Long latency event-related potentials in mice: effects of stimulus characteristics and strain.
- Authors
- Ehlers, Cindy L; Somes, Chris
- Year
- 2002
- Journal
- Brain research
- PMID
- 12443987
- DOI
- 10.1016/s0006-8993(02)03612-0
The P3, or P300 component of the event-related potentials (ERPs) is a positive going waveform that can be averaged from the EEG approximately 250-500 ms following the presentation of task or context 'relevant' stimuli. This potential has been demonstrated to be a sensitive measure of both normal and abnormal cognitive functioning. P300 models have been developed in monkeys, cats and rats. The aim of the present study was to develop an auditory ERP paradigm suitable for use in mice that resembled those used in humans and other animal models. The results of the studies showed that late positive potentials in the 200-400 ms range could be generated in cortical sites in response to auditory stimuli. Additionally, like passive ERPs recorded in humans, mouse ERPs were sensitive to changes in stimulus characteristics. An earlier negative component designated the N1 was found to be sensitive to tone frequency and loudness but not to stimulus probability, whereas the mouse P300 component was sensitive to probability but not to tone frequency or loudness. C57BL/6 mice, a strain known to have a strong alcohol preference, were found to have significantly lower P300 amplitudes when compared to the DBA/2 strain. These findings also parallel human studies, and studies of selected lines of rats, demonstrating that decrements in P300 amplitude can be associated with a genetic vulnerability to alcoholism/alcohol preference. These studies further suggest that ERPs are an electrophysiological assay suitable for the exploration of the effects of genetic manipulations on neurosensory processing in mice.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Auditory evoked-potential abnormalities in a mouse model of 22q11.2 Deletion Syndrome and their interactions with hearing impairment. | Lu C et al. | β | 2025 | β |
| Disrupted gut microbiota aggravates working memory dysfunction induced by high-altitude exposure in mice. | Zhao Z et al. | β | 2022 | β |
| Classical and controlled auditory mismatch responses to multiple physical deviances in anaesthetised and conscious mice. | O'Reilly JA et al. | β | 2021 | β |
| Unsuccessful reduction of high-frequency alpha activity during cognitive activation in schizophrenia. | Jang KI et al. | β | 2019 | β |
| Auditory-induced response in the primary sensory cortex of rodents. | Maruyama AT et al. | β | 2018 | β |
| Cholinergic Mechanisms of Target Oddball Stimuli Detection: The Late "P300-Like" Event-Related Potential in Rats. | Ahnaou A et al. | β | 2018 | β |
| Mismatch negativity in preclinical models of schizophrenia. | Featherstone RE et al. | β | 2018 | β |
| EEG biomarkers of target engagement, therapeutic effect, and disease process. | Featherstone RE et al. | β | 2015 | β |
| Endophenotypes for Alcohol Use Disorder: An Update on the Field. | Salvatore JE et al. | β | 2015 | β |
| Event-related potential responses to the acute and chronic effects of alcohol in adolescent and adult Wistar rats. | Ehlers CL et al. | β | 2014 | β |
| Heritability and molecular-genetic basis of the P3 event-related brain potential: a genome-wide association study. | Malone SM et al. | β | 2014 | β |
| Mismatch negativity as a "translatable" brain marker toward early intervention for psychosis: a review. | Nagai T et al. | β | 2013 | β |
| Role of murine models in psychiatric illness drug discovery: a dimensional view. | Hoffman KL | β | 2013 | β |
| Event-Related Oscillations in Alcoholism Research: A Review. | Pandey AK et al. | β | 2012 | β |
| The interrelationship between movement and cognition: ΞΈ rhythm and the P300 event-related potential. | Shin J | β | 2011 | β |
| Changes in mid-to-late latency auditory evoked responses in the chicken during neural maturation. | Atkinson R et al. | β | 2010 | β |
| Event-related oscillations in the parietal cortex of adult alcohol-preferring (P) and alcohol-nonpreferring rats (NP). | Criado JR et al. | β | 2010 | β |
| Event-related oscillations as risk markers in genetic mouse models of high alcohol preference. | Criado JR et al. | β | 2009 | β |
| Event-related oscillations in mice: effects of stimulus characteristics. | Ehlers CL et al. | β | 2009 | β |
| Neurophysiological and neurochemical animal models of schizophrenia: focus on glutamate. | Bickel S et al. | β | 2009 | β |
| Deviance-elicited changes in event-related potentials are attenuated by ketamine in mice. | Ehrlichman RS et al. | β | 2008 | β |
| Neurophysiological biomarkers for drug development in schizophrenia. | Javitt DC et al. | β | 2008 | β |
| Genetic variations of the NR3A subunit of the NMDA receptor modulate prefrontal cerebral activity in humans. | Gallinat J et al. | β | 2007 | β |
| Symptomatic treatment of Alzheimer's disease: identification of biomarkers to aid translation from bench to bedside. | Irving EA et al. | β | 2007 | β |
| Corticosterone modulates auditory gating in mouse. | Maxwell CR et al. | β | 2006 | β |
| Deviance-related electrophysiological activity in mice: is there mismatch negativity in mice? | Umbricht D et al. | β | 2005 | β |
| Midlatency auditory event-related potentials in mice: comparison to midlatency auditory ERPs in humans. | Umbricht D et al. | β | 2004 | β |
| EEG and ERP profiles in the high alcohol preferring (HAP) and low alcohol preferring (LAP) mice: relationship to ethanol preference. | Slawecki CJ et al. | β | 2003 | β |
| Inhibition of auditory evoked potentials and prepulse inhibition of startle in DBA/2J and DBA/2Hsd inbred mouse substrains. | Connolly PM et al. | β | 2003 | β |