Suppression of conditioned nicotine and sucrose seeking by the cannabinoid-1 receptor antagonist SR141716A.
paper
Cited
Public
Unavailable
- Authors
- De Vries, Taco J; de Vries, Wendy; Janssen, Mieke C W; Schoffelmeer, Anton N M
- Year
- 2005
- Journal
- Behavioural brain research
- PMID
- 15904723
- DOI
- 10.1016/j.bbr.2005.02.021
The present study shows that the selective cannabinoid CB1 receptor antagonist SR141716A attenuated responding for both nicotine- and sucrose-associated stimuli in a long-term extinction-reinstatement model. The results suggest that endocannabinoids play a general role in modulating cue reactivity or conditioned reinforcement following prolonged abstinence of both drug and natural reinforcers. In line with previous preclinical and recent clinical observations, our results provide a strong rationale for the use of CB1 antagonists in the treatment of addictive behaviors.
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| Title | Year | PMID |
|---|---|---|
| The genetics of substance dependence. | 2012 | 22703173 |
| The incentive salience of alcohol: translating the effects of genetic variant in CNR1. | 2008 | 18606956 |
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