Bitter receptor gene (TAS2R38), 6-n-propylthiouracil (PROP) bitterness and alcohol intake.
paper
Cited
Public
Unavailable
- Authors
- Duffy, Valerie B; Davidson, Andrew C; Kidd, Judith R; Kidd, Kenneth K; Speed, William C; Pakstis, Andrew J; Reed, Danielle R; Snyder, Derek J; Bartoshuk, Linda M
- Year
- 2004
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 15547448
- DOI
- 10.1097/01.alc.0000145789.55183.d4
- PMCID
- PMC1397913
BACKGROUND: Phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP), chemically related compounds, are probes for genetic variation in bitter taste, although PROP is safer with less sulfurous odor. Threshold for PROP distinguishes nontasters (increased threshold) from tasters (lower threshold); perceived intensity subdivides tasters into medium tasters (PROP is bitter) and supertasters (PROP is very bitter). Compared with supertasters, nontasters have fewer taste papillae on the anterior tongue (fungiform papillae) and experience less negative (e.g., bitterness) and more positive (eg, sweetness) sensations from alcohol. We determined whether the TAS2R38 gene at 7q36 predicted PROP bitterness, alcohol sensation and use. METHODS: Healthy adults (53 women, 31 men; mean age 36 years)--primarily light and moderate drinkers--reported the bitterness of five PROP concentrations (0.032-3.2 mM) and intensity of 50% ethanol on the general Labeled Magnitude Scale. PROP threshold and density of fungiform papillae were also measured. Subjects had common TAS2R38 gene haplotypes [alanine-valine-isoleucine (AVI) and proline-alanine-valine (PAV)]. RESULTS: PROP bitterness varied significantly across genotypes with repeated measures ANOVA: 26 AVI/AVI homozygotes tasted less bitterness than either 37 PAV/AVI heterozygotes or 21 PAV/PAV homozygotes. The PAV/PAV group exceeded the PAV/AVI group for bitterness only for the top PROP concentrations. The elevated bitterness was musch less than if we defined the groups using psychophysical criteria. With multiple regression analyses, greater bitterness from 3.2 mM PROP was a significant predictor of greater ethanol intensity and less alcohol intake--effects separate from age and sex. Genotype was a significant predictor of alcohol intake, but not ethanol intensity. With ANOVA, AVI/AVI homozygotes reported higher alcohol use than either PAV/AVI heterozygotes or PAV/PAV homozygotes. When age effects were minimized, PROP bitterness explained more variance in alcohol intake than did the TAS2R38 genotype. CONCLUSIONS: These results support taste genetic effects on alcohol intake. PROP bitterness serves as a marker of these effects.
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| Title | Year | PMID |
|---|---|---|
| Genetic analysis of the maximum drinks phenotype. | 2005 | 16451582 |
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Spicy Personality: On the Relationship Between Personality Traits and the Preference for Spicy Foods. | UΓ§uk C et al. | β | 2026 | β |
| Association of PROP bitter taste sensitivity with anhedonia and emotional eating in the Chinese population. | Lin K et al. | β | 2025 | β |
| Bitter and Sweet Diets Alter Taste Response and Alcohol Consumption Behavior in Mice. | Koh AP et al. | β | 2025 | β |
| Bitter Sensing Protects <i>Drosophila</i> from Developing Experience-Dependent Cocaine Consumption Preference. | Philyaw TJ et al. | β | 2025 | β |
| Bitter taste receptors as sensors of gut luminal contents. | Sternini C et al. | β | 2025 | β |
| Blunted Hazard Detection and Enhanced Appetitive Odor Recognition in Risky Alcohol Consumers. | Agarwal K et al. | β | 2025 | β |
| Comfort Foods in the Twenty-First Century: Friend or Foe? | Holt RR et al. | β | 2025 | β |
| Genetic Variants Increasing TAS2R38 Bitter Taste Receptor Sensitivity Are Associated With Lower Postprandial Glycemia. | Gervis JE et al. | β | 2025 | β |
| Phenome-wide investigation of dietary and health outcomes associated with bitter taste receptor gene TAS2R38. | Brito Nunes C et al. | β | 2025 | β |
| The contributions of taste cues to ethanol responses in female and male rats. | Ho T et al. | β | 2025 | β |
| Association of the bitter taste genes TAS2R38 and CA6 and breast cancer risk; a case-control study of Polish women in Poland and Polish immigrants in USA. | Εukasiewicz-ΕmietaΕska D et al. | β | 2024 | β |
| Bitter taste function-related genes are implicated in the behavioral association between taste preference and ethanol preference in male mice. | Koh AP et al. | β | 2024 | β |
| Bitter Taste Sensitivity, Food Cravings, and Risk of Chronic Disease: A Cross-Sectional Study. | Jehi T et al. | β | 2024 | β |
| Cocaine and amphetamine regulated transcript (CART) mediates sex differences in binge drinking through central taste circuits. | Maddern XJ et al. | β | 2024 | β |
| Differential Activation of <i>TAS2R4</i> May Recover Ability to Taste Propylthiouracil for Some <i>TAS2R38</i> AVI Homozygotes. | Nolden AA et al. | β | 2024 | β |
| Analysis of Genetic Polymorphism of Bitter Taste Receptor TAS2R38 and TAS2R46, and Its Relationship with Eating and Drinking Habits in Japanese ToMMo Subjects. | Yamaki M et al. | β | 2023 | β |
| An Investigation of TAS2R38 Haplotypes, Dietary Intake, and Risk Factors for Chronic Disease in the Canadian Longitudinal Study on Aging. | Meng T et al. | β | 2023 | β |
| Association between Genetic Variation in the <i>TAS2R38</i> Bitter Taste Receptor and Propylthiouracil Bitter Taste Thresholds among Adults Living in Japan Using the Modified 2AFC Procedure with the Quest Method. | Aoki K et al. | β | 2023 | β |
| A Supervised Learning Regression Method for the Analysis of the Taste Functions of Healthy Controls and Patients with Chemosensory Loss. | Naciri LC et al. | β | 2023 | β |
| Change in preference for vegetables and their perceptual attributes as a function of age and pickiness. | Gotow N et al. | β | 2023 | β |
| Clinical Associations of Bitter Taste Perception and Bitter Taste Receptor Variants and the Potential for Personalized Healthcare. | Mao Z et al. | β | 2023 | β |
| Consumer Liking of Turnip Cooked by Different Methods: The Influence of Sensory Profile and Consumer Bitter Taste Genotype. | Nor NDM et al. | β | 2023 | β |
| Effect of moderate beer consumption (with and without ethanol) on cardiovascular health in postmenopausal women. | Trius-Soler M et al. | β | 2023 | β |
| Influence of the TAS2R38 Gene Single Nucleotide Polymorphisms in Metabolism and Anthropometry in Thyroid Dysfunction. | Costa MM et al. | β | 2023 | β |
| TAS2R38 bitter taste perception in the KoαΉ kaαΉΔ« SΔrasvata Brahmin population. | Sequeira JJ et al. | β | 2023 | β |
| Taste Preference-Related Genetic Polymorphisms Modify Alcohol Consumption Behavior of the Hungarian General and Roma Populations. | Kurshed AAM et al. | β | 2023 | β |
| Trigeminal Function in Sino-Nasal Health and Disease. | Shusterman D | β | 2023 | β |
| Associations between Sweet Taste Sensitivity and Polymorphisms (SNPs) in the <i>TAS1R2</i> and <i>TAS1R3</i> Genes, Gender, PROP Taster Status, and Density of Fungiform Papillae in a Genetically Homogeneous Sardinian Cohort. | Melis M et al. | β | 2022 | β |
| Automated Classification of 6-n-Propylthiouracil Taster Status with Machine Learning. | Naciri LC et al. | β | 2022 | β |
| Independent of differences in taste, B6N mice consume less alcohol than genetically similar B6J mice, and exhibit opposite polarity modulation of tonic GABA<sub>A</sub>R currents by alcohol. | Erikson CM et al. | β | 2022 | β |
| Landscape of Variability in Chemosensory Genes Associated With Dietary Preferences in Indian Population: Analysis of 1029 Indian Genomes. | Prakrithi P et al. | β | 2022 | β |
| Re-evaluating how sweet-liking and PROP-tasting are related. | Yeomans MR et al. | β | 2022 | β |
| TAS2R38 polymorphisms, Helicobacter pylori infection and susceptibility to gastric cancer and premalignant gastric lesions. | Giaccherini M et al. | β | 2022 | β |
| The Impact of Taste Preference-Related Gene Polymorphisms on Alcohol Consumption Behavior: A Systematic Review. | Kurshed AAM et al. | β | 2022 | β |
| Variation in TAS2R receptor genes explains differential bitterness of two common antibiotics. | Nolden AA et al. | β | 2022 | β |
| Activation of specific bitter taste receptors by olive oil phenolics and secoiridoids. | Cui M et al. | β | 2021 | β |
| An update on extra-oral bitter taste receptors. | Tuzim K et al. | β | 2021 | β |
| Associations between Taste Perception Profiles and Empirically Derived Dietary Patterns: An Exploratory Analysis among Older Adults with Metabolic Syndrome. | Gervis JE et al. | β | 2021 | β |
| Bitter taste receptors: Genes, evolution and health. | Wooding SP et al. | β | 2021 | β |
| Changes of Taste, Smell and Eating Behavior in Patients Undergoing Bariatric Surgery: Associations with PROP Phenotypes and Polymorphisms in the Odorant-Binding Protein OBPIIa and CD36 Receptor Genes. | Melis M et al. | β | 2021 | β |
| Data-Driven Clustering Approach to Derive Taste Perception Profiles from Sweet, Salt, Sour, Bitter, and Umami Perception Scores: An Illustration among Older Adults with Metabolic Syndrome. | Gervis JE et al. | β | 2021 | β |
| Effects of Bitter Substances on GI Function, Energy Intake and Glycaemia-Do Preclinical Findings Translate to Outcomes in Humans? | Rezaie P et al. | β | 2021 | β |
| Molecular and Genetic Factors Involved in Olfactory and Gustatory Deficits and Associations with Microbiota in Parkinson's Disease. | Melis M et al. | β | 2021 | β |
| Political taste: Exploring how perception of bitter substances may reveal risk tolerance and political preferences. | Friesen A et al. | β | 2021 | β |
| Relationships between Intensity and Liking for Chemosensory Stimuli in Food Models: A Large-Scale Consumer Segmentation. | Endrizzi I et al. | β | 2021 | β |
| The influence of TAS2R38 bitter taste gene polymorphisms on obesity risk in three racially diverse groups. | Chupeerach C et al. | β | 2021 | β |
| Whole-Exome Sequencing to Identify Potential Genetic Risk in Substance Use Disorders: A Pilot Feasibility Study. | AshaRani PV et al. | β | 2021 | β |
| Agonists of Orally Expressed TRP Channels Stimulate Salivary Secretion and Modify the Salivary Proteome. | Houghton JW et al. | β | 2020 | β |
| Clinical Role of Extraoral Bitter Taste Receptors. | Jeruzal-ΕwiΔ tecka J et al. | β | 2020 | β |
| Comparison of manual and machine learning image processing approaches to determine fungiform papillae on the tongue. | Cattaneo C et al. | β | 2020 | β |
| Consumer-Based Sensory Characterization of Steviol Glycosides (Rebaudioside A, D, and M). | Tao R et al. | β | 2020 | β |
| Electrophysiological Responses from the Human Tongue to the Six Taste Qualities and Their Relationships with PROP Taster Status. | Melis M et al. | β | 2020 | β |
| Factors influencing the choice of beer: A review. | Betancur MI et al. | β | 2020 | β |
| Genetic Differences in Taste Receptors: Implications for the Food Industry. | Nolden AA et al. | β | 2020 | β |
| Genetic variants of TAS2R38 bitter taste receptor associate with distinct gut microbiota traits in Parkinson's disease: A pilot study. | Vascellari S et al. | β | 2020 | β |
| Investigating the Relationships between Basic Tastes Sensitivities, Fattiness Sensitivity, and Food Liking in 11-Year-Old Children. | Ervina E et al. | β | 2020 | β |
| Pain reduction in burning mouth syndrome (BMS) may be associated with selective improvement of taste: a retrospective study. | Su N et al. | β | 2020 | β |
| Predominant Qualities Evoked by Quinine, Sucrose, and Capsaicin Associate With PROP Bitterness, but not TAS2R38 Genotype. | Nolden AA et al. | β | 2020 | β |
| Profiling Individual Differences in Alcoholic Beverage Preference and Consumption: New Insights from a Large-Scale Study. | Cravero MC et al. | β | 2020 | β |
| The Effects of Caffeine Mouth Rinsing on Exercise Performance: A Systematic Review. | Ehlert AM et al. | β | 2020 | β |
| A cross-talk between fat and bitter taste modalities. | Khan AS et al. | β | 2019 | β |
| Anatomical stability of human fungiform papillae and relationship with oral perception measured by salivary response and intensity rating. | Gardner A et al. | β | 2019 | β |
| Are caffeine's performance-enhancing effects partially driven by its bitter taste? | Pickering C | β | 2019 | β |
| Brain Imaging-Guided Analysis Reveals DNA Methylation Profiles Correlated with Insular Surface Area and Alcohol Use Disorder. | Zhao Y et al. | β | 2019 | β |
| Chemosensory Changes from Cancer Treatment and Their Effects on Patients' Food Behavior: A Scoping Review. | Nolden AA et al. | β | 2019 | β |
| Complex relationship between TAS2 receptor variations, bitterness perception, and alcohol consumption observed in a population of wine consumers. | Fu D et al. | β | 2019 | β |
| Faster escalation from first drink to first intoxication as a risk factor for binge and high-intensity drinking among adolescents. | Patrick ME et al. | β | 2019 | β |
| Genetic Background of Taste Perception, Taste Preferences, and Its Nutritional Implications: A Systematic Review. | DiΓ³szegi J et al. | β | 2019 | β |
| Genetic determinants of beverage consumption: Implications for nutrition and health. | Cornelis MC | β | 2019 | β |
| Human Tongue Electrophysiological Response to Oleic Acid and Its Associations with PROP Taster Status and the <i>CD36</i> Polymorphism (<i>rs1761667</i>). | Sollai G et al. | β | 2019 | β |
| Review: Chemosensing of nutrients and non-nutrients in the human and porcine gastrointestinal tract. | Roura E et al. | β | 2019 | β |
| TAS2R38 bitter taste receptor and attainment of exceptional longevity. | Melis M et al. | β | 2019 | β |
| Taste receptor function. | TΓΆle JC et al. | β | 2019 | β |
| Taste Receptors: New Players in Sperm Biology. | Luddi A et al. | β | 2019 | β |
| The role of taste in alcohol preference, consumption and risk behavior. | Thibodeau M et al. | β | 2019 | β |
| The roles of genes in the bitter taste. | Smail HO | β | 2019 | β |
| Tissue-Dependent Expression of Bitter Receptor TAS2R38 mRNA. | Douglas JE et al. | β | 2019 | β |
| 6-n-propylthiouracil taste disruption and TAS2R38 nontasting form in Parkinson's disease. | Cossu G et al. | β | 2018 | β |
| A review of the associations between single nucleotide polymorphisms in taste receptors, eating behaviors, and health. | Chamoun E et al. | β | 2018 | β |
| Association of the bitter taste receptor gene TAS2R38 (polymorphism RS713598) with sensory responsiveness, food preferences, biochemical parameters and body-composition markers. A cross-sectional study in Italy. | Perna S et al. | β | 2018 | β |
| Associations between human fungiform papillae and responsiveness to oral stimuli: effects of individual variability, population characteristics, and methods for papillae quantification. | Piochi M et al. | β | 2018 | β |
| Brief Exposures to the Taste of Ethanol (EtOH) and Quinine Promote Subsequent Acceptance of EtOH in a Paradigm that Minimizes Postingestive Consequences. | Loney GC et al. | β | 2018 | β |
| Effect of chemical interaction between oleic acid and L-Arginine on oral perception, as a function of polymorphisms of CD36 and OBPIIa and genetic ability to taste 6-n-propylthiouracil. | Melis M et al. | β | 2018 | β |
| Individual Variation in PROP Status, Fungiform Papillae Density, and Responsiveness to Taste Stimuli in a Large Population Sample. | Dinnella C et al. | β | 2018 | β |
| Nutrient-Sensing Biology in Mammals and Birds. | Roura E et al. | β | 2018 | β |
| Orosensory detection of bitter in fat-taster healthy and obese participants: Genetic polymorphism of CD36 and TAS2R38. | Karmous I et al. | β | 2018 | β |
| Self-reported Smoking Status, TAS2R38 Variants, and Propylthiouracil Phenotype: An Exploratory Crowdsourced Cohort Study. | Baker AN et al. | β | 2018 | β |
| Single Nucleotide Polymorphisms in Taste Receptor Genes Are Associated with Snacking Patterns of Preschool-Aged Children in the Guelph Family Health Study: A Pilot Study. | Chamoun E et al. | β | 2018 | β |
| Understanding the role of bitter taste perception in coffee, tea and alcohol consumption through Mendelian randomization. | Ong JS et al. | β | 2018 | β |
| A bio-cultural approach to the study of food choice: The contribution of taste genetics, population and culture. | Risso DS et al. | β | 2017 | β |
| An automated system for the objective evaluation of human gustatory sensitivity using tongue biopotential recordings. | Pani D et al. | β | 2017 | β |
| A potential sex dimorphism in the relationship between bitter taste and alcohol consumption. | Beckett EL et al. | β | 2017 | β |
| Association between taste receptor (TAS) genes and the perception of wine characteristics. | Carrai M et al. | β | 2017 | β |
| Caffeine Bitterness is Related to Daily Caffeine Intake and Bitter Receptor mRNA Abundance in Human Taste Tissue. | Lipchock SV et al. | β | 2017 | β |
| Comparing Manual Counting to Automated Image Analysis for the Assessment of Fungiform Papillae Density on Human Tongue. | Piochi M et al. | β | 2017 | β |
| Contributory role of sex differences in the variations of gustatory function. | Martin LJ et al. | β | 2017 | β |
| Do alcohol use reasons and contexts differentiate adolescent high-intensity drinking? Data from U.S. high school seniors, 2005-2016. | Terry-McElrath YM et al. | β | 2017 | β |
| Factors Influencing the Phenotypic Characterization of the Oral Marker, PROP. | Tepper BJ et al. | β | 2017 | β |
| Genetic variation in bitter taste receptor gene TAS2R38, PROP taster status and their association with body mass index and food preferences in Indian population. | Deshaware S et al. | β | 2017 | β |
| Influence of biological, experiential and psychological factors in wine preference segmentation. | Pickering GJ et al. | β | 2017 | β |
| Intragastric infusion of denatonium benzoate attenuates interdigestive gastric motility and hunger scores in healthy female volunteers. | Deloose E et al. | β | 2017 | β |
| Participants with Normal Weight or with Obesity Show Different Relationships of 6-n-Propylthiouracil (PROP) Taster Status with BMI and Plasma Endocannabinoids. | Carta G et al. | β | 2017 | β |
| Taste loss in the elderly: Possible implications for dietary habits. | Sergi G et al. | β | 2017 | β |
| Taste Perception of Sweet, Sour, Salty, Bitter, and Umami and Changes Due to l-Arginine Supplementation, as a Function of Genetic Ability to Taste 6-n-Propylthiouracil. | Melis M et al. | β | 2017 | β |
| Taste receptor polymorphisms and male infertility. | Gentiluomo M et al. | β | 2017 | β |
| Use of Adult Sensory Panel to Study Individual Differences in the Palatability of a Pediatric HIV Treatment Drug. | Mennella JA et al. | β | 2017 | β |
| Alterations in taste perception as a result of hyperbaric oxygen therapy. | Hartman-Petrycka M et al. | β | 2016 | β |
| A pain in the bud? Implications of cross-modal sensitivity for pain experience. | Perkins M et al. | β | 2016 | β |
| Automatic counting of fungiform papillae by shape using cross-correlation. | Valencia E et al. | β | 2016 | β |
| Bitter taste receptors: Extraoral roles in pathophysiology. | Shaik FA et al. | β | 2016 | β |
| Copy Number Variation in TAS2R Bitter Taste Receptor Genes: Structure, Origin, and Population Genetics. | Roudnitzky N et al. | β | 2016 | β |
| Differential bitterness in capsaicin, piperine, and ethanol associates with polymorphisms in multiple bitter taste receptor genes. | Nolden AA et al. | β | 2016 | β |
| Genetic Variation in the TAS2R38 Bitter Taste Receptor and Gastric Cancer Risk in Koreans. | Choi JH et al. | β | 2016 | β |
| Variation in the Ability to Taste Bitter Thiourea Compounds: Implications for Food Acceptance, Dietary Intake, and Obesity Risk in Children. | Keller KL et al. | β | 2016 | β |
| Association of a novel TAS2R38 haplotype with alcohol intake among Mexican-Mestizo population. | Ramos-Lopez O et al. | β | 2015 | β |
| Denver Papillae Protocol for Objective Analysis of Fungiform Papillae. | Nuessle TM et al. | β | 2015 | β |
| Development of a molecular method for the rapid screening and identification of the three functionally relevant polymorphisms in the human TAS2R38 receptor gene in studies of sensitivity to the bitter taste of PROP. | OrrΓΉ R et al. | β | 2015 | β |
| Dose-Dependent Effects of L-Arginine on PROP Bitterness Intensity and Latency and Characteristics of the Chemical Interaction between PROP and L-Arginine. | Melis M et al. | β | 2015 | β |
| Genetic factors affecting dental caries risk. | Opal S et al. | β | 2015 | β |
| Genome-wide association analysis on five isolated populations identifies variants of the HLA-DOA gene associated with white wine liking. | Pirastu N et al. | β | 2015 | β |
| Imaging methodologies and applications for nutrition research: what can functional MRI offer? | Francis ST et al. | β | 2015 | β |
| Involvement of the gut chemosensory system in the regulation of colonic anion secretion. | Kuwahara A | β | 2015 | β |
| Perceptual Qualities of Ethanol Depend on Concentration, and Variation in These Percepts Associates with Drinking Frequency. | Nolden AA et al. | β | 2015 | β |
| Polymorphisms in sweet taste genes (TAS1R2 and GLUT2), sweet liking, and dental caries prevalence in an adult Italian population. | Robino A et al. | β | 2015 | β |
| Relationship of 6-n-propylthiouracil taste intensity and chili pepper use with body mass index, energy intake, and fat intake within an ethnically diverse population. | Choi SE et al. | β | 2015 | β |
| Relationships of PROP Taste Phenotype, Taste Receptor Genotype, and Oral Nicotine Replacement Use. | Ahijevych K et al. | β | 2015 | β |
| Striatal-enriched protein tyrosine phosphatase controls responses to aversive stimuli: implication for ethanol drinking. | Legastelois R et al. | β | 2015 | β |
| TAS2R bitter taste receptors regulate thyroid function. | Clark AA et al. | β | 2015 | β |
| Taste perception, associated hormonal modulation, and nutrient intake. | Loper HB et al. | β | 2015 | β |
| The gustin (CA6) gene polymorphism, rs2274333 (A/G), is associated with fungiform papilla density, whereas PROP bitterness is mostly due to TAS2R38 in an ethnically-mixed population. | Barbarossa IT et al. | β | 2015 | β |
| The impact of individual variations in taste sensitivity on coffee perceptions and preferences. | Masi C et al. | β | 2015 | β |
| Using Animal Models to Determine the Role of Gustatory Neural Input in the Control of Ingestive Behavior and the Maintenance of Body Weight. | Ciullo DL et al. | β | 2015 | β |
| Variability in Human Bitter Taste Sensitivity to Chemically Diverse Compounds Can Be Accounted for by Differential TAS2R Activation. | Roura E et al. | β | 2015 | β |
| Bitter taste genetics--the relationship to tasting, liking, consumption and health. | Beckett EL et al. | β | 2014 | β |
| Exploring associations between taste perception, oral anatomy and polymorphisms in the carbonic anhydrase (gustin) gene CA6. | Feeney EL et al. | β | 2014 | β |
| Extrasensory perception: odorant and taste receptors beyond the nose and mouth. | Foster SR et al. | β | 2014 | β |
| Genetic sensitivity to the bitter taste of 6-n-propylthiouracil (PROP) and its association with physiological mechanisms controlling body mass index (BMI). | Tepper BJ et al. | β | 2014 | β |
| Genetic signature of differential sensitivity to stevioside in the Italian population. | Risso D et al. | β | 2014 | β |
| Genetics of taste receptors. | Bachmanov AA et al. | β | 2014 | β |
| Polymorphisms in TRPV1 and TAS2Rs associate with sensations from sampled ethanol. | Allen AL et al. | β | 2014 | β |
| Prevalence and Genetic Analysis of Bitter Taste Perception for Phenylthiocarbamide (PTC) Among Some Muslim Populations of Uttar Pradesh, India. | Hussain R et al. | β | 2014 | β |
| Racial differences between African Americans and Asian Americans in the effect of 6-n-propylthiouracil taste intensity and food liking on body mass index. | Choi SE | β | 2014 | β |
| Taste sensitivity, nutritional status and metabolic syndrome: Implication in weight loss dietary interventions. | Bertoli S et al. | β | 2014 | β |
| The association of taste with change in adiposity-related health measures. | Fischer ME et al. | β | 2014 | β |
| The associations between 6-n-propylthiouracil (PROP) intensity and taste intensities differ by TAS2R38 haplotype. | Fischer ME et al. | β | 2014 | β |
| Bitterness of the non-nutritive sweetener acesulfame potassium varies with polymorphisms in TAS2R9 and TAS2R31. | Allen AL et al. | β | 2013 | β |
| Declinol, a Complex Containing Kudzu, Bitter Herbs (Gentian, Tangerine Peel) and Bupleurum, Significantly Reduced Alcohol Use Disorders Identification Test (AUDIT) Scores in Moderate to Heavy Drinkers: A Pilot Study. | Kushner S et al. | β | 2013 | β |
| Do polymorphisms in chemosensory genes matter for human ingestive behavior? | Hayes JE et al. | β | 2013 | β |
| Factors related to fungiform papillae density: the beaver dam offspring study. | Fischer ME et al. | β | 2013 | β |
| Genetic, functional, and phenotypic diversity in TAS2R38-mediated bitter taste perception. | Behrens M et al. | β | 2013 | β |
| Ghrelin knockout mice show decreased voluntary alcohol consumption and reduced ethanol-induced conditioned place preference. | Bahi A et al. | β | 2013 | β |
| Marked increase in PROP taste responsiveness following oral supplementation with selected salivary proteins or their related free amino acids. | Melis M et al. | β | 2013 | β |
| NONDRINKER MORTALITY RISK IN THE UNITED STATES. | Rogers RG et al. | β | 2013 | β |
| Rebaudioside A and Rebaudioside D bitterness do not covary with Acesulfame K bitterness or polymorphisms in <i>TAS2R9</i> and <i>TAS2R31.</i> | Allen AL et al. | β | 2013 | β |
| Taking the bitter with the sweet: relationship of supertasting and sweet preference with metabolic syndrome and dietary intake. | Turner-McGrievy G et al. | β | 2013 | β |
| TAS2R38 and its influence on smoking behavior and glucose homeostasis in the German Sorbs. | Keller M et al. | β | 2013 | β |
| Taste sensitivity to 6-n-propylthiouracil is associated with endocannabinoid plasma levels in normal-weight individuals. | Tomassini Barbarossa I et al. | β | 2013 | β |
| The gustin (CA6) gene polymorphism, rs2274333 (A/G), as a mechanistic link between PROP tasting and fungiform taste papilla density and maintenance. | Melis M et al. | β | 2013 | β |
| Variations in bitter-taste receptor genes, dietary intake, and colorectal adenoma risk. | Schembre SM et al. | β | 2013 | β |
| Bitter taste receptor polymorphisms and human aging. | Campa D et al. | β | 2012 | β |
| Development of eating behavior: biology and context. | Gahagan S | β | 2012 | β |
| Responsiveness to 6-n-propylthiouracil (PROP) is associated with salivary levels of two specific basic proline-rich proteins in humans. | Cabras T et al. | β | 2012 | β |
| Sensation and perception of sucrose and fat stimuli predict the reinforcing value of food. | Panek-Scarborough LM et al. | β | 2012 | β |
| Variation in the gene TAS2R13 is associated with differences in alcohol consumption in patients with head and neck cancer. | Dotson CD et al. | β | 2012 | β |
| Wine Expertise Predicts Taste Phenotype. | Hayes JE et al. | β | 2012 | β |
| 6-n-propylthiouracil taster status not related to reported cruciferous vegetable intake among ethnically diverse children. | Baranowski T et al. | β | 2011 | β |
| Allelic variation in TAS2R bitter receptor genes associates with variation in sensations from and ingestive behaviors toward common bitter beverages in adults. | Hayes JE et al. | β | 2011 | β |
| A rapid screening method for the identification of a single-nucleotide polymorphism in the carbonic anhydrase VI gene in studies of sensitivity to the bitter taste of 6-n-propylthiouracil. | Barbarossa IT et al. | β | 2011 | β |
| "Bioelectronic super-taster" device based on taste receptor-carbon nanotube hybrid structures. | Kim TH et al. | β | 2011 | β |
| Genetic variation in taste perception: does it have a role in healthy eating? | Feeney E et al. | β | 2011 | β |
| Genomic, genetic and functional dissection of bitter taste responses to artificial sweeteners. | Roudnitzky N et al. | β | 2011 | β |
| Greater energy intake from a buffet meal in lean, young women is associated with the 6-n-propylthiouracil (PROP) non-taster phenotype. | Tepper BJ et al. | β | 2011 | β |
| Increased ethanol intake and preference in cyclin D2 knockout mice. | Jaholkowski P et al. | β | 2011 | β |
| Polymorphisms in TAS2R38 and the taste bud trophic factor, gustin gene co-operate in modulating PROP taste phenotype. | CalΓ² C et al. | β | 2011 | β |
| Psychophysical dissection of genotype effects on human bitter perception. | Mennella JA et al. | β | 2011 | β |
| Recent advances in understanding the role of nutrition in human genome evolution. | Ye K et al. | β | 2011 | β |
| Strain differences in the neural, behavioral, and molecular correlates of sweet and salty taste in naive, ethanol- and sucrose-exposed P and NP rats. | Coleman J et al. | β | 2011 | β |
| TAS2R38 bitter taste genetics, dietary vitamin C, and both natural and synthetic dietary folic acid predict folate status, a key micronutrient in the pathoaetiology of adenomatous polyps. | Lucock M et al. | β | 2011 | β |
| The relation between 6-n-propylthiouracil sensitivity and caries activity in schoolchildren. | Γter B et al. | β | 2011 | β |
| Two decades of supertasting: where do we stand? | Hayes JE et al. | β | 2011 | β |
| Validation of edible taste strips for identifying PROP taste recognition thresholds. | Desai H et al. | β | 2011 | β |
| Value and pitfalls in iodine fortification and supplementation in the 21st century. | Speeckaert MM et al. | β | 2011 | β |
| Age modifies the genotype-phenotype relationship for the bitter receptor TAS2R38. | Mennella JA et al. | β | 2010 | β |
| A gene-wide investigation on polymorphisms in the taste receptor 2R14 (TAS2R14) and susceptibility to colorectal cancer. | Campa D et al. | β | 2010 | β |
| Association of thermal taste and PROP responsiveness with food liking, neophobia, body mass index, and waist circumference | Bajec MR et al. | β | 2010 | β |
| Genetics of taste and smell: poisons and pleasures. | Reed DR et al. | β | 2010 | β |
| Individual differences in prefrontal cortex activity during perception of bitter taste using fNIRS methodology. | Bembich S et al. | β | 2010 | β |
| Response to "Lack of relation between bitter taste receptor TAS2R38 and BMI in adults". | Hayes JE | β | 2010 | β |
| Sensitivity to 6-n-propylthiouracil is associated with gustin (carbonic anhydrase VI) gene polymorphism, salivary zinc, and body mass index in humans. | Padiglia A et al. | β | 2010 | β |
| Using a pharmacokinetic model to relate an individual's susceptibility to alcohol dependence to genotypes. | Mustavich LF et al. | β | 2010 | β |
| Vegetable Intake in College-Aged Adults Is Explained by Oral Sensory Phenotypes and TAS2R38 Genotype. | Duffy VB et al. | β | 2010 | β |
| Effects of a diagnosis or family history of alcoholism on the taste intensity and hedonic value of sucrose. | Tremblay KA et al. | β | 2009 | β |
| Genetic variation in taste and its influence on food selection. | Garcia-Bailo B et al. | β | 2009 | β |
| Genetic variation in taste sensitivity to 6-n-propylthiouracil and its relationship to taste perception and food selection. | Tepper BJ et al. | β | 2009 | β |
| Perspectives on population-based epidemiological studies of olfactory and taste impairment. | Hoffman HJ et al. | β | 2009 | β |
| Reliability of Threshold and Suprathreshold Methods for Taste Phenotyping: Characterization with PROP and Sodium Chloride. | Galindo-Cuspinera V et al. | β | 2009 | β |
| Secretory effects of a luminal bitter tastant and expressions of bitter taste receptors, T2Rs, in the human and rat large intestine. | Kaji I et al. | β | 2009 | β |
| Surveying food and beverage liking: a tool for epidemiological studies to connect chemosensation with health outcomes. | Duffy VB et al. | β | 2009 | β |
| The relationship between fungiform papillae density and detection threshold for sucrose in the young males. | Zhang GH et al. | β | 2009 | β |
| A test for measuring gustatory function. | Smutzer G et al. | β | 2008 | β |
| Bitter taste receptors influence glucose homeostasis. | Dotson CD et al. | β | 2008 | β |
| Impact of genetic and environmental determinants of taste with food preferences in older adults. | Navarro-Allende A et al. | β | 2008 | β |
| Measures of individual differences in taste and creaminess perception. | Lim J et al. | β | 2008 | β |
| Nutritional implications of genetic taste variation: the role of PROP sensitivity and other taste phenotypes. | Tepper BJ | β | 2008 | β |
| Supertasting and PROP bitterness depends on more than the TAS2R38 gene. | Hayes JE et al. | β | 2008 | β |
| Thermal taste, PROP responsiveness, and perception of oral sensations. | Bajec MR et al. | β | 2008 | β |
| Variation in the bitter-taste receptor gene TAS2R38, and adiposity in a genetically isolated population in Southern Italy. | Tepper BJ et al. | β | 2008 | β |
| A complex relationship among chemical concentration, detection threshold, and suprathreshold intensity of bitter compounds. | Keast RS et al. | β | 2007 | β |
| Behavioral genetics and taste. | Boughter JD et al. | β | 2007 | β |
| Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin. | Wang JC et al. | β | 2007 | β |
| Gene-alcohol interactions in the metabolic syndrome. | Corella D | β | 2007 | β |
| Influence of PROP taster status and maternal variables on energy intake and body weight of pre-adolescents. | Goldstein GL et al. | β | 2007 | β |
| Refining associations between TAS2R38 diplotypes and the 6-n-propylthiouracil (PROP) taste test: findings from the Avon Longitudinal Study of Parents and Children. | Timpson NJ et al. | β | 2007 | β |
| Sweet and bitter taste of ethanol in C57BL/6J and DBA2/J mouse strains. | Blizard DA | β | 2007 | β |
| Taste receptor genes. | Bachmanov AA et al. | β | 2007 | β |
| The International society for developmental psychobiology 39th annual meeting symposium: Alcohol and development: beyond fetal alcohol syndrome. | Molina JC et al. | β | 2007 | β |
| Variation in oral sensation: implications for diet and health. | Duffy VB | β | 2007 | β |
| Bitter taste markers explain variability in vegetable sweetness, bitterness, and intake. | Dinehart ME et al. | β | 2006 | β |
| Diverse tastes: Genetics of sweet and bitter perception. | Reed DR et al. | β | 2006 | β |
| Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence. | Hinrichs AL et al. | β | 2006 | β |
| Phenylthiocarbamide: a 75-year adventure in genetics and natural selection. | Wooding S | β | 2006 | β |
| Psychophysics of sweet and fat perception in obesity: problems, solutions and new perspectives. | Bartoshuk LM et al. | β | 2006 | β |
| The genetics of alcohol dependence. | Dick DM et al. | β | 2006 | β |
| Association between 6-n-propylthiouracil (PROP) bitterness and colonic neoplasms. | Basson MD et al. | β | 2005 | β |
| Associations between phenylthiocarbamide gene polymorphisms and cigarette smoking. | Cannon DS et al. | β | 2005 | β |
| Genetic analysis of the maximum drinks phenotype. | Saccone SF et al. | β | 2005 | β |
| Genetic and environmental determinants of bitter perception and sweet preferences. | Mennella JA et al. | β | 2005 | β |
| Human taste genetics. | Drayna D | β | 2005 | β |
| The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception. | Bufe B et al. | β | 2005 | β |