Serotonin transporter gene variation is associated with alcohol sensitivity in rhesus macaques exposed to early-life stress.
paper
Cited
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- Authors
- Barr, Christina S; Newman, Timothy K; Becker, Michelle L; Champoux, Maribeth; Lesch, Klaus Peter; Suomi, Stephen J; Goldman, David; Higley, J Dee
- Year
- 2003
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 12766626
- DOI
- 10.1097/01.ALC.0000067976.62827.ED
BACKGROUND: Decreased sensitivity to alcohol has been demonstrated to be a predictor of alcoholism in humans, and variation in the gene-linked polymorphic region of the serotonin transporter (5-HTTLPR) is associated with the response to the motor-impairing effects of alcohol. In a nonhuman primate model of excessive alcohol intake, we have shown that decreased serotonin turnover is associated with both lower initial sensitivity to alcohol and higher prospective alcohol consumption using rhesus macaques. In addition, we have demonstrated that macaques separated from their mothers and reared in peer-only groups are more likely to consume alcohol as adults. METHOD: To examine the relationship between serotonin transporter genotype, early rearing experience, and initial sensitivity to alcohol, peer- and mother-reared, adolescent, alcohol-naive rhesus macaques (n = 123) were rated for intoxication after intravenous administration of ethanol (2.2 g/kg and 2.0 g/kg for males and females, respectively) during two testing periods. Serotonin transporter (rh5-HTTLPR) genotype was determined using polymerase chain reaction followed by gel electrophoresis, and data were analyzed using ANOVA and the Mann-Whitney U test. RESULTS: Our analyses demonstrate an effect of serotonin transporter gene variation on ethanol sensitivity, such that animals homozygous for the l allele exhibited decreased sensitivity to the ataxic and sedating effects of alcohol. This effect remained after correction for blood ethanol concentrations and birth cohort. When animals were segregated according to rearing condition, serotonin transporter gene variation predicted intoxication scores among peer-reared animals. CONCLUSIONS: As in some human reports, this study demonstrates a diminution in the response to alcohol in animals homozygous for the l rh5-HTTLPR allele. The phenotypic expression of this genotype in l/s animals, however, is environmentally dependent.
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
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| Early life adversities and lifelong health outcomes: A review of the literature on large, social, long-lived nonhuman mammals. | Dettmer AM et al. | — | 2023 | → |
| A nonhuman primate model of human non-suicidal self-injury: serotonin-transporter genotype-mediated typologies. | Wood EK et al. | — | 2022 | → |
| Effects of personality on assessments of anxiety and cognition. | Améndola L et al. | — | 2022 | → |
| Genetics and epigenetics: paternal adolescent ethanol consumption in serotonin transporter knock-out rats and offspring sensitivity to ethanol. | Hussain S et al. | — | 2022 | → |
| Neurobiological Bases of Alcohol Consumption After Social Stress. | Miczek KA et al. | — | 2022 | → |
| Does early ethanol exposure increase seeking-like behavior in zebrafish? | Pinheiro-da-Silva J et al. | — | 2021 | → |
| Transient serotonin depletion at adolescence, but not at early infancy, reduced subsequent anxiety-like behavior and alcohol intake in female mice. | Bellia F et al. | — | 2021 | → |
| Translational dynamics of alcohol tolerance of preclinical models and human laboratory studies. | Haass-Koffler CL et al. | — | 2020 | → |
| Serotonin transporter gene linked polymorphism (5-HTTLPR) determines progredience of alcohol dependence in Belarusian young males. | Kapitau A et al. | — | 2019 | → |
| Adaptive developmental plasticity in rhesus macaques: the serotonin transporter gene interacts with maternal care to affect juvenile social behaviour. | Madrid JE et al. | — | 2018 | → |
| Effects of Ethanol on Sensory Inputs to the Medial Giant Interneurons of Crayfish. | Swierzbinski ME et al. | — | 2018 | → |
| Low Inherent Sensitivity to the Intoxicating Effects of Ethanol in Rhesus Monkeys with Low CSF Concentrations of the Serotonin Metabolite 5-Hydroxyindoleacetic Acid. | Wood EK et al. | — | 2018 | → |
| Neural and psychological characteristics of college students with alcoholic parents differ depending on current alcohol use. | Brown-Rice KA et al. | — | 2018 | → |
| The behavioral genetics of nonhuman primates: Status and prospects. | Rogers J | — | 2018 | → |
| Prior social experience affects the behavioral and neural responses to acute alcohol in juvenile crayfish. | Swierzbinski ME et al. | — | 2017 | → |
| The Serotonin Transporter and Early Life Stress: Translational Perspectives. | Houwing DJ et al. | — | 2017 | → |
| The effects of childhood maltreatment on brain structure, function and connectivity. | Teicher MH et al. | — | 2016 | → |
| Amphetamine self-administration and dopamine function: assessment of gene × environment interactions in Lewis and Fischer 344 rats. | Meyer AC et al. | — | 2015 | → |
| Serotonin transporter linked polymorphic region (5-HTTLPR) genotype moderates the longitudinal impact of early caregiving on externalizing behavior. | Brett ZH et al. | — | 2015 | → |
| A brief history of research on the genetics of alcohol and other drug use disorders. | Schuckit MA | — | 2014 | → |
| The evolutionary history of SLC6A4 and the role of plasticity in Macaca. | Shattuck MR et al. | — | 2014 | → |
| Determination of genotype combinations that can predict the outcome of the treatment of alcohol dependence using the 5-HT(3) antagonist ondansetron. | Johnson BA et al. | — | 2013 | → |
| How genes and the social environment moderate each other. | Reiss D et al. | — | 2013 | → |
| Is the rodent maternal separation model a valid and effective model for studies on the early-life impact on ethanol consumption? | Nylander I et al. | — | 2013 | → |
| Serotonin transporter genotype affects serotonin 5-HT1A binding in primates. | Christian BT et al. | — | 2013 | → |
| Serotonin transporter genotype modulates HPA axis output during stress: effect of stress, dexamethasone test and ACTH challenge. | Sorenson AN et al. | — | 2013 | → |
| The value of extended pedigrees for next-generation analysis of complex disease in the rhesus macaque. | Vinson A et al. | — | 2013 | → |
| Are Internet use and video-game-playing addictive behaviors? Biological, clinical and public health implications for youths and adults. | Yau YH et al. | — | 2012 | → |
| Behavioural genetics of the serotonin transporter. | Haddley K et al. | — | 2012 | → |
| Childhood adversity, serotonin transporter (5-HTTLPR) genotype, and risk for cigarette smoking and nicotine dependence in alcohol dependent adults. | Mingione CJ et al. | — | 2012 | → |
| Differential serotonin transport is linked to the rh5-HTTLPR in peripheral blood cells. | Singh YS et al. | — | 2012 | → |
| Management of alcohol abuse. | Albanese AP | — | 2012 | → |
| Serotonin transporter genomic biomarker for quantitative assessment of ondansetron treatment response in alcoholics. | Seneviratne C et al. | — | 2012 | → |
| The serotonin transporter gene polymorphism (5HTTLPR) moderates the effect of adolescent environmental conditions on self-esteem in young adulthood: a structural equation modeling approach. | Jonassaint CR et al. | — | 2012 | → |
| Alcohol research: past, present, and future. | Gunzerath L et al. | — | 2011 | → |
| Diverse behavioral, monoaminergic and Fos protein responses to opioids in Warsaw high-alcohol preferring and Warsaw low-alcohol preferring rats. | Taracha E et al. | — | 2011 | → |
| Early-life stress, corpus callosum development, hippocampal volumetrics, and anxious behavior in male nonhuman primates. | Jackowski A et al. | — | 2011 | → |
| Ethanol-induced effects on the dopamine and serotonin systems in adult Wistar rats are dependent on early-life experiences. | Oreland S et al. | — | 2011 | → |
| Molecular targets of alcohol action: Translational research for pharmacotherapy development and screening. | Gorini G et al. | — | 2011 | → |
| Pharmacogenomics of alcohol metabolism: implications for legal testing. | Lippi G et al. | — | 2011 | → |
| Risk, resilience, and gene-environment interplay in primates. | Suomi SJ | — | 2011 | → |
| The investigation into CYP2E1 in relation to the level of response to alcohol through a combination of linkage and association analysis. | Webb A et al. | — | 2011 | → |
| Acute ethanol effects on brain activation in low- and high-level responders to alcohol. | Trim RS et al. | — | 2010 | → |
| Alcohol response and consumption in adolescent rhesus macaques: life history and genetic influences. | Schwandt ML et al. | — | 2010 | → |
| Alcohol self-administration in rats: Modulation by temporal parameters related to repeated mild social defeat stress. | Caldwell EE et al. | — | 2010 | → |
| Alteration of serotonin transporter messenger RNA level in the peripheral blood mononuclear cells from simian/human immunodeficiency virus infected Chinese rhesus macaques (Macaca mulatta). | Yu K et al. | — | 2010 | → |
| Biological contribution to social influences on alcohol drinking: evidence from animal models. | Anacker AM et al. | — | 2010 | → |
| Boron-Doped Diamond Microelectrodes Reveal Reduced Serotonin Uptake Rates in Lymphocytes from Adult Rhesus Monkeys Carrying the Short Allele of the 5-HTTLPR. | Singh YS et al. | — | 2010 | → |
| Description and validation of a dynamical systems model of presynaptic serotonin function: genetic variation, brain activation and impulsivity. | Stoltenberg SF et al. | — | 2010 | → |
| Does the transcription factor AP-2beta have an impact on the genetic and early environmental influence on ethanol consumption? | Oreland S et al. | — | 2010 | → |
| Quantification of ethanol methyl (1)H magnetic resonance signal intensity following intravenous ethanol administration in primate brain. | Flory GS et al. | — | 2010 | → |
| Alcohol-use disorders. | Schuckit MA | — | 2009 | → |
| Drinking histories in alcohol-use-disordered youth: preliminary findings on relationships to platelet serotonin transporter expression with genotypes of the serotonin transporter. | Dawes MA et al. | — | 2009 | → |
| Early life stress, the development of aggression and neuroendocrine and neurobiological correlates: what can we learn from animal models? | Veenema AH | — | 2009 | → |
| Impact of age at first drink on vulnerability to alcohol-related problems: testing the marker hypothesis in a prospective study of young adults. | Buchmann AF et al. | — | 2009 | → |
| Impact of psychosocial adversity on alcohol intake in young adults: moderation by the LL genotype of the serotonin transporter polymorphism. | Laucht M et al. | — | 2009 | → |
| Risk and resilience: early manipulation of macaque social experience and persistent behavioral and neurophysiological outcomes. | Stevens HE et al. | — | 2009 | → |
| Serotonin transporter binding and genotype in the nonhuman primate brain using [C-11]DASB PET. | Christian BT et al. | — | 2009 | → |
| Serotonin transporter gene variation, infant abuse, and responsiveness to stress in rhesus macaque mothers and infants. | McCormack K et al. | — | 2009 | → |
| Serotonin transporter genotype modulates social reward and punishment in rhesus macaques. | Watson KK et al. | — | 2009 | → |
| The overlap in predicting alcohol outcome for two measures of the level of response to alcohol. | Schuckit MA et al. | — | 2009 | → |
| Two repeated maternal separation procedures differentially affect brain 5-hydroxytryptamine transporter and receptors in young and adult male and female rats. | Oreland S et al. | — | 2009 | → |
| Evidence of biologic epistasis between BDNF and SLC6A4 and implications for depression. | Pezawas L et al. | — | 2008 | → |
| Functional variation in the 3' untranslated region of the serotonin transporter in human and rhesus macaque. | Vallender EJ et al. | — | 2008 | → |
| Gene environment interplay: nonhuman primate models in the study of resilience and vulnerability. | Bennett AJ | — | 2008 | → |
| Genetic factors influencing alcohol dependence. | Mayfield RD et al. | — | 2008 | → |
| Impulse control disorders in women with eating disorders. | Fernández-Aranda F et al. | — | 2008 | → |
| Level of response to alcohol within the context of alcohol-related domains: an examination of longitudinal approaches assessing changes over time. | Trim RS et al. | — | 2008 | → |
| Neurobiology of addiction. An integrative review. | Goodman A | — | 2008 | → |
| Rapid tolerance and locomotor sensitization in ethanol-naïve adolescent rhesus macaques. | Schwandt ML et al. | — | 2008 | → |
| Relationship between ethanol's acute locomotor effects and ethanol self-administration in male Long-Evans rats. | Chappell AM et al. | — | 2008 | → |
| The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis. | Uher R et al. | — | 2008 | → |
| The self-rating of the effects of alcohol questionnaire as a predictor of alcohol-related outcomes in 12-year-old subjects. | Schuckit MA et al. | — | 2008 | → |
| Age-dependent variation in behavior following acute ethanol administration in male and female adolescent rhesus macaques (Macaca mulatta). | Schwandt ML et al. | — | 2007 | → |
| Association between the recombinant human serotonin transporter linked promoter region polymorphism and behavior in rhesus macaques during a separation paradigm. | Spinelli S et al. | — | 2007 | → |
| Dissociation between the aversive and pharmacokinetic effects of ethanol in female Fischer and Lewis rats. | Roma PG et al. | — | 2007 | → |
| Early adversity and alcohol availability persistently modify serotonin and hypothalamic-pituitary-adrenal-axis metabolism and related behavior: what experimental research on rodents and primates can tell us. | Macrì S et al. | — | 2007 | → |
| Expression of serotonin transporters by peripheral blood mononuclear cells of rhesus monkeys (Macaca mulatta). | Yang GB et al. | — | 2007 | → |
| Genetic research with intermediate phenotypes: phenocopies, perspectives and pitfalls. | Heinz A et al. | — | 2007 | → |
| Long story short: the serotonin transporter in emotion regulation and social cognition. | Canli T et al. | — | 2007 | → |
| Pharmacogenetic aspects of addictive behaviors. | Hejazi NS | — | 2007 | → |
| The functional impact of SLC6 transporter genetic variation. | Hahn MK et al. | — | 2007 | → |
| Differential functional variability of serotonin transporter and monoamine oxidase a genes in macaque species displaying contrasting levels of aggression-related behavior. | Wendland JR et al. | — | 2006 | → |
| Effects of chronic fluvoxamine on ethanol- and food-maintained behaviors. | Ginsburg BC et al. | — | 2006 | → |
| Genetic and other contributions to alcohol intake in rhesus macaques (Macaca mulatta). | Lorenz JG et al. | — | 2006 | → |
| Genetic strategies for clarifying a nosology of relational distress. | Wamboldt MZ et al. | — | 2006 | → |
| Lower serotonin transporter binding in caudate in alcoholics. | Storvik M et al. | — | 2006 | → |
| Low level of response to alcohol as associated with serotonin transporter genotype and high alcohol intake in adolescents. | Hinckers AS et al. | — | 2006 | → |
| Non-human primate models of inheritance vulnerability to alcohol use disorders. | Barr CS et al. | — | 2006 | → |
| Relationships among the level of response to alcohol and the number of alcoholic relatives in predicting alcohol-related outcomes. | Schuckit M et al. | — | 2006 | → |
| Serotonergic dysfunction: brain imaging and behavioral correlates. | Wrase J et al. | — | 2006 | → |
| Time-dependent alterations in ethanol intake in male wistar rats exposed to short and prolonged daily maternal separation in a 4-bottle free-choice paradigm. | Gustafsson L et al. | — | 2006 | → |
| A cross-generational comparison of alcohol challenges at about age 20 in 40 father-offspring pairs. | Schuckit MA et al. | — | 2005 | → |
| Alcohol and gene interactions. | Whitfield JB | — | 2005 | → |
| Alcohol dependence and gene x environment interaction in emotion regulation: Is serotonin the link? | Lesch KP | — | 2005 | → |
| An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk. | Hu X et al. | — | 2005 | → |
| Autosomal linkage analysis for the level of response to alcohol. | Schuckit MA et al. | — | 2005 | → |
| Monoamine oxidase A gene promoter variation and rearing experience influences aggressive behavior in rhesus monkeys. | Newman TK et al. | — | 2005 | → |
| Role of the serotonin transporter gene and family function in adolescent alcohol consumption. | Nilsson KW et al. | — | 2005 | → |
| Serotonin and aggressive behavior in rodents and nonhuman primates: predispositions and plasticity. | Ferrari PF et al. | — | 2005 | → |
| Short and prolonged periods of maternal separation and voluntary ethanol intake in male and female ethanol-preferring AA and ethanol-avoiding ANA rats. | Roman E et al. | — | 2005 | → |
| The genetics of addictions: uncovering the genes. | Goldman D et al. | — | 2005 | → |
| The impact of emotional stress early in life on adult voluntary ethanol intake-results of maternal separation in rats. | Roman E et al. | — | 2005 | → |
| Controlled and behaviorally relevant levels of oral ethanol intake in rhesus macaques using a flavorant-fade procedure. | Katner SN et al. | — | 2004 | → |
| Early experience and sex interact to influence limbic-hypothalamic-pituitary-adrenal-axis function after acute alcohol administration in rhesus macaques (Macaca mulatta). | Barr CS et al. | — | 2004 | → |
| Fetal-maternal interactions: prenatal psychobiological precursors to adaptive infant development. | Novak MF | — | 2004 | → |
| From infant crying to political action: what is the basic science of developmental-behavioral pediatrics? | Barr RG | — | 2004 | → |
| Gene-environment interaction and the genetics of depression. | Lesch KP | — | 2004 | → |
| Genetics, pharmacokinetics, and neurobiology of adolescent alcohol use. | — | — | 2004 | → |
| Pharmacogenetic insights to monoaminergic dysfunction in alcohol dependence. | Heinz A et al. | — | 2004 | → |
| Role of alcohol consumption in escalation to violence. | Miczek KA et al. | — | 2004 | → |
| Sexual dichotomy of an interaction between early adversity and the serotonin transporter gene promoter variant in rhesus macaques. | Barr CS et al. | — | 2004 | → |
| Social stratification, health, and violence in the very young. | Boyce WT | — | 2004 | → |
| The search for genes contributing to the low level of response to alcohol: patterns of findings across studies. | Schuckit MA et al. | — | 2004 | → |
| The use of adolescent nonhuman primates to model human alcohol intake: neurobiological, genetic, and psychological variables. | Barr CS et al. | — | 2004 | → |
| Understanding behaviour in a complex environment. The sixth annual meeting of the International Behavioural and Neural Genetics Society, New Orleans, LA, USA, November 5-7, 2003. | Bouwknecht JA et al. | — | 2004 | → |
| Advances in nonhuman primate alcohol abuse and alcoholism research. | Grant KA et al. | — | 2003 | → |
| Anxiety-related traits in mice with modified genes of the serotonergic pathway. | Lesch KP et al. | — | 2003 | → |
| Gene-environment interactions and the neurobiology of social conflict. | Suomi SJ | — | 2003 | → |
| Pharmacogenomics of alcohol response and addiction. | Enoch MA | — | 2003 | → |
| The utility of the non-human primate; model for studying gene by environment interactions in behavioral research. | Barr CS et al. | — | 2003 | → |