Rates of opioid misuse, abuse, and addiction in chronic pain: a systematic review and data synthesis.
paper
Cited
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- Authors
- Vowles, Kevin E; McEntee, Mindy L; Julnes, Peter Siyahhan; Frohe, Tessa; Ney, John P; van der Goes, David N
- Year
- 2015
- Journal
- Pain
- PMID
- 25785523
- DOI
- 10.1097/01.j.pain.0000460357.01998.f1
Opioid use in chronic pain treatment is complex, as patients may derive both benefit and harm. Identification of individuals currently using opioids in a problematic way is important given the substantial recent increases in prescription rates and consequent increases in morbidity and mortality. The present review provides updated and expanded information regarding rates of problematic opioid use in chronic pain. Because previous reviews have indicated substantial variability in this literature, several steps were taken to enhance precision and utility. First, problematic use was coded using explicitly defined terms, referring to different patterns of use (ie, misuse, abuse, and addiction). Second, average prevalence rates were calculated and weighted by sample size and study quality. Third, the influence of differences in study methodology was examined. In total, data from 38 studies were included. Rates of problematic use were quite broad, ranging from <1% to 81% across studies. Across most calculations, rates of misuse averaged between 21% and 29% (range, 95% confidence interval [CI]: 13%-38%). Rates of addiction averaged between 8% and 12% (range, 95% CI: 3%-17%). Abuse was reported in only a single study. Only 1 difference emerged when study methods were examined, where rates of addiction were lower in studies that identified prevalence assessment as a primary, rather than secondary, objective. Although significant variability remains in this literature, this review provides guidance regarding possible average rates of opioid misuse and addiction and also highlights areas in need of further clarification.
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| Title | Year | PMID |
|---|---|---|
| Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond. | 2022 | 36207451 |
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| Preexisting opioid use disorder is associated with poor outcomes in hospitalized acute pancreatitis patients. | Shaikh AS et al. | โ | 2021 | โ |
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| The mixed kappa and delta opioid receptor agonist, MP1104, attenuates chemotherapy-induced neuropathic pain. | Atigari DV et al. | โ | 2021 | โ |
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| Development and validation of the Capacity to Treat Chronic Pain and Opioid Use Disorder (CAP-POD) questionnaire. | Varley AL et al. | โ | 2020 | โ |
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| Do Lidocaine Patches Reduce Opioid Use in Acute Rib Fractures? | Johnson M et al. | โ | 2020 | โ |
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| Enhanced Recovery After Surgery (ERAS): A Perspective Review of Postoperative Pain Management Under ERAS Pathways and Its Role on Opioid Crisis in the United States. | Echeverria-Villalobos M et al. | โ | 2020 | โ |
| Fourth Amendment Protections of Prescription Drug Monitoring Programs: Patient Privacy in the Opioid Crisis. | Knox R | โ | 2020 | โ |
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| How the presentation of patient information and decision-support advisories influences opioid prescribing behavior: A simulation study. | Hussain MI et al. | โ | 2020 | โ |
| Identifying the Role of Block Length in Neural Heat Block to Reduce Temperatures During Infrared Neural Inhibition. | Ford JB et al. | โ | 2020 | โ |
| Increased Experimental Pain Sensitivity in Chronic Pain Patients Who Developed Opioid Use Disorder. | Compton PA et al. | โ | 2020 | โ |
| Innovative patient education and pain management protocols to achieve opioid-free shoulder arthroplasty. | Sabesan VJ et al. | โ | 2020 | โ |
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| Preoperative quality-of-life measures predict acute postoperative pain in endoscopic sinus surgery. | Chowdhury NI et al. | โ | 2019 | โ |
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| Prescription Dispensing Patterns Before and After a Workers' Compensation Claim: An Historical Cohort Study of Workers With Low Back Pain Injuries in British Columbia. | Carnide N et al. | โ | 2018 | โ |
| Prescription Opioid Access Patterns and Factors Associated with Increasing Number of Prescribers, Pharmacies, and Dispensings: An Observational Study Using Pharmaceutical Claims. | Blanch B et al. | โ | 2018 | โ |
| Prevalence and Correlates of Loss of Control Eating among Adults Presenting for Methadone Maintenance Treatment. | Goldschmidt AB et al. | โ | 2018 | โ |
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| Principles for managing OUD related to chronic pain in the Nordic countries based on a structured assessment of current practice. | Kakko J et al. | โ | 2018 | โ |
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| Response to Capsule Commentary on Merlin et al., Managing Concerning Behaviors in Patients Prescribed Opioids for Chronic Pain: A Delphi Study. | Merlin JS et al. | โ | 2018 | โ |
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| The Use of the Patient Reported Outcomes Measurement Information System and the RAND VSQ9 to Measure the Quality of Life and Visit-Specific Satisfaction of Pregnant Patients Under Chiropractic Care Utilizing the Webster Technique. | Alcantara J et al. | โ | 2018 | โ |
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| Association Between Initial Opioid Prescribing Patterns and Subsequent Long-Term Use Among Opioid-Naรฏve Patients: A Statewide Retrospective Cohort Study. | Deyo RA et al. | โ | 2017 | โ |
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| Dopamine D1 receptor agonist treatment attenuates extinction of morphine conditioned place preference while increasing dendritic complexity in the nucleus accumbens core. | Kobrin KL et al. | โ | 2017 | โ |
| Early Prescription Opioid Use for Musculoskeletal Disorders and Work Outcomes: A Systematic Review of the Literature. | Carnide N et al. | โ | 2017 | โ |
| Editorial. | โ | โ | 2017 | โ |
| Ethical Conundrums in Pain Medicine: The Intersection of Industry Sponsorship, Fee-for-Service Interventions, and Access to Care. | Cohen SP et al. | โ | 2017 | โ |
| Factors associated with prescription opioid misuse in a cross-sectional cohort of patients with chronic non-cancer pain. | Hah JM et al. | โ | 2017 | โ |
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| Higher Prescription Opioid Dose is Associated With Worse Patient-Reported Pain Outcomes and More Health Care Utilization. | Morasco BJ et al. | โ | 2017 | โ |
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| Long-term safety and analgesic efficacy of buprenorphine buccal film in patients with moderate-to-severe chronic pain requiring around-the-clock opioids. | Hale M et al. | โ | 2017 | โ |
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| Pain, hedonic regulation, and opioid misuse: Modulation of momentary experience by Mindfulness-Oriented Recovery Enhancement in opioid-treated chronic pain patients. | Garland EL et al. | โ | 2017 | โ |
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| Screening, brief intervention, and referral to treatment for opioid and other substance use during infertility treatment. | Wright TE | โ | 2017 | โ |
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| Substance Use Disorders among Patients with Type 2 Diabetes: a Dangerous but Understudied Combination. | Walter KN et al. | โ | 2017 | โ |
| The comparative pharmacokinetics of physical manipulation by crushing of Xtampza<sup>ยฎ</sup> ER compared with OxyContin<sup>ยฎ</sup>. | Brennan MJ et al. | โ | 2017 | โ |
| The content validation of the Self-Reported Misuse, Abuse and Diversion of Prescription Opioids (SR-MAD) instrument for use in patients with acute or chronic pain. | Setnik B et al. | โ | 2017 | โ |
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| Efficacy and tolerability of buccal buprenorphine in opioid-naive patients with moderate to severe chronic low back pain. | Rauck RL et al. | โ | 2016 | โ |
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