Selective breeding for differential saccharin intake as an animal model of drug abuse.
paper
Cited
Public
Unavailable
- Authors
- Carroll, Marilyn E; Morgan, Andrew D; Anker, Justin J; Perry, Jennifer L; Dess, Nancy K
- Year
- 2008
- Journal
- Behavioural pharmacology
- PMID
- 18690102
- DOI
- 10.1097/FBP.0b013e32830c3632
A positive relationship between the consumption of sweetened dietary substances (e.g. saccharin and sucrose) and drug abuse has been reported in both the human and other animal literature. The proposed genetic contribution to this relationship has been based on evidence from behavioral, neurobiological, and linkage studies in heterogeneous and homogeneous animal populations. Initial work in several laboratories indicated that rodents that are selected for high alcohol consumption also display an increased preference for sweets compared with low alcohol-consuming animals. More recently, Sprague-Dawley rats have been selectively bred based on high saccharin (HiS) or low saccharin (LoS) consumption, and these lines represent an ideal opportunity to determine whether a reciprocal genetic relationship exists between the consumption of sweetened substances and self-administration of drugs of abuse. The purpose of this review is to examine a series of studies on the HiS and LoS rats for drug-seeking and drug-taking behavior using laboratory animal models that represent critical phases of drug abuse in humans. The data support the hypothesis that sweet consumption and drug self-administration are closely related and genetically influenced. Other characteristics of HiS and LoS rats are discussed as possible mediators of the genetic differences such as activity, impulsivity, novelty reactivity, stress, and emotionality. The interaction of sweet preference with biological variables related to drug abuse, such as age, sex, and hormonal influences, was considered, as they may be additive vulnerability factors with consumption of sweet substances. In the studies that are discussed, the HiS and LoS lines emerge as ideal addiction-prone and addiction-resistant models, respectively, with vulnerability or resilience factors that will inform prevention and treatment strategies for drug abuse.
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| Title | Year | PMID |
|---|---|---|
| Endophenotypes for Alcohol Use Disorder: An Update on the Field. | 2015 | 26236574 |
| Genetics of sweet taste preferences. | 2011 | 21743773 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| IRAS/Nischarin is associated with attenuated deficit of cognition during morphine abstinence in mice. | Li S et al. | — | 2025 | → |
| Sweet-liking and sugar supplementation as innovative components in substance use disorder treatment: A systematic review. | van Amsterdam J et al. | — | 2025 | → |
| TRPV1 deletion enhances consumption but not seeking behavior for sweetened nicotine solution in male mice. | Tannous S et al. | — | 2025 | → |
| Selective pressure on a saccharin intake phenotype and its correlates: a replication study. | Dess NK et al. | — | 2023 | → |
| HPA axis dysfunction during morphine withdrawal in offspring of female rats exposed to opioids preconception. | Vassoler FM et al. | — | 2022 | → |
| Inter-Individual Differences in Cognitive Tasks: Focusing on the Shaping of Decision-Making Strategies. | Pittaras E et al. | — | 2022 | → |
| Poor decision-makers: motivation, working memory performance, and repartition across two inbred strains of rats | Fitoussi AY | — | 2022 | — |
| A breeding strategy to identify modifiers of high genetic risk for methamphetamine intake. | Reed C et al. | — | 2021 | → |
| Behavioral predictors of individual differences in opioid addiction vulnerability as measured using i.v. self-administration in rats. | Swain Y et al. | — | 2021 | → |
| Females develop features of an addiction-like phenotype sooner during withdrawal than males. | Towers EB et al. | — | 2021 | → |
| Sugar Intake: Are All Children Made of Sugar? | Diani L et al. | — | 2021 | → |
| Translational opportunities in animal and human models to study alcohol use disorder. | Nieto SJ et al. | — | 2021 | → |
| Higher anhedonia during withdrawal from initial opioid exposure is protective against subsequent opioid self-administration in rats. | Swain Y et al. | — | 2020 | → |
| Parametric Characterization of a Taste Phenotype in Rats Selectively Bred for High Versus Low Saccharin Intake. | Dess NK et al. | — | 2020 | → |
| Prospects for finding the mechanisms of sex differences in addiction with human and model organism genetic analysis. | Datta U et al. | — | 2020 | → |
| "Us vs. Them" Pair Housing: Effects on Body Weight, Open Field Behavior, and Gut Microbiota in Rats Selectively Bred on a Taste Phenotype. | Dess NK et al. | — | 2020 | → |
| Developmental Vitamin D Deficiency in the Rat Impairs Recognition Memory, but Has No Effect on Social Approach or Hedonia. | Overeem K et al. | — | 2019 | → |
| Dopamine and opioid systems adaptation in alcoholism revisited: Convergent evidence from positron emission tomography and postmortem studies. | Hansson AC et al. | — | 2019 | → |
| Prolonged ad libitum access to low-concentration sucrose changes the neurochemistry of the nucleus accumbens in male Sprague-Dawley rats. | Hakim JD et al. | — | 2019 | → |
| Stability of individual differences in sucralose taste preference. | Bacharach SZ et al. | — | 2019 | → |
| Exposure to environmental enrichment attenuates addiction-like behavior and alters molecular effects of heroin self-administration in rats. | Imperio CG et al. | — | 2018 | → |
| Family history of alcoholism and the human brain response to oral sucrose. | Eiler WJA et al. | — | 2018 | → |
| Rat animal models for screening medications to treat alcohol use disorders. | Bell RL et al. | — | 2017 | → |
| Sweet taste liking is associated with subjective response to amphetamine in women but not men. | Weafer J et al. | — | 2017 | → |
| The phosphodiesterase-4 inhibitor roflumilast decreases ethanol consumption in C57BL/6J mice. | Liu X et al. | — | 2017 | → |
| Cocaine-induced reward enhancement measured with intracranial self-stimulation in rats bred for low versus high saccharin intake. | Radke AK et al. | — | 2016 | → |
| Gut Microbiota and a Selectively Bred Taste Phenotype: A Novel Model of Microbiome-Behavior Relationships. | Lyte M et al. | — | 2016 | → |
| Individual differences in saccharin acceptance predict rats' food intake. | Boakes RA et al. | — | 2016 | → |
| Bitter taste and nicotine preference: evidence for sex differences in rats. | Nesil T et al. | — | 2015 | → |
| Cocaine self-administration punished by intravenous histamine in adolescent and adult rats. | Holtz NA et al. | — | 2015 | → |
| Cocaine withdrawal in rats selectively bred for low (LoS) versus high (HiS) saccharin intake. | Radke AK et al. | — | 2015 | → |
| Commonalities and Distinctions Among Mechanisms of Addiction to Alcohol and Other Drugs. | Ozburn AR et al. | — | 2015 | → |
| Distinct ethanol drinking microstructures in two replicate lines of mice selected for drinking to intoxication. | Barkley-Levenson AM et al. | — | 2015 | → |
| Drinking sucrose or saccharin enhances sensitivity of rats to quinpirole-induced yawning. | Serafine KM et al. | — | 2015 | → |
| Endophenotypes for Alcohol Use Disorder: An Update on the Field. | Salvatore JE et al. | — | 2015 | → |
| Examination of the perception of sweet- and bitter-like taste qualities in sucralose preferring and avoiding rats. | Torregrossa AM et al. | — | 2015 | → |
| Fructose:glucose ratios--a study of sugar self-administration and associated neural and physiological responses in the rat. | Levy A et al. | — | 2015 | → |
| Intracranial self-stimulation reward thresholds during morphine withdrawal in rats bred for high (HiS) and low (LoS) saccharin intake. | Holtz NA et al. | — | 2015 | → |
| Sex Differences in Behavioral Dyscontrol: Role in Drug Addiction and Novel Treatments. | Carroll ME et al. | — | 2015 | → |
| Brucine suppresses ethanol intake and preference in alcohol-preferring Fawn-Hooded rats. | Li YL et al. | — | 2014 | → |
| Chronic wheel running affects cocaine-induced c-Fos expression in brain reward areas in rats. | Zlebnik NE et al. | — | 2014 | → |
| Cocaine-, caffeine-, and stress-evoked cocaine reinstatement in high vs. low impulsive rats: treatment with allopregnanolone. | Regier PS et al. | — | 2014 | → |
| Sex chromosome complement influences operant responding for a palatable food in mice. | Seu E et al. | — | 2014 | → |
| A preliminary study of the human brain response to oral sucrose and its association with recent drinking. | Kareken DA et al. | — | 2013 | → |
| Cocaine self-administration punished by i.v. histamine in rat models of high and low drug abuse vulnerability: effects of saccharin preference, impulsivity, and sex. | Holtz NA et al. | — | 2013 | → |
| Escalation of i.v. cocaine intake in peri-adolescent vs. adult rats selectively bred for high (HiS) vs. low (LoS) saccharin intake. | Holtz NA et al. | — | 2013 | → |
| From passive overeating to "food addiction": a spectrum of compulsion and severity. | Davis C | — | 2013 | → |
| Increased impulsive choice for saccharin during PCP withdrawal in female monkeys: influence of menstrual cycle phase. | Carroll ME et al. | — | 2013 | → |
| Individual differences and social influences on the neurobehavioral pharmacology of abused drugs. | Bardo MT et al. | — | 2013 | → |
| "Jello® shots" and cocktails as ethanol vehicles: parametric studies with high- and low-saccharin-consuming rats. | Dess NK et al. | — | 2013 | → |
| Nine generations of selection for high and low nicotine intake in outbred Sprague-Dawley rats. | Nesil T et al. | — | 2013 | → |
| Predicting extinction and reinstatement of alcohol and sucrose self-administration in outbred rats. | Kosten TA et al. | — | 2013 | → |
| Rats classified as low or high cocaine locomotor responders: a unique model involving striatal dopamine transporters that predicts cocaine addiction-like behaviors. | Yamamoto DJ et al. | — | 2013 | → |
| Reduced emotional signs of opiate withdrawal in rats selectively bred for low (LoS) versus high (HiS) saccharin intake. | Radke AK et al. | — | 2013 | → |
| Cocaine-induced c-Fos expression in rats selectively bred for high or low saccharin intake and in rats selected for high or low impulsivity. | Regier PS et al. | — | 2012 | → |
| Determinants of taste preference and acceptability: quality versus hedonics. | Loney GC et al. | — | 2012 | → |
| Differential orexin/hypocretin expression in addiction-prone and -resistant rats selectively bred for high (HiS) and low (LoS) saccharin intake. | Holtz NA et al. | — | 2012 | → |
| Effects of progesterone on escalation of intravenous cocaine self-administration in rats selectively bred for high or low saccharin intake. | Anker JJ et al. | — | 2012 | → |
| Exercise to reduce the escalation of cocaine self-administration in adolescent and adult rats. | Zlebnik NE et al. | — | 2012 | → |
| Neurobiology of consummatory behavior: mechanisms underlying overeating and drug use. | Barson JR et al. | — | 2012 | → |
| Preference for sucralose predicts behavioral responses to sweet and bittersweet tastants. | Loney GC et al. | — | 2012 | → |
| Sweet success, bitter defeat: a taste phenotype predicts social status in selectively bred rats. | Eaton JM et al. | — | 2012 | → |
| Trisomy of the G protein-coupled K+ channel gene, Kcnj6, affects reward mechanisms, cognitive functions, and synaptic plasticity in mice. | Cooper A et al. | — | 2012 | → |
| Baclofen has opposite effects on escalation of cocaine self-administration: increased intake in rats selectively bred for high (HiS) saccharin intake and decreased intake in those selected for low (LoS) saccharin intake. | Holtz NA et al. | — | 2011 | → |
| Derivation and characterization of replicate high- and low-alcohol preferring lines of mice and a high-drinking crossed HAP line. | Oberlin B et al. | — | 2011 | → |
| Food dependence in rats selectively bred for low versus high saccharin intake. Implications for "food addiction". | Yakovenko V et al. | — | 2011 | → |
| Genetics of sweet taste preferences. | Bachmanov AA et al. | — | 2011 | → |
| Inhibition of phosphodiesterase-4 decreases ethanol intake in mice. | Hu W et al. | — | 2011 | → |
| Rats display a robust bimodal preference profile for sucralose. | Loney GC et al. | — | 2011 | → |
| Responding during signaled availability and nonavailability of iv cocaine and food in rats: age and sex differences. | Anker JJ et al. | — | 2011 | → |
| Strain differences in the neural, behavioral, and molecular correlates of sweet and salty taste in naive, ethanol- and sucrose-exposed P and NP rats. | Coleman J et al. | — | 2011 | → |
| The ghrelin signalling system is involved in the consumption of sweets. | Landgren S et al. | — | 2011 | → |
| Differential effects of allopregnanolone on the escalation of cocaine self-administration and sucrose intake in female rats. | Anker JJ et al. | — | 2010 | → |
| Operant responding for sucrose by rats bred for high or low saccharin consumption. | Gosnell BA et al. | — | 2010 | → |
| Predictors of ethanol consumption in adult Sprague-Dawley rats: relation to hypothalamic peptides that stimulate ethanol intake. | Karatayev O et al. | — | 2010 | → |
| Reinstatement of cocaine seeking induced by drugs, cues, and stress in adolescent and adult rats. | Anker JJ et al. | — | 2010 | → |
| Repeated ethanol administration modifies the temporal structure of sucrose intake patterns in mice: effects associated with behavioral sensitization. | Pastor R et al. | — | 2010 | → |
| Sex differences and ovarian hormones in animal models of drug dependence. | Carroll ME et al. | — | 2010 | → |
| The emergence of gonadal hormone influences on dopaminergic function during puberty. | Kuhn C et al. | — | 2010 | → |
| Consumption of SC45647 and sucralose by rats selectively bred for high and low saccharin intake. | Dess NK et al. | — | 2009 | → |
| Impulsivity as a behavioral measure of withdrawal of orally delivered PCP and nondrug rewards in male and female monkeys. | Carroll ME et al. | — | 2009 | → |
| Impulsivity predicts the escalation of cocaine self-administration in rats. | Anker JJ et al. | — | 2009 | → |
| Modeling risk factors for nicotine and other drug abuse in the preclinical laboratory. | Carroll ME et al. | — | 2009 | → |
| Natural addiction: a behavioral and circuit model based on sugar addiction in rats. | Hoebel BG et al. | — | 2009 | → |
| The role of impulsive behavior in drug abuse. | Perry JL et al. | — | 2008 | → |