African Americans' participation in clinical research: importance, barriers, and solutions.
paper
Cited
Public
Unavailable
- Authors
- Branson, Richard D; Davis, Kenneth; Butler, Karyn L
- Year
- 2007
- Journal
- American journal of surgery
- PMID
- 17188084
- DOI
- 10.1016/j.amjsurg.2005.11.007
Ethical and scientifically sound research requires that any sample population represent the population as a whole. African-Americans suffer disproportionately from cancer, hypertension, and heart failure compared with whites, but they are commonly underrepresented in clinical trials of these diseases. Failure to include African-American subjects in clinical trials prevents generalizability of the results to this population. African-Americans are often underrepresented in clinical research for numerous historic, societal, educational, and economic reasons. Efforts to improve enrollment of African-American subjects requires recognition of the problem, planning, educational efforts, and investigator training. The incidence of heart disease and prostate cancer in African-Americans dictates that these patients be targeted for clinical trials of surgical research. The research team must appreciate the importance of community involvement and support in recruiting African-Americans participants. Additionally, the continued effort to recruit and train African-American investigators must be a priority.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Post-GWAS in Psychiatric Genetics: A Developmental Perspective on the "Other" Next Steps. | 2018 | 29227573 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Association Between Comorbidity and Clinical Trial Enrollment for Patients With Uterine Cancer. | Oluloro A et al. | — | 2026 | → |
| Area Deprivation Index as a proxy for socioeconomic status in outpatient orthopaedic surgery patients - A prospective registry cross sectional study. | Kaveeshwar S et al. | — | 2025 | → |
| Burden of non-motor symptoms of Parkinson's disease: cost-of-illness and quality-of-life estimates through a scoping review. | van der Meer F et al. | — | 2025 | → |
| Exploring effective strategies in promoting diversity, equity, and inclusivity in surgery: scoping review. | Sharmin A et al. | — | 2025 | → |
| "Lord Knows What's Being Done with My Blood!": Black Women's Perceptions of Biospecimen Donation for Clinical Research in the United States. | Brown KK et al. | — | 2025 | → |
| Racial and Ethnic Diversity in American Plastic Surgery Residency. | Elmorsi R et al. | — | 2025 | → |
| Roses & Thorns of academic surgery: Paving the way for others with Dr. Colin Martin. | Kathawate RG et al. | — | 2025 | → |
| Understanding Barriers and Facilitators for Ethnic Minority Groups to Audio Recording Recruitment Discussions in Clinical Trials: A Participatory Approach to Improving Informed Consent and Participation. | Faisal S et al. | — | 2025 | → |
| Diversity in the US Academic Microsurgery Pathway. | Musavi L et al. | — | 2024 | → |
| Importance of Diversity, Equity, and Inclusion in the Hepatopancreatobiliary Workforce. | Rengers TA et al. | — | 2024 | → |
| Increasing Clinical Trial Participation of Black Women Diagnosed with Breast Cancer. | Fairley R et al. | — | 2024 | → |
| Underrepresented and Underserved Populations in Neurological Research. | Windon CC et al. | — | 2024 | → |
| Community-Based Culturally Tailored Education Programs for Black Communities with Cardiovascular Disease, Diabetes, Hypertension, and Stroke: Systematic Review Findings. | Singh H et al. | — | 2023 | → |
| Culturally Adapting Mind-Body Interventions for Black Individuals with Chronic Pain: Arguments and Recommendations Towards a Task-Sharing Approach. | Pham TV et al. | — | 2023 | → |
| Diversity, Equity, and Inclusion in Clinical Trials. | Keegan G et al. | — | 2023 | → |
| Educational Attainment and Dementia: Mediation by Mid-Life Vascular Risk Factors. | Liu C et al. | — | 2023 | → |
| Effects of Communication Source and Racial Representation in Clinical Trial Recruitment Flyers. | Lee S et al. | — | 2023 | → |
| Examining Community Engagement Research Strategies Used in Flint, Michigan: The Church Challenge. | Key K et al. | — | 2023 | → |
| Overcoming Black Americans' Psychological and Cognitive Barriers to Clinical Trial Participation: Effects of News Framing and Exemplars. | Kirkpatrick CE et al. | — | 2023 | → |
| Programmatic engagement in diversity, equity, and inclusion in U.S. vascular surgery training programs. | Bose S et al. | — | 2023 | → |
| Racial diversity amongst Otolaryngology-Head and Neck Surgery programs in Canada. | Horton G et al. | — | 2023 | → |
| The Role of Transportation in the Enrollment of Elderly African Americans into Exercise and Memory Study: GEMS Study. | Graham L et al. | — | 2023 | → |
| Trust and Biomedical Research Engagement of Minority and Under-Represented Communities in Mississippi, USA. | Antoine-LaVigne D et al. | — | 2023 | → |
| If You Can See It, You Can Be It: Perceptions of Diversity in Surgery Among Under-Represented Minority High School Students. | Lane JC et al. | — | 2022 | → |
| Improving African American women's engagement in clinical research: A systematic review of barriers to participation in clinical trials. | Le D et al. | — | 2022 | → |
| Improving diversity in study participation: Patient perspectives on barriers, racial differences and the role of communities. | Shea L et al. | — | 2022 | → |
| Improving Enrollment of Underrepresented Racial and Ethnic Populations in Heart Failure Trials: A Call to Action From the Heart Failure Collaboratory. | DeFilippis EM et al. | — | 2022 | → |
| Moving the Dial Toward Equity in Parkinson's Disease Clinical Research: a Review of Current Literature and Future Directions in Diversifying PD Clinical Trial Participation. | Adrissi J et al. | — | 2022 | → |
| Prostate Cancer Disparities and Management in Southern Africa: Insights into Practices, Norms and Values. | Marima R et al. | — | 2022 | → |
| Representation of racial minorities in cardiac surgery randomized clinical trials. | Cancelli G et al. | — | 2022 | → |
| Role of Precision Oncology in Type II Endometrial and Prostate Cancers in the African Population: Global Cancer Genomics Disparities. | Marima R et al. | — | 2022 | → |
| Strategies to Increase Racial and Ethnic Diversity in the Surgical Workforce: A State of the Art Review. | Burks CA et al. | — | 2022 | → |
| Understanding Willingness to Participate in Cancer Clinical Trials Among Patients and Caregivers Attending a Minority-Serving Academic Cancer Center. | Ginossar T et al. | — | 2022 | → |
| What Influences the Willingness of Blacks and African Americans to Enroll in Preclinical Alzheimer's Disease Biomarker Research? A Qualitative Vignette Analysis. | Ketchum FB et al. | — | 2022 | → |
| Diversity and Inclusion: A Review of Effective Initiatives in Surgery. | Hemal K et al. | — | 2021 | → |
| Engaging rural communities in cancer prevention and control research: Development and preliminary insights from a community-based research registry. | Thomson MD et al. | — | 2021 | → |
| Health promotion interventions for African Americans delivered in U.S. barbershops and hair salons- a systematic review. | Palmer KNB et al. | — | 2021 | → |
| Is There Color or Sex Behind the Mask and Sterile Blue? Examining Sex and Racial Demographics Within Academic Surgery. | Aggarwal A et al. | — | 2021 | → |
| Motivational Interviewing for Loved Ones in Early Psychosis: Development and Pilot Feasibility Trial of a Brief Psychoeducational Intervention for Caregivers. | Kline ER et al. | — | 2021 | → |
| Prevalence of Workforce Diversity Research Among Surgical Specialties in the United States: How Does Plastic Surgery Compare? | Reghunathan M et al. | — | 2021 | → |
| Structural Racism in the COVID-19 Pandemic: Moving Forward. | Sabatello M et al. | — | 2021 | → |
| The Diversity Bonus in Oral and Maxillofacial Surgery. | Haviland C et al. | — | 2021 | → |
| The Role of Race and Gender in the Career Experiences of Black/African American Academic Surgeons: A Survey of the Society of Black Academic Surgeons and a Call to Action. | Crown A et al. | — | 2021 | → |
| Using Communication Theory of Identity to Evaluate Decision Aids: Focus Group Research with African American Prostate Cancer Survivors. | Upshaw SJ | — | 2021 | → |
| I Can't Breathe - Race, Violence, and COVID-19. | Roberts SE | — | 2020 | → |
| Protocol for a systematic review of health promotion interventions for African Americans delivered in US barbershops and hair salons. | Palmer K et al. | — | 2020 | → |
| Pursing a career in academic surgery among African American medical students. | Roberts SE et al. | — | 2020 | → |
| The Impact of African Ancestry on Prostate Cancer Disparities in the Era of Precision Medicine. | Lewis DD et al. | — | 2020 | → |
| African-American and Caucasian participation in postmortem human brain donation for neuropsychiatric research. | Deep-Soboslay A et al. | — | 2019 | → |
| Count me in: using a patient portal to minimize implicit bias in clinical research recruitment. | Kannan V et al. | — | 2019 | → |
| Efficacy and Safety of Alemtuzumab in Patients of African Descent with Relapsing-Remitting Multiple Sclerosis: 8-Year Follow-up of CARE-MS I and II (TOPAZ Study). | Okai AF et al. | — | 2019 | → |
| Factors associated with participation by African Americans in a study of the genetics of glaucoma. | Parikh R et al. | — | 2019 | → |
| Leading From the Front: An Approach to Increasing Racial and Ethnic Diversity in Surgical Training Programs. | Butler PD et al. | — | 2019 | → |
| Minorities in leadership: are we moving the needle? | Pryor AD et al. | — | 2019 | → |
| Recruitment of hard to contact, hard to engage child populations in clinics and schools. | Rice M et al. | — | 2019 | → |
| The Impact of an Educational Video on Clinical Trial Enrollment and Knowledge in Ethnic Minorities: A Randomized Control Trial. | Skinner JS et al. | — | 2019 | → |
| African American Screening and Enrollment in (Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage III) CLEAR III. | Lane K et al. | — | 2018 | → |
| Developing and Piloting a Community Scientist Academy to Engage Communities and Patients in Research. | Stewart MK et al. | — | 2018 | → |
| Diversity in Otolaryngology Residency Programs: A Survey of Otolaryngology Program Directors. | Newsome H et al. | — | 2018 | → |
| Investigating relations among stress, sleep and nail cortisol and DHEA. | Doan SN et al. | — | 2018 | → |
| Linking Education to Action: A Program to Increase Research Participation Among African American Women. | Radecki Breitkopf C et al. | — | 2018 | → |
| Methodological Considerations for Research With Black Male Victims of Violent Injury in an Urban Trauma Unit. | St Vil C et al. | — | 2018 | → |
| Outreach Strategies to Recruit Low-Income African American Men to Participate in Health Promotion Programs and Research: Lessons From the Men of Color Health Awareness (MOCHA) Project. | Graham LF et al. | — | 2018 | → |
| Participation of Racial and Ethnic Minorities in Technology-Based Interventions to Self-Manage Type 2 Diabetes: A Scoping Review. | Jang M et al. | — | 2018 | → |
| Post-GWAS in Psychiatric Genetics: A Developmental Perspective on the "Other" Next Steps. | Dick DM et al. | — | 2018 | → |
| Results of ASERTAA, a Randomized Prospective Crossover Pharmacogenetic Study of Immediate-Release Versus Extended-Release Tacrolimus in African American Kidney Transplant Recipients. | Trofe-Clark J et al. | — | 2018 | → |
| Sistas Taking a Stand for Breast Cancer Research (STAR) Study: A Community-Based Participatory Genetic Research Study to Enhance Participation and Breast Cancer Equity among African American Women in Memphis, TN. | Smith A et al. | — | 2018 | → |
| Surgical time out: Our counts are still short on racial diversity in academic surgery. | Abelson JS et al. | — | 2018 | → |
| African Americans and Clinical Research: Evidence Concerning Barriers and Facilitators to Participation and Recruitment Recommendations. | Hughes TB et al. | — | 2017 | → |
| African American Women's Perspectives on Donating Healthy Breast Tissue for Research: Implications for Recruitment. | Ridley-Merriweather KE et al. | — | 2017 | → |
| Analysis of Common Eligibility Criteria of Randomized Controlled Trials in Newly Diagnosed Multiple Myeloma Patients and Extrapolating Outcomes. | Shah JJ et al. | — | 2017 | → |
| Barriers and Strategies for Recruitment of Racial and Ethnic Minorities: Perspectives from Neurological Clinical Research Coordinators. | Haley SJ et al. | — | 2017 | → |
| Development of Plain Language Supplemental Materials for the Biobank Informed Consent Process. | Drake BF et al. | — | 2017 | → |
| Factors Influencing Participation in Clinical Trials: Emergency Medicine vs. Other Specialties. | Kurt A et al. | — | 2017 | → |
| Protocol for the home hazards removal program (HARP) study: a pragmatic, randomized clinical trial and implementation study. | Stark S et al. | — | 2017 | → |
| Video intervention increases participation of black breast cancer patients in therapeutic trials. | Robinson BN et al. | — | 2017 | → |
| African-American patients with cancer Talking About Clinical Trials (TACT) with oncologists during consultations: evaluating the efficacy of tailored health messages in a randomised controlled trial-the TACT study protocol. | Brown RF et al. | — | 2016 | → |
| Barriers to Clinical Research Participation Among African Americans. | Luebbert R et al. | — | 2016 | → |
| Beliefs and Preferences for Medical Research Among African-Americans. | Cain GE et al. | — | 2016 | → |
| Communicating Effectively About Clinical Trials With African American Communities: A Comparison of African American and White Information Sources and Needs. | Tanner A et al. | — | 2016 | → |
| Racial Differences Among Factors Associated with Participation in Clinical Research Trials. | Kurt A et al. | — | 2016 | → |
| Referral Patterns and Clinical Outcomes for Transplant-Eligible Lymphoma and Myeloma Patients Evaluated at an Urban County Hospital. | Yun HD et al. | — | 2016 | → |
| The Effect of Message Framing on African American Women's Intention to Participate in Health-Related Research. | Balls-Berry JE et al. | — | 2016 | → |
| The Inclusion of African-American Study Participants in Web-Based Research Studies: Viewpoint. | Watson B et al. | — | 2016 | → |
| Barriers to medical research participation as perceived by clinical trial investigators: communicating with rural and african american communities. | Tanner A et al. | — | 2015 | → |
| Clinical Trial Decision Making in Pediatric Sickle Cell Disease: A Qualitative Study of Perceived Benefits and Barriers to Participation. | Patterson CA et al. | — | 2015 | → |
| Community Engagement in Health-Related Research: A Case Study of a Community-Linked Research Infrastructure, Jefferson County, Arkansas, 2011-2013. | Stewart MK et al. | — | 2015 | → |
| Connect MM Registry: The Importance of Establishing Baseline Disease Characteristics. | Rifkin RM et al. | — | 2015 | → |
| Promoting clinical research to medically underserved communities: current practices and perceptions about clinical trial recruiting strategies. | Tanner A et al. | — | 2015 | → |
| Systematic review of racial disparities in human papillomavirus-associated anal dysplasia and anal cancer among men who have sex with men. | Walsh T et al. | — | 2015 | → |
| The diverse surgeons' initiative: longitudinal assessment of a successful national program. | Butler PD et al. | — | 2015 | → |
| The Mela Study: exploring barriers to diabetes research in black and minority ethnic groups. | Hood GA et al. | — | 2015 | → |
| Willingness to Participate in Cardiovascular Clinical Research among African-Americans. | Stuchlik P et al. | — | 2015 | → |
| A systematic review of barriers and facilitators to minority research participation among African Americans, Latinos, Asian Americans, and Pacific Islanders. | George S et al. | — | 2014 | → |
| How are we communicating about clinical trials?: an assessment of the content and readability of recruitment resources. | Friedman DB et al. | — | 2014 | → |
| African American men's and women's perceptions of clinical trials research: focusing on prostate cancer among a high-risk population in the South. | Owens OL et al. | — | 2013 | → |
| A systematic review of the factors influencing African Americans' participation in cancer clinical trials. | Rivers D et al. | — | 2013 | → |
| Initial development of a questionnaire evaluating perceived benefits and barriers to pediatric clinical trials participation. | Barakat LP et al. | — | 2013 | → |
| Perceptions of participation in a phase I, II, or III clinical trial among African American patients with cancer: what do refusers say? | Brown RF et al. | — | 2013 | → |
| Reaching beyond disparity: safely improving asthma control in the at-risk African-American population. | Brown RW et al. | — | 2013 | → |
| A framework to evaluate the cultural appropriateness of intervention research. | Crowder SJ et al. | — | 2012 | → |
| African American men's perspectives on promoting physical activity: "We're not that difficult to figure out!". | Friedman DB et al. | — | 2012 | → |
| A pilot study of a culturally targeted video intervention to increase participation of African American patients in cancer clinical trials. | Banda DR et al. | — | 2012 | → |
| Barriers to therapeutic clinical trials enrollment: differences between African-American and white cancer patients identified at the time of eligibility assessment. | Penberthy L et al. | — | 2012 | → |
| Design, methodological issues and participation in a multiple sclerosis case-control study. | Williamson DM et al. | — | 2012 | → |
| Encouraging participation of minorities in research studies. | Diaz V | — | 2012 | → |
| Fatherhood intervention development in collaboration with African American non-resident fathers. | Julion WA et al. | — | 2012 | → |
| Randomized controlled trials: what are they and who needs them? | Pihlstrom BL et al. | — | 2012 | → |
| African American participation in Alzheimer's disease research that includes brain donation. | Darnell KR et al. | — | 2011 | → |
| Conducting HIV research in racial and ethnic minority communities: building a successful interdisciplinary research team. | Polanco FR et al. | — | 2011 | → |
| Inclusion of African Americans in genetic studies: what is the barrier? | Hartz SM et al. | — | 2011 | → |
| Addressing the paucity of underrepresented minorities in academic surgery: can the "Rooney Rule" be applied to academic surgery? | Butler PD et al. | — | 2010 | → |
| Enhancing recruitment of African-American families into genetic research: lessons learned from Project SuGar. | Spruill IJ | — | 2010 | → |
| More than Tuskegee: understanding mistrust about research participation. | Scharff DP et al. | — | 2010 | → |
| Parental attitudes toward research participation in pediatric sickle cell disease. | Liem RI et al. | — | 2010 | → |
| Racial diversity in American oral and maxillofacial surgery. | Aziz SR | — | 2010 | → |
| Racial diversity in uterine leiomyoma clinical studies. | Taran FA et al. | — | 2010 | → |
| Recruitment of infants with sickle cell anemia to a Phase III trial: data from the BABY HUG study. | Wynn L et al. | — | 2010 | → |
| The diverse surgeons initiative: an effective method for increasing the number of under-represented minorities in academic surgery. | Butler PD et al. | — | 2010 | → |
| Consent administrator training to reduce disparities in research participation. | Larson EL et al. | — | 2009 | → |
| Under-representation of women and ethnic minorities in vascular surgery randomized controlled trials. | Hoel AW et al. | — | 2009 | → |
| A process to manage recruitment to multiple competing studies. | Carpenter JS et al. | — | 2008 | → |
| Participation in environmental health research by placenta donation - a perception study. | Lind U et al. | — | 2007 | → |
| Racial disparities in blacks with gynecologic cancers. | Farley J et al. | — | 2007 | → |