Tumour heterogeneity and cancer cell plasticity.
paper
Cited
Public
Unavailable
- Authors
- Meacham, Corbin E; Morrison, Sean J
- Year
- 2013
- Journal
- Nature
- PMID
- 24048065
- DOI
- 10.1038/nature12624
- PMCID
- PMC4521623
Phenotypic and functional heterogeneity arise among cancer cells within the same tumour as a consequence of genetic change, environmental differences and reversible changes in cell properties. Some cancers also contain a hierarchy in which tumorigenic cancer stem cells differentiate into non-tumorigenic progeny. However, it remains unclear what fraction of cancers follow the stem-cell model and what clinical behaviours the model explains. Studies using lineage tracing and deep sequencing could have implications for the cancer stem-cell model and may help to determine the extent to which it accounts for therapy resistance and disease progression.
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| How germline genes promote malignancy in cancer cells. | Bruggeman JW et al. | β | 2023 | β |
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| Impact of nanoparticles on amyloid Ξ²-induced Alzheimer's disease, tuberculosis, leprosy and cancer: a systematic review. | Chakraborty A et al. | β | 2023 | β |
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| Molecular Aspects and Therapeutic Implications of Herbal Compounds Targeting Different Types of Cancer. | Sharma A et al. | β | 2023 | β |
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