Event-related potentials and the prediction of differential drug response in psychiatry.
- Authors
- Hegerl, U; Herrmann, W M
- Year
- 1990
- Journal
- Neuropsychobiology
- PMID
- 2077439
- DOI
- 10.1159/000119434
Differences in physiological trait or state characteristics of the organism are ultimately responsible for the wide range of interindividual variability in the clinical response to psychoactive drugs. Event-related potentials (ERPs) appear especially valuable in assessing these physiological characteristics, and might therefore be useful as predictors of the individual drug response. Seven criteria for the selection of potential predictor variables are presented. A review of the literature reveals consistent, prospective and cross-validated results concerning the prediction of the clinical response to psychostimulants in hyperkinetic children. Consistent findings have also been reported concerning the relationship between ERPs and the antidepressive as well as prophylactic effects of lithium. Relating to other aspects of drug therapy in psychiatry, there have been isolated studies describing ERP differences between responders and nonresponders. It is concluded that the use of ERPs in the prediction of differential drug response is a promising research strategy, deserving more attention. Its relevance will be seen not only in its practical value for therapeutic decisions, but also in the clarification of therapeutic mechanisms.
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Advances in Electrophysiological Research. | 2015 | 26259089 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Personality and Augmenting/Reducing (A/R) in auditory event-related potentials (ERPs) during emotional visual stimulation. | De Pascalis V et al. | — | 2017 | → |
| Advances in Electrophysiological Research. | Kamarajan C et al. | — | 2015 | → |
| The promise of the quantitative electroencephalogram as a predictor of antidepressant treatment outcomes in major depressive disorder. | Hunter AM et al. | — | 2007 | → |
| Imaging technologies in drug development: Anxiety and depression. | Rabiner EA | — | 2005 | → |
| Is auditory evoked potential augmenting/reducing affected by acute tryptophan depletion? | Debener S et al. | — | 2002 | → |
| Anticonvulsant drugs in bipolar disorder. | Grunze H et al. | — | 1999 | → |
| Auditory event-related potentials to a two-tone discrimination paradigm in attention deficit hyperactivity disorder. | Johnstone SJ et al. | — | 1996 | → |
| Endogenous evoked potentials assessment in depression: a review. | Nandrino J et al. | — | 1996 | → |
| Intensity dependence of auditory evoked potentials in behaving cats. | Juckel G et al. | — | 1996 | → |
| Effects of the dopamine-related drug bromocriptine on event-related potentials and its relation to the law of initial value. | Nishimura N et al. | — | 1995 | → |
| Effect of the dopamine D2 antagonist sulpiride on event-related potentials and its relation to the law of initial value. | Takeshita S et al. | — | 1994 | → |
| Intensity dependence of auditory evoked potentials as an indicator of central serotonergic neurotransmission: a new hypothesis. | Hegerl U et al. | — | 1993 | → |