Does cannabis use affect treatment outcome in bipolar disorder? A longitudinal analysis.
paper
Cited
Public
Unavailable
- Authors
- van Rossum, Inge; Boomsma, Maarten; Tenback, Diederik; Reed, Catherine; van Os, Jim; EMBLEM Advisory Board
- Year
- 2009
- Journal
- The Journal of nervous and mental disease
- PMID
- 19155808
- DOI
- 10.1097/NMD.0b013e31819292a6
Research suggests that cannabis use affects negatively on onset and outcome of schizophrenia, but less is known about possible effects in mood disorders. Bipolar in- and outpatients (N = 3459) were enrolled in an observational study. The influence of cannabis exposure on clinical and social treatment outcome measures was examined over the course of 1 year, as well as the effects on these associations of third mediating variables. Over 12 months of treatment, cannabis users exhibited less compliance and higher levels of overall illness severity, mania, and psychosis compared with nonusers. Additionally, cannabis users experienced less satisfaction with life and had a lower probability of having a relationship compared with nonusers. There was little evidence that cannabis-outcome associations were mediated by third variables. An independent impact of cannabis use on psychopathologic outcomes in patients with bipolar disorder was apparent, whereas the impact on social outcomes was modest.
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Association of polygenic risk for cannabis use disorder with brain structure among youth with and without bipolar disorder. | Sultan AA et al. | — | 2026 | → |
| Cannabis and Mental Health: A Review. | Kansagara D et al. | — | 2026 | → |
| The highs and lows: Cannabis use and positive valence bipolar mood and emotion processes in emerging adults. | Rosa L et al. | — | 2026 | → |
| Correlates of cannabis use and cannabis use disorder among adolescents with major depressive disorder and bipolar disorder in the National Comorbidity Survey-Adolescent Supplement (NCS-A). | Sultan AA et al. | — | 2025 | → |
| Substance Use Disorder Among Patients with Primary Mental Illnesses in Southwestern Uganda. | Rubega A et al. | — | 2025 | → |
| The Complex Relationship Between Cannabis Use and Mental Health: Considering the Influence of Cannabis Use Patterns and Individual Factors. | Sagar KA et al. | — | 2025 | → |
| Avatar Intervention in Virtual Reality for Cannabis Use Disorder in Individuals With Severe Mental Disorders: Results From a 1-Year, Single-Arm Clinical Trial. | Giguere S et al. | — | 2024 | → |
| Cannabis use and mood disorders: a systematic review. | Sorkhou M et al. | — | 2024 | → |
| Early exposure to cannabis and bipolar disorder incidence: Findings from a 22-year birth cohort study in Brazil. | Jorge ACR et al. | — | 2024 | → |
| Absconding among admitted patients with bipolar affective disorder diagnosis in Uganda. | Abaatyo J et al. | — | 2023 | → |
| A Prospective Comparison of Bipolar I and II Subjects with and without Comorbid Cannabis Use Disorders from the COGA Dataset. | Preuss UW et al. | — | 2023 | → |
| Association of cannabis use with neurocognition in adolescents with bipolar disorder. | Sultan AA et al. | — | 2023 | → |
| Avatar Intervention for Cannabis Use Disorder in Individuals with Severe Mental Disorders: A Pilot Study. | Giguère S et al. | — | 2023 | → |
| Canadian Network for Mood and Anxiety Treatments (CANMAT) Task Force Report: A Systematic Review and Recommendations of Cannabis use in Bipolar Disorder and Major Depressive Disorder. | Tourjman SV et al. | — | 2023 | → |
| Cannabis update: Anxiety disorders and post-traumatic stress disorder. | Haycraft AL | — | 2023 | → |
| The association of CNR1 genetic variants with resting-state functional connectivity in youth bipolar disorder. | Sultan AA et al. | — | 2023 | → |
| The experience of mood disorder and substance use: An integrative review. | Crowe M et al. | — | 2023 | → |
| Associations between cannabis use, cannabis use disorder, and mood disorders: longitudinal, genetic, and neurocognitive evidence. | Kuhns L et al. | — | 2022 | → |
| Cannabinoids and solid organ transplantation: Psychiatric perspectives and recommendations. | Winder GS et al. | — | 2022 | → |
| Cannabis and Mental Health: Adverse Outcomes and Self-Reported Impact of Cannabis Use by Mental Health Status. | Rup J et al. | — | 2022 | → |
| Cannabis use and medication nonadherence in bipolar disorder: A nationwide inpatient sample database analysis. | Oladunjoye AF et al. | — | 2022 | → |
| Exploring Social Context and Psychological Distress in Adult Canadians with Cannabis Use Disorder: To What Extent Do Social Isolation and Negative Relationships Predict Mental Health? | Gulliver TL et al. | — | 2022 | → |
| Is there an association between inflammatory/anti-oxidant markers and the presence of psychotic symptoms or severity of illness in mood and psychotic disorders? A multi-centric study on a drug-free sample. | Caldiroli A et al. | — | 2022 | → |
| Multimodal Correlates of Cannabis Use among U.S. Veterans with Bipolar Disorder: An Integrated Study of Clinical, Cognitive, and Functional Outcomes. | Selloni A et al. | — | 2022 | → |
| Results from a randomized, double-blind, placebo-controlled, crossover, multimodal-MRI pilot study of gabapentin for co-occurring bipolar and cannabis use disorders. | Prisciandaro JJ et al. | — | 2022 | → |
| A systematic review and meta-analysis of sex differences in cannabis use disorder amongst people with comorbid mental illness. | Kozak K et al. | — | 2021 | → |
| Bipolar Disorder and Comorbid Use of Illicit Substances. | Preuss UW et al. | — | 2021 | → |
| Cannabis: A Toxin-Producing Plant with Potential Therapeutic Uses. | Breijyeh Z et al. | — | 2021 | → |
| Cannabis use and resting state functional connectivity in adolescent bipolar disorder. | Sultan AA et al. | — | 2021 | → |
| Evidence for Use of Cannabinoids in Mood Disorders, Anxiety Disorders, and PTSD: A Systematic Review. | Stanciu CN et al. | — | 2021 | → |
| Neurostructural Correlates of Cannabis Use in Adolescent Bipolar Disorder. | Sultan AA et al. | — | 2021 | → |
| Cannabis Use and the Risk for Psychosis and Affective Disorders. | Sideli L et al. | — | 2020 | → |
| Cannabis use in early adulthood is prospectively associated with prescriptions of antipsychotics, mood stabilizers, and antidepressants. | Rognli EB et al. | — | 2020 | → |
| Mapping the pathways between recreational cannabis use and mood disorders: A Behaviour Sequence Analysis approach. | Keatley DA et al. | — | 2020 | → |
| Sex differences in bipolar disorder: Impact of lifetime cannabis use on clinical course, functioning, and quality of life in bipolar disorder. | de la Fuente-Tomás L et al. | — | 2020 | → |
| Violence and Cannabis Use: A Focused Review of a Forgotten Aspect in the Era of Liberalizing Cannabis. | Dellazizzo L et al. | — | 2020 | → |
| Bipolar disorder and the endocannabinoid system. | Arjmand S et al. | — | 2019 | → |
| Cannabis for the Treatment of Chronic Pain in the Era of an Opioid Epidemic: A Symposium-Based Review of Sociomedical Science. | Maher DP et al. | — | 2019 | → |
| Cannabis use and violence in patients with severe mental illnesses: A meta-analytical investigation. | Dellazizzo L et al. | — | 2019 | → |
| Cannabis use disorder and suicide attempts in bipolar disorder: A meta-analysis. | Bartoli F et al. | — | 2019 | → |
| Cannabis and Mood Disorders. | Lucatch AM et al. | — | 2018 | → |
| Cannabis regulatory science: risk-benefit considerations for mental disorders. | Borodovsky JT et al. | — | 2018 | → |
| Reducing relapse and suicide in bipolar disorder: practical clinical approaches to identifying risk, reducing harm and engaging service users in planning and delivery of care – the PARADES (Psychoeducation, Anxiety, Relapse, Advance Directive Evaluation and Suicidality) programme | Jones S et al. | — | 2018 | → |
| Commentary on Ostergaard et al. (2017): Evidence of an association between cannabis use and suicide in subjects with bipolar disorder. | Bartoli F | — | 2017 | → |
| Medical cannabis and mental health: A guided systematic review. | Walsh Z et al. | — | 2017 | → |
| Cannabis use disorder is associated with greater illness severity in tobacco smoking patients with bipolar disorder. | Lagerberg TV et al. | — | 2016 | → |
| Cannabis use in first-treatment bipolar I disorder: relations to clinical characteristics. | Kvitland LR et al. | — | 2016 | → |
| Demographic and clinical characteristics associated with comorbid cannabis use disorders (CUDs) in hospitalized patients with bipolar I disorder. | Weinstock LM et al. | — | 2016 | → |
| Joint Effects: A Pilot Investigation of the Impact of Bipolar Disorder and Marijuana Use on Cognitive Function and Mood. | Sagar KA et al. | — | 2016 | → |
| Prevalence of comorbid bipolar and substance use disorders in clinical settings, 1990-2015: Systematic review and meta-analysis. | Hunt GE et al. | — | 2016 | → |
| The Effects of Cannabis on Inpatient Agitation, Aggression, and Length of Stay. | Johnson JM et al. | — | 2016 | → |
| Cannabis and bipolar disorder: does quitting cannabis use during manic/mixed episode improve clinical/functional outcomes? | Zorrilla I et al. | — | 2015 | → |
| Cannabis use and mania symptoms: a systematic review and meta-analysis. | Gibbs M et al. | — | 2015 | → |
| Comprehensive Review of Medicinal Marijuana, Cannabinoids, and Therapeutic Implications in Medicine and Headache: What a Long Strange Trip It's Been …. | Baron EP | — | 2015 | → |
| Continued cannabis use at one year follow up is associated with elevated mood and lower global functioning in bipolar I disorder. | Kvitland LR et al. | — | 2015 | → |
| Impact of Cannabis Use on Long-Term Remission in Bipolar I and Schizoaffective Disorder. | Kim SW et al. | — | 2015 | → |
| Long term course of bipolar I disorder in India: using retrospective life chart method. | Karthick S et al. | — | 2015 | → |
| The relationship between bipolar disorder and cannabis use in daily life: an experience sampling study. | Tyler E et al. | — | 2015 | → |
| The Use of Cannabis as a Predictor of Early Onset of Bipolar Disorder and Suicide Attempts. | Leite RT et al. | — | 2015 | → |
| Cannabis use and first-episode psychosis: relationship with manic and psychotic symptoms, and with age at presentation. | Stone JM et al. | — | 2014 | → |
| Cannabis use and first manic episode. | Bally N et al. | — | 2014 | → |
| Marijuana not ready for prime time as an analgesic. | Saxon AJ et al. | — | 2014 | → |
| Bipolar disorder and co-occurring cannabis use disorders: characteristics, co-morbidities and clinical correlates. | Lev-Ran S et al. | — | 2013 | → |
| No association of endocannabinoid genes with bipolar disorder or lithium response in a Sardinian sample. | Pisanu C et al. | — | 2013 | → |
| Predictors of medication adherence in patients with schizophrenia and bipolar disorder. | Jónsdóttir H et al. | — | 2013 | → |
| Cannabinoid modulation of noradrenergic circuits: implications for psychiatric disorders. | Carvalho AF et al. | — | 2012 | → |
| Clinical presentations of substance abuse in bipolar heroin addicts at time of treatment entry. | Maremmani I et al. | — | 2012 | → |
| Cognitive and clinical outcomes associated with cannabis use in patients with bipolar I disorder. | Braga RJ et al. | — | 2012 | → |
| Marijuana impacts mood in bipolar disorder: a pilot study. | Gruber SA et al. | — | 2012 | → |
| Phytocannabinoids as novel therapeutic agents in CNS disorders. | Hill AJ et al. | — | 2012 | → |
| Psychopathologic differences between cannabis-induced psychoses and recent-onset primary psychoses with abuse of cannabis. | Rubio G et al. | — | 2012 | → |
| Cannabis involvement in individuals with bipolar disorder. | Agrawal A et al. | — | 2011 | → |
| Clinical symptoms and neurocognitive performance: potential impact of substance use. | Richardson T et al. | — | 2011 | → |
| Effects of cannabis use on age at onset in schizophrenia and bipolar disorder. | De Hert M et al. | — | 2011 | → |
| Genetic association between bipolar disorder and 524A>C (Leu133Ile) polymorphism of CNR2 gene, encoding for CB2 cannabinoid receptor. | Minocci D et al. | — | 2011 | → |
| [Managing the use of cannabis in a young population in primary care]. | Madoz-Gúrpide A et al. | — | 2011 | → |
| Antidepressant-like effect of delta9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L. | El-Alfy AT et al. | — | 2010 | → |
| [Cannabis and mood]. | Sanches RF et al. | — | 2010 | → |
| The cost of relapse for patients with a manic/mixed episode of bipolar disorder in the EMBLEM study. | Hong J et al. | — | 2010 | → |
| Chronic toxicology of cannabis. | Reece AS | — | 2009 | → |