Association of EEG alpha variants and alpha power with alcohol dependence in Mexican American young adults.
- Authors
- Ehlers, Cindy L; Phillips, Evelyn
- Year
- 2007
- Journal
- Alcohol (Fayetteville, N.Y.)
- PMID
- 17452295
- DOI
- 10.1016/j.alcohol.2007.02.001
- PMCID
- PMC2047338
Several studies support an association between electroencephalogram (EEG) voltage and alcohol dependence. However, the distribution of EEG variants also appears to differ depending on an individual's ethnic heritage, suggesting significant genetic stratification of this EEG phenotype. The present study's aims were to investigate the incidence of EEG alpha variants and spectral power in the alpha frequency range in Mexican American young adults based on gender, and personal and family history of alcohol dependence. Clinical ratings (high-, medium-, and low alpha voltage variants) and spectral characteristics of the EEG in the alpha frequency range (7.5-12 Hz) were investigated in young adult (age 18-25 years) Mexican American men (n=98) and women (n=138) who were recruited from the community. Nineteen percent (n=45) of the participants had a low-voltage alpha EEG variant, 18% had a high-voltage variant, and 63% had a medium-voltage variant. There were no significant differences in the distribution of the EEG variants based on family history of alcohol dependence. There was a significant relationship between gender and the three alpha variants (chi2=9.7; df=2; P<.008), and there were no male participants with alcohol dependence with high alpha variants (chi2=5.8; df=2; P<.056). Alcohol dependence, but not a family history of alcohol dependence, was associated with lower spectral power in the alpha frequency range in the right (F=4.4; df=1,96; P<.04) and left (F=5.3; df=1.96; P<.02) occipital areas in the men but not in the women. In conclusion, in this select population of Mexican American young adults, male gender and alcohol dependence are associated with an absence of high-voltage alpha variants and lower alpha power in the EEG. These data suggest that EEG low voltage, a highly heritable trait, may represent an important endophenotype in male Mexican Americans that may aid in linking brain function with genetic factors underlying alcohol dependence in this ethnic group.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Endophenotype best practices. | 2017 | 27473600 |
| Endophenotypes for Alcohol Use Disorder: An Update on the Field. | 2015 | 26236574 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Effects of Alcohol on EEG Activity: A Systematic Review Focused on Sex-Related Differences in Youth. | Elliott AS et al. | — | 2025 | → |
| [Features of decision-making in patients with alcohol dependence]. | Galkin SA et al. | — | 2023 | → |
| Neural correlates of visuoperceptive changes in severe alcohol use disorder: A critical review of neuroimaging and electrophysiological findings. | Creupelandt C et al. | — | 2021 | → |
| Alterations of Functional Connectivity During the Resting State and Their Associations With Visual Memory in College Students Who Binge Drink. | Kim BM et al. | — | 2020 | → |
| CR-19-0950: Event-related responses to alcohol-related stimuli in Mexican-American young adults: Relation to age, gender, comorbidity and "dark side" symptoms. | Ehlers CL et al. | — | 2019 | → |
| A review on EEG-based methods for screening and diagnosing alcohol use disorder. | Mumtaz W et al. | — | 2018 | → |
| An EEG-based machine learning method to screen alcohol use disorder. | Mumtaz W et al. | — | 2017 | → |
| Endophenotype best practices. | Iacono WG et al. | — | 2017 | → |
| Whole genome sequence association and ancestry-informed polygenic profile of EEG alpha in a Native American population. | Peng Q et al. | — | 2017 | → |
| Genetic variation in FAAH is associated with cannabis use disorders in a young adult sample of Mexican Americans. | Melroy-Greif WE et al. | — | 2016 | → |
| Lifetime history of traumatic events in a young adult Mexican American sample: Relation to substance dependence, affective disorder, acculturation stress, and PTSD. | Ehlers CL et al. | — | 2016 | → |
| Endophenotypes for Alcohol Use Disorder: An Update on the Field. | Salvatore JE et al. | — | 2015 | → |
| Low voltage alpha EEG phenotype is associated with reduced amplitudes of alpha event-related oscillations, increased cortical phase synchrony, and a low level of response to alcohol. | Ehlers CL et al. | — | 2015 | → |
| Variants Near CCK Receptors are Associated With Electrophysiological Responses to Pre-pulse Startle Stimuli in a Mexican American Cohort. | Norden-Krichmar TM et al. | — | 2015 | → |
| CHRNA5 and CHRNA3 variants and level of neuroticism in young adult Mexican American men and women. | Criado JR et al. | — | 2014 | → |
| Interpreting EEG alpha activity. | Bazanova OM et al. | — | 2014 | → |
| N4 component responses to pre-pulse startle stimuli in young adults: relationship to alcohol dependence. | Ehlers CL et al. | — | 2011 | → |
| EEG spectral phenotypes: heritability and association with marijuana and alcohol dependence in an American Indian community study. | Ehlers CL et al. | — | 2010 | → |
| HTR3B is associated with alcoholism with antisocial behavior and alpha EEG power--an intermediate phenotype for alcoholism and co-morbid behaviors. | Ducci F et al. | — | 2009 | → |