Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease.
paper
Cited
Public
Unavailable
- Authors
- Lohmueller, Kirk E; Pearce, Celeste L; Pike, Malcolm; Lander, Eric S; Hirschhorn, Joel N
- Year
- 2003
- Journal
- Nature genetics
- PMID
- 12524541
- DOI
- 10.1038/ng1071
Association studies offer a potentially powerful approach to identify genetic variants that influence susceptibility to common disease, but are plagued by the impression that they are not consistently reproducible. In principle, the inconsistency may be due to false positive studies, false negative studies or true variability in association among different populations. The critical question is whether false positives overwhelmingly explain the inconsistency. We analyzed 301 published studies covering 25 different reported associations. There was a large excess of studies replicating the first positive reports, inconsistent with the hypothesis of no true positive associations (P < 10(-14)). This excess of replications could not be reasonably explained by publication bias and was concentrated among 11 of the 25 associations. For 8 of these 11 associations, pooled analysis of follow-up studies yielded statistically significant replication of the first report, with modest estimated genetic effects. Thus, a sizable fraction (but under half) of reported associations have strong evidence of replication; for these, false negative, underpowered studies probably contribute to inconsistent replication. We conclude that there are probably many common variants in the human genome with modest but real effects on common disease risk, and that studies using large samples will convincingly identify such variants.
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| Six novel rare non-synonymous mutations for migraine without aura identified by exome sequencing. | Jiang Y et al. | β | 2015 | β |
| Systems Biology and Biomarkers of Early Effects for Occupational Exposure Limit Setting. | DeBord DG et al. | β | 2015 | β |
| The primary open-angle african american glaucoma genetics study: baseline demographics. | Charlson ES et al. | β | 2015 | β |
| UGMDR: a unified conceptual framework for detection of multifactor interactions underlying complex traits. | Lou XY | β | 2015 | β |
| UGT1A1*28 is associated with greater decrease in serum KβΊ levels following oral intake of procaterol. | Yokoe N et al. | β | 2015 | β |
| A genome-wide CNV analysis of schizophrenia reveals a potential role for a multiple-hit model. | Rudd DS et al. | β | 2014 | β |
| Apolipoprotein E genotype and outcome in infants with hypoxic-ischemic encephalopathy. | Cotten CM et al. | β | 2014 | β |
| A sociability gene? Meta-analysis of oxytocin receptor genotype effects in humans. | Bakermans-Kranenburg MJ et al. | β | 2014 | β |
| Association between KIR polymorphisms and ankylosing spondylitis in populations: a meta-analysis. | Fan D et al. | β | 2014 | β |
| Association between type 2 diabetes mellitus-related SNP variants and obesity traits in a Saudi population. | Al-Daghri NM et al. | β | 2014 | β |
| Association claims in the sequencing era. | Pulit SL et al. | β | 2014 | β |
| Association of IL-6 G-174C polymorphism with bone mineral density. | Ni Y et al. | β | 2014 | β |
| Challenges and prospects in genome-wide quantitative trait loci mapping of standing genetic variation in natural populations. | Schielzeth H et al. | β | 2014 | β |
| Circadian rhythms and mood: opportunities for multi-level analyses in genomics and neuroscience: circadian rhythm dysregulation in mood disorders provides clues to the brain's organizing principles, and a touchstone for genomics and neuroscience. | Li JZ | β | 2014 | β |
| Genetic associations in diabetic nephropathy. | Mooyaart AL | β | 2014 | β |
| Genetic variants in CCNB1 associated with differential gene transcription and risk of coronary in-stent restenosis. | Silvestre-Roig C et al. | β | 2014 | β |
| Genome-wide association study for radiographic vertebral fractures: a potential role for the 16q24 BMD locus. | Oei L et al. | β | 2014 | β |
| Genome-wide exploration identifies sex-specific genetic effects of alleles upstream NPY to increase the risk of severe periodontitis in men. | Freitag-Wolf S et al. | β | 2014 | β |
| Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma. | Stacey SN et al. | β | 2014 | β |
| Heterogeneous effect of two selectin gene polymorphisms on coronary artery disease risk: a meta-analysis. | Wu Z et al. | β | 2014 | β |
| Impact of p73 gene polymorphism on cancer susceptibility: a meta analysis. | Liu Y et al. | β | 2014 | β |
| Influence of the COMT val(108/158)met polymorphism on continuous performance task indices. | Park Y et al. | β | 2014 | β |
| In utero effects. In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism. | Radford EJ et al. | β | 2014 | β |
| Lack of association of INS VNTR polymorphism with polycystic ovary syndrome: a meta-analysis. | Song LY et al. | β | 2014 | β |
| Lack of association of P2RX7 gene rs2230912 polymorphism with mood disorders: a meta-analysis. | Feng WP et al. | β | 2014 | β |
| Lack of validation of genetic variants associated with anti-tumor necrosis factor therapy response in rheumatoid arthritis: a genome-wide association study replication and meta-analysis. | MΓ‘rquez A et al. | β | 2014 | β |
| LAPTM4B polymorphism increases susceptibility to multiple cancers in Chinese populations: a meta-analysis. | Mo C et al. | β | 2014 | β |
| Lessons and Implications from Genome-Wide Association Studies (GWAS) Findings of Blood Cell Phenotypes. | Chami N et al. | β | 2014 | β |
| Nonparametric tests of associations with disease based on U-statistics. | Jin L et al. | β | 2014 | β |
| Parathyroid hormone gene rs6256 and calcium sensing receptor gene rs1801725 variants are not associated with susceptibility to colorectal cancer in Iran. | Mahmoudi T et al. | β | 2014 | β |
| Pathogenesis of coronary artery disease: focus on genetic risk factors and identification of genetic variants. | Sayols-Baixeras S et al. | β | 2014 | β |
| Quantitative assessment of the effect of KCNJ11 gene polymorphism on the risk of type 2 diabetes. | Qiu L et al. | β | 2014 | β |
| Quantitative assessment of the influence of common variations on 6p21 and lung cancer risk. | TanTai J et al. | β | 2014 | β |
| Rare and low-frequency variants in human common diseases and other complex traits. | Lettre G | β | 2014 | β |
| Rare variants in BMP2 and BMP4 found in otosclerosis patients reduce Smad signaling. | Ealy M et al. | β | 2014 | β |
| Resistin -420C>G promoter variant and colorectal cancer risk. | Mahmoudi T et al. | β | 2014 | β |
| Screening of susceptibility genes and multi-gene risk analysis in gastric cancer. | Shen XB et al. | β | 2014 | β |
| The effect of TLX3 expression on the prognosis of pediatric T cell acute lymphocytic leukemia--a systematic review. | Ma J et al. | β | 2014 | β |
| The energy intake modulates the association of the -55CT polymorphism of UCP3 with body weight in type 2 diabetic patients. | Lapice E et al. | β | 2014 | β |
| The genetic inheritance of the blue-eyed white phenotype in alpacas (Vicugna pacos). | Jackling FC et al. | β | 2014 | β |
| The role of common variants of ABCB1 and CYP7A1 genes in serum lipid levels and lipid-lowering efficacy of statin treatment: a meta-analysis. | Li Q et al. | β | 2014 | β |
| The SEMA5A gene is associated with hippocampal volume, and their interaction is associated with performance on Raven's Progressive Matrices. | Zhu B et al. | β | 2014 | β |
| Two functional polymorphisms in microRNAs and lung cancer risk: a meta-analysis. | Wang G et al. | β | 2014 | β |
| Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia. | Goodbourn PT et al. | β | 2014 | β |
| Vitamin D status and vitamin D receptor gene polymorphisms and susceptibility to type 1 diabetes in Egyptian children. | Abd-Allah SH et al. | β | 2014 | β |
| XPC Lys939Gln and Ala499Val polymorphisms in colorectal cancer susceptibility: a meta-analysis of case-control studies. | Liu C et al. | β | 2014 | β |
| XRCC1 polymorphisms and cervical cancer risk: an updated meta-analysis. | Mei J et al. | β | 2014 | β |
| A blood pressure genetic risk score is a significant predictor of incident cardiovascular events in 32,669 individuals. | Havulinna AS et al. | β | 2013 | β |
| Advances in blood pressure genomics. | Munroe PB et al. | β | 2013 | β |
| Advances in the genomics of common eye diseases. | Cooke Bailey JN et al. | β | 2013 | β |
| A functional trinucleotide repeat polymorphism in the 5'-untranslated region of the glutathione biosynthetic gene GCLC is associated with increased risk for lung and aerodigestive tract cancers. | Nichenametla SN et al. | β | 2013 | β |
| A meta-analysis of evidences on XPC polymorphisms and lung cancer susceptibility. | Liu C et al. | β | 2013 | β |
| A meta-analysis of the relationship of the Parkin p.Val380Leu polymorphism to Parkinson's disease. | Zhang Y et al. | β | 2013 | β |
| Apolipoprotein M T-778C polymorphism is associated with serum lipid levels and the risk of coronary artery disease in the Chinese population: a meta-analysis. | Zhang Z et al. | β | 2013 | β |
| Assessing interactions between the association of common genetic variant at 1p11 (rs11249433) and hormone receptor status with breast cancer risk. | Chen Q et al. | β | 2013 | β |
| Assessment of systematic effects of methodological characteristics on candidate genetic associations. | Aljasir B et al. | β | 2013 | β |
| Association of BDNF gene polymorphisms with schizophrenia and clinical symptoms in a Chinese population. | Li W et al. | β | 2013 | β |
| Association of CDKN1B gene polymorphisms with susceptibility to breast cancer: a meta-analysis. | Xiang H et al. | β | 2013 | β |
| Association of genetic risk severity with ADHD clinical characteristics. | Kotte A et al. | β | 2013 | β |
| Causes, mechanisms and management of paediatric osteoporosis. | MΓ€kitie O | β | 2013 | β |
| Child development and molecular genetics: 14 years later. | Plomin R | β | 2013 | β |
| Clinical neurogenetics: stroke. | Rost NS | β | 2013 | β |
| Fine-mapping of genome-wide association study-identified risk loci for colorectal cancer in African Americans. | Wang H et al. | β | 2013 | β |
| Free radicals, antioxidant defense systems, and schizophrenia. | Wu JQ et al. | β | 2013 | β |
| Functional polymorphism in the 5'-UTR of CR2 is associated with susceptibility to nasopharyngeal carcinoma. | Fan Q et al. | β | 2013 | β |
| Genetic determinants of mortality. Can findings from genome-wide association studies explain variation in human mortality? | Ganna A et al. | β | 2013 | β |
| Genome wide analysis reveals single nucleotide polymorphisms associated with fatness and putative novel copy number variants in three pig breeds. | Fowler KE et al. | β | 2013 | β |
| High trans-ethnic replicability of GWAS results implies common causal variants. | Marigorta UM et al. | β | 2013 | β |
| Human genome epidemiology, progress and future. | Shen H et al. | β | 2013 | β |
| Impact of natural genetic variation on gene expression dynamics. | Ackermann M et al. | β | 2013 | β |
| Intersectin-1s: an important regulator of cellular and molecular pathways in lung injury. | Predescu DN et al. | β | 2013 | β |
| Introduction to the special section on genomics. | Grigorenko EL et al. | β | 2013 | β |
| Meta-analysis of the association between urokinase-plasminogen activator gene rs2227564 polymorphism and Alzheimer's disease. | Wu W et al. | β | 2013 | β |
| Multi-cultural association of the serotonin transporter gene (SLC6A4) with substance use disorder. | Cao J et al. | β | 2013 | β |
| Myeloperoxidase G-463A polymorphism and susceptibility to coronary artery disease: a meta-analysis. | Tang N et al. | β | 2013 | β |
| Peroxisome proliferator-activated receptors alpha and gamma2 polymorphisms in nonalcoholic fatty liver disease: a study in Brazilian patients. | Domenici FA et al. | β | 2013 | β |
| Population-based and family-based studies on the protein tyrosine phosphatase non-receptor 22 gene polymorphism and type 1 diabetes: a meta-analysis. | Wang XF et al. | β | 2013 | β |
| quantitative assessment of the influence of cytochrome P450 1A2 gene polymorphism and colorectal cancer risk. | Zhao Y et al. | β | 2013 | β |
| Quantitative assessment of the influence of PPARG P12A polymorphism on gestational diabetes mellitus risk. | Wang C et al. | β | 2013 | β |
| Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration. | Seddon JM et al. | β | 2013 | β |
| Replication and fine mapping of asthma-associated loci in individuals of African ancestry. | Kantor DB et al. | β | 2013 | β |
| Statistical testing of shared genetic control for potentially related traits. | Wallace C | β | 2013 | β |
| Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data. | Denny JC et al. | β | 2013 | β |
| The genetics of NAFLD. | Anstee QM et al. | β | 2013 | β |
| The genetics of pigment dispersion syndrome and pigmentary glaucoma. | Lascaratos G et al. | β | 2013 | β |
| The hMLH1 promoter polymorphisms and cancer susceptibility in Asian populations: a meta-analysis. | He Y et al. | β | 2013 | β |
| The MyD88 rs6853 and TIRAP rs8177374 polymorphic sites are associated with resistance to human pulmonary tuberculosis. | Capparelli R et al. | β | 2013 | β |
| The power of meta-analysis in genome-wide association studies. | Panagiotou OA et al. | β | 2013 | β |
| Therapygenetics: Using genetic markers to predict response to psychological treatment for mood and anxiety disorders. | Lester KJ et al. | β | 2013 | β |
| A common missense variant in the ATP receptor P2X7 is associated with reduced risk of cardiovascular events. | GidlΓΆf O et al. | β | 2012 | β |
| A common variant in the adiponectin gene and polycystic ovary syndrome risk. | Ranjzad F et al. | β | 2012 | β |
| Additional Common Polymorphisms in the PON Gene Cluster Predict PON1 Activity but Not Vascular Disease. | Kim DS et al. | β | 2012 | β |
| Alcohol dehydrogenase-1B Arg47His polymorphism and upper aerodigestive tract cancer risk: a meta-analysis including 24,252 subjects. | Guo H et al. | β | 2012 | β |
| A replication study and genome-wide scan of single-nucleotide polymorphisms associated with pancreatic cancer risk and overall survival. | Willis JA et al. | β | 2012 | β |
| Association between genetic variant on chromosome 12p13 and stroke survival and recurrence: a one year prospective study in Taiwan. | Hsieh YC et al. | β | 2012 | β |
| Association between the SUMO4 M55V (A163G) polymorphism and susceptibility to type 1 diabetes: a meta-analysis. | Song GG et al. | β | 2012 | β |
| Association between XPF polymorphisms and cancer risk: a meta-analysis. | Shi TY et al. | β | 2012 | β |
| Association of DRD2 gene polymorphisms with mood disorders: a meta-analysis. | Zou YF et al. | β | 2012 | β |
| Association of estrogen receptor alpha gene polymorphisms and risk of fracture. | Wei G et al. | β | 2012 | β |
| Association of the IL-10 polymorphisms and periodontitis: a meta-analysis. | Albuquerque CM et al. | β | 2012 | β |
| Association of VEGF gene polymorphisms with advanced retinopathy of prematurity: a meta-analysis. | Liu P et al. | β | 2012 | β |
| Association of Ξ²-defensin copy number and psoriasis in three cohorts of European origin. | Stuart PE et al. | β | 2012 | β |
| Associations between the p53 codon 72 polymorphisms and susceptibility to systemic lupus erythematosus and rheumatoid arthritis: a meta-analysis. | Lee YH et al. | β | 2012 | β |
| Association testing of previously reported variants in a large case-control meta-analysis of diabetic nephropathy. | Williams WW et al. | β | 2012 | β |
| A systematic review and meta-analysis on the association between BDNF val(66)met and hippocampal volume--a genuine effect or a winners curse? | Molendijk ML et al. | β | 2012 | β |
| Comparison of family history and SNPs for predicting risk of complex disease. | Do CB et al. | β | 2012 | β |
| Copy number variations in neurodevelopmental disorders. | Grayton HM et al. | β | 2012 | β |
| CYP1A2 rs762551 polymorphism contributes to cancer susceptibility: a meta-analysis from 19 case-control studies. | Wang H et al. | β | 2012 | β |
| Dietary fat intake and polymorphisms at the PPARG locus modulate BMI and type 2 diabetes risk in the D.E.S.I.R. prospective study. | Lamri A et al. | β | 2012 | β |
| Dissection of complex adult traits in a mouse synthetic population. | Burke DT et al. | β | 2012 | β |
| Double genomic control is not effective to correct for population stratification in meta-analysis for genome-wide association studies. | Wang S et al. | β | 2012 | β |
| Evaluating the evidence for transmission distortion in human pedigrees. | Meyer WK et al. | β | 2012 | β |
| Genetic association of the EGR2 gene with bipolar disorder in Korea. | Kim SH et al. | β | 2012 | β |
| Genetic association studies in pre-eclampsia: systematic meta-analyses and field synopsis. | Staines-Urias E et al. | β | 2012 | β |
| Genetic causation of neointimal hyperplasia in hemodialysis vascular access dysfunction. | Lee T et al. | β | 2012 | β |
| Genetic evidence for the association between the early growth response 3 (EGR3) gene and schizophrenia. | Zhang R et al. | β | 2012 | β |
| Genetic polymorphisms of glutathione S-transferase genes GSTM1, GSTT1 and risk of hepatocellular carcinoma. | Song K et al. | β | 2012 | β |
| Genetic variants of the class A scavenger receptor gene are associated with coronary artery disease in Chinese. | Zhang M et al. | β | 2012 | β |
| Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA. | Ramasamy A et al. | β | 2012 | β |
| Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment. | Wu Y et al. | β | 2012 | β |
| Interleukin-1Ξ² and interleukin-6 expression and gene polymorphisms in subjects with peri-implant disease. | Melo RF et al. | β | 2012 | β |
| Introduction to genetic association studies. | Lewis CM et al. | β | 2012 | β |
| Lack of association between hOGG1 Ser326Cys polymorphism and the risk of bladder cancer: a meta-analysis. | Li D et al. | β | 2012 | β |
| Lack of association between p.Ser167Asn variant of Parkin and Parkinson's disease: a meta-analysis of 15 studies involving 2,280 cases and 2,459 controls. | Zhang Y et al. | β | 2012 | β |
| Localising loci underlying complex trait variation using Regional Genomic Relationship Mapping. | Nagamine Y et al. | β | 2012 | β |
| Meta-analysis of 125 rheumatoid arthritis-related single nucleotide polymorphisms studied in the past two decades. | Jiang Y et al. | β | 2012 | β |
| Meta-analysis of the NAD(P)H: quinine oxidoreductase 1 gene 609 C>T polymorphism with esophageal cancer risk. | Wang Z et al. | β | 2012 | β |
| Multicenter cohort association study of SLC2A1 single nucleotide polymorphisms and age-related macular degeneration. | Baas DC et al. | β | 2012 | β |
| Neuropsychological assessment and the paradox of ADHD. | Koziol LF et al. | β | 2012 | β |
| Opportunities and challenges associated with clinical diagnostic genome sequencing: a report of the Association for Molecular Pathology. | Schrijver I et al. | β | 2012 | β |
| Rare and low frequency variant stratification in the UK population: description and impact on association tests. | Babron MC et al. | β | 2012 | β |
| Simulating gene-gene and gene-environment interactions in complex diseases: Gene-Environment iNteraction Simulator 2. | Pinelli M et al. | β | 2012 | β |
| Social-emotional development through a behavior genetics lens: infancy through preschool. | DiLalla LF et al. | β | 2012 | β |
| The -4817 G>A (rs2238136) variant of the vitamin D receptor gene: a probable risk factor for colorectal cancer. | Mahmoudi T et al. | β | 2012 | β |
| The association between UGT1A7 polymorphism and cancer risk: a meta-analysis. | Han SX et al. | β | 2012 | β |
| The association of NAT1 polymorphisms and colorectal carcinoma risk: evidence from 20,000 subjects. | Cai J et al. | β | 2012 | β |
| The genetics of multiple sclerosis: an up-to-date review. | Gourraud PA et al. | β | 2012 | β |
| The indicative effect of Notch1 expression for the prognosis of T-cell acute lymphocytic leukemia: a systematic review. | Ma J et al. | β | 2012 | β |
| The influence of five monoamine genes on trajectories of depressive symptoms across adolescence and young adulthood. | Adkins DE et al. | β | 2012 | β |
| The role of neurexins in schizophrenia and autistic spectrum disorder. | Reichelt AC et al. | β | 2012 | β |
| The role of SNPs in the Ξ±-chain of the IL-7R gene in CD4+ T-cell recovery in HIV-infected African patients receiving suppressive cART. | Rajasuriar R et al. | β | 2012 | β |
| The search for genetic modifiers of disease severity in the Ξ²-hemoglobinopathies. | Lettre G | β | 2012 | β |
| Tracking replicability as a method of post-publication open evaluation. | Hartshorne JK et al. | β | 2012 | β |
| Variation in the XKR4 gene was significantly associated with subcutaneous rump fat thickness in indicine and composite cattle. | Porto Neto LR et al. | β | 2012 | β |
| Vitamin D receptor ApaI, TaqI, BsmI, and FokI polymorphisms and psoriasis susceptibility: a meta-analysis. | Lee YH et al. | β | 2012 | β |
| XPC 939A>C and 499C>T polymorphisms and skin cancer risk: a meta-analysis. | Ji G et al. | β | 2012 | β |
| A candidate gene study of antiepileptic drug tolerability and efficacy identifies an association of CYP2C9 variants with phenytoin toxicity. | Depondt C et al. | β | 2011 | β |
| A computational pipeline for comparative ChIP-seq analyses. | Bardet AF et al. | β | 2011 | β |
| A flexible genome-wide bootstrap method that accounts for ranking and threshold-selection bias in GWAS interpretation and replication study design. | Faye LL et al. | β | 2011 | β |
| A methodology based on molecular interactions and pathways to find candidate genes associated to diseases: its application to schizophrenia and Alzheimer's disease. | OchagavΓa ME et al. | β | 2011 | β |
| Association between polymorphism of methylenetetrahydrofolate reductase (MTHFR) C677T and risk of myocardial infarction: a meta-analysis for 8,140 cases and 10,522 controls. | Xuan C et al. | β | 2011 | β |
| Association of intima-media thickening of carotid artery with genetic polymorphisms of the regulator of G-protein signaling 2 gene in patients with hypertension and in the general population. | Kamide K et al. | β | 2011 | β |
| Association of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PPARGC1A) gene polymorphisms and type 2 diabetes mellitus: a meta-analysis. | Yang Y et al. | β | 2011 | β |
| Associations between vitamin D receptor polymorphisms and susceptibility to rheumatoid arthritis and systemic lupus erythematosus: a meta-analysis. | Lee YH et al. | β | 2011 | β |
| A systems genetics approach provides a bridge from discovered genetic variants to biological pathways in rheumatoid arthritis. | Nakaoka H et al. | β | 2011 | β |
| Candidate gene association study for diabetic retinopathy in persons with type 2 diabetes: the Candidate gene Association Resource (CARe). | Sobrin L et al. | β | 2011 | β |
| Combining disease models to test for gene-environment interaction in nuclear families. | Hoffmann TJ et al. | β | 2011 | β |
| Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. | Yu Y et al. | β | 2011 | β |
| Coronary artery disease: an example case study. | Barrett JH | β | 2011 | β |
| D2 Thr92Ala and PPARΞ³2 Pro12Ala polymorphisms interact in the modulation of insulin resistance in type 2 diabetic patients. | Estivalet AA et al. | β | 2011 | β |
| Do COMT, BDNF and NRG1 polymorphisms influence P50 sensory gating in psychosis? | Shaikh M et al. | β | 2011 | β |
| Dopamine polymorphisms and depressive symptoms predict foods intake. Results from a nationally representative sample. | Agurs-Collins T et al. | β | 2011 | β |
| Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function. | Soler Artigas M et al. | β | 2011 | β |
| Four genetic polymorphisms of paraoxonase gene and risk of coronary heart disease: a meta-analysis based on 88 case-control studies. | Wang M et al. | β | 2011 | β |
| Frequency of single nucleotide polymorphisms of some immune response genes in a population sample from SΓ£o Paulo, Brazil. | Oliveira LC et al. | β | 2011 | β |
| Gene-environment interactions: early life stress and risk for depressive and anxiety disorders. | Nugent NR et al. | β | 2011 | β |
| Genetic analysis of complex traits via Bayesian variable selection: the utility of a mixture of uniform priors. | KnΓΌrr T et al. | β | 2011 | β |
| Genetic association between NLRP3 variants and Crohn's disease does not replicate in a large UK panel. | Lewis GJ et al. | β | 2011 | β |
| Genetic associations in diabetic nephropathy: a meta-analysis. | Mooyaart AL et al. | β | 2011 | β |
| Genetic factors in contact allergy--review and future goals. | Schnuch A et al. | β | 2011 | β |
| Genetic risk score predicting risk of rheumatoid arthritis phenotypes and age of symptom onset. | Chibnik LB et al. | β | 2011 | β |
| Genetic variants associated with breast-cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence. | Zhang B et al. | β | 2011 | β |
| Genetic variants of the monocyte chemoattractant protein-1 gene and its receptor CCR2 and risk of coronary artery disease: a meta-analysis. | Wang Y et al. | β | 2011 | β |
| Genome-wide association studies (GWAS): impact on elucidating the aetiology of diabetes. | Hakonarson H et al. | β | 2011 | β |
| Genome-wide association studies of chronic kidney disease: what have we learned? | O'Seaghdha CM et al. | β | 2011 | β |
| Genome-wide association studies: results from the first few years and potential implications for clinical medicine. | Hirschhorn JN et al. | β | 2011 | β |
| Genome-wide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe. | GΓ©nin E et al. | β | 2011 | β |
| Genomics and genetics in the biology of adaptation to exercise. | Bouchard C et al. | β | 2011 | β |
| Genomics of cardiovascular disease. | O'Donnell CJ et al. | β | 2011 | β |
| Glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) null polymorphisms, smoking, and their interaction in oral cancer: a HuGE review and meta-analysis. | Zhang ZJ et al. | β | 2011 | β |
| Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum. | Van Tyne D et al. | β | 2011 | β |
| IL-16 rs11556218 gene polymorphism is associated with coronary artery disease in the Chinese Han population. | Chen Y et al. | β | 2011 | β |
| Implications of host genetic variation on the risk and prevalence of infectious diseases transmitted through the environment. | Doeschl-Wilson AB et al. | β | 2011 | β |
| Introduction to genetics and childhood obesity: relevance to nursing practice. | Seal N | β | 2011 | β |
| Joint ancestry and association testing in admixed individuals. | Shriner D et al. | β | 2011 | β |
| Lack of association of IL-10 gene polymorphisms with prostate cancer: evidence from 11,581 subjects. | Zou YF et al. | β | 2011 | β |
| Lack of association of SULT1A1 R213H polymorphism with colorectal cancer: a meta-analysis. | Zhang C et al. | β | 2011 | β |
| Low but sustained coagulation activation ameliorates glucose-induced podocyte apoptosis: protective effect of factor V Leiden in diabetic nephropathy. | Wang H et al. | β | 2011 | β |
| Meet me halfway: when genomics meets structural bioinformatics. | Gong S et al. | β | 2011 | β |
| Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease. | Sookoian S et al. | β | 2011 | β |
| New type 2 diabetes risk genes provide new insights in insulin secretion mechanisms. | SchΓ€fer SA et al. | β | 2011 | β |
| New variants at 10q26 and 15q21 are associated with aggressive prostate cancer in a genome-wide association study from a prostate biopsy screening cohort. | Nam RK et al. | β | 2011 | β |
| No replication of genetic association between candidate polymorphisms and Alzheimer's disease. | Cousin E et al. | β | 2011 | β |
| Periodontal genetics: a decade of genetic association studies mandates better study designs. | SchΓ€fer AS et al. | β | 2011 | β |
| Planning a genome-wide association study: points to consider. | Hakonarson H et al. | β | 2011 | β |
| Polymorphism of peroxisome proliferator-activated receptor Ξ³ (PPARΞ³) Pro12Ala in the Iranian population: relation with insulin resistance and response to treatment with pioglitazone in type 2 diabetes. | Namvaran F et al. | β | 2011 | β |
| Polymorphisms in the 5' flank of COL1A1 gene and osteoporosis: meta-analysis of published studies. | Jin H et al. | β | 2011 | β |
| Quantifying and correcting for the winner's curse in quantitative-trait association studies. | Xiao R et al. | β | 2011 | β |
| Recent human evolution has shaped geographical differences in susceptibility to disease. | Marigorta UM et al. | β | 2011 | β |
| Recommendations for publication of genetic association studies in Arthritis & Rheumatism. | Plenge RM et al. | β | 2011 | β |
| Review: association between angiotensin converting enzyme G2350A polymorphism and hypertension risk: a meta-analysis. | Wenquan Niu et al. | β | 2011 | β |
| Sequence Variants and the Risk of Head and Neck Cancer: Pooled Analysis in the INHANCE Consortium. | Chuang SC et al. | β | 2011 | β |
| Start codon FokI and intron 8 BsmI variants in the vitamin D receptor gene and susceptibility to colorectal cancer. | Mahmoudi T et al. | β | 2011 | β |
| Systems genetics for drug target discovery. | Penrod NM et al. | β | 2011 | β |
| The association of SERPINE2 gene with COPD in a Chinese Han population. | Wang A et al. | β | 2011 | β |
| The effect of CYP1A1 polymorphisms on the risk of lung cancer: a global meta-analysis based on 71 case-control studies. | Chen Z et al. | β | 2011 | β |
| The effect of measurement error of phenotypes on genome wide association studies. | Barendse W | β | 2011 | β |
| The effect of retrospective sampling on estimates of prediction error for multifactor dimensionality reduction. | Winham SJ et al. | β | 2011 | β |
| The false-positive to false-negative ratio in epidemiologic studies. | Ioannidis JP et al. | β | 2011 | β |
| The grainyhead-like 2 gene (GRHL2) single nucleotide polymorphism is not associated with age-related hearing impairment in Han Chinese. | Lin YH et al. | β | 2011 | β |
| The use of genome-wide eQTL associations in lymphoblastoid cell lines to identify novel genetic pathways involved in complex traits. | Min JL et al. | β | 2011 | β |
| TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies. | Erhardt A et al. | β | 2011 | β |
| TNF -308G > a promoter polymorphism (rs1800629) and outcome from critical illness. | Paskulin DD et al. | β | 2011 | β |
| Variable set enrichment analysis in genome-wide association studies. | Yang W et al. | β | 2011 | β |
| Variants of gene for microsomal prostaglandin E2 synthase show association with disease and severe inflammation in rheumatoid arthritis. | Korotkova M et al. | β | 2011 | β |
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| Common polymorphisms in the CACNA1H gene associated with childhood absence epilepsy in Chinese Han population. | Liang J et al. | β | 2007 | β |
| Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer. | Stacey SN et al. | β | 2007 | β |
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| Genetic susceptibility to peripheral arterial disease: a dark corner in vascular biology. | Knowles JW et al. | β | 2007 | β |
| Genetic variation at the low-density lipoprotein receptor-related protein 5 (LRP5) locus modulates Wnt signaling and the relationship of physical activity with bone mineral density in men. | Kiel DP et al. | β | 2007 | β |
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| Haplotype of thrombomodulin gene associated with plasma thrombomodulin level and deep vein thrombosis in the Japanese population. | Sugiyama S et al. | β | 2007 | β |
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| IL23R Arg381Gln is associated with childhood onset inflammatory bowel disease in Scotland. | Van Limbergen J et al. | β | 2007 | β |
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| Protective effect of the Nramp1 BB genotype against Brucella abortus in the water buffalo (Bubalus bubalis). | Capparelli R et al. | β | 2007 | β |
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| Quantitative assessment of the effect of angiotensinogen gene polymorphisms on the risk of coronary heart disease. | Xu MQ et al. | β | 2007 | β |
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| Relevance of genetics and genomics for prevention and treatment of cardiovascular disease: a scientific statement from the American Heart Association Council on Epidemiology and Prevention, the Stroke Council, and the Functional Genomics and Translational Biology Interdisciplinary Working Group. | Arnett DK et al. | β | 2007 | β |
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| Replication of genetic association studies between markers at the Epsin 4 gene locus and schizophrenia in two Han Chinese samples. | Gurling H et al. | β | 2007 | β |
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| Screening of 134 single nucleotide polymorphisms (SNPs) previously associated with type 2 diabetes replicates association with 12 SNPs in nine genes. | Willer CJ et al. | β | 2007 | β |
| Searching for alleles associated with complicated outcomes after burn injury. | Barber RC et al. | β | 2007 | β |
| Searching for genes underlying susceptibility to osteoporotic fracture: current progress and future prospect. | Lei SF et al. | β | 2007 | β |
| Simulating association studies: a data-based resampling method for candidate regions or whole genome scans. | Wright FA et al. | β | 2007 | β |
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| STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. | Remmers EF et al. | β | 2007 | β |
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| Susceptibility genes in Graves' ophthalmopathy: searching for a needle in a haystack? | Bednarczuk T et al. | β | 2007 | β |
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| The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. | Lyon HN et al. | β | 2007 | β |
| The coding polymorphism T263I in TGF-beta1 is associated with otosclerosis in two independent populations. | Thys M et al. | β | 2007 | β |
| The genetic basis of psoriasis. | Valdimarsson H | β | 2007 | β |
| The human GIMAP5 gene has a common polyadenylation polymorphism increasing risk to systemic lupus erythematosus. | Hellquist A et al. | β | 2007 | β |
| The LOC387715 polymorphism and age-related macular degeneration: replication in three case-control samples. | Ross RJ et al. | β | 2007 | β |
| The new type 2 diabetes gene TCF7L2. | Florez JC | β | 2007 | β |
| The Nramp1AA genotype confers susceptibility to Brucella abortus in water buffalo. | Capparelli R et al. | β | 2007 | β |
| The role of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma in diabetes risk. | TΓΆnjes A et al. | β | 2007 | β |
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| The urokinase-type plasminogen activator polymorphism PLAU_1 is a risk factor for APOE-epsilon4 non-carriers in the Italian Alzheimer's disease population and does not affect the plasma Abeta(1-42) level. | Pesaresi M et al. | β | 2007 | β |
| The V103I polymorphism of the MC4R gene and obesity: population based studies and meta-analysis of 29 563 individuals. | Young EH et al. | β | 2007 | β |
| The X-files of inflammation: cellular mosaicism of X-linked polymorphic genes and the female advantage in the host response to injury and infection. | Spolarics Z | β | 2007 | β |
| Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus. | Graham RR et al. | β | 2007 | β |
| Toward further mapping of the association between the IL2RA locus and type 1 diabetes. | Qu HQ et al. | β | 2007 | β |
| Use of pairwise marker combination and recursive partitioning in a pharmacogenetic genome-wide scan. | Warren LL et al. | β | 2007 | β |
| Vitamin D receptor 3' haplotypes are unequally expressed in primary human bone cells and associated with increased fracture risk: the MrOS Study in Sweden and Hong Kong. | Grundberg E et al. | β | 2007 | β |
| Vitamin D receptor gene polymorphisms are associated with increased risk and progression of renal cell carcinoma in a Japanese population. | Obara W et al. | β | 2007 | β |
| Weak independent association signals between IDE polymorphisms, Alzheimer's disease and cognitive measures. | Mueller JC et al. | β | 2007 | β |
| A common genetic variant is associated with adult and childhood obesity. | Herbert A et al. | β | 2006 | β |
| A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus. | Graham RR et al. | β | 2006 | β |
| A functional polymorphism in MMP-9 is associated with childhood atopic asthma. | Nakashima K et al. | β | 2006 | β |
| Analysis of functional polymorphisms in three synaptic plasticity-related genes (BDNF, COMT AND UCHL1) in Alzheimer's disease in Colombia. | Forero DA et al. | β | 2006 | β |
| Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases. | Smyth DJ et al. | β | 2006 | β |
| An association between asthma and TNF-308G/A polymorphism: meta-analysis. | Aoki T et al. | β | 2006 | β |
| An evaluation of the performance of tag SNPs derived from HapMap in a Caucasian population. | Montpetit A et al. | β | 2006 | β |
| Application of microarray technology in psychotropic drug trials. | Murphy GM | β | 2006 | β |
| A prospective assessment of the Y402H variant in complement factor H, genetic variants in C-reactive protein, and risk of age-related macular degeneration. | Schaumberg DA et al. | β | 2006 | β |
| A relook into the association of the estrogen receptor [alpha] gene (PvuII, XbaI) and adolescent idiopathic scoliosis: a study of 540 Chinese cases. | Tang NL et al. | β | 2006 | β |
| Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk. | Groves CJ et al. | β | 2006 | β |
| Association analysis of the AIRE and insulin genes in Finnish type 1 diabetic patients. | Turunen JA et al. | β | 2006 | β |
| Association between PADI4 and rheumatoid arthritis: a meta-analysis. | Iwamoto T et al. | β | 2006 | β |
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