Analysis of quantitative trait loci that influence animal behavior.
- Authors
- Flint, Jonathan
- Year
- 2003
- Journal
- Journal of neurobiology
- PMID
- 12486698
- DOI
- 10.1002/neu.10161
Behavioral differences between inbred strains of mice and rats have a genetic basis that can now be dissected using quantitative trait locus (QTL) analysis. Over the last 10 years, a large number of genetic loci that influence behavior have been mapped. In this article I review what that information has revealed about the genetic architecture of behavior. I show that most behaviors are influenced by QTL of small effect, each contributing to less than 10% of the variance of a behavioral trait. The small effect of each QTL on behavioral variation suggests that the mutational spectrum is different from that which results in Mendelian disorders. Regions of DNA should be appropriately prioritized to find the molecular variants, for instance by looking at sequences that control the level of gene expression rather than variants in coding regions. While the number of allelic loci that can contribute to a trait is large, this is not necessarily the case: the analysis of selected strains shows that a remarkably small number of QTL can explain the bulk of the genetic variation in behavior. I conclude by arguing that genetic mapping has more to offer than a starting point for positional cloning projects. With advances in multivariate analyses, mapping can also test hypotheses about the psychological processes that give rise to behavioral variation.
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Discrete genetic modules underlie divergent reproductive strategies in three-spined stickleback. | Behrens C et al. | β | 2026 | β |
| Tit wit: environmental and genetic drivers of cognitive variation along an urbanization gradient. | Thompson MJ et al. | β | 2025 | β |
| Adaptive Differences in Cellular and Behavioral Responses to Circadian Disruption between C57BL/6 and BALB/c Strains. | Ma C et al. | β | 2024 | β |
| Bioenergetic phenotype of hippocampal neurons in various inbred mouse strains | Zelentsova AS et al. | β | 2024 | β |
| Novel pathways linked to the expression of temperament in Merino sheep: a genome-wide association study. | Ding L et al. | β | 2024 | β |
| Genetic polymorphisms in the serotonin, dopamine and opioid pathways influence social attention in rhesus macaques (Macaca mulatta). | Howarth ERI et al. | β | 2023 | β |
| Genetics of behavioural evolution in giant mice from Gough Island. | Stratton JA et al. | β | 2023 | β |
| Hunting for Genes Underlying Emotionality in the Laboratory Rat: Maps, Tools and Traps. | Ramos A et al. | β | 2023 | β |
| Behavioral genetics and genomics: Mendel's peas, mice, and bees. | Hoekstra HE et al. | β | 2022 | β |
| Mouse hybrid genome mediates diverse brain phenotypes with the specificity of reciprocal crosses. | Chou MY et al. | β | 2022 | β |
| Evolution of Boldness and Exploratory Behavior in Giant Mice from Gough Island. | Stratton JA et al. | β | 2021 | β |
| Inbred lab mice are not isogenic: genetic variation within inbred strains used to infer the mutation rate per nucleotide site. | Chebib J et al. | β | 2021 | β |
| Genetic Architecture of Innate Fear Behavior in Chickens. | Ishikawa A et al. | β | 2020 | β |
| The genetic basis of animal behavioural diversity in natural populations. | Bubac CM et al. | β | 2020 | β |
| Genetic dissection of complex behaviour traits in German Shepherd dogs. | Friedrich J et al. | β | 2019 | β |
| Assessing the Genetic Landscape of Animal Behavior. | York RA | β | 2018 | β |
| Genetic analysis reveals candidate genes for activity QTL in the blind Mexican tetra, <i>Astyanax mexicanus</i>. | Carlson BM et al. | β | 2018 | β |
| Genetics and Genomics of Social Behavior in a Chicken Model. | Johnsson M et al. | β | 2018 | β |
| Space Radiation Alters Genotype-Phenotype Correlations in Fear Learning and Memory Tests. | Iancu OD et al. | β | 2018 | β |
| Genetic Characterization of Dog Personality Traits. | Ilska J et al. | β | 2017 | β |
| Peromyscus burrowing: A model system for behavioral evolution. | Hu CK et al. | β | 2017 | β |
| Genetical Genomics of Behavior: A Novel Chicken Genomic Model for Anxiety Behavior. | Johnsson M et al. | β | 2016 | β |
| Genome-wide association mapping of heritable temperament variation in the Tennessee Walking Horse. | Staiger EA et al. | β | 2016 | β |
| Genome-wide association study for behavior, type traits, and muscular development in Charolais beef cattle. | VallΓ©e A et al. | β | 2016 | β |
| Identification of quantitative trait loci and candidate genes for an anxiolytic-like response to ethanol in BXD recombinant inbred strains. | Putman AH et al. | β | 2016 | β |
| Genetic mapping of natural variation in schooling tendency in the threespine stickleback. | Greenwood AK et al. | β | 2015 | β |
| Integrated Genome-wide association and hypothalamus eQTL studies indicate a link between the circadian rhythm-related gene PER1 and coping behavior. | Ponsuksili S et al. | β | 2015 | β |
| MicroRNA hsa-miR-4717-5p regulates RGS2 and may be a risk factor for anxiety-related traits. | Hommers L et al. | β | 2015 | β |
| RGS2 ggenetic variation: association analysis with panic disorder and dimensional as well as intermediate phenotypes of anxiety. | Hohoff C et al. | β | 2015 | β |
| The Genetic Architecture of Domestication in Animals. | Wright D | β | 2015 | β |
| Behavior genetics and the domestication of animals. | Jensen P | β | 2014 | β |
| Genetic control of startle behavior in medaka fish. | Tsuboko S et al. | β | 2014 | β |
| Genetic influences on brain gene expression in rats selected for tameness and aggression. | Heyne HO et al. | β | 2014 | β |
| Genomics: moving behavioural ecology beyond the phenotypic gambit. | Rittschof CC et al. | β | 2014 | β |
| Identification of QTLs for behavioral reactivity to social separation and humans in sheep using the OvineSNP50 BeadChip. | Hazard D et al. | β | 2014 | β |
| The use of mouse models to unravel genetic architecture of physical activity: a review. | Kostrzewa E et al. | β | 2014 | β |
| Genetic and neural modularity underlie the evolution of schooling behavior in threespine sticklebacks. | Greenwood AK et al. | β | 2013 | β |
| High-precision genetic mapping of behavioral traits in the diversity outbred mouse population. | Logan RW et al. | β | 2013 | β |
| Role of murine models in psychiatric illness drug discovery: a dimensional view. | Hoffman KL | β | 2013 | β |
| Varieties of behavioral natural variation. | McGrath PT | β | 2013 | β |
| What are we measuring when we test strain differences in anxiety in mice? | O'Leary TP et al. | β | 2013 | β |
| Forward genetic approaches to understanding complex behaviors. | Tarantino LM et al. | β | 2012 | β |
| Genome-wide association study of comorbid depressive syndrome and alcohol dependence. | Edwards AC et al. | β | 2012 | β |
| Long-range regulatory polymorphisms affecting a GABA receptor constitute a quantitative trait locus (QTL) for social behavior in Caenorhabditis elegans. | Bendesky A et al. | β | 2012 | β |
| Maternal separation is associated with strain-specific responses to stress and epigenetic alterations to Nr3c1, Avp, and Nr4a1 in mouse. | Kember RL et al. | β | 2012 | β |
| Opportunities for bioinformatics in the classification of behavior and psychiatric disorders. | Chesler EJ et al. | β | 2012 | β |
| PTSD and gene variants: new pathways and new thinking. | Skelton K et al. | β | 2012 | β |
| RGS2 mediates the anxiolytic effect of oxytocin. | Okimoto N et al. | β | 2012 | β |
| Association of RGS2 variants with panic disorder in a Japanese population. | Otowa T et al. | β | 2011 | β |
| Breeder and batch-dependent variability in the acquisition and performance of a motor skill in adult Long-Evans rats. | O'Bryant AJ et al. | β | 2011 | β |
| Gene networks associated with conditional fear in mice identified using a systems genetics approach. | Park CC et al. | β | 2011 | β |
| Genetic contributions to behavioural diversity at the gene-environment interface. | Bendesky A et al. | β | 2011 | β |
| Integrative genome-wide association analysis of cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders. | Kim S et al. | β | 2011 | β |
| Second-generation high-throughput forward genetic screen in mice to isolate subtle behavioral mutants. | Kumar V et al. | β | 2011 | β |
| The clinical implications of mouse models of enhanced anxiety. | Sartori SB et al. | β | 2011 | β |
| The influence of sex and estrous cycle on QTL for emotionality and ethanol consumption. | IzΓdio GS et al. | β | 2011 | β |
| Behavioural battery testing: evaluation and behavioural outcomes in 8 inbred mouse strains. | Lad HV et al. | β | 2010 | β |
| Genetic approaches to modeling anxiety in animals. | Jacobson LH et al. | β | 2010 | β |
| Genetic mapping of social interaction behavior in B6/MSM consomic mouse strains. | Takahashi A et al. | β | 2010 | β |
| High-throughput behavioral phenotyping in the expanded panel of BXD recombinant inbred strains. | Philip VM et al. | β | 2010 | β |
| Quantitative trait loci contributing to physiological and behavioural ethanol responses after acute and chronic treatment. | Drews E et al. | β | 2010 | β |
| Quantitative trait locus and haplotype mapping in closely related inbred strains identifies a locus for open field behavior. | Eisener-Dorman AF et al. | β | 2010 | β |
| Six quantitative trait loci influence task thresholds for hygienic behaviour in honeybees (Apis mellifera). | Oxley PR et al. | β | 2010 | β |
| Ten ways to improve the quality of descriptions of whole-animal movement. | Benjamini Y et al. | β | 2010 | β |
| Whole genome sequencing highlights genetic changes associated with laboratory domestication of C. elegans. | Weber KP et al. | β | 2010 | β |
| An E3 ubiquitin ligase, Really Interesting New Gene (RING) Finger 41, is a candidate gene for anxiety-like behavior and beta-carboline-induced seizures. | Kim S et al. | β | 2009 | β |
| Anxiety in mice and men: a comparison. | Hohoff C | β | 2009 | β |
| Expression of alpha-synuclein is increased in the hippocampus of rats with high levels of innate anxiety. | Chiavegatto S et al. | β | 2009 | β |
| Genetic architecture of tameness in a rat model of animal domestication. | Albert FW et al. | β | 2009 | β |
| Genetics of anxiety and trauma-related disorders. | Norrholm SD et al. | β | 2009 | β |
| Heart rate variability response to mental arithmetic stress is abnormal in first-degree relatives of individuals with schizophrenia. | Castro MN et al. | β | 2009 | β |
| Mapping of quantitative trait loci affecting behaviour in swine. | Reiner G et al. | β | 2009 | β |
| QTL analyses of temporal and intensity components of home-cage activity in KJR and C57BL/6J strains. | Umemori J et al. | β | 2009 | β |
| Quantitative mapping of a digenic behavioral trait implicates globin variation in C. elegans sensory behaviors. | McGrath PT et al. | β | 2009 | β |
| 5-HT2C and GABAB receptors influence handling-induced convulsion severity in chromosome 4 congenic and DBA/2J background strain mice. | Reilly MT et al. | β | 2008 | β |
| Are designer guppies inbred? Microsatellite variation in five strains of ornamental guppies, Poecilia reticulata, used for behavioral research. | Bleakley BH et al. | β | 2008 | β |
| Experiential and genetic contributions to depressive- and anxiety-like disorders: clinical and experimental studies. | Anisman H et al. | β | 2008 | β |
| Genetic determinants of emotionality and stress response in AcB/BcA recombinant congenic mice and in silico evidence of convergence with cardiovascular candidate genes. | Thifault S et al. | β | 2008 | β |
| Genetics of anxiety disorders: complexities and opportunities. | Smoller JW et al. | β | 2008 | β |
| Identification of quantitative trait loci affecting cattle temperament. | GutiΓ©rrez-Gil B et al. | β | 2008 | β |
| Prepulse inhibition (PPI) of tactile startle response in recombinant congenic strains of mice: QTL mapping and comparison with acoustic PPI. | Torkamanzehi A et al. | β | 2008 | β |
| Quantitative trait locus analysis: multiple cross and heterogeneous stock mapping. | Hitzemann R et al. | β | 2008 | β |
| Systematic analysis of emotionality in consomic mouse strains established from C57BL/6J and wild-derived MSM/Ms. | Takahashi A et al. | β | 2008 | β |
| Behavioral genomics of honeybee foraging and nest defense. | Hunt GJ et al. | β | 2007 | β |
| Chromosomal loci that influence oral nicotine consumption in C57BL/6J x C3H/HeJ F2 intercross mice. | Li XC et al. | β | 2007 | β |
| Feeling strained? Influence of genetic background on depression-related behavior in mice: a review. | Jacobson LH et al. | β | 2007 | β |
| Flight and fight: a comparative view of the neurophysiology and genetics of honey bee defensive behavior. | Hunt GJ | β | 2007 | β |
| Integrating animal temperament within ecology and evolution. | RΓ©ale D et al. | β | 2007 | β |
| A mouse model system for genetic analysis of sociability: C57BL/6J versus BALB/cJ inbred mouse strains. | Sankoorikal GM et al. | β | 2006 | β |
| Animal models of behavioral dysfunctions: basic concepts and classifications, and an evaluation strategy. | van der Staay FJ | β | 2006 | β |
| Evidence for a female-specific effect of a chromosome 4 locus on anxiety-related behaviors and ethanol drinking in rats. | Vendruscolo LF et al. | β | 2006 | β |
| Further studies on using multiple-cross mapping (MCM) to map quantitative trait loci. | Malmanger B et al. | β | 2006 | β |
| Genetics of affective and anxiety disorders. | Leonardo ED et al. | β | 2006 | β |
| Identification of informative strains and provisional QTL mapping of amphetamine (AMPH)-induced locomotion in recombinant congenic strains (RCS) of mice. | Torkamanzehi A et al. | β | 2006 | β |
| Maternal and genetic effects on anxiety-related behavior of C3H/HeN, DBA/2J and NMRI mice in a motility-box following blastocyst transfer. | Rose C et al. | β | 2006 | β |
| QTL analysis of behavioral and morphological differentiation between wild and laboratory zebrafish (Danio rerio). | Wright D et al. | β | 2006 | β |
| Reflections on the relationship between psychiatric genetics and psychiatric nosology. | Kendler KS | β | 2006 | β |
| Rgs 2 gene polymorphisms as modulators of anxiety in humans? | Leygraf A et al. | β | 2006 | β |
| Social organization, grouping, and domestication in fish. | Wright D et al. | β | 2006 | β |
| Stability of inbred mouse strain differences in behavior and brain size between laboratories and across decades. | Wahlsten D et al. | β | 2006 | β |
| The genetic architecture of sucrose responsiveness in the honeybee (Apis mellifera L.). | Rueppell O et al. | β | 2006 | β |
| The genetic contribution to canine personality. | Saetre P et al. | β | 2006 | β |
| The molecular genetic architecture of human personality: beyond self-report questionnaires. | Ebstein RP | β | 2006 | β |
| The nature of genetic influences on behavior: lessons from "simpler" organisms. | Kendler KS et al. | β | 2006 | β |
| Variation in anti-predator behavior among five strains of inbred guppies, Poecilia reticulata. | Bleakley BH et al. | β | 2006 | β |
| A genome scan with AFLP markers to detect fearfulness-related QTLs in Japanese quail. | Beaumont C et al. | β | 2005 | β |
| Complex genetics of interactions of alcohol and CNS function and behavior. | Matthews DB et al. | β | 2005 | β |
| Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function. | Chesler EJ et al. | β | 2005 | β |
| Computational, integrative, and comparative methods for the elucidation of genetic coexpression networks. | Baldwin NE et al. | β | 2005 | β |
| Digit ratio (2D:4D) and behavioral differences between inbred mouse strains. | Bailey AA et al. | β | 2005 | β |
| Fine mapping of a major locus on chromosome 10 for exploratory and fear-like behavior in mice. | Zhang S et al. | β | 2005 | β |
| Genetics of developmental psychiatric disorders: pathways to discovery. | Joober R et al. | β | 2005 | β |
| Heritability, correlations and in silico mapping of locomotor behavior and neurochemistry in inbred strains of mice. | Mhyre TR et al. | β | 2005 | β |
| Human personality traits are associated with individual environmental traits in male adolescents--a pilot study. | Nakamura-Tani T | β | 2005 | β |
| Impact of genomics on research in the rat. | Lazar J et al. | β | 2005 | β |
| Lineage is an epigenetic modifier of QTL influencing behavioral coping with stress. | Ahmadiyeh N et al. | β | 2005 | β |
| Looking forward in geriatric anxiety and depression: implications of basic science for the future. | Gershenfeld HK et al. | β | 2005 | β |
| Mapping quantitative trait loci for anxiety in chromosome substitution strains of mice. | Singer JB et al. | β | 2005 | β |
| Maternal influences on adult stress and anxiety-like behavior in C57BL/6J and BALB/cJ mice: a cross-fostering study. | Priebe K et al. | β | 2005 | β |
| Strategies for mapping and cloning quantitative trait genes in rodents. | Flint J et al. | β | 2005 | β |
| Supportive evidence for an allelic association of the human KCNJ10 potassium channel gene with idiopathic generalized epilepsy. | Lenzen KP et al. | β | 2005 | β |
| The ascent of mouse: advances in modelling human depression and anxiety. | Cryan JF et al. | β | 2005 | β |
| The Flinders Sensitive Line rat: a selectively bred putative animal model of depression. | Overstreet DH et al. | β | 2005 | β |
| The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice. | Cryan JF et al. | β | 2005 | β |
| Using progenitor strain information to identify quantitative trait nucleotides in outbred mice. | Yalcin B et al. | β | 2005 | β |
| Allelic variations in gene expression. | Yan H et al. | β | 2004 | β |
| Behavioral characterization of wild derived male mice (Mus musculus musculus) of the PWD/Ph inbred strain: high exploration compared to C57BL/6J. | Fernandes C et al. | β | 2004 | β |
| Brain gene expression: genomics and genetics. | Chesler EJ et al. | β | 2004 | β |
| From hormones to immunity: the physiology of immunology. | Kelley KW | β | 2004 | β |
| Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice. | Yalcin B et al. | β | 2004 | β |
| Hippocampal gene expression profiling across eight mouse inbred strains: towards understanding the molecular basis for behaviour. | Fernandes C et al. | β | 2004 | β |
| How species evolve collectively: implications of gene flow and selection for the spread of advantageous alleles. | Morjan CL et al. | β | 2004 | β |
| In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice. | Cryan JF et al. | β | 2004 | β |
| Maternal behavior modulates X-linked inheritance of behavioral coping in the defensive burying test. | Ahmadiyeh N et al. | β | 2004 | β |
| Multivariate analysis of quantitative trait loci influencing variation in anxiety-related behavior in laboratory mice. | Turri MG et al. | β | 2004 | β |
| On the integration of alcohol-related quantitative trait loci and gene expression analyses. | Hitzemann R et al. | β | 2004 | β |
| Pharmacogenetic studies of alcohol self-administration and withdrawal. | Crabbe JC et al. | β | 2004 | β |
| QTL analysis of multiple behavioral measures of anxiety in mice. | Henderson ND et al. | β | 2004 | β |
| The genetic basis of neuroticism. | Flint J | β | 2004 | β |
| Abnormal anxiety-related behavior in serotonin transporter null mutant mice: the influence of genetic background. | Holmes A et al. | β | 2003 | β |
| A strategy for the integration of QTL, gene expression, and sequence analyses. | Hitzemann R et al. | β | 2003 | β |
| N-ethyl-N-nitrosourea mouse mutants in the dissection of behavioural and psychiatric disorders. | Keays DA et al. | β | 2003 | β |
| The nicotinic acetylcholine receptor subunit alpha 5 mediates short-term effects of nicotine in vivo. | Salas R et al. | β | 2003 | β |
| Untangling genetic networks of panic, phobia, fear and anxiety. | Villafuerte S et al. | β | 2003 | β |