Human kappa opioid receptor gene (OPRK1) polymorphism is associated with opiate addiction.
paper
Cited
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- Authors
- Gerra, G; Leonardi, C; Cortese, E; D'Amore, A; Lucchini, A; Strepparola, G; Serio, G; Farina, G; Magnelli, F; Zaimovic, A; Mancini, A; Turci, M; Manfredini, M; Donnini, C
- Year
- 2007
- Journal
- American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
- PMID
- 17373729
- DOI
- 10.1002/ajmg.b.30510
Variants of the opioid receptors are the obvious candidates underlying addiction. The kappa opioid receptor (KOR) system seems to play a role in stress responsivity, opiate withdrawal and responses to psycho-stimulants, inhibiting mesolimbic dopamine. KOR gene polymorphisms have been reported to contribute to predisposition to voluntary alcohol-drinking behavior in experimental animals. In humans, the 36G > T single nucleotide polymorphism (SNP) on KOR gene, that was recently identified, has been found associate with substance dependence, with inconclusive findings. In the present study, 106 heroin addicts (West European, Caucasians) and 70 healthy control subjects matched for race and gender, with no history of substance use disorder, have been genotyped. The frequency of KOR 36G > T SNP was significantly higher among heroin-dependent individuals compared with control subjects (Fisher's exact = 0.044; Pearson chi(2) = 4.2734, P = 0.039; likelihood ratio chi(2) tests = 4.6156, P = 0.032). Although KOR silent polymorphisms may apparently have no consequences on mRNA transcription, post-transcriptional mechanisms, such as mRNA stability, translation efficiency, and regulability may impair the function of kappa receptors system, with increased risk for substance use disorders. In specific, the neurobiological changes induced by mu-kappa opioid imbalance could underlie vulnerable personality traits and risk behavior.
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| A GWAS Meta-meta-analysis and In-depth Silico Pharmacogenomic Investigations in Identification of APOE and Other Genes Associated with Pain, Anti-inflammatory, and Immunomodulating Agents in Opioid Use Disorder (OUD) Derived from 14.91 M Subjects. | Sharafshah A et al. | β | 2025 | β |
| Genetic Associations of Persistent Opioid Use After Surgery Point to OPRM1 but Not Other Opioid-Related Loci as the Main Driver of Opioid Use Disorder. | Annis AC et al. | β | 2025 | β |
| <i>Kappa</i>-opioid receptor gene (<i>OPRK1</i>) variations associated with opioid abstinence behaviors among chronic heroin users. | Greenwald MK et al. | β | 2025 | β |
| Association Between Opioid Receptor Kappa 1 Gene Polymorphism, Kappa Opioid Receptor Level and Dynorphin Level with Non-Suicidal Self-Injury. | Liza RG et al. | β | 2024 | β |
| Solving the Global Opioid Crisis: Incorporating Genetic Addiction Risk Assessment with Personalized Dopaminergic Homeostatic Therapy and Awareness Integration Therapy. | Zeine F et al. | β | 2024 | β |
| Association of <i>OPRK1</i> rs963549 and rs997917 polymorphisms with opioid use disorder and related phenotypes. | Γzkan-KotiloΔlu S et al. | β | 2023 | β |
| Genetic associations of persistent opioid use after surgery: a hypothesis-driven analysis of high-value genetic variants in the Michigan Genomics Initiative dataset | Brummett C et al. | β | 2023 | β |
| CpH methylome analysis in human cortical neurons identifies novel gene pathways and drug targets for opioid use disorder. | Nagamatsu ST et al. | β | 2022 | β |
| Down-regulation of kappa opioid receptor promotes ESCC proliferation, invasion and metastasis via the PDK1-AKT signaling pathway. | Huang HM et al. | β | 2022 | β |
| Kappa Opioid Signaling at the Crossroads of Chronic Pain and Opioid Addiction. | Cahill CM et al. | β | 2022 | β |
| KOR Control over Addiction Processing: An Exploration of the Mesolimbic Dopamine Pathway. | Estave PM et al. | β | 2022 | β |
| Stress decreases serotonin tone in the nucleus accumbens in male mice to promote aversion and potentiate cocaine preference via decreased stimulation of 5-HT<sub>1B</sub> receptors. | Fontaine HM et al. | β | 2022 | β |
| Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development. | Koob GF | β | 2021 | β |
| Pharmacogenomics of Pain Management: The Impact of Specific Biological Polymorphisms on Drugs and Metabolism. | Cornett EM et al. | β | 2020 | β |
| Molecular Imaging of Opioid and Dopamine Systems: Insights Into the Pharmacogenetics of Opioid Use Disorders. | Burns JA et al. | β | 2019 | β |
| Polymorphism A118G of opioid receptor mu 1 (OPRM1) is associated with emergence of suicidal ideation at antidepressant onset in a large naturalistic cohort of depressed outpatients. | Nobile B et al. | β | 2019 | β |
| An analysis of genetic association in opioid dependence susceptibility. | Nagaya D et al. | β | 2018 | β |
| Genetic association analyses and meta-analysis of Dynorphin-Kappa Opioid system potential functional variants with heroin dependence. | Yuanyuan J et al. | β | 2018 | β |
| Hypermethylation of the ΞΊ1 opioid receptor promoter in Chinese heroin and methamphetamine addicts. | Ji H et al. | β | 2018 | β |
| Opioid K receptor variant is associated with a delayed onset of dyskinesias in Parkinson's disease. | Cilia R et al. | β | 2018 | β |
| Opioid Receptors Gene Polymorphism and Heroin Dependence in Iran. | Soleimani Asl S et al. | β | 2018 | β |
| Association of OPRK1 gene polymorphisms with opioid dependence in addicted men undergoing methadone treatment in an Iranian population. | Albonaim A et al. | β | 2017 | β |
| Biochemical Diagnosis in Substance and Non-substance Addiction. | Shen W et al. | β | 2017 | β |
| Comorbidity of Alcohol Use Disorder and Chronic Pain: Genetic Influences on Brain Reward and Stress Systems. | Yeung EW et al. | β | 2017 | β |
| Genetic Analysis of Mu and Kappa Opioid Receptor and COMT Enzyme in Cancer Pain Tunisian Patients Under Opioid Treatment. | Chatti I et al. | β | 2017 | β |
| A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction. | Bell RL et al. | β | 2016 | β |
| Kappa Opioids, Salvinorin A and Major Depressive Disorder. | Taylor GT et al. | β | 2016 | β |
| Nociceptin/orphanin FQ receptor gene variation is associated with smoking status in Japanese. | Kasai S et al. | β | 2016 | β |
| Searching for evidence of genetic mediation of opioid withdrawal by opioid receptor gene polymorphisms. | Jones JD et al. | β | 2016 | β |
| Bioinformatics and evolution of vertebrate nociceptin and opioid receptors. | Stevens CW | β | 2015 | β |
| Variations in opioid receptor genes in neonatal abstinence syndrome. | Wachman EM et al. | β | 2015 | β |
| Association between gene variants and response to buprenorphine maintenance treatment. | Gerra G et al. | β | 2014 | β |
| Genetics of Opioid Dependence: A Review of the Genetic Contribution to Opioid Dependence. | Mistry CJ et al. | β | 2014 | β |
| The association of genetic polymorphisms in the ΞΊ-opioid receptor 1 gene with body weight, alcohol use, and withdrawal symptoms in patients with methadone maintenance. | Wang SC et al. | β | 2014 | β |
| Using genetic information from candidate gene and genome-wide association studies in risk prediction for alcohol dependence. | Yan J et al. | β | 2014 | β |
| A variant on the kappa opioid receptor gene (OPRK1) is associated with stress response and related drug craving, limbic brain activation and cocaine relapse risk. | Xu K et al. | β | 2013 | β |
| Long-term antagonism of ΞΊ opioid receptors prevents escalation of and increased motivation for heroin intake. | Schlosburg JE et al. | β | 2013 | β |
| NCK2 is significantly associated with opiates addiction in African-origin men. | Liu Z et al. | β | 2013 | β |
| [Pharmacogenetic use in clinical practice: treatment of pain]. | PeirΓ³ PeirΓ³ AM | β | 2013 | β |
| Pharmacogenomics study in a Taiwan methadone maintenance cohort. | Wang SC et al. | β | 2013 | β |
| Polymorphisms of the kappa opioid receptor and prodynorphin genes: HIV risk and HIV natural history. | Proudnikov D et al. | β | 2013 | β |
| The ΞΊ-opioid receptor gene as a predictor of response in a cocaine vaccine clinical trial. | Nielsen DA et al. | β | 2013 | β |
| Common and specific liability to addiction: approaches to association studies of opioid addiction. | Nielsen DA et al. | β | 2012 | β |
| Epistatic effects between variants of kappa-opioid receptor gene and A118G of mu-opioid receptor gene increase susceptibility to addiction in Indian population. | Kumar D et al. | β | 2012 | β |
| The genetics of addiction-a translational perspective. | Agrawal A et al. | β | 2012 | β |
| The genetics of the opioid system and specific drug addictions. | Levran O et al. | β | 2012 | β |
| Zebrafish: a model for the study of addiction genetics. | Klee EW et al. | β | 2012 | β |
| A polymorphism of the CREB binding protein (CREBBP) gene is a risk factor for addiction. | Kumar D et al. | β | 2011 | β |
| Molecular mechanisms of opioid receptor-dependent signaling and behavior. | Al-Hasani R et al. | β | 2011 | β |
| Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment. | Yuferov V et al. | β | 2010 | β |
| The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse. | Wee S et al. | β | 2010 | β |
| Genomewide SNP screen to detect quantitative trait loci for alcohol preference in the high alcohol preferring and low alcohol preferring mice. | Bice P et al. | β | 2009 | β |
| Opiate and cocaine addiction: from bench to clinic and back to the bench. | Kreek MJ et al. | β | 2009 | β |
| A regulatory variation in OPRK1, the gene encoding the kappa-opioid receptor, is associated with alcohol dependence. | Edenberg HJ et al. | β | 2008 | β |
| Endogenous opiates and behavior: 2007. | Bodnar RJ | β | 2008 | β |
| Genetic susceptibility to heroin addiction: a candidate gene association study. | Levran O et al. | β | 2008 | β |
| Role of pharmacogenetics in variable response to drugs: focus on opioids. | Kadiev E et al. | β | 2008 | β |