Functional importance of ventricular enlargement and cortical atrophy in healthy subjects and alcoholics as assessed with PET, MR imaging, and neuropsychologic testing.
paper
Cited
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- Authors
- Wang, G J; Volkow, N D; Roque, C T; Cestaro, V L; Hitzemann, R J; Cantos, E L; Levy, A V; Dhawan, A P
- Year
- 1993
- Journal
- Radiology
- PMID
- 8416587
- DOI
- 10.1148/radiology.186.1.8416587
The authors assessed the relationship between ventricular enlargement, cortical atrophy, regional brain glucose metabolism, and neuropsychologic performance in 10 alcoholics and 10 control subjects. Regional brain glucose metabolism was measured with fluorine-18 fluorodeoxyglucose (FDG) and positron emission tomography (PET). Cortical atrophy and ventricular size were evaluated quantitatively with magnetic resonance (MR) imaging. Alcoholics had decreased brain glucose metabolism and more cortical atrophy but did not have significantly greater ventricular size than did control subjects. The degree of ventricular enlargement and of cortical atrophy was associated with decreased metabolism predominantly in the frontal cortices and subcortical structures in both alcoholics and control subjects. There were no significant correlations between neuropsychologic performance and MR imaging structural changes, whereas various subtest scores were significantly correlated with frontal lobe metabolism. These data show that F-18 FDG PET is a sensitive technique for detecting early functional changes in the brain due to alcohol and/or aging before structural changes can be detected with MR imaging.
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|---|---|---|---|---|
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| Fluorodeoxyglucose positron emission tomography scans in patients with alcohol use disorder. | Bralet MC et al. | — | 2022 | → |
| How do substance use disorders compare to other psychiatric conditions on structural brain abnormalities? A cross-disorder meta-analytic comparison using the ENIGMA consortium findings. | Navarri X et al. | — | 2022 | → |
| Intranasal Insulin: a Treatment Strategy for Addiction. | Kashyap B et al. | — | 2020 | → |
| Aberrations of anterior insular cortex functional connectivity in nontreatment-seeking alcoholics. | Halcomb ME et al. | — | 2019 | → |
| Association Between Reduced Brain Glucose Metabolism and Cortical Thickness in Alcoholics: Evidence of Neurotoxicity. | Tomasi DG et al. | — | 2019 | → |
| Cerebellar Hypermetabolism in Alcohol Use Disorder: Compensatory Mechanism or Maladaptive Plasticity? | Ritz L et al. | — | 2019 | → |
| Reduced Hypoxic Tissue and Cognitive Improvement after Revascularization Surgery for Chronic Cerebral Ischemia. | Shimada Y et al. | — | 2019 | → |
| Using Mismatch Negativity to Investigate the Pathophysiology of Substance Use Disorders and Comorbid Psychosis. | Ramlakhan JU et al. | — | 2018 | → |
| Cannabis Abusers Show Hypofrontality and Blunted Brain Responses to a Stimulant Challenge in Females but not in Males. | Wiers CE et al. | — | 2016 | → |
| Direct voxel-based comparisons between grey matter shrinkage and glucose hypometabolism in chronic alcoholism. | Ritz L et al. | — | 2016 | → |
| Alcohol decreases baseline brain glucose metabolism more in heavy drinkers than controls but has no effect on stimulation-induced metabolic increases. | Volkow ND et al. | — | 2015 | → |
| Brain perfusion in polysubstance users: relationship to substance and tobacco use, cognition, and self-regulation. | Murray DE et al. | — | 2015 | → |
| FDG-PET Contributions to the Pathophysiology of Memory Impairment. | Segobin S et al. | — | 2015 | → |
| Brain glucose metabolism in adults with ataxia-telangiectasia and their asymptomatic relatives. | Volkow ND et al. | — | 2014 | → |
| PET imaging reveals brain functional changes in internet gaming disorder. | Tian M et al. | — | 2014 | → |
| Reactions to media violence: it's in the brain of the beholder. | Alia-Klein N et al. | — | 2014 | → |
| Acute alcohol intoxication decreases glucose metabolism but increases acetate uptake in the human brain. | Volkow ND et al. | — | 2013 | → |
| A selective insular perfusion deficit contributes to compromised salience network connectivity in recovering alcoholic men. | Sullivan EV et al. | — | 2013 | → |
| Association between dopamine D4 receptor polymorphism and age related changes in brain glucose metabolism. | Volkow ND et al. | — | 2013 | → |
| Energetic cost of brain functional connectivity. | Tomasi D et al. | — | 2013 | → |
| Predominance of D2 receptors in mediating dopamine's effects in brain metabolism: effects of alcoholism. | Volkow ND et al. | — | 2013 | → |
| Translating positron emission tomography studies in animals to stimulant addiction: promises and pitfalls. | Caprioli D et al. | — | 2013 | → |
| Neurocognitive deficits in male alcoholics: an ERP/sLORETA analysis of the N2 component in an equal probability Go/NoGo task. | Pandey AK et al. | — | 2012 | → |
| Preservation of retinotopic map in retinal degeneration. | Xie J et al. | — | 2012 | → |
| Regional brain structural dysmorphology in human immunodeficiency virus infection: effects of acquired immune deficiency syndrome, alcoholism, and age. | Pfefferbaum A et al. | — | 2012 | → |
| Alcohol and the human brain: a systematic review of different neuroimaging methods. | Bühler M et al. | — | 2011 | → |
| Effects of alcohol administration during adulthood on parvalbumin and glial fibrillary acidic protein immunoreactivity in the rat cerebral cortex. | Udomuksorn W et al. | — | 2011 | → |
| Effects of cell phone radiofrequency signal exposure on brain glucose metabolism. | Volkow ND et al. | — | 2011 | → |
| Modeling and percept of transcorneal electrical stimulation in humans. | Xie J et al. | — | 2011 | → |
| Positive emotionality is associated with baseline metabolism in orbitofrontal cortex and in regions of the default network. | Volkow ND et al. | — | 2011 | → |
| Reduced metabolism in brain "control networks" following cocaine-cues exposure in female cocaine abusers. | Volkow ND et al. | — | 2011 | → |
| Cognitive control of drug craving inhibits brain reward regions in cocaine abusers. | Volkow ND et al. | — | 2010 | → |
| Contributions of studies on alcohol use disorders to understanding cerebellar function. | Zahr NM et al. | — | 2010 | → |
| Effects of low-field magnetic stimulation on brain glucose metabolism. | Volkow ND et al. | — | 2010 | → |
| Methylphenidate attenuates limbic brain inhibition after cocaine-cues exposure in cocaine abusers. | Volkow ND et al. | — | 2010 | → |
| Recruitment of additional brain regions to accomplish simple motor tasks in chronic alcohol-dependent patients. | Parks MH et al. | — | 2010 | → |
| Chronic alcoholism: insights from neurophysiology. | Campanella S et al. | — | 2009 | → |
| Inverse association between BMI and prefrontal metabolic activity in healthy adults. | Volkow ND et al. | — | 2009 | → |
| Low dopamine striatal D2 receptors are associated with prefrontal metabolism in obese subjects: possible contributing factors. | Volkow ND et al. | — | 2008 | → |
| Methamphetamine causes microglial activation in the brains of human abusers. | Sekine Y et al. | — | 2008 | → |
| Methylphenidate decreased the amount of glucose needed by the brain to perform a cognitive task. | Volkow ND et al. | — | 2008 | → |
| Neuroinflammation as a neurotoxic mechanism in alcoholism: commentary on "Increased MCP-1 and microglia in various regions of human alcoholic brain". | Sullivan EV et al. | — | 2008 | → |
| Alcohol: effects on neurobehavioral functions and the brain. | Oscar-Berman M et al. | — | 2007 | → |
| Altered brain activation by a false recognition task in young abstinent patients with alcohol dependence. | Akine Y et al. | — | 2007 | → |
| Brain morphometry and cognitive performance in detoxified alcohol-dependents with preserved psychosocial functioning. | Chanraud S et al. | — | 2007 | → |
| Profound decreases in dopamine release in striatum in detoxified alcoholics: possible orbitofrontal involvement. | Volkow ND et al. | — | 2007 | → |
| Effects of expectation on the brain metabolic responses to methylphenidate and to its placebo in non-drug abusing subjects. | Volkow ND et al. | — | 2006 | → |
| Low doses of alcohol substantially decrease glucose metabolism in the human brain. | Volkow ND et al. | — | 2006 | → |
| Suppression of early evoked gamma band response in male alcoholics during a visual oddball task. | Padmanabhapillai A et al. | — | 2006 | → |
| Activation of orbital and medial prefrontal cortex by methylphenidate in cocaine-addicted subjects but not in controls: relevance to addiction. | Volkow ND et al. | — | 2005 | → |
| Correlation of ventricular asymmetry with metabolic asymmetry in frontotemporal dementia. | Jeong Y et al. | — | 2005 | → |
| Genetic influences in emotional dysfunction and alcoholism-related brain damage. | Oscar-Berman M et al. | — | 2005 | → |
| The utility of neurophysiological markers in the study of alcoholism. | Porjesz B et al. | — | 2005 | → |
| Alcohol abuse and traumatic brain injury: quantitative magnetic resonance imaging and neuropsychological outcome. | Wilde EA et al. | — | 2004 | → |
| Comparisons of Korsakoff and non-Korsakoff alcoholics on neuropsychological tests of prefrontal brain functioning. | Oscar-Berman M et al. | — | 2004 | → |
| Partial recovery of brain metabolism in methamphetamine abusers after protracted abstinence. | Wang GJ et al. | — | 2004 | → |
| Severity of neuropsychological impairment in cocaine and alcohol addiction: association with metabolism in the prefrontal cortex. | Goldstein RZ et al. | — | 2004 | → |
| Abnormal CNV in chronic heavy drinkers. | Chao LL et al. | — | 2003 | → |
| Association of dopamine transporter loss in the orbitofrontal and dorsolateral prefrontal cortices with methamphetamine-related psychiatric symptoms. | Sekine Y et al. | — | 2003 | → |
| Cerebral blood flow in alcohol withdrawal: relation to severity of dependence and cognitive impairment. | Hamdi E et al. | — | 2003 | → |
| Epidemiology of substance use disorders in women. | Greenfield SF et al. | — | 2003 | → |
| Expectation enhances the regional brain metabolic and the reinforcing effects of stimulants in cocaine abusers. | Volkow ND et al. | — | 2003 | → |
| Interaction of aging and intermittent ethanol exposure on brain cytochrome c oxidase activity levels. | Jaatinen P et al. | — | 2003 | → |
| Cortical gray matter loss in treatment-naïve alcohol dependent individuals. | Fein G et al. | — | 2002 | → |
| The orbitofrontal cortex in methamphetamine addiction: involvement in fear. | Goldstein RZ et al. | — | 2002 | → |
| Addiction changes orbitofrontal gyrus function: involvement in response inhibition. | Goldstein RZ et al. | — | 2001 | → |
| fMRI measurement of brain dysfunction in alcohol-dependent young women. | Tapert SF et al. | — | 2001 | → |
| Higher cortical and lower subcortical metabolism in detoxified methamphetamine abusers. | Volkow ND et al. | — | 2001 | → |
| Low level of brain dopamine D2 receptors in methamphetamine abusers: association with metabolism in the orbitofrontal cortex. | Volkow ND et al. | — | 2001 | → |
| Association of methylphenidate-induced craving with changes in right striato-orbitofrontal metabolism in cocaine abusers: implications in addiction. | Volkow ND et al. | — | 1999 | → |
| Brain shrinkage in alcoholics: a decade on and what have we learned? | Kril JJ et al. | — | 1999 | → |
| Dose-related neurobehavioral effects of chronic cocaine use. | Bolla KI et al. | — | 1999 | → |
| Hypoperfusion of the cerebellum and aging effects on cerebral cortex blood flow in abstinent alcoholics: a SPECT study. | Harris GJ et al. | — | 1999 | → |
| Multiple previous alcohol detoxifications are associated with decreased medial temporal and paralimbic function in the postwithdrawal period. | George MS et al. | — | 1999 | → |
| Regional brain metabolic activation during craving elicited by recall of previous drug experiences. | Wang GJ et al. | — | 1999 | → |
| Structural and functional neuroimaging findings in substance-related disorders. | Netrakom P et al. | — | 1999 | → |
| Suppression of mismatch negativity by backward masking predicts impaired working-memory performance in alcoholics. | Ahveninen J et al. | — | 1999 | → |
| Brain imaging. Functional consequences of ethanol in the central nervous system. | Lyons D et al. | — | 1998 | → |
| Brain imaging in alcoholism. | Estruch R et al. | — | 1998 | → |
| Regional cerebral metabolism in female alcoholics of moderate severity does not differ from that of controls. | Wang GJ et al. | — | 1998 | → |
| The neuropsychiatry of chronic cocaine abuse. | Bolla KI et al. | — | 1998 | → |
| The significance of family history status in relation to neuropsychological test performance and cerebral glucose metabolism studied with positron emission tomography in older alcoholic patients. | Adams KM et al. | — | 1998 | → |
| Effects of methylphenidate on regional brain glucose metabolism in humans: relationship to dopamine D2 receptors. | Volkow ND et al. | — | 1997 | → |
| Frontal lobe volume loss observed with magnetic resonance imaging in older chronic alcoholics. | Pfefferbaum A et al. | — | 1997 | → |
| Functional brain imaging and aging in schizophrenia. | Buchsbaum MS et al. | — | 1997 | → |
| Gender differences in cerebellar metabolism: test-retest reproducibility. | Volkow ND et al. | — | 1997 | → |
| Impairments of brain and behavior: the neurological effects of alcohol. | Oscar-Berman M et al. | — | 1997 | → |
| Effects of disulfiram on positron emission tomography and neuropsychological studies in severe chronic alcoholism. | Gilman S et al. | — | 1996 | → |
| Glucose metabolic changes in nontumoral brain tissue of patients with brain tumor following radiotherapy: a preliminary study. | Wang GJ et al. | — | 1996 | → |
| Mechanical lesions of the fimbria fornix in rat brain studied by 1H-magnetic resonance imaging. Evidence for long-lasting dynamic alterations in the ipsilateral ventricular system. | Dijkhuizen RM et al. | — | 1996 | → |
| MR-PET image coregistration for quantitation of striatal dopamine D2 receptors. | Wang GJ et al. | — | 1996 | → |
| Single photon emission computed tomography with iodoamphetamine-123 and neuropsychological studies in long-term abstinent alcoholics. | Dupont RM et al. | — | 1996 | → |
| Visuospatial information processing in intoxicated, recently detoxified, and long-term abstinent alcoholics. | Schandler SL et al. | — | 1996 | → |
| Delayed P3A in abstinent elderly male chronic alcoholics. | Biggins CA et al. | — | 1995 | → |
| Drug-induced disorders of the central nervous system. | Lexa FJ | — | 1995 | → |
| Evaluation of age-related changes in serotonin 5-HT2 and dopamine D2 receptor availability in healthy human subjects. | Wang GJ et al. | — | 1995 | → |
| Monitoring the Brain's Response to Alcohol With Positron Emission Tomography. | Volkow N et al. | — | 1995 | → |
| Serotonin 5-HT2 receptor availability in chronic cocaine abusers. | Wang GJ et al. | — | 1995 | → |
| Structural Brain Alterations Associated With Alcoholism. | Rosenbloom MJ et al. | — | 1995 | → |
| Methylphenidate decreases regional cerebral blood flow in normal human subjects. | Wang GJ et al. | — | 1994 | → |
| Striatal D2 dopamine receptor binding characteristics in vivo in patients with alcohol dependence. | Hietala J et al. | — | 1994 | → |