Dynamic and static interactions between p120 catenin and E-cadherin regulate the stability of cell-cell adhesion.
paper
Cited
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- Authors
- Ishiyama, Noboru; Lee, Seung-Hye; Liu, Shuang; Li, Guang-Yao; Smith, Matthew J; Reichardt, Louis F; Ikura, Mitsuhiko
- Year
- 2010
- Journal
- Cell
- PMID
- 20371349
- DOI
- 10.1016/j.cell.2010.01.017
The association of p120 catenin (p120) with the juxtamembrane domain (JMD) of the cadherin cytoplasmic tail is critical for the surface stability of cadherin-catenin cell-cell adhesion complexes. Here, we present the crystal structure of p120 isoform 4A in complex with the JMD core region (JMD(core)) of E-cadherin. The p120 armadillo repeat domain contains modular binding pockets that are complementary to electrostatic and hydrophobic properties of the JMD(core). Single-residue mutations within the JMD(core)-binding site of p120 abolished its interaction with E- and N-cadherins in vitro and in cultured cells. These mutations of p120 enabled us to clearly differentiate between N-cadherin-dependent and -independent steps of neuronal dendritic spine morphogenesis crucial for synapse development. NMR studies revealed that p120 regulates the stability of cadherin-mediated cell-cell adhesion by associating with the majority of the JMD, including residues implicated in clathrin-mediated endocytosis and Hakai-dependent ubiquitination of E-cadherin, through its discrete "dynamic" and "static" binding sites.
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| CAPN15 is a non-proteasomal, ubiquitin-directed calpain protease that regulates cell adhesion by cleaving E-cadherin. | Noguchi A et al. | β | 2026 | β |
| Planar cell polarity protein Vangl2 interacts with M-cadherin and stabilizes its cell surface expression in mouse C2C12 myoblasts. | Nagaoka T et al. | β | 2026 | β |
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| Alternative Splicing in Embryo Implantation. | Yu L et al. | β | 2025 | β |
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| Genetic Mutations in Cell Junction Proteins Associated with Brain Calcification. | Yang D et al. | β | 2025 | β |
| Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder. | Strom NI et al. | β | 2025 | β |
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| Outside-in engineering of cadherin endocytosis using a conformation strengthening antibody. | Xie B et al. | β | 2025 | β |
| Repeated extrinsic and anisotropic mechanical inputs promote C. elegans polarized adherens junction elongation. | Yang X et al. | β | 2025 | β |
| Role of vinculin in the structural dynamics of cadherin-catenin complexes and its implications for F-actin binding. | Hui B et al. | β | 2025 | β |
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| The Intrinsically Disordered Region of HBx and Virus-Host Interactions: Uncovering New Therapeutic Approaches for HBV and Cancer. | Villanueva RA et al. | β | 2025 | β |
| The Lego hypothesis of tissue morphogenesis: stereotypic organization of parallel orientational cell adhesions for epithelial self-assembly. | Zhang L et al. | β | 2025 | β |
| A computational study for understanding the impact of p120-catenin on the cis-dimerization of cadherin. | Su Z et al. | β | 2024 | β |
| A novel strategy to facilitate uniform epithelial cell maturation using liquid-liquid interfaces. | Sonoi R et al. | β | 2024 | β |
| Characterization and Physiological Differences of Two Primary Cultures of Human Normal and Hypertrophic Scar Dermal Fibroblasts: A Pilot Study. | Yudintceva NM et al. | β | 2024 | β |
| Cryo-EM reveals a phosphorylated R-domain envelops the NBD1 catalytic domain in an ABC transporter. | Souza Amado de Carvalho R et al. | β | 2024 | β |
| CTNND1 is involved in germline predisposition to early-onset gastric cancer by affecting cell-to-cell interactions. | Herrera-Pariente C et al. | β | 2024 | β |
| Essential role of obscurin kinase-1 in cardiomyocyte coupling via N-cadherin phosphorylation. | Wang L et al. | β | 2024 | β |
| Functional analysis of ESRP1/2 gene variants and CTNND1 isoforms in orofacial cleft pathogenesis. | Caetano da Silva C et al. | β | 2024 | β |
| Functions of p120-catenin in physiology and diseases. | Jin X et al. | β | 2024 | β |
| Genome-wide meta-analysis, functional genomics and integrative analyses implicate new risk genes and therapeutic targets for anxiety disorders. | Li W et al. | β | 2024 | β |
| Identification of domains in Plasmodium falciparum proteins of unknown function using DALI search on AlphaFold predictions. | Behrens HM et al. | β | 2024 | β |
| Inhibition of Ξ΄-catenin palmitoylation slows the progression of prostate cancer. | Wang B et al. | β | 2024 | β |
| MARCH family E3 ubiquitin ligases selectively target and degrade cadherin family proteins. | Seo T et al. | β | 2024 | β |
| MicroRNA-409: Molecular functions and clinical applications in cancer. | Rajabloo Y et al. | β | 2024 | β |
| Multiomics2Targets identifies targets from cancer cohorts profiled with transcriptomics, proteomics, and phosphoproteomics. | Deng EZ et al. | β | 2024 | β |
| The Scribble-SGEF-Dlg1 complex regulates E-cadherin and ZO-1 stability, turnover and transcription in epithelial cells. | Rabino A et al. | β | 2024 | β |
| USP11 deubiquitinates E-cadherin and maintains the luminal fate of mammary tumor cells to suppress breast cancer. | Qian T et al. | β | 2024 | β |
| Whole-genome sequencing identifies novel genes for autism in Chinese trios. | Chang S et al. | β | 2024 | β |
| Ξ±-catenin middle- and actin-binding domain unfolding mutants differentially impact epithelial strength and sheet migration. | Quinn JM et al. | β | 2024 | β |
| An ensemble of cadherin-catenin-vinculin complex employs vinculin as the major F-actin binding mode. | Shi B et al. | β | 2023 | β |
| Calpain Regulation and Dysregulation-Its Effects on the Intercalated Disk. | Yoder MW et al. | β | 2023 | β |
| Chemoproteomic strategy identified p120-catenin glutathionylation regulates E-cadherin degradation and cell migration. | Kukulage DSK et al. | β | 2023 | β |
| Dynamic interactions between E-cadherin and Ankyrin-G mediate epithelial cell polarity maintenance. | Kong C et al. | β | 2023 | β |
| Mechanisms Underlying Rare Inherited Pediatric Retinal Vascular Diseases: FEVR, Norrie Disease, Persistent Fetal Vascular Syndrome. | Le V et al. | β | 2023 | β |
| Microtubule plus-end tracking proteins: novel modulators of cardiac sodium channels and arrhythmogenesis. | Marchal GA et al. | β | 2023 | β |
| p120-catenin promotes innate antiviral immunity through stabilizing TBK1-IRF3 complex. | Wu H et al. | β | 2023 | β |
| Plakophilin-3 Binds the Membrane and Filamentous Actin without Bundling F-Actin. | Gupta J et al. | β | 2023 | β |
| Structural and regulatory insights into the glideosome-associated connector from <i>Toxoplasma gondii</i>. | Kumar A et al. | β | 2023 | β |
| Targeting Protein-Protein Interfaces with Peptides: The Contribution of Chemical Combinatorial Peptide Library Approaches. | Monti A et al. | β | 2023 | β |
| Tissue Morphogenesis Through Dynamic Cell and Matrix Interactions. | Wu D et al. | β | 2023 | β |
| Ξ΄-Catenin controls astrocyte morphogenesis via layer-specific astrocyte-neuron cadherin interactions. | Tan CX et al. | β | 2023 | β |
| Arvcf Dependent Adherens Junction Stability is Required to Prevent Age-Related Cortical Cataracts. | Martin JB et al. | β | 2022 | β |
| Circulating Tumor Cells: Does Ion Transport Contribute to Intravascular Survival, Adhesion, Extravasation, and Metastatic Organotropism? | Stock C | β | 2022 | β |
| Classical epithelial-mesenchymal transition (EMT) and alternative cell death process-driven blebbishield metastatic-witch (BMW) pathways to cancer metastasis. | Jinesh GG et al. | β | 2022 | β |
| Claudin-4 localization in epithelial ovarian cancer. | Neville MC et al. | β | 2022 | β |
| CTNND1 variants cause familial exudative vitreoretinopathy through the Wnt/cadherin axis. | Yang M et al. | β | 2022 | β |
| Delta-Catenin as a Modulator of Rho GTPases in Neurons. | Donta MS et al. | β | 2022 | β |
| Dephosphorylation of Y228 and Y217 and phosphorylation of Y335 in p120 catenin activate convergent extension during zebrafish gastrulation. | Shan B et al. | β | 2022 | β |
| <i>CDH1</i> Germline Variants in a Tunisian Cohort with Hereditary Diffuse Gastric Carcinoma. | Ben Aissa-Haj J et al. | β | 2022 | β |
| Knowledge mapping of alternative splicing of cancer from 2012 to 2021: A bibliometric analysis. | Tian B et al. | β | 2022 | β |
| Lactobacilli metabolites restore E-cadherin and suppress MMP9 in cervical cancer cells. | Pawar K et al. | β | 2022 | β |
| Landscape of Druggable Molecular Pathways Downstream of Genomic CDH1/Cadherin-1 Alterations in Gastric Cancer. | Malpeli G et al. | β | 2022 | β |
| Loss of E-Cadherin Staining Continuity in the Trophoblastic Basal Membrane Correlates with Increased Resistance in Uterine Arteries and Proteinuria in Patients with Pregnancy-Induced Hypertension. | PΔksa M et al. | β | 2022 | β |
| Nucleation of cadherin clusters on cell-cell interfaces. | Ibata N et al. | β | 2022 | β |
| Overexpression of PTPRZ1 Regulates p120/<i>Ξ²</i>-Catenin Phosphorylation to Promote Carcinogenesis of Oral Submucous Fibrosis. | Ma L et al. | β | 2022 | β |
| PTP-PEST Regulated Membranous/Cytoplasmic Translocation of p120ctn in the Lung Cancer Resistance to Tyrosine Kinase Inhibitor. | Liu WW et al. | β | 2022 | β |
| Reconstitution of the full transmembrane cadherin-catenin complex. | Maker A et al. | β | 2022 | β |
| Regulation of Alternative Splicing during Epithelial-Mesenchymal Transition. | Lyu J et al. | β | 2022 | β |
| Retinal cadherins and the retinal cadherinopathies: Current concepts and future directions. | Yusuf IH et al. | β | 2022 | β |
| Activated nanoscale actin-binding domain motion in the catenin-cadherin complex revealed by neutron spin echo spectroscopy. | Farago B et al. | β | 2021 | β |
| CDK5 Targeting as a Therapy for Recovering Neurovascular Unit Integrity in Alzheimer's Disease. | Posada-Duque RA et al. | β | 2021 | β |
| Cytoplasmic P120ctn Promotes Gefitinib Resistance in Lung Cancer Cells by Activating PAK1 and ERK Pathway. | Liu WW et al. | β | 2021 | β |
| Effects of advanced glycation end products on neutrophil migration and aggregation in diabetic wounds. | Kang Y et al. | β | 2021 | β |
| IGF2BP1 is a targetable SRC/MAPK-dependent driver of invasive growth in ovarian cancer. | Bley N et al. | β | 2021 | β |
| Methylation Modification, Alternative Splicing, and Noncoding RNA Play a Role in Cancer Metastasis through Epigenetic Regulation. | Yu B et al. | β | 2021 | β |
| P120 catenin potentiates constitutive E-cadherin dimerization at the plasma membrane and regulates trans binding. | Vu V et al. | β | 2021 | β |
| Pancreas morphogenesis: Branching in and then out. | Flasse L et al. | β | 2021 | β |
| PLEKHA7, an Apical Adherens Junction Protein, Suppresses Inflammatory Breast Cancer in the Context of High E-Cadherin and p120-Catenin Expression. | Pence LJ et al. | β | 2021 | β |
| Sorting of cadherin-catenin-associated proteins into individual clusters. | Troyanovsky RB et al. | β | 2021 | β |
| The Cross-Talk Between EGFR and E-Cadherin. | RamΓrez Moreno M et al. | β | 2021 | β |
| A Catalogue of 59,732 Human-Specific Regulatory Sequences Reveals Unique-to-Human Regulatory Patterns Associated with Virus-Interacting Proteins, Pluripotency, and Brain Development. | Glinsky GV | β | 2020 | β |
| Cryo-EM Structure of the Fork Protection Complex Bound to CMG at a Replication Fork. | BaretiΔ D et al. | β | 2020 | β |
| Endocytosis, cadherins and tissue dynamics. | Katsuno-Kambe H et al. | β | 2020 | β |
| Epithelial-Mesenchymal Transition: Role in Cancer Progression and the Perspectives of Antitumor Treatment. | Gaponova AV et al. | β | 2020 | β |
| hnRNPA2/B1 Ameliorates LPS-Induced Endothelial Injury through NF-<i>ΞΊ</i>B Pathway and VE-Cadherin/<i>Ξ²</i>-Catenin Signaling Modulation In Vitro. | Chen Y et al. | β | 2020 | β |
| Hsa-miR-425-5p promotes tumor growth and metastasis by activating the CTNND1-mediated Ξ²-catenin pathway and EMT in colorectal cancer. | Liu D et al. | β | 2020 | β |
| Interplay between actomyosin and E-cadherin dynamics regulates cell shape in the <i>Drosophila</i> embryonic epidermis. | Greig J et al. | β | 2020 | β |
| MicroRNAs Involved in Metastasis of Hepatocellular Carcinoma: Target Candidates, Functionality and Efficacy in Animal Models and Prognostic Relevance. | Weidle UH et al. | β | 2020 | β |
| Modulator-Dependent RBPs Changes Alternative Splicing Outcomes in Kidney Cancer. | Wang Y et al. | β | 2020 | β |
| Molecular Mobility-Mediated Regulation of E-Cadherin Adhesion. | Biswas KH | β | 2020 | β |
| Monoubiquitination of p120-catenin is essential for TGFΞ²-induced epithelial-mesenchymal transition and tumor metastasis. | Wu Q et al. | β | 2020 | β |
| Novel truncating mutations in CTNND1 cause a dominant craniofacial and cardiac syndrome. | Alharatani R et al. | β | 2020 | β |
| P120 and E-cadherin: Double-edged swords in tumor metastasis. | Venhuizen JH et al. | β | 2020 | β |
| p120-catenin-dependent collective brain infiltration by glioma cell networks. | Gritsenko PG et al. | β | 2020 | β |
| The crosstalk between microtubules, actin and membranes shapes cell division. | Rizzelli F et al. | β | 2020 | β |
| The multifarious regulation of the apical junctional complex. | Rusu AD et al. | β | 2020 | β |
| Tissue Inhibitor of Metalloproteinase 3 Deficiency Disrupts the Hepatocyte E-Cadherin/Ξ²-Catenin Complex and Induces Cell Death in Liver Ischemia/Reperfusion Injury. | Fujii T et al. | β | 2020 | β |
| Unfractionated heparin attenuates endothelial barrier dysfunction via the phosphatidylinositol-3 kinase/serine/threonine kinase/nuclear factor kappa-B pathway. | Mu ST et al. | β | 2020 | β |
| VE-cadherin endocytosis controls vascular integrity and patterning during development. | Grimsley-Myers CM et al. | β | 2020 | β |
| Afatinib, an EGFR inhibitor, decreases EMT and tumorigenesis of Huhβ7 cells by regulating the ERKβVEGF/MMP9 signaling pathway. | Chen Y et al. | β | 2019 | β |
| Clinical spectrum and pleiotropic nature of <i>CDH1</i> germline mutations. | Figueiredo J et al. | β | 2019 | β |
| E-cadherin Beyond Structure: A Signaling Hub in Colon Homeostasis and Disease. | Daulagala AC et al. | β | 2019 | β |
| Epithelial Viscoelasticity Is Regulated by Mechanosensitive E-cadherin Turnover. | Iyer KV et al. | β | 2019 | β |
| Getting a grip on adhesion: Cadherin switching and collagen signaling. | Huang H et al. | β | 2019 | β |
| Glycyrrhizin Attenuates the Process of Epithelial-to-Mesenchymal Transition by Modulating HMGB1 Initiated Novel Signaling Pathway in Prostate Cancer Cells. | Chang HY et al. | β | 2019 | β |
| Multiscale Simulations of Biological Membranes: The Challenge To Understand Biological Phenomena in a Living Substance. | Enkavi G et al. | β | 2019 | β |
| P120-Catenin And Its Phosphorylation On Tyr228 Inhibits Proliferation And Invasion In Colon Adenocarcinoma Cells. | Ding X et al. | β | 2019 | β |
| p120-catenin regulates WNT signaling and EMT in the mouse embryo. | HernΓ‘ndez-MartΓnez R et al. | β | 2019 | β |
| S-nitrosylation and its role in breast cancer angiogenesis and metastasis. | Ehrenfeld P et al. | β | 2019 | β |
| When ubiquitin meets E-cadherin: Plasticity of the epithelial cellular barrier. | NiΓ±o CA et al. | β | 2019 | β |
| Cell-Cell Contact and Receptor Tyrosine Kinase Signaling. | Chiasson-MacKenzie C et al. | β | 2018 | β |
| Detachment of Chain-Forming Neuroblasts by Fyn-Mediated Control of cell-cell Adhesion in the Postnatal Brain. | Fujikake K et al. | β | 2018 | β |
| Drawing on disorder: How viruses use histone mimicry to their advantage. | Tarakhovsky A et al. | β | 2018 | β |
| E-cadherin: Its dysregulation in carcinogenesis and clinical implications. | Wong SHM et al. | β | 2018 | β |
| Hepatoma cell-secreted exosomal microRNA-103 increases vascular permeability and promotes metastasis by targeting junction proteins. | Fang JH et al. | β | 2018 | β |
| Junctional E-cadherin/p120-catenin Is Correlated with the Absence of Supporting Cells to Hair Cells Conversion in Postnatal Mice Cochleae. | Luo WW et al. | β | 2018 | β |
| Mutations in the Epithelial Cadherin-p120-Catenin Complex Cause Mendelian Non-Syndromic Cleft Lip with or without Cleft Palate. | Cox LL et al. | β | 2018 | β |
| New genomic data and analyses challenge the traditional vision of animal epithelium evolution. | Belahbib H et al. | β | 2018 | β |
| p120-catenin is required for regulating epidermal proliferation, differentiation, and barrier function. | Xie Z et al. | β | 2018 | β |
| Peptides derived from cadherin juxtamembrane region inhibit platelet function. | Golla K et al. | β | 2018 | β |
| Recovery of Neurovascular Unit Integrity by CDK5-KD Astrocyte Transplantation in a Global Cerebral Ischemia Model. | Becerra-Calixto A et al. | β | 2018 | β |
| Regulation of Epithelial Plasticity Determines Metastatic Organotropism in Pancreatic Cancer. | Reichert M et al. | β | 2018 | β |
| Src- and confinement-dependent FAK activation causes E-cadherin relaxation and Ξ²-catenin activity. | Gayrard C et al. | β | 2018 | β |
| Variants in members of the cadherin-catenin complex, CDH1 and CTNND1, cause blepharocheilodontic syndrome. | Kievit A et al. | β | 2018 | β |
| Cell division orientation is coupled to cell-cell adhesion by the E-cadherin/LGN complex. | Gloerich M et al. | β | 2017 | β |
| Chromatin remodeling protein MORC2 promotes breast cancer invasion and metastasis through a PRD domain-mediated interaction with CTNND1. | Liao XH et al. | β | 2017 | β |
| DcR3 combined with hematological traits serves as a valuable biomarker for the diagnosis of cancer metastasis. | Li J et al. | β | 2017 | β |
| DcR3 promotes hepatoma cell migration by downregulating E-cadherin expression. | Zhang H et al. | β | 2017 | β |
| EMT and stemness: flexible processes tuned by alternative splicing in development and cancer progression. | Pradella D et al. | β | 2017 | β |
| Endothelial cell SHP-2 negatively regulates neutrophil adhesion and promotes transmigration by enhancing ICAM-1-VE-cadherin interaction. | Yan M et al. | β | 2017 | β |
| Evolution and diversity of cadherins and catenins. | Gul IS et al. | β | 2017 | β |
| Functional roles of p120ctn family of proteins in central neurons. | Yuan L et al. | β | 2017 | β |
| Glycoprotein 90K Promotes E-Cadherin Degradation in a Cell Density-Dependent Manner via Dissociation of E-Cadherin-p120-Catenin Complex. | Park SY et al. | β | 2017 | β |
| Homeodomain-containing gene 10 inhibits cell apoptosis and promotes cell invasion and migration in osteosarcoma cell lines. | Xiong W et al. | β | 2017 | β |
| Integration of Cadherin Adhesion and Cytoskeleton at <i>Adherens</i> Junctions. | MΓ¨ge RM et al. | β | 2017 | β |
| Metaplasia: tissue injury adaptation and a precursor to the dysplasia-cancer sequence. | Giroux V et al. | β | 2017 | β |
| Metazoan evolution of the armadillo repeat superfamily. | Gul IS et al. | β | 2017 | β |
| Mib1 contributes to persistent directional cell migration by regulating the Ctnnd1-Rac1 pathway. | Mizoguchi T et al. | β | 2017 | β |
| miR-223 promotes colon cancer by directly targeting p120 catenin. | Liu L et al. | β | 2017 | β |
| Molecular Architecture of the Major Membrane Ring Component of the Nuclear Pore Complex. | Upla P et al. | β | 2017 | β |
| p120-catenin regulates VE-cadherin endocytosis and degradation induced by the Kaposi sarcoma-associated ubiquitin ligase K5. | Nanes BA et al. | β | 2017 | β |
| Regulation of endothelial barrier function by p120-cateninβVE-cadherin interaction. | Garrett JP et al. | β | 2017 | β |
| Relationships of MMP-9, E-cadherin, and VEGF expression with clinicopathological features and response to chemosensitivity in gastric cancer. | Gao H et al. | β | 2017 | β |
| The VE-cadherin cytoplasmic domain undergoes proteolytic processing during endocytosis. | Su W et al. | β | 2017 | β |
| ΞΌ2-Dependent endocytosis of N-cadherin is regulated by Ξ²-catenin to facilitate neurite outgrowth. | Chen YT et al. | β | 2017 | β |
| A Computational Model for Kinetic Studies of Cadherin Binding and Clustering. | Chen J et al. | β | 2016 | β |
| Activation of zebrafish Src family kinases by the prion protein is an amyloid-Ξ²-sensitive signal that prevents the endocytosis and degradation of E-cadherin/Ξ²-catenin complexes in vivo. | Sempou E et al. | β | 2016 | β |
| Adhesion Properties of Human Oral Epithelial-Derived Cells to Zirconia. | Okabe E et al. | β | 2016 | β |
| Cadherin tales: Regulation of cadherin function by endocytic membrane trafficking. | Cadwell CM et al. | β | 2016 | β |
| Correlations of fascin-1 and cadherin-17 protein expression with clinicopathologic features and prognosis of patients with gastric cancer. | Tu L et al. | β | 2016 | β |
| DDR1 promotes E-cadherin stability via inhibition of integrin-Ξ²1-Src activation-mediated E-cadherin endocytosis. | Chen HR et al. | β | 2016 | β |
| Dynamic Protein Interaction Networks and New Structural Paradigms in Signaling. | Csizmok V et al. | β | 2016 | β |
| Endocytosis and serpentine filopodia drive blebbishield-mediated resurrection of apoptotic cancer stem cells. | Jinesh GG et al. | β | 2016 | β |
| Facilitation of uniform maturation of human retinal pigment epithelial cells through collective movement in culture. | Sonoi R et al. | β | 2016 | β |
| Inhibition of E-cadherin/catenin complex formation by O-linked N-acetylglucosamine transferase is partially independent of its catalytic activity. | Liu H et al. | β | 2016 | β |
| Integrative proteomic analysis reveals reprograming tumor necrosis factor signaling in epithelial mesenchymal transition. | Zhao Y et al. | β | 2016 | β |
| MicroRNA-409-3p inhibits osteosarcoma cell migration and invasion by targeting catenin-Ξ΄1. | Wu S et al. | β | 2016 | β |
| p120-catenin controls contractility along the vertical axis of epithelial lateral membranes. | Yu HH et al. | β | 2016 | β |
| p120 Catenin-Mediated Stabilization of E-Cadherin Is Essential for Primitive Endoderm Specification. | Pieters T et al. | β | 2016 | β |
| p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis. | van de Ven RA et al. | β | 2016 | β |
| P120-Catenin Regulates Early Trafficking Stages of the N-Cadherin Precursor Complex. | Wehrendt DP et al. | β | 2016 | β |
| p120 Catenin Suppresses Basal Epithelial Cell Extrusion in Invasive Pancreatic Neoplasia. | Hendley AM et al. | β | 2016 | β |
| Phosphorylation and isoform use in p120-catenin during development and tumorigenesis. | Hong JY et al. | β | 2016 | β |
| Regulation of Immunity by Butyrophilins. | Rhodes DA et al. | β | 2016 | β |
| Structures of designed armadillo-repeat proteins show propagation of inter-repeat interface effects. | Reichen C et al. | β | 2016 | β |
| 3D model for Cancerous Inhibitor of Protein Phosphatase 2A armadillo domain unveils highly conserved protein-protein interaction characteristics. | DahlstrΓΆm KM et al. | β | 2015 | β |
| Activation of human Ξ³Ξ΄ T cells by cytosolic interactions of BTN3A1 with soluble phosphoantigens and the cytoskeletal adaptor periplakin. | Rhodes DA et al. | β | 2015 | β |
| Cadherin-6B undergoes macropinocytosis and clathrin-mediated endocytosis during cranial neural crest cell EMT. | Padmanabhan R et al. | β | 2015 | β |
| Catenin-Ξ΄1, negatively regulated by miR-145, promotes tumour aggressiveness in gastric cancer. | Xing AY et al. | β | 2015 | β |
| Cell adhesion in epidermal development and barrier formation. | Sumigray KD et al. | β | 2015 | β |
| Cell regulation by phosphotyrosine-targeted ubiquitin ligases. | Cooper JA et al. | β | 2015 | β |
| Correlation of cadherin-17 protein expression with clinicopathological features and prognosis of patients with sporadic gastric cancer. | Meng W et al. | β | 2015 | β |
| Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120Β catenin activity. | Kourtidis A et al. | β | 2015 | β |
| Epigenetic Regulation of Epidermal Stem Cell Biomarkers and Their Role in Wound Healing. | Saldanha SN et al. | β | 2015 | β |
| Expressions of E-cadherin, p120ctn, Ξ²-catenin and NF-ΞΊB in ulcerative colitis. | Zhang C et al. | β | 2015 | β |
| Intrinsically disordered proteins in cellular signalling and regulation. | Wright PE et al. | β | 2015 | β |
| Measurement of State-Specific Association Constants in Allosteric Sensors through Molecular Stapling and NMR. | Moleschi KJ et al. | β | 2015 | β |
| p120-catenin down-regulation and epidermal growth factor receptor overexpression results in a transformed epithelium that mimics esophageal squamous cell carcinoma. | Lehman HL et al. | β | 2015 | β |
| p120 Catenin is required for normal tubulogenesis but not epithelial integrity in developing mouse pancreas. | Hendley AM et al. | β | 2015 | β |
| p120-catenin participates in the progress of gastric cancer through regulating the Rac1 and Pak1 signaling pathway. | Li TF et al. | β | 2015 | β |
| Polarized E-cadherin endocytosis directs actomyosin remodeling during embryonic wound repair. | Hunter MV et al. | β | 2015 | β |
| Pro-Tumorigenic Phosphorylation of p120 Catenin in Renal and Breast Cancer. | Kourtidis A et al. | β | 2015 | β |
| Regulation of cell adhesion and cell sorting at embryonic boundaries. | Fagotto F | β | 2015 | β |
| Repeated intraperitoneal injections of liposomes containing phosphatidic acid and cardiolipin reduce amyloid-Ξ² levels in APP/PS1 transgenic mice. | OrdΓ³Γ±ez-GutiΓ©rrez L et al. | β | 2015 | β |
| Role of Dynamics in the Autoinhibition and Activation of the Hyperpolarization-activated Cyclic Nucleotide-modulated (HCN) Ion Channels. | VanSchouwen B et al. | β | 2015 | β |
| Synaptopodin couples epithelial contractility to Ξ±-actinin-4-dependent junction maturation. | Kannan N et al. | β | 2015 | β |
| The Src non-receptor tyrosine kinase paradigm: New insights into mammalian Sertoli cell biology. | Chojnacka K et al. | β | 2015 | β |
| Ξ±5-nAChR modulates nicotine-induced cell migration and invasion in A549 lung cancer cells. | Sun H et al. | β | 2015 | β |
| Ξ΄-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity. | He Y et al. | β | 2015 | β |
| Adherens junction treadmilling during collective migration. | Peglion F et al. | β | 2014 | β |
| Cadherin juxtamembrane region derived peptides inhibit TGFΞ²1 induced gene expression. | Stavropoulos I et al. | β | 2014 | β |
| Common themes in PrP signaling: the Src remains the same. | Ochs K et al. | β | 2014 | β |
| Computational modeling of the interplay between cadherin-mediated cell adhesion and Wnt signaling pathway. | Chen J et al. | β | 2014 | β |
| Dimeric switch of Hakai-truncated monomers during substrate recognition: insights from solution studies and NMR structure. | Mukherjee M et al. | β | 2014 | β |
| Dynamic contacts: rearranging adherens junctions to drive epithelial remodelling. | Takeichi M | β | 2014 | β |
| Flotillins in intercellular adhesion - from cellular physiology to human diseases. | Bodin S et al. | β | 2014 | β |
| Glial cell-derived neurotrophic factor attenuates neuropathic pain in a mouse model of chronic constriction injury: possible involvement of E-cadherin/p120ctn signaling. | Wang C et al. | β | 2014 | β |
| Impact of p120-catenin isoforms 1A and 3A on epithelial mesenchymal transition of lung cancer cells expressing E-cadherin in different subcellular locations. | Zhang Y et al. | β | 2014 | β |
| p120-catenin regulates REST and CoREST, and modulates mouse embryonic stem cell differentiation. | Lee M et al. | β | 2014 | β |
| p120 modulates LPS-induced NF-ΞΊB activation partially through RhoA in bronchial epithelial cells. | Qin L et al. | β | 2014 | β |
| Palmitoylation of Ξ΄-catenin by DHHC5 mediates activity-induced synapse plasticity. | Brigidi GS et al. | β | 2014 | β |
| Prediction of the repeat domain structures and impact of parkinsonism-associated variations on structure and function of all functional domains of leucine-rich repeat kinase 2 (LRRK2). | Mills RD et al. | β | 2014 | β |
| Pre-metazoan origins and evolution of the cadherin adhesome. | Murray PS et al. | β | 2014 | β |
| Protection after stroke: cellular effectors of neurovascular unit integrity. | Posada-Duque RA et al. | β | 2014 | β |
| PTP-PEST targets a novel tyrosine site in p120 catenin to control epithelial cell motility and Rho GTPase activity. | Espejo R et al. | β | 2014 | β |
| Suppressed KrΓΌppelβlike factor 17 expression induces tumor proliferation, metastasis and a poor prognosis in papillary thyroid carcinoma. | Ye WC et al. | β | 2014 | β |
| An autoinhibited structure of Ξ±-catenin and its implications for vinculin recruitment to adherens junctions. | Ishiyama N et al. | β | 2013 | β |
| CAR regulates epithelial cell junction stability through control of E-cadherin trafficking. | Morton PE et al. | β | 2013 | β |
| Cigarette smoke disrupts the integrity of airway adherens junctions through the aberrant interaction of p120-catenin with the cytoplasmic tail of MUC1. | Zhang L et al. | β | 2013 | β |
| CLASP2 interacts with p120-catenin and governs microtubule dynamics at adherens junctions. | Shahbazi MN et al. | β | 2013 | β |
| Concomitant loss of p120-catenin and Ξ²-catenin membrane expression and oral carcinoma progression with E-cadherin reduction. | Sasaya K et al. | β | 2013 | β |
| Down-regulated KLF17 expression is associated with tumor invasion and poor prognosis in hepatocellular carcinoma. | Liu FY et al. | β | 2013 | β |
| Dynamics and regulation of epithelial adherens junctions: recent discoveries and controversies. | Ivanov AI et al. | β | 2013 | β |
| E-cadherin polarity is determined by a multifunction motif mediating lateral membrane retention through ankyrin-G and apical-lateral transcytosis through clathrin. | Jenkins PM et al. | β | 2013 | β |
| Holding on and letting go: cadherin turnover in cell intercalation. | Morita H et al. | β | 2013 | β |
| Interaction of p190RhoGAP with C-terminal domain of p120-catenin modulates endothelial cytoskeleton and permeability. | Zebda N et al. | β | 2013 | β |
| Mechanistic basis of desmosome-targeted diseases. | Al-Jassar C et al. | β | 2013 | β |
| p120catenin alteration in cancer and its role in tumour invasion. | Peglion F et al. | β | 2013 | β |
| p120 catenin: an essential regulator of cadherin stability, adhesion-induced signaling, and cancer progression. | Kourtidis A et al. | β | 2013 | β |
| Pou5f1-dependent EGF expression controls E-cadherin endocytosis, cell adhesion, and zebrafish epiboly movements. | Song S et al. | β | 2013 | β |
| Rac1 and Cdc42 differentially modulate cigarette smoke-induced airway cell migration through p120-catenin-dependent and -independent pathways. | Zhang L et al. | β | 2013 | β |
| Shaping dendrites with machinery borrowed from epithelia. | McLachlan IG et al. | β | 2013 | β |
| Signaling through dynamic linkers as revealed by PKA. | Akimoto M et al. | β | 2013 | β |
| Targeting CDH17 suppresses tumor progression in gastric cancer by downregulating Wnt/Ξ²-catenin signaling. | Qiu HB et al. | β | 2013 | β |
| TIMP-2 modulates cancer cell transcriptional profile and enhances E-cadherin/beta-catenin complex expression in A549 lung cancer cells. | Bourboulia D et al. | β | 2013 | β |
| Wnt/beta-catenin signaling and small molecule inhibitors. | Voronkov A et al. | β | 2013 | β |
| Adherens junction assembly. | Troyanovsky S | β | 2012 | β |
| Adherens junctions and cancer. | Vasioukhin V | β | 2012 | β |
| Adherens junction turnover: regulating adhesion through cadherin endocytosis, degradation, and recycling. | Kowalczyk AP et al. | β | 2012 | β |
| Afadin, a Ras/Rap effector that controls cadherin function, promotes spine and excitatory synapse density in the hippocampus. | Beaudoin GM et al. | β | 2012 | β |
| Analysis of LRRK2 accessory repeat domains: prediction of repeat length, number and sites of Parkinson's disease mutations. | Mills RD et al. | β | 2012 | β |
| Biological influence of Hakai in cancer: a 10-year review. | Aparicio LA et al. | β | 2012 | β |
| Cdc42 GTPase and Rac1 GTPase act downstream of p120 catenin and require GTP exchange during gastrulation of zebrafish mesoderm. | Hsu CL et al. | β | 2012 | β |
| Cell adhesion and its endocytic regulation in cell migration during neural development and cancer metastasis. | Kawauchi T | β | 2012 | β |
| Competitive regulation of E-cadherin juxtamembrane domain degradation by p120-catenin binding and Hakai-mediated ubiquitination. | Hartsock A et al. | β | 2012 | β |
| Conformational epitopes at cadherin calcium-binding sites and p120-catenin phosphorylation regulate cell adhesion. | Petrova YI et al. | β | 2012 | β |
| Cross talk between focal adhesion kinase and cadherins: role in regulating endothelial barrier function. | Quadri SK | β | 2012 | β |
| E-cadherin destabilization accounts for the pathogenicity of missense mutations in hereditary diffuse gastric cancer. | SimΓ΅es-Correia J et al. | β | 2012 | β |
| Guilt by association: what p120-catenin has to hide. | Perez-Moreno M et al. | β | 2012 | β |
| Mutational analysis supports a core role for Drosophila Ξ±-catenin in adherens junction function. | Sarpal R et al. | β | 2012 | β |
| New insights into the regulation of E-cadherin distribution by endocytosis. | de Beco S et al. | β | 2012 | β |
| p120-Catenin: a novel regulator of innate immunity and inflammation. | Hu G | β | 2012 | β |
| p120-catenin binding masks an endocytic signal conserved in classical cadherins. | Nanes BA et al. | β | 2012 | β |
| p120-catenin modulates airway epithelial cell migration induced by cigarette smoke. | Zhang L et al. | β | 2012 | β |
| PKCΞ± activation of p120-catenin serine 879 phospho-switch disassembles VE-cadherin junctions and disrupts vascular integrity. | Vandenbroucke St Amant E et al. | β | 2012 | β |
| Reduced surface expression of epithelial E-cadherin evoked by interferon-gamma is Fyn kinase-dependent. | Smyth D et al. | β | 2012 | β |
| [Regulation of intercellular adhesion during epithelial morphogenesis]. | Levayer R | β | 2012 | β |
| Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma. | Mann KM et al. | β | 2012 | β |
| S-Nitrosation of Ξ²-catenin and p120 catenin: a novel regulatory mechanism in endothelial hyperpermeability. | MarΓn N et al. | β | 2012 | β |
| The juxtamembrane domain of the E-cadherin cytoplasmic tail contributes to its interaction with Myosin VI. | Mangold S et al. | β | 2012 | β |
| The regulation of cell-cell adhesion during epithelial-mesenchymal transition, motility and tumor progression. | Le Bras GF et al. | β | 2012 | β |
| The three-dimensional structure of the cadherin-catenin complex. | Ishiyama N et al. | β | 2012 | β |
| Ubiquitin links to cytoskeletal dynamics, cell adhesion and migration. | Schaefer A et al. | β | 2012 | β |
| Cadherin-catenin adhesion complexes at the synapse. | Brigidi GS et al. | β | 2011 | β |
| Characterizing the RNA targets and position-dependent splicing regulation by TDP-43. | Tollervey JR et al. | β | 2011 | β |
| Crystal structure of the armadillo repeat domain of adenomatous polyposis coli which reveals its inherent flexibility. | Zhang Z et al. | β | 2011 | β |
| Crystal structures of the armadillo repeat domain of adenomatous polyposis coli and its complex with the tyrosine-rich domain of Sam68. | Morishita EC et al. | β | 2011 | β |
| Deletion of p120-catenin results in a tumor microenvironment with inflammation and cancer that establishes it as a tumor suppressor gene. | Stairs DB et al. | β | 2011 | β |
| Dynamics of adherens junctions in epithelial establishment, maintenance, and remodeling. | Baum B et al. | β | 2011 | β |
| E-cadherin: gatekeeper of airway mucosa and allergic sensitization. | Nawijn MC et al. | β | 2011 | β |
| Endocytic sorting of transmembrane protein cargo. | Kelly BT et al. | β | 2011 | β |
| Numb controls E-cadherin endocytosis through p120 catenin with aPKC. | Sato K et al. | β | 2011 | β |
| P-cadherin cooperates with insulin-like growth factor-1 receptor to promote metastatic signaling of gonadotropin-releasing hormone in ovarian cancer via p120 catenin. | Cheung LW et al. | β | 2011 | β |
| Phosphorylation of VE-cadherin controls endothelial phenotypes via p120-catenin coupling and Rac1 activation. | Hatanaka K et al. | β | 2011 | β |
| RPTPΞΌ tyrosine phosphatase promotes adipogenic differentiation via modulation of p120 catenin phosphorylation. | Kim WK et al. | β | 2011 | β |
| Signaling mechanism of cell adhesion molecules in breast cancer metastasis: potential therapeutic targets. | Li DM et al. | β | 2011 | β |
| Structure and binding mechanism of vascular endothelial cadherin: a divergent classical cadherin. | Brasch J et al. | β | 2011 | β |
| The extracellular architecture of adherens junctions revealed by crystal structures of type I cadherins. | Harrison OJ et al. | β | 2011 | β |
| Tissue organization by cadherin adhesion molecules: dynamic molecular and cellular mechanisms of morphogenetic regulation. | Niessen CM et al. | β | 2011 | β |
| Zeppo1 is a novel metastasis promoter that represses E-cadherin expression and regulates p120-catenin isoform expression and localization. | Slorach EM et al. | β | 2011 | β |
| Ξ±-Catenin contributes to the strength of E-cadherin-p120 interactions. | Troyanovsky RB et al. | β | 2011 | β |
| Ξ²-catenin as a potential key target for tumor suppression. | Fu Y et al. | β | 2011 | β |
| Adherens junctions: from molecules to morphogenesis. | Harris TJ et al. | β | 2010 | β |
| Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): Positive and negative regulators in tumor cell adhesion. | Bourboulia D et al. | β | 2010 | β |
| p120-Catenin is essential for N-cadherin-mediated formation of proper junctional structure, thereby establishing cell polarity in epithelial cells. | Ozaki C et al. | β | 2010 | β |
| Salivary gland branching morphogenesis--recent progress and future opportunities. | Hsu JC et al. | β | 2010 | β |
| Ξ΄-Catenin dysregulation in cancer: interactions with E-cadherin and beyond. | Lu Q | β | 2010 | β |