Widespread evidence for non-additive genetic variation in Cloninger's and Eysenck's personality dimensions using a twin plus sibling design.
paper
Cited
Public
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- Authors
- Keller, Matthew C; Coventry, William L; Heath, Andrew C; Martin, Nicholas G
- Year
- 2005
- Journal
- Behavior genetics
- PMID
- 16273321
- DOI
- 10.1007/s10519-005-6041-7
Studies using the classical twin design often conclude that most genetic variation underlying personality is additive in nature. However, studies analyzing only twins are very limited in their ability to detect non-additive genetic variation and are unable to detect sources of variation unique to twins, which can mask non-additive genetic variation. The current study assessed 9672 MZ and DZ twin individuals and 3241 of their siblings to investigate the environmental and genetic architecture underlying eight dimensions of personality: four from Eysenck's Personality Questionnaire and four from Cloninger's Temperament and Character Inventory. Broad-sense heritability estimates from best-fitting models were two to three times greater than the narrow-sense heritability estimates for Harm Avoidance, Novelty Seeking, Reward Dependence, Persistence, Extraversion, and Neuroticism. This genetic non-additivity could be due to dominance, additive-by-additive epistasis, or to additive genetic effects combined with higher-order epistasis. Environmental effects unique to twins were detected for both Lie and Psychoticism but accounted for little overall variation. Our results illustrate the increased sensitivity afforded by extending the classical twin design to include siblings, and may provide clues to the evolutionary origins of genetic variation underlying personality.
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| Maternal temperament and character: associations to child behavior at the age of 3 years. | Agnafors S et al. | — | 2021 | → |
| Three genetic-environmental networks for human personality. | Zwir I et al. | — | 2021 | → |
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| Genotype-Environment Correlation and Its Relation to Personality - A Twin and Family Study. | Persson B | — | 2020 | → |
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| Uncovering the complex genetics of human character. | Zwir I et al. | — | 2020 | → |
| Uncovering the complex genetics of human temperament. | Zwir I et al. | — | 2020 | → |
| Genetic and Environmental Associations Between Child Personality and Parenting. | Ayoub M et al. | — | 2019 | → |
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| Kids becoming less alike: A behavioral genetic analysis of developmental increases in personality variance from childhood to adolescence. | Mõttus R et al. | — | 2019 | → |
| Modeling human temperament and character on the basis of combined theoretical approaches. | Fountoulakis KN et al. | — | 2019 | → |
| The complex genetics and biology of human temperament: a review of traditional concepts in relation to new molecular findings. | Cloninger CR et al. | — | 2019 | → |
| The Problem of Non-Shared Environment in Behavioral Genetics. | Tikhodeyev ON et al. | — | 2019 | → |
| Genetic and Environmental Contributions to the Covariation Between Cardiometabolic Traits. | Chen X et al. | — | 2018 | → |
| Genetic and Environmental Overlaps Among Sasang Constitution Types: A Multivariate Twin Study. | Hur YM et al. | — | 2018 | → |
| What is the natural measurement unit of temperament: single traits or profiles? | Cloninger CR et al. | — | 2018 | → |
| Beyond dual systems: A genetically-informed, latent factor model of behavioral and self-report measures related to adolescent risk-taking. | Harden KP et al. | — | 2017 | → |
| Factor analysis of temperament and personality traits in bipolar patients: Correlates with comorbidity and disorder severity. | Qiu F et al. | — | 2017 | → |
| Harm avoidance and childhood adversities in patients with obsessive-compulsive disorder and their unaffected first-degree relatives. | Bey K et al. | — | 2017 | → |
| Modeling prior information of common genetic variants improves gene discovery for neuroticism. | Lo MT et al. | — | 2017 | → |
| Sensation seeking and impulsive traits as personality endophenotypes for antisocial behavior: Evidence from two independent samples. | Mann FD et al. | — | 2017 | → |
| Spatial and temporal expression patterns of genes around nine neuroticism-associated loci. | Ohi K et al. | — | 2017 | → |
| Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci. | Smith DJ et al. | — | 2016 | → |
| Individual Differences in Personality Masculinity-Femininity: Examining the Effects of Genes, Environment, and Prenatal Hormone Transfer. | Verweij KJ et al. | — | 2016 | → |
| Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium. | van den Berg SM et al. | — | 2016 | → |
| Personality Polygenes, Positive Affect, and Life Satisfaction. | Weiss A et al. | — | 2016 | → |
| The influence of genes on "positive valence systems" constructs: A systematic review. | Hess JL et al. | — | 2016 | → |
| ABO Blood Type and Personality Traits in Healthy Japanese Subjects. | Tsuchimine S et al. | — | 2015 | → |
| Dominant Genetic Variation and Missing Heritability for Human Complex Traits: Insights from Twin versus Genome-wide Common SNP Models. | Chen X et al. | — | 2015 | → |
| Genetic and environmental influences underlying the relationship between autistic traits and temperament and character dimensions in adulthood. | Picardi A et al. | — | 2015 | → |
| Genetic and Environmental Stability of Neuroticism From Adolescence to Adulthood. | Nivard MG et al. | — | 2015 | → |
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| The genetic and environmental roots of variance in negativity toward foreign nationals. | Kandler C et al. | — | 2015 | → |
| The Power of Theory, Research Design, and Transdisciplinary Integration in Moving Psychopathology Forward. | Vaidyanathan U et al. | — | 2015 | → |
| Behavior Genetics and the Within-Person Variability of Daily Interpersonal Styles: The Heritability of Flux, Spin and Pulse. | Markey PM et al. | — | 2014 | → |
| Does Harm Avoidance mediate effects of recollected parental bonding on mental distress in adulthood? | Stenbæk DS et al. | — | 2014 | → |
| Genetic and environmental bases of the interplay between magical ideation and personality. | Brambilla P et al. | — | 2014 | → |
| Genetic and environmental continuity in personality development: a meta-analysis. | Briley DA et al. | — | 2014 | → |
| Genetic strategies for probing conscientiousness and its relationship to aging. | South SC et al. | — | 2014 | → |
| Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory. | van den Berg SM et al. | — | 2014 | → |
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| Model endophenotype for bipolar disorder: Qualitative Analysis, etiological factors, and research areas. | Tavares Nde O et al. | — | 2014 | → |
| Biological pathways and genetic mechanisms involved in social functioning. | Ordoñana JR et al. | — | 2013 | → |
| Genetic associations between the ADHD symptom dimensions and Cloninger's temperament dimensions in adult twins. | Merwood A et al. | — | 2013 | → |
| Genetics of impulsive behaviour. | Bevilacqua L et al. | — | 2013 | → |
| Heritability and linkage analysis of personality in bipolar disorder. | Greenwood TA et al. | — | 2013 | → |
| Relations between Cloninger's dimensions of temperament and steepness of delay and effort discounting of monetary rewards. | Malesza M et al. | — | 2013 | → |
| Shared environmental influences on personality: a combined twin and adoption approach. | Matteson LK et al. | — | 2013 | → |
| Temperament and character in the Child and Adolescent Twin Study in Sweden (CATSS): comparison to the general population, and genetic structure analysis. | Garcia D et al. | — | 2013 | → |
| The genetic correlation between height and IQ: shared genes or assortative mating? | Keller MC et al. | — | 2013 | → |
| A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales. | Service SK et al. | — | 2012 | → |
| Common SNPs explain some of the variation in the personality dimensions of neuroticism and extraversion. | Vinkhuyzen AA et al. | — | 2012 | → |
| Genetic and environmental influences on the relationship between flow proneness, locus of control and behavioral inhibition. | Mosing MA et al. | — | 2012 | → |
| Genetic influences on life span and its relationship to personality: a 16-year follow-up study of a sample of aging twins. | Mosing MA et al. | — | 2012 | → |
| Maintenance of genetic variation in human personality: testing evolutionary models by estimating heritability due to common causal variants and investigating the effect of distant inbreeding. | Verweij KJ et al. | — | 2012 | → |
| Maternal BIS Sensitivity, Overprotective Parenting, and Children's Internalizing Behaviors. | Kiel EJ et al. | — | 2012 | → |
| Parent Personality and Positive Parenting as Predictors of Positive Adolescent Personality Development Over Time. | Schofield TJ et al. | — | 2012 | → |
| Personality traits and life dissatisfaction as risk factors for disability pension due to low back diagnoses: a 30-year longitudinal cohort study of Finnish twins. | Ropponen A et al. | — | 2012 | → |
| The complexity of personality: advantages of a genetically sensitive multi-group design. | Hahn E et al. | — | 2012 | → |
| The majority of genetic variation in orangutan personality and subjective well-being is nonadditive. | Adams MJ et al. | — | 2012 | → |
| The profile and familiality of personality traits in mood disorder families. | Wu PJ et al. | — | 2012 | → |
| ADRA2A polymorphisms and ADHD in adults: possible mediating effect of personality. | de Cerqueira CC et al. | — | 2011 | → |
| Genetic and environmental influences on impulsivity: a meta-analysis of twin, family and adoption studies. | Bezdjian S et al. | — | 2011 | → |
| Heritability of problem drinking and the genetic overlap with personality in a general population sample. | de Moor MH et al. | — | 2011 | → |
| Personality and illness: genetic connections? | Hobgood DK | — | 2011 | → |
| Personality traits of aggression-submissiveness and perfectionism associate with ABO blood groups through catecholamine activities. | Hobgood DK | — | 2011 | → |
| Predicting sensation seeking from dopamine genes: use and misuse of genetic prediction. | Powell JE et al. | — | 2011 | → |
| Sexual orientation and psychiatric vulnerability: a twin study of neuroticism and psychoticism. | Zietsch BP et al. | — | 2011 | → |
| Using non-normal SEM to resolve the ACDE model in the classical twin design. | Ozaki K et al. | — | 2011 | → |
| A genome-wide association study of Cloninger's temperament scales: implications for the evolutionary genetics of personality. | Verweij KJ et al. | — | 2010 | → |
| A population based family study of symptoms of anxiety and depression: the HUNT study. | Czajkowski N et al. | — | 2010 | → |
| Child and adolescent psychiatric genetics. | Hebebrand J et al. | — | 2010 | → |
| Familial resemblance for loneliness. | Distel MA et al. | — | 2010 | → |
| Family matters: happiness in nuclear families and twins. | Nes RB et al. | — | 2010 | → |
| Genetic modelling of childhood social development and personality in twins and siblings with schizophrenia. | Picchioni MM et al. | — | 2010 | → |
| Neurocognitive phenotypes and genetic dissection of disorders of brain and behavior. | Congdon E et al. | — | 2010 | → |
| The genetic epidemiology of personality disorders. | Reichborn-Kjennerud T | — | 2010 | → |
| Antecedents of children's adult outcomes in the Texas Adoption Project. | Loehlin JC et al. | — | 2009 | → |
| Cloninger's temperament traits and preclinical atherosclerosis: the Cardiovascular Risk in Young Finns Study. | Hintsanen M et al. | — | 2009 | → |
| Emotional instability, poor emotional awareness, and the development of borderline personality. | Cole PM et al. | — | 2009 | → |
| Familial resemblance of borderline personality disorder features: genetic or cultural transmission? | Distel MA et al. | — | 2009 | → |
| Genetic and environmental influences on the junior temperament and character inventory in a preadolescent twin sample. | Isen JD et al. | — | 2009 | → |
| The five-factor model of personality and borderline personality disorder: a genetic analysis of comorbidity. | Distel MA et al. | — | 2009 | → |
| The heritability of hedonic capacity and perceived stress: a twin study evaluation of candidate depressive phenotypes. | Bogdan R et al. | — | 2009 | → |
| A genome-wide scan for Eysenckian personality dimensions in adolescent twin sibships: psychoticism, extraversion, neuroticism, and lie. | Gillespie NA et al. | — | 2008 | → |
| A review of potential cognitive and environmental risk markers in children of bipolar parents. | Jones SH et al. | — | 2008 | → |
| Genetics of anxiety: would the genome recognize the DSM? | Smoller JW et al. | — | 2008 | → |
| Heritability of borderline personality disorder features is similar across three countries. | Distel MA et al. | — | 2008 | → |
| Latent profiles of temperament and their relations to psychopathology and wellness. | Rettew DC et al. | — | 2008 | → |
| Non-additive and additive genetic effects on extraversion in 3314 Dutch adolescent twins and their parents. | Rettew DC et al. | — | 2008 | → |
| The relationship between obstetric complications and temperament in eating disorders: a mediation hypothesis. | Favaro A et al. | — | 2008 | → |
| The role of personality in psychotherapy for anxiety and depression. | Zinbarg RE et al. | — | 2008 | → |
| Evidence for nonadditive genetic effects on Eysenck Personality Scales in South Korean twins. | Hur YM | — | 2007 | → |
| Food neophobia shows heritable variation in humans. | Knaapila A et al. | — | 2007 | → |
| Heritability of type-D personality. | Kupper N et al. | — | 2007 | → |
| Increased anxiety and other similarities in temperament of alcoholics with and without antisocial personality disorder across three diverse populations. | Ducci F et al. | — | 2007 | → |
| Personality traits in Sardinia: testing founder population effects on trait means and variances. | Costa PT et al. | — | 2007 | → |
| Religious upbringing and neuroticism in Dutch twin families. | Willemsen G et al. | — | 2007 | → |
| The genetics of brain wiring: from molecule to mind. | Mitchell KJ | — | 2007 | → |
| Interactions between child and parent temperament and child behavior problems. | Rettew DC et al. | — | 2006 | → |
| Nonadditive genetic effects on hostility in South Korean adolescent and young adult twins. | Hur YM | — | 2006 | → |
| The mechanism of emergenesis. | Lykken DT | — | 2006 | → |
| The molecular genetic architecture of human personality: beyond self-report questionnaires. | Ebstein RP | — | 2006 | → |