lack of evidence for association between the endothelial nitric oxide synthase gene and hypertension. | Kato N et al. | — | 1999 | → |
| Linkage detection adaptive to linkage disequilibrium: the disequilibrium maximum-likelihood-binomial test for affected-sibship data. | Huang J et al. | — | 1999 | → |
| Linkage mapping for hypertension susceptibility genes. | Kato N et al. | — | 1999 | → |
| Methionine synthase: high-resolution mapping of the human gene and evaluation as a candidate locus for neural tube defects. | Brody LC et al. | — | 1999 | → |
| Methods for detection of parent-of-origin effects in genetic studies of case-parents triads. | Weinberg CR | — | 1999 | → |
| Modeling linkage and association with evaluation of common sampling schemes. | Wicks J et al. | — | 1999 | → |
| Multipoint linkage disequilibrium mapping with particular reference to the African-American population. | Zheng C et al. | — | 1999 | → |
| No evidence for association of multiple sclerosis with the complement factors C6 and C7. | Chataway J et al. | — | 1999 | → |
| Nonparametric linkage and family-based association studies of a simulated complex disorder. | Koller DL et al. | — | 1999 | → |
| Physical mapping of the serotonin 5-HT(7) receptor gene (HTR7) to chromosome 10 and pseudogene (HTR7P) to chromosome 12, and testing of linkage disequilibrium between HTR7 and autistic disorder. | Lassig JP et al. | — | 1999 | → |
| Polycystic ovary syndrome. Phenotype to genotype. | Legro RS | — | 1999 | → |
| Power loss for multiallelic transmission/disequilibrium test when errors introduced: GAW11 simulated data. | Gordon D et al. | — | 1999 | → |
| Relative power of linkage and transmission disequilibrium test strategies to detect non-HLA linked coeliac disease susceptibility genes. | Bevan S et al. | — | 1999 | → |
| Search for susceptibility genes, gene x gene interactions, and gene x environment interactions utilizing nonparametric linkage analysis. | Ehm MG et al. | — | 1999 | → |
| Serotonin transporter (5-HTT) and gamma-aminobutyric acid receptor subunit beta3 (GABRB3) gene polymorphisms are not associated with autism in the IMGSA families. The International Molecular Genetic Study of Autism Consortium. | Maestrini E et al. | — | 1999 | → |
| Serotonin transporter gene (HTTLPR) is not in linkage disequilibrium with prepubertal and early adolescent bipolarity. | Geller B et al. | — | 1999 | → |
| Significant evidence for linkage of a simulated trait to D1G024--a conclusion reached using multiallelic transmission/disequilibrium tests. | Ziegler A et al. | — | 1999 | → |
| Summary of analyses of problem 2 simulated data for GAW11. | Greenberg DA | — | 1999 | → |
| Systematic search for susceptibility genes in different populations. | Schmidt S et al. | — | 1999 | → |
| TDT clarification. | Spielman RS et al. | — | 1999 | → |
| The early development of child psychopharmacogenetics. | Cook EH | — | 1999 | → |
| The Emerging Importance of Genetics in Epidemiologic Research III. Bioinformatics and statistical genetic methods. | Ellsworth DL et al. | — | 1999 | → |
| The interpretation of the parameters in the transmission/disequilibrium test. | Zhao H | — | 1999 | → |
| The role of genetic factors in autoimmune disease: implications for environmental research. | Cooper GS et al. | — | 1999 | → |
| The transmission/disequilibrium test and parental-genotype reconstruction: the reconstruction-combined transmission/ disequilibrium test. | Knapp M | — | 1999 | → |
| Tumour necrosis factor-alpha promoter polymorphisms in primary biliary cirrhosis. | Jones DE et al. | — | 1999 | → |
| Two tests of association for a susceptibility locus for families of variable size: an example using two sampling strategies. | Monks SA et al. | — | 1999 | → |
| A comparative study of sibship tests of linkage and/or association. | Monks SA et al. | — | 1998 | → |
| A family-based analysis of the association of the dopamine D2 receptor (DRD2) with alcoholism. | Edenberg HJ et al. | — | 1998 | → |
| A family-based analysis of whether the functional promoter alleles of the serotonin transporter gene HTT affect the risk for alcohol dependence. | Edenberg HJ et al. | — | 1998 | → |
| A genome-wide screen for susceptibility loci in ankylosing spondylitis. | Brown MA et al. | — | 1998 | → |
| Allele frequency distributions in pooled DNA samples: applications to mapping complex disease genes. | Shaw SH et al. | — | 1998 | → |
| A log-linear approach to case-parent-triad data: assessing effects of disease genes that act either directly or through maternal effects and that may be subject to parental imprinting. | Weinberg CR et al. | — | 1998 | → |
| A sibship test for linkage in the presence of association: the sib transmission/disequilibrium test. | Spielman RS et al. | — | 1998 | → |
| Association and linkage of the dopamine transporter gene and attention-deficit hyperactivity disorder in children: heterogeneity owing to diagnostic subtype and severity. | Waldman ID et al. | — | 1998 | → |
| Association of MSX1 and TGFB3 with nonsyndromic clefting in humans. | Lidral AC et al. | — | 1998 | → |
| Current developments in the molecular genetics of the polycystic ovary syndrome. | Franks S et al. | — | 1998 | → |
| DNA variation and the future of human genetics. | Schafer AJ et al. | — | 1998 | → |
| Genes in the spondyloarthropathies. | Wordsworth P | — | 1998 | → |
| Genetic association mapping based on discordant sib pairs: the discordant-alleles test. | Boehnke M et al. | — | 1998 | → |
| Genetics of alcoholism. | Edenberg HJ | — | 1998 | → |
| Genetics of polycystic ovary syndrome. | Franks S et al. | — | 1998 | → |
| Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1p, 3q, and 4q: evidence for epistasis between 1p and IBD1. | Cho JH et al. | — | 1998 | → |
| Inheritance of susceptibility to multiple sclerosis. | Sawcer S et al. | — | 1998 | → |
| Issues and strategies in the genetic analysis of alcoholism and related addictive behaviors. | Schork NJ et al. | — | 1998 | → |
| Lack of association between the alpha-adducin locus and essential hypertension in the Japanese population. | Kato N et al. | — | 1998 | → |
| Linkage analysis, kinship, and the short-term evolution of chromosomes. | Schork NJ et al. | — | 1998 | → |
| Linkage analysis of human leukocyte antigen (HLA) markers in familial psoriasis: strong disequilibrium effects provide evidence for a major determinant in the HLA-B/-C region. | Jenisch S et al. | — | 1998 | → |
| Linkage and association. | Elston RC | — | 1998 | → |
| Marker selection for the transmission/disequilibrium test, in recently admixed populations. | Kaplan NL et al. | — | 1998 | → |
| Promoter sequence, expression, and fine chromosomal mapping of the human gene (MLP) encoding the MARCKS-like protein: identification of neighboring and linked polymorphic loci for MLP and MACS and use in the evaluation of human neural tube defects. | Stumpo DJ et al. | — | 1998 | → |
| Significance levels in complex inheritance. | Morton NE | — | 1998 | → |
| Support for a chromosome 18p locus conferring susceptibility to functional psychoses in families with schizophrenia, by association and linkage analysis. | Schwab SG et al. | — | 1998 | → |
| The effect of family structure on linkage tests using allelic association. | Whittaker JC et al. | — | 1998 | → |
| The inheritance of alcoholic liver disease. | Bassendine MF et al. | — | 1998 | → |
| The relation of the dopamine transporter gene (DAT1) to symptoms of internalizing disorders in children. | Rowe DC et al. | — | 1998 | → |
| Transmission disequilibrium, family controls, and great expectations. | Schaid DJ | — | 1998 | → |
| Using association studies to test for gene-environment interaction asthma and other complex diseases. | Beaty TH | — | 1998 | → |
| Using information from both parents when testing for association between marker and disease loci. | Whittaker JC et al. | — | 1998 | → |
| Why different rules are required for polygenic inheritance: lessons from studies of the DRD2 gene. | Comings DE | — | 1998 | → |
| Application of transmission disequilibrium tests to nonsyndromic oral clefts: including candidate genes and environmental exposures in the models. | Maestri NE et al. | — | 1997 | → |
| Exact transmission-disequilibrium tests with multiallelic markers. | Cleves MA et al. | — | 1997 | → |
| Genetics of asthma: a review. | Manian P | — | 1997 | → |
| Genetics of complex disease: approaches, problems, and solutions. | Schork NJ | — | 1997 | → |
| Genomewide transmission/disequilibrium testing--consideration of the genotypic relative risks at disease loci. | Camp NJ | — | 1997 | → |
| Genotype relative-risks and association tests for nuclear families with missing parental data. | Schaid DJ et al. | — | 1997 | → |
| Investigation of the candidate genes ACTHR and golf for bipolar illness by the transmission/disequilibrium test. | Bickeböller H et al. | — | 1997 | → |
| Linkage disequilibrium between the dopamine transporter gene (DAT1) and bipolar disorder: extending the transmission disequilibrium test (TDT) to examine genetic heterogeneity. | Waldman ID et al. | — | 1997 | → |
| Molecular genetics and the epidemiology of common mental disorders: new opportunities. | Henderson S et al. | — | 1997 | → |
| Power studies for the transmission/disequilibrium tests with multiple alleles. | Kaplan NL et al. | — | 1997 | → |
| Tests for linkage and association in nuclear families. | Martin ER et al. | — | 1997 | → |
| The maddening hunt for madness genes. | Moldin SO | — | 1997 | → |
| Transmission/disequilibrium tests for multiallelic loci. | Sham P | — | 1997 | → |