Analysis of single nucleotide polymorphisms and haplotypes in the neuropeptide Y gene: no evidence for association with alcoholism in a German population sample.
- Authors
- Zill, Peter; Preuss, Ulrich W; Koller, Gabrielle; Bondy, Brigitta; Soyka, Michael
- Year
- 2008
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 18241322
- DOI
- 10.1111/j.1530-0277.2007.00586.x
BACKGROUND: Several lines of evidence from animal and electrophysiological studies indicate that the neuropeptide Y (NPY) gene is involved in the pathophysiology of alcohol dependence. Recent studies have provided evidence for an association between a Leu7Pro polymorphism, as well as 2 promoter single nucleotide polymorphisms (SNPs) in the NPY gene (G-602T, T-399C) and alcohol dependence. The aim of the present study was to analyze these variants in a large sample of the Munich Gene Bank of Alcoholism. METHODS: We performed single SNP and haplotype studies in 465 alcohol dependent patients and 448 healthy controls with 3 SNPs in the promoter region (-883ins/del, G-602T, T-399C) and the Leu7Pro polymorphism in exon 2 of the NPY gene. RESULTS: Neither single SNP-, nor haplotype analysis could detect significant associations with alcohol dependence. Additionally we could not detect any relation to Cloninger's Type 1/2 or Babor's Type A/B classification, to withdrawal symptoms, to the age of onset or to the amount of alcohol intake. CONCLUSIONS: In conclusion, our results suggest that the analyzed SNPs, as well as the corresponding haplotypes of the NPY gene are unlikely to play a major role in the pathophysiology of alcohol dependence in the investigated sample from the German population. Further analyses are needed to confirm the present results.
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. | 2008 | 18828811 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Meta-Analysis on the Association of Neuropeptide Y rs16139 Variant With the Risk of Alcoholism. | Chen B et al. | — | 2021 | → |
| Neuropeptide Y in Alcohol Addiction and Affective Disorders. | Thorsell A et al. | — | 2017 | → |
| The Role of Neuropeptide Y (NPY) in Alcohol and Drug Abuse Disorders. | Robinson SL et al. | — | 2017 | → |
| Neuropeptide Y response to alcohol is altered in nucleus accumbens of mice selectively bred for drinking to intoxication. | Barkley-Levenson AM et al. | — | 2016 | → |
| Association between neuropeptide Y gene polymorphisms and alcohol dependence: a case-control study in two independent populations. | Bhaskar LV et al. | — | 2013 | → |
| Genetic modulation of plasma NPY stress response is suppressed in substance abuse: association with clinical outcomes. | Xu K et al. | — | 2012 | → |
| Genetic variation in the neuropeptide Y gene promoter is associated with increased risk of tobacco smoking. | Mutschler J et al. | — | 2012 | → |
| Central functions of neuropeptide Y in mood and anxiety disorders. | Wu G et al. | — | 2011 | → |
| Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption. | Kovanen L et al. | — | 2010 | → |
| Functional NPY variation as a factor in stress resilience and alcohol consumption in rhesus macaques. | Lindell SG et al. | — | 2010 | → |
| Human NPY promoter variation rs16147:T>C as a moderator of prefrontal NPY gene expression and negative affect. | Sommer WH et al. | — | 2010 | → |
| PreproNPY Pro7 protects against depression despite exposure to environmental risk factors. | Sjöholm LK et al. | — | 2009 | → |
| Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. | Wetherill L et al. | — | 2008 | → |