Efficient generation of astrocytes from human pluripotent stem cells in defined conditions.
paper
Cited
Public
Unavailable
- Authors
- Shaltouki, Atossa; Peng, Jun; Liu, Qiuyue; Rao, Mahendra S; Zeng, Xianmin
- Year
- 2013
- Journal
- Stem cells (Dayton, Ohio)
- PMID
- 23341249
- DOI
- 10.1002/stem.1334
Astrocytes can be generated from various tissue sources including human pluripotent stem cells (PSC). In this manuscript, we describe a chemically defined xeno-free medium culture system for rapidly generating astrocytes from neural stem cells derived from PSC. We show that astrocyte development in vitro, mimics normal development in vivo, and also passes through a CD44(+) astrocyte precursor stage. Astrocytes generated by our method display similar gene expression patterns, morphological characteristics and functional properties to primary astrocytes, and they survive and integrate after xenotransplantation. Whole genome expression profiling of astrocyte differentiation was performed at several time points of differentiation, and the results indicate the importance of known regulators and identify potential novel regulators and stage-specific lineage markers.
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| DHM/SERS reveals cellular morphology and molecular changes during iPSCs-derived activation of astrocytes. | Bu X et al. | β | 2024 | β |
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| In vitro human cell culture models in a bench-to-bedside approach to epilepsy. | DanaΔΓkovΓ‘ Ε et al. | β | 2024 | β |
| Neuronal Cell Differentiation of iPSCs for the Clinical Treatment of Neurological Diseases. | Lee DH et al. | β | 2024 | β |
| Paving the way to a neural fate - RNA signatures in naive and trans-differentiating mesenchymal stem cells. | Diener C et al. | β | 2024 | β |
| Pluripotent stem cells for target organ developmental toxicity testing. | Wu X et al. | β | 2024 | β |
| Alzheimer's disease and synapse Loss: What can we learn from induced pluripotent stem Cells? | Rodriguez-Jimenez FJ et al. | β | 2023 | β |
| An overall view of the most common experimental models for multiple sclerosis. | Dedoni S et al. | β | 2023 | β |
| Applications of Induced Pluripotent Stem Cell-Derived Glia in Brain Disease Research and Treatment. | Yang Z et al. | β | 2023 | β |
| Cell type and sex specific mitochondrial phenotypes in iPSC derived models of Alzheimer's disease. | Flannagan K et al. | β | 2023 | β |
| Cortical Astrocyte Progenitors and Astrocytes from Human Pluripotent Stem Cells. | Battistella I et al. | β | 2023 | β |
| Differentiation of neurosphere after transplantation into the damaged spinal cord. | Gramatiuk SM et al. | β | 2023 | β |
| From neurodevelopment to neurodegeneration: utilizing human stem cell models to gain insight into Down syndrome. | Watson LA et al. | β | 2023 | β |
| Human iPSC-derived glia models for the study of neuroinflammation. | StΓΆberl N et al. | β | 2023 | β |
| Loss of maturity and homeostatic functions in Tuberous Sclerosis Complex-derived astrocytes. | Luinenburg MJ et al. | β | 2023 | β |
| Mature iPSC-derived astrocytes of an ALS/FTD patient carrying the TDP43<sup><i>A90V</i></sup> mutation display a mild reactive state and release polyP toxic to motoneurons. | Rojas F et al. | β | 2023 | β |
| Systems Medicine as a Strategy to Deal with Alzheimer's Disease. | Zeng XX et al. | β | 2023 | β |
| The Multifaceted Role of WNT Signaling in Alzheimer's Disease Onset and Age-Related Progression. | Kostes WW et al. | β | 2023 | β |
| An hiPSC-Derived In Vitro Model of the Blood-Brain Barrier. | Goodwin-Trotman M et al. | β | 2022 | β |
| Animal and Cellular Models of Alzheimer's Disease: Progress, Promise, and Future Approaches. | Trujillo-Estrada L et al. | β | 2022 | β |
| Building in vitro models of the brain to understand the role of <i>APOE</i> in Alzheimer's disease. | Pinals RL et al. | β | 2022 | β |
| Direct Conversion to Achieve Glial Cell Fates: Oligodendrocytes and Schwann Cells. | Yun W et al. | β | 2022 | β |
| Disease Modeling of Neurodegenerative Disorders Using Direct Neural Reprogramming. | Legault EM et al. | β | 2022 | β |
| Excessive release of inorganic polyphosphate by ALS/FTD astrocytes causes non-cell-autonomous toxicity to motoneurons. | Arredondo C et al. | β | 2022 | β |
| Generation of Human iPSC-Derived Astrocytes with a mature star-shaped phenotype for CNS modeling. | Voulgaris D et al. | β | 2022 | β |
| Human-Induced Pluripotent Stem Cell-Based Models for Studying Sex-Specific Differences in Neurodegenerative Diseases. | Kiris E | β | 2022 | β |
| Human iPSC-Derived Neural Models for Studying Alzheimer's Disease: from Neural Stem Cells to Cerebral Organoids. | Barak M et al. | β | 2022 | β |
| Human stem cell models of neurodegeneration: From basic science of amyotrophic lateral sclerosis to clinical translation. | Giacomelli E et al. | β | 2022 | β |
| Insights into Human-Induced Pluripotent Stem Cell-Derived Astrocytes in Neurodegenerative Disorders. | Kumar M et al. | β | 2022 | β |
| Microglia and Astrocyte Function and Communication: What Do We Know in Humans? | Garland EF et al. | β | 2022 | β |
| Modeling and Targeting Neuroglial Interactions with Human Pluripotent Stem Cell Models. | Bigarreau J et al. | β | 2022 | β |
| Multielectrode Arrays for Functional Phenotyping of Neurons from Induced Pluripotent Stem Cell Models of Neurodevelopmental Disorders. | McCready FP et al. | β | 2022 | β |
| Pluripotent stem cell strategies for rebuilding the human brain. | Limone F et al. | β | 2022 | β |
| Promising Strategies for the Development of Advanced In Vitro Models with High Predictive Power in Ischaemic Stroke Research. | Van Breedam E et al. | β | 2022 | β |
| Rapid Generation of Ventral Spinal Cord-like Astrocytes from Human iPSCs for Modeling Non-Cell Autonomous Mechanisms of Lower Motor Neuron Disease. | Soubannier V et al. | β | 2022 | β |
| Reactive and Senescent Astroglial Phenotypes as Hallmarks of Brain Pathologies. | Lazic A et al. | β | 2022 | β |
| 3D hydrogel models of the neurovascular unit to investigate blood-brain barrier dysfunction. | Potjewyd G et al. | β | 2021 | β |
| Astrocyte-Neuron Metabolic Crosstalk in Neurodegeneration: A Mitochondrial Perspective. | Mulica P et al. | β | 2021 | β |
| Astrocytic reactivity triggered by defective autophagy and metabolic failure causes neurotoxicity in frontotemporal dementia type 3. | Chandrasekaran A et al. | β | 2021 | β |
| Blood-Brain Barrier and Neurodegenerative Diseases-Modeling with iPSC-Derived Brain Cells. | Wu YC et al. | β | 2021 | β |
| Comparative Neurodevelopment Effects of Bisphenol A and Bisphenol F on Rat Fetal Neural Stem Cell Models. | Gill S et al. | β | 2021 | β |
| Differentiation of Human Pluripotent Stem Cells Into Specific Neural Lineages. | Chang CY et al. | β | 2021 | β |
| Direct Reprogramming of Fibroblasts to Astrocytes Using Small Molecules. | Tian E et al. | β | 2021 | β |
| Dissecting the non-neuronal cell contribution to Parkinson's disease pathogenesis using induced pluripotent stem cells. | Pons-Espinal M et al. | β | 2021 | β |
| Downregulation of GABA Transporter 3 (GAT3) is Associated with Deficient Oxidative GABA Metabolism in Human Induced Pluripotent Stem Cell-Derived Astrocytes in Alzheimer's Disease. | Salcedo C et al. | β | 2021 | β |
| Estimating Brain Permeability Using In Vitro Blood-Brain Barrier Models. | Nozohouri S et al. | β | 2021 | β |
| Functional Metabolic Mapping Reveals Highly Active Branched-Chain Amino Acid Metabolism in Human Astrocytes, Which Is Impaired in iPSC-Derived Astrocytes in Alzheimer's Disease. | Salcedo C et al. | β | 2021 | β |
| Human iPSC-Derived Astrocytes: A Powerful Tool to Study Primary Astrocyte Dysfunction in the Pathogenesis of Rare Leukodystrophies. | Lanciotti A et al. | β | 2021 | β |
| Human iPSC-Derived Glia as a Tool for Neuropsychiatric Research and Drug Development. | Heider J et al. | β | 2021 | β |
| Identification of the gliogenic state of human neural stem cells to optimize in vitro astrocyte differentiation. | Alisch M et al. | β | 2021 | β |
| MicroRNA-195 rescues ApoE4-induced cognitive deficits and lysosomal defects in Alzheimer's disease pathogenesis. | Cao J et al. | β | 2021 | β |
| N-3 polyunsaturated fatty acids promote astrocyte differentiation and neurotrophin production independent of cAMP in patient-derived neural stem cells. | Yu JZ et al. | β | 2021 | β |
| NFIB induces functional astrocytes from human pluripotent stem cell-derived neural precursor cells mimicking in vivo astrogliogenesis. | Yeon GB et al. | β | 2021 | β |
| Organophosphorus flame retardants are developmental neurotoxicants in a rat primary brainsphere in vitro model. | Hogberg HT et al. | β | 2021 | β |
| Patient-derived glial enriched progenitors repair functional deficits due to white matter stroke and vascular dementia in rodents. | Llorente IL et al. | β | 2021 | β |
| Potential protective role of astrocytes in the pathogenesis of astrocyte-mediated synaptic plasticity of Parkinson's disease. | Zhang Y et al. | β | 2021 | β |
| Recent progress and new challenges in modeling of human pluripotent stem cell-derived blood-brain barrier. | Yan L et al. | β | 2021 | β |
| Reliable generation of glial enriched progenitors from human fibroblast-derived iPSCs. | Llorente IL et al. | β | 2021 | β |
| Role of Astrocytes in Major Neuropsychiatric Disorders. | Zhang X et al. | β | 2021 | β |
| Simultaneous deep generative modeling and clustering of single cell genomic data. | Liu Q et al. | β | 2021 | β |
| Soft surfaces promote astrocytic differentiation of mouse embryonic neural stem cells via dephosphorylation of MRLC in the absence of serum. | Oyama H et al. | β | 2021 | β |
| Taking Cellular Heterogeneity Into Consideration When Modeling Astrocyte Involvement in Amyotrophic Lateral Sclerosis Using Human Induced Pluripotent Stem Cells. | Stifani S | β | 2021 | β |
| The Path to Progress Preclinical Studies of Age-Related Neurodegenerative Diseases: A Perspective on Rodent and hiPSC-Derived Models. | MacDougall G et al. | β | 2021 | β |
| Utilising Induced Pluripotent Stem Cells in Neurodegenerative Disease Research: Focus on Glia. | Albert K et al. | β | 2021 | β |
| A Defined and Scalable Peptide-Based Platform for the Generation of Human Pluripotent Stem Cell-Derived Astrocytes. | Raman S et al. | β | 2020 | β |
| Approach to Neurotoxicity using Human iPSC Neurons: Consortium for Safety Assessment using Human iPS Cells. | Shirakawa T et al. | β | 2020 | β |
| Comparative Transcriptional Profiling of Motor Neuron Disorder-Associated Genes in Various Human Cell Culture Models. | Hauser S et al. | β | 2020 | β |
| EpiMogrify Models H3K4me3 Data to Identify Signaling Molecules that Improve Cell Fate Control and Maintenance. | Kamaraj US et al. | β | 2020 | β |
| Glutamate-glutamine homeostasis is perturbed in neurons and astrocytes derived from patient iPSC models of frontotemporal dementia. | Aldana BI et al. | β | 2020 | β |
| Human iPSC-derived Down syndrome astrocytes display genome-wide perturbations in gene expression, an altered adhesion profile, and increased cellular dynamics. | Ponroy Bally B et al. | β | 2020 | β |
| Human Pluripotent Stem Cell-Derived Neural Cells as a Relevant Platform for Drug Screening in Alzheimer's Disease. | Garcia-Leon JA et al. | β | 2020 | β |
| Increased Expression of Y-Encoded Demethylases During Differentiation of Human Male Neural Stem Cells. | Pottmeier P et al. | β | 2020 | β |
| Induced Pluripotent Stem Cell (iPSC)-Based Neurodegenerative Disease Models for Phenotype Recapitulation and Drug Screening. | Chang CY et al. | β | 2020 | β |
| Integration of CRISPR-engineering and hiPSC-based models of psychiatric genomics. | Matos MR et al. | β | 2020 | β |
| Modeling Alzheimer's disease with iPSC-derived brain cells. | Penney J et al. | β | 2020 | β |
| Modelling multiple sclerosis using induced pluripotent stem cells. | MartΓnez-Larrosa J et al. | β | 2020 | β |
| Models of the blood-brain barrier using iPSC-derived cells. | Delsing L et al. | β | 2020 | β |
| Novel C1q receptor-mediated signaling controls neural stem cell behavior and neurorepair. | Benavente F et al. | β | 2020 | β |
| Nucleus size and DNA accessibility are linked to the regulation of paraspeckle formation in cellular differentiation. | Grosch M et al. | β | 2020 | β |
| Pro-maturational Effects of Human iPSC-Derived Cortical Astrocytes upon iPSC-Derived Cortical Neurons. | Hedegaard A et al. | β | 2020 | β |
| Rapid differentiation of astrocytes from human embryonic stem cells. | Byun JS et al. | β | 2020 | β |
| Short and long TNF-alpha exposure recapitulates canonical astrogliosis events in human-induced pluripotent stem cells-derived astrocytes. | Trindade P et al. | β | 2020 | β |
| The transcription factor PITX1 drives astrocyte differentiation by regulating the SOX9 gene. | Byun JS et al. | β | 2020 | β |
| Using human induced pluripotent stem cells (hiPSCs) to investigate the mechanisms by which Apolipoprotein E (APOE) contributes to Alzheimer's disease (AD) risk. | Raman S et al. | β | 2020 | β |
| Variable Outcomes in Neural Differentiation of Human PSCs Arise from Intrinsic Differences in Developmental Signaling Pathways. | Strano A et al. | β | 2020 | β |
| All Together Now: Modeling the Interaction of Neural With Non-neural Systems Using Organoid Models. | Chukwurah E et al. | β | 2019 | β |
| Amelioration of Huntington's disease phenotype in astrocytes derived from iPSC-derived neural progenitor cells of Huntington's disease monkeys. | Cho IK et al. | β | 2019 | β |
| An industry perspective: A streamlined screening strategy using alternative models for chemical assessment of developmental neurotoxicity. | Li J et al. | β | 2019 | β |
| Astrocyte Subtype Vulnerability in Stem Cell Models of Vanishing White Matter. | Leferink PS et al. | β | 2019 | β |
| Brain-stiffness-mimicking tilapia collagen gel promotes the induction of dorsal cortical neurons from human pluripotent stem cells. | Iwashita M et al. | β | 2019 | β |
| Cell Type Specific Expression of Toll-Like Receptors in Human Brains and Implications in Alzheimer's Disease. | Frederiksen HR et al. | β | 2019 | β |
| Comprehensive Cell Surface Antigen Analysis Identifies Transferrin Receptor Protein-1 (CD71) as a Negative Selection Marker for Human Neuronal Cells. | Menon V et al. | β | 2019 | β |
| Co-stimulation with IL-1Ξ² and TNF-Ξ± induces an inflammatory reactive astrocyte phenotype with neurosupportive characteristics in a human pluripotent stem cell model system. | HyvΓ€rinen T et al. | β | 2019 | β |
| Decoding cell signalling and regulation of oligodendrocyte differentiation. | Santos AK et al. | β | 2019 | β |
| Detecting Neurodevelopmental Toxicity of Domoic Acid and Ochratoxin A Using Rat Fetal Neural Stem Cells. | Gill S et al. | β | 2019 | β |
| Dystrophin deficiency leads to dysfunctional glutamate clearance in iPSC derived astrocytes. | Patel AM et al. | β | 2019 | β |
| Enhanced xeno-free differentiation of hiPSC-derived astroglia applied in a blood-brain barrier model. | Delsing L et al. | β | 2019 | β |
| Examining the relationship between astrocyte dysfunction and neurodegeneration in ALS using hiPSCs. | Halpern M et al. | β | 2019 | β |
| Fast and Efficient Differentiation of Mouse Embryonic Stem Cells Into ATP-Responsive Astrocytes. | Juneja DS et al. | β | 2019 | β |
| Hierarchical Ordered Assembly of Genetically Modifiable Viruses into Nanoridge-in-Microridge Structures. | Zhou N et al. | β | 2019 | β |
| Human Pluripotent Stem Cells as Tools for Predicting Developmental Neural Toxicity of Chemicals: Strategies, Applications, and Challenges. | Liang S et al. | β | 2019 | β |
| Induced Pluripotent Stem Cell-Derived Astroglia: A New Tool for Research Towards the Treatment of Alzheimer's Disease. | Atkinson-Dell R et al. | β | 2019 | β |
| Modeling Neurological Disorders with Human Pluripotent Stem Cell-Derived Astrocytes. | Suga M et al. | β | 2019 | β |
| Neuroinflammatory astrocytes generated from cord blood-derived human induced pluripotent stem cells. | Zhou Q et al. | β | 2019 | β |
| Neurovascular Organotypic Culture Models Using Induced Pluripotent Stem Cells to Assess Adverse Chemical Exposure Outcomes. | Nguyen EH et al. | β | 2019 | β |
| Stroke target identification guided by astrocyte transcriptome analysis. | Rakers C et al. | β | 2019 | β |
| Studying Human Neurological Disorders Using Induced Pluripotent Stem Cells: From 2D Monolayer to 3D Organoid and Blood Brain Barrier Models. | Logan S et al. | β | 2019 | β |
| Using human stem cells as a model system to understand the neural mechanisms of alcohol use disorders: Current status and outlook. | Scarnati MS et al. | β | 2019 | β |
| Utilizing microphysiological systems and induced pluripotent stem cells for disease modeling: a case study for blood brain barrier research in a pharmaceutical setting. | Fabre KM et al. | β | 2019 | β |
| Astrocytes as targets for drug discovery. | Gorshkov K et al. | β | 2018 | β |
| Astrocytes Attenuate Mitochondrial Dysfunctions in Human Dopaminergic Neurons Derived from iPSC. | Du F et al. | β | 2018 | β |
| Cell reprogramming approaches in gene- and cell-based therapies for Parkinson's disease. | Man JHK et al. | β | 2018 | β |
| Differentiation of Glial Cells From hiPSCs: Potential Applications in Neurological Diseases and Cell Replacement Therapy. | Zheng W et al. | β | 2018 | β |
| Effects of 3D culturing conditions on the transcriptomic profile of stem-cell-derived neurons. | Tekin H et al. | β | 2018 | β |
| Fast Generation of Functional Subtype Astrocytes from Human Pluripotent Stem Cells. | Li X et al. | β | 2018 | β |
| Generation of defined neural populations from pluripotent stem cells. | McComish SF et al. | β | 2018 | β |
| Human iPS-Derived Astroglia from a Stable Neural Precursor State Show Improved Functionality Compared with Conventional Astrocytic Models. | Lundin A et al. | β | 2018 | β |
| Human Models Are Needed for Studying Human Neurodevelopmental Disorders. | Zhao X et al. | β | 2018 | β |
| <i>In vitro</i> Models for Seizure-Liability Testing Using Induced Pluripotent Stem Cells. | Grainger AI et al. | β | 2018 | β |
| Illustrating the potency of current Good Manufacturing Practice-compliant induced pluripotent stem cell lines as a source of multiple cell lineages using standardized protocols. | Rao MS et al. | β | 2018 | β |
| Induced pluripotent stem cells (iPSCs) as model to study inherited defects of neurotransmission in inborn errors of metabolism. | Jung-Klawitter S et al. | β | 2018 | β |
| Modeling neurological diseases using iPSC-derived neural cells : iPSC modeling of neurological diseases. | Li L et al. | β | 2018 | β |
| Modelling Sporadic Alzheimer's Disease Using Induced Pluripotent Stem Cells. | Rowland HA et al. | β | 2018 | β |
| Neonatal mouse cortical but not isogenic human astrocyte feeder layers enhance the functional maturation of induced pluripotent stem cell-derived neurons in culture. | Lischka FW et al. | β | 2018 | β |
| Recent advances in lineage differentiation from stem cells: hurdles and opportunities? | Terryn J et al. | β | 2018 | β |
| Recent advances in lineage differentiation from stem cells: hurdles and opportunities? | Terryn J et al. | β | 2018 | β |
| Representing Diversity in the Dish: Using Patient-Derived <i>in Vitro</i> Models to Recreate the Heterogeneity of Neurological Disease. | Ghaffari LT et al. | β | 2018 | β |
| Research Models and Tools for the Identification of Antivirals and Therapeutics against Zika Virus Infection. | Alves MP et al. | β | 2018 | β |
| Aberrant iPSC-derived human astrocytes in Alzheimer's disease. | Jones VC et al. | β | 2017 | β |
| Aligned Poly(Ξ΅-caprolactone) Nanofibers Guide the Orientation and Migration of Human Pluripotent Stem Cell-Derived Neurons, Astrocytes, and Oligodendrocyte Precursor Cells In Vitro. | Hyysalo A et al. | β | 2017 | β |
| An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells. | Tcw J et al. | β | 2017 | β |
| APOE Ξ΅4/Ξ΅4 diminishes neurotrophic function of human iPSC-derived astrocytes. | Zhao J et al. | β | 2017 | β |
| Differentiation of Inflammation-Responsive Astrocytes from Glial Progenitors Generated from Human Induced Pluripotent Stem Cells. | Santos R et al. | β | 2017 | β |
| Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells. | Sloan SA et al. | β | 2017 | β |
| Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation. | Koss KM et al. | β | 2017 | β |
| Mitochondria in Multiple Sclerosis: Molecular Mechanisms of Pathogenesis. | Patergnani S et al. | β | 2017 | β |
| Neutrophils Induce Astroglial Differentiation and Migration of Human Neural Stem Cells via C1q and C3a Synthesis. | Hooshmand MJ et al. | β | 2017 | β |
| Paving the Way Toward Complex Blood-Brain Barrier Models Using Pluripotent Stem Cells. | Lauschke K et al. | β | 2017 | β |
| The Importance of Non-neuronal Cell Types in hiPSC-Based Disease Modeling and Drug Screening. | Gonzalez DM et al. | β | 2017 | β |
| Adult Neurogenesis and Gliogenesis: Possible Mechanisms for Neurorestoration. | RusznΓ‘k Z et al. | β | 2016 | β |
| Astrocyte Differentiation of Human Pluripotent Stem Cells: New Tools for Neurological Disorder Research. | Chandrasekaran A et al. | β | 2016 | β |
| Common pitfalls of stem cell differentiation: a guide to improving protocols for neurodegenerative disease models and research. | Engel M et al. | β | 2016 | β |
| Comparative neurotoxicity screening in human iPSC-derived neural stem cells, neurons and astrocytes. | Pei Y et al. | β | 2016 | β |
| Enrichment of Oligodendrocyte Progenitors from Differentiated Neural Precursors by Clonal Sphere Preparations. | Umebayashi D et al. | β | 2016 | β |
| Establishment of a Human Neuronal Network Assessment System by Using a Human Neuron/Astrocyte Co-Culture Derived from Fetal Neural Stem/Progenitor Cells. | Fukushima K et al. | β | 2016 | β |
| Functional and phenotypic differences of pure populations of stem cell-derived astrocytes and neuronal precursor cells. | Kleiderman S et al. | β | 2016 | β |
| Generation of GFAP::GFP astrocyte reporter lines from human adult fibroblast-derived iPS cells using zinc-finger nuclease technology. | Zhang PW et al. | β | 2016 | β |
| High-Throughput Phenotypic Screening of Human Astrocytes to Identify Compounds That Protect Against Oxidative Stress. | Thorne N et al. | β | 2016 | β |
| Human iPSC-Derived Immature Astroglia Promote Oligodendrogenesis by Increasing TIMP-1 Secretion. | Jiang P et al. | β | 2016 | β |
| Human pluripotent stem cell models of Fragile X syndrome. | Bhattacharyya A et al. | β | 2016 | β |
| Human Stem Cell-Derived Astrocytes: Specification and Relevance for Neurological Disorders. | Tyzack G et al. | β | 2016 | β |
| Induced Pluripotent Stem Cells inΒ Huntington's Disease Research: ProgressΒ and Opportunity. | Tousley A et al. | β | 2016 | β |
| iPSC-based drug screening for Huntington's disease. | Zhang N et al. | β | 2016 | β |
| Neural stem cells secrete factors facilitating brain regeneration upon constitutive Raf-Erk activation. | Rhee YH et al. | β | 2016 | β |
| Neural Subtype Specification from Human Pluripotent Stem Cells. | Tao Y et al. | β | 2016 | β |
| Neuroinflammation - using big data to inform clinical practice. | Dendrou CA et al. | β | 2016 | β |
| Stem cell-derived astrocytes: are they physiologically credible? | Hill E et al. | β | 2016 | β |
| The Regulation of rRNA Gene Transcription during Directed Differentiation of Human Embryonic Stem Cells. | Woolnough JL et al. | β | 2016 | β |
| A platform for rapid generation of single and multiplexed reporters in human iPSC lines. | Pei Y et al. | β | 2015 | β |
| Current proceedings of cerebral palsy. | Fan HC et al. | β | 2015 | β |
| Direct conversion of fibroblasts into functional astrocytes by defined transcription factors. | Caiazzo M et al. | β | 2015 | β |
| Identification of stable reference genes in differentiating human pluripotent stem cells. | Holmgren G et al. | β | 2015 | β |
| Pluripotent stem cell-derived radial glia-like cells as stable intermediate for efficient generation of human oligodendrocytes. | Gorris R et al. | β | 2015 | β |
| Rescue of an in vitro neuron phenotype identified in Niemann-Pick disease, type C1 induced pluripotent stem cell-derived neurons by modulating the WNT pathway and calcium signaling. | Efthymiou AG et al. | β | 2015 | β |
| Stem and Progenitor Cell-Derived Astroglia Therapies for Neurological Diseases. | Chen C et al. | β | 2015 | β |
| Stem cell reprogramming: basic implications and future perspective for movement disorders. | BrΓ€ndl B et al. | β | 2015 | β |
| A star is born: new insights into the mechanism of astrogenesis. | Kanski R et al. | β | 2014 | β |
| Comparison of the gene expression profiles of human fetal cortical astrocytes with pluripotent stem cell derived neural stem cells identifies human astrocyte markers and signaling pathways and transcription factors active in human astrocytes. | Malik N et al. | β | 2014 | β |
| Compounds with species and cell type specific toxicity identified in a 2000 compound drug screen of neural stem cells and rat mixed cortical neurons. | Malik N et al. | β | 2014 | β |
| "Footprint-free" human induced pluripotent stem cell-derived astrocytes for in vivo cell-based therapy. | Mormone E et al. | β | 2014 | β |
| Functional screening assays with neurons generated from pluripotent stem cell-derived neural stem cells. | Efthymiou A et al. | β | 2014 | β |
| Genome wide profiling of dopaminergic neurons derived from human embryonic and induced pluripotent stem cells. | MomΔiloviΔ O et al. | β | 2014 | β |
| Production of neural stem cells from human pluripotent stem cells. | Wen Y et al. | β | 2014 | β |
| Self-renewal and cell lineage differentiation strategies in human embryonic stem cells and induced pluripotent stem cells. | Efthymiou AG et al. | β | 2014 | β |
| A cellular star atlas: using astrocytes from human pluripotent stem cells for disease studies. | Krencik R et al. | β | 2013 | β |
| hESC-derived Olig2+ progenitors generate a subtype of astroglia with protective effects against ischaemic brain injury. | Jiang P et al. | β | 2013 | β |
| Human stem cell-derived spinal cord astrocytes with defined mature or reactive phenotypes. | Roybon L et al. | β | 2013 | β |
| Modeling astrocytic contribution toward neurodegeneration with pluripotent stem cells: focus on Alzheimer's and Parkinson's diseases. | Rinaldi F et al. | β | 2013 | β |
| Neural stem cells as tools for drug discovery: novel platforms and approaches. | Gorba T et al. | β | 2013 | β |
| The cytoskeletal protein RHAMM and ERK1/2 activity maintain the pluripotency of murine embryonic stem cells. | Jiang J et al. | β | 2013 | β |