Polysubstance abuse-vulnerability genes: genome scans for association, using 1,004 subjects and 1,494 single-nucleotide polymorphisms.
paper
Cited
Public
Unavailable
- Authors
- Uhl, G R; Liu, Q R; Walther, D; Hess, J; Naiman, D
- Year
- 2001
- Journal
- American journal of human genetics
- PMID
- 11704927
- DOI
- 10.1086/324467
- PMCID
- PMC1235541
Strong genetic contributions to drug abuse vulnerability are well documented, but few chromosomal locations for human drug-abuse vulnerability alleles have been confirmed. We now identify chromosomal markers whose alleles distinguish drug abusers from control individuals in each of two samples, on the basis of pooled-sample microarray and association analyses. Reproducibly positive chromosomal regions defined by these markers in conjunction with previous results were especially unlikely to have been identified by chance. Positive markers identify the alcohol dehydrogenase (ADH) locus, flank the brain-derived neurotropic factor (BDNF) locus, and mark seven other regions previously linked to vulnerability to nicotine or alcohol abuse. These data support polygenic contributions of common allelic variants to polysubstance abuse vulnerability.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| <i>BDNF</i> gene polymorphisms and substance use disorders: a systematic review. | Peregud D et al. | β | 2026 | β |
| Association of Brain-derived Neurotrophic Factor Polymorphisms With Alcohol Use Disorder: An Updated Meta-Analysis of Genetic Association Studies. | Jenwitheesuk A et al. | β | 2025 | β |
| Hippocampal overexpression of tissue-type plasminogen activator "tPA" attenuates social defeat-induced depression and ethanol related behavior in mice. | Bahi A | β | 2025 | β |
| The Association between a MAOB Variable Number Tandem Repeat Polymorphism and Cocaine and Opiate Addictions in Polyconsumers. | Mateu C et al. | β | 2021 | β |
| The Role of Melanocortin Plasticity in Pain-Related Outcomes After Alcohol Exposure. | Sharfman N et al. | β | 2021 | β |
| Activation of Melanocortin-4 Receptor Inhibits Both Neuroinflammation Induced by Early Exposure to Ethanol and Subsequent Voluntary Alcohol Intake in Adulthood in Animal Models: Is BDNF the Key Mediator? | Flores-BastΓas O et al. | β | 2020 | β |
| BDNF and nicotine dependence: associations and potential mechanisms. | Huang Z et al. | β | 2020 | β |
| Increased Alcohol Consumption in Mice Lacking Sodium Bicarbonate Transporter NBCn1. | Schank JR et al. | β | 2020 | β |
| Prospects for finding the mechanisms of sex differences in addiction with human and model organism genetic analysis. | Datta U et al. | β | 2020 | β |
| The Streetlight Effect: Reappraising the Study of Addiction in Light of the Findings of Genome-wide Association Studies. | Hall FS et al. | β | 2020 | β |
| Exercise-driven restoration of the alcohol-damaged brain. | West RK et al. | β | 2019 | β |
| Sex differences in neural mechanisms mediating reward and addiction. | Becker JB et al. | β | 2019 | β |
| Sex-Dimorphic Interactions of <i>MAOA</i> Genotype and Child Maltreatment Predispose College Students to Polysubstance Use. | Fite PJ et al. | β | 2019 | β |
| A longitudinal assessment of change in marijuana use with other substance use problems. | Choi NG et al. | β | 2018 | β |
| Gut microbiota modulates alcohol withdrawal-induced anxiety in mice. | Xiao HW et al. | β | 2018 | β |
| Neuroepigenetics and addiction. | Walker DM et al. | β | 2018 | β |
| The Role of Cell Adhesion Molecule Genes Regulating Neuroplasticity in Addiction. | Muskiewicz DE et al. | β | 2018 | β |
| Alternative transcription of sodium/bicarbonate transporter SLC4A7 gene enhanced by single nucleotide polymorphisms. | Park HJ et al. | β | 2017 | β |
| Contribution of Genetic Polymorphisms and Haplotypes in DRD2, BDNF, and Opioid Receptors to Heroin Dependence and Endophenotypes Among the Han Chinese. | Gao X et al. | β | 2017 | β |
| Adolescent Alcohol Exposure: Burden of Epigenetic Reprogramming, Synaptic Remodeling, and Adult Psychopathology. | Kyzar EJ et al. | β | 2016 | β |
| Overexpression of BDNF in the ventral tegmental area enhances binge cocaine self-administration in rats exposed to repeated social defeat. | Wang J et al. | β | 2016 | β |
| What does addiction medicine expect from neuroscience? From genes and neurons to treatment responses. | Le Foll B | β | 2016 | β |
| Changes in expression of BDNF and its receptors TrkB and p75NTR in the hippocampus of a dog model of chronic alcoholism and abstinence. | Xu R et al. | β | 2015 | β |
| Contribution of BDNF and DRD2 genetic polymorphisms to continued opioid use in patients receiving methadone treatment for opioid use disorder: an observational study. | Bawor M et al. | β | 2015 | β |
| Effects of acute ethanol exposure on class I HDACs family enzymes in wild-type and BDNF(+/-) mice. | Caputi FF et al. | β | 2015 | β |
| Smoking and BDNF Val66Met polymorphism in male schizophrenia: a case-control study. | Zhang XY et al. | β | 2015 | β |
| Cation-coupled bicarbonate transporters. | Aalkjaer C et al. | β | 2014 | β |
| Curious cases: Altered dose-response relationships in addiction genetics. | Uhl GR et al. | β | 2014 | β |
| Genetics of Opioid Dependence: A Review of the Genetic Contribution to Opioid Dependence. | Mistry CJ et al. | β | 2014 | β |
| Mood Disorders and BDNF Relationship with Alcohol Drinking Trajectories among PLWH Receiving Care. | MΓguez-Burbano MJ et al. | β | 2014 | β |
| Role of mitochondria in alcoholic liver disease. | Nassir F et al. | β | 2014 | β |
| Smoking quit success genotype score predicts quit success and distinct patterns of developmental involvement with common addictive substances. | Uhl GR et al. | β | 2014 | β |
| Association of genetic variation in pharmacodynamic factors with methadone dose required for effective treatment of opioid addiction. | Levran O et al. | β | 2013 | β |
| Association study of 37 genes related to serotonin and dopamine neurotransmission and neurotrophic factors in cocaine dependence. | FernΓ ndez-Castillo N et al. | β | 2013 | β |
| BDNF overexpression in the ventral tegmental area prolongs social defeat stress-induced cross-sensitization to amphetamine and increases ΞFosB expression in mesocorticolimbic regions of rats. | Wang J et al. | β | 2013 | β |
| Brain-derived neurotrophic factor Val66Met polymorphism and alcohol-related phenotypes. | Nedic G et al. | β | 2013 | β |
| Estimation of BDNF gene polymorphism and predisposition to dependence development for selected psychoactive compounds: genetic aspects of addiction with the selected drugs, amphetamine, tetrahydrocannabinol and opiates. | Biskupska J et al. | β | 2013 | β |
| Implications of genome wide association studies for addiction: are our a priori assumptions all wrong? | Hall FS et al. | β | 2013 | β |
| The genetics of alcohol dependence. | Rietschel M et al. | β | 2013 | β |
| A common genetic network underlies substance use disorders and disruptive or externalizing disorders. | Arcos-Burgos M et al. | β | 2012 | β |
| Alcohol-induced plasticity in the dynorphin/kappa-opioid receptor system. | Sirohi S et al. | β | 2012 | β |
| BDNF Val66Met variant and smoking in a Chinese population. | Zhang XY et al. | β | 2012 | β |
| Custom genotyping for substance addiction susceptibility genes in Jordanians of Arab descent. | Al-Eitan LN et al. | β | 2012 | β |
| Enhanced extinction of cocaine seeking in brain-derived neurotrophic factor Val66Met knock-in mice. | Briand LA et al. | β | 2012 | β |
| Influence of brain-derived neurotrophic factor genetic polymorphisms on the ages of onset for heroin dependence in a Chinese population. | Meng C et al. | β | 2012 | β |
| Nerve growth factor Ξ² polypeptide (NGFB) genetic variability: association with the methadone dose required for effective maintenance treatment. | Levran O et al. | β | 2012 | β |
| Alcohol-preferring (P) rats are more sensitive than Wistar rats to the reinforcing effects of cocaine self-administered directly into the nucleus accumbens shell. | Katner SN et al. | β | 2011 | β |
| Brain derived neurotrophic factor (BDNF) expression is regulated by microRNAs miR-26a and miR-26b allele-specific binding. | Caputo V et al. | β | 2011 | β |
| Effects of BDNF polymorphisms on brain function and behavior in health and disease. | Hong CJ et al. | β | 2011 | β |
| Ethanol-induced increases in extracellular dopamine are blunted in brain-derived neurotrophic factor heterozygous mice. | Bosse KE et al. | β | 2011 | β |
| Genomic regions identified by overlapping clusters of nominally-positive SNPs from genome-wide studies of alcohol and illegal substance dependence. | Johnson C et al. | β | 2011 | β |
| "Replicated" genome wide association for dependence on illegal substances: genomic regions identified by overlapping clusters of nominally positive SNPs. | Drgon T et al. | β | 2011 | β |
| The role of amygdaloid brain-derived neurotrophic factor, activity-regulated cytoskeleton-associated protein and dendritic spines in anxiety and alcoholism. | Moonat S et al. | β | 2011 | β |
| Alcoholic liver disease. | O'Shea RS et al. | β | 2010 | β |
| Alcoholic liver disease. | O'Shea RS et al. | β | 2010 | β |
| Chronic ecstasy use increases neurotrophin-4 gene expression and protein levels in the rat brain. | Hatami H et al. | β | 2010 | β |
| Fine mapping of calcineurin (PPP3CA) gene reveals novel alternative splicing patterns, association of 5'UTR trinucleotide repeat with addiction vulnerability, and differential isoform expression in Alzheimer's disease. | Chiocco MJ et al. | β | 2010 | β |
| Genome wide association for addiction: replicated results and comparisons of two analytic approaches. | Drgon T et al. | β | 2010 | β |
| Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement. | Uhl GR et al. | β | 2010 | β |
| Genome-wide association study identifies genes that may contribute to risk for developing heroin addiction. | Nielsen DA et al. | β | 2010 | β |
| GPFrontend and GPGraphics: graphical analysis tools for genetic association studies. | Uebe S et al. | β | 2010 | β |
| Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | Rose JE et al. | β | 2010 | β |
| Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment. | Yuferov V et al. | β | 2010 | β |
| Addiction genetics and pleiotropic effects of common haplotypes that make polygenic contributions to vulnerability to substance dependence. | Uhl GR et al. | β | 2009 | β |
| Association between Val66Met brain-derived neurotrophic factor (BDNF) gene polymorphism and post-treatment relapse in alcohol dependence. | Wojnar M et al. | β | 2009 | β |
| Convergent genome wide association results for bipolar disorder and substance dependence. | Johnson C et al. | β | 2009 | β |
| Developing a quantitative measure of alcohol consumption for genomic studies on prospective cohorts. | Agrawal A et al. | β | 2009 | β |
| Endogenous BDNF in the dorsolateral striatum gates alcohol drinking. | Jeanblanc J et al. | β | 2009 | β |
| Escalating ethanol intake is associated with altered corticostriatal BDNF expression. | Logrip ML et al. | β | 2009 | β |
| Genetic and non-genetic influences on the development of co-occurring alcohol problem use and internalizing symptomatology in adolescence: a review. | Saraceno L et al. | β | 2009 | β |
| Genetic association studies of methamphetamine use disorders: A systematic review and synthesis. | Bousman CA et al. | β | 2009 | β |
| Genome-wide association for nicotine dependence and smoking cessation success in NIH research volunteers. | Drgon T et al. | β | 2009 | β |
| Genome-wide association for smoking cessation success: participants in a trial with adjunctive denicotinized cigarettes. | Drgon T et al. | β | 2009 | β |
| Heritability and a genome-wide linkage analysis of a Type II/B cluster construct for cannabis dependence in an American Indian community. | Ehlers CL et al. | β | 2009 | β |
| Opiate and cocaine addiction: from bench to clinic and back to the bench. | Kreek MJ et al. | β | 2009 | β |
| Addiction Reviews. Preface. | Uhl GR | β | 2008 | β |
| Alpha synuclein protein levels are increased in serum from recently abstinent cocaine abusers. | Mash DC et al. | β | 2008 | β |
| Are there genetic influences on addiction: evidence from family, adoption and twin studies. | Agrawal A et al. | β | 2008 | β |
| Association of PTPRB gene polymorphism with drug addiction. | Ishiguro H et al. | β | 2008 | β |
| Autosomal linkage analysis for cannabis use behaviors in Australian adults. | Agrawal A et al. | β | 2008 | β |
| Dynorphin is a downstream effector of striatal BDNF regulation of ethanol intake. | Logrip ML et al. | β | 2008 | β |
| Effector immediate-early gene arc in the amygdala plays a critical role in alcoholism. | Pandey SC et al. | β | 2008 | β |
| Ethanol-BDNF interactions: still more questions than answers. | Davis MI | β | 2008 | β |
| Evidence for a two-stage model of dependence using the NESARC and its implications for genetic association studies. | Heiman GA et al. | β | 2008 | β |
| Genome wide association for substance dependence: convergent results from epidemiologic and research volunteer samples. | Johnson C et al. | β | 2008 | β |
| Genome-wide linkage scan for nicotine dependence in European Americans and its converging results with African Americans in the Mid-South Tobacco Family sample. | Li MD et al. | β | 2008 | β |
| Genotype patterns that contribute to increased risk for or protection from developing heroin addiction. | Nielsen DA et al. | β | 2008 | β |
| "Higher order" addiction molecular genetics: convergent data from genome-wide association in humans and mice. | Uhl GR et al. | β | 2008 | β |
| Human gamma-aminobutyric acid A receptor alpha2 gene moderates the acute effects of alcohol and brain mRNA expression. | Haughey HM et al. | β | 2008 | β |
| Inhibiting activator protein-1 activity alters cocaine-induced gene expression and potentiates sensitization. | Paletzki RF et al. | β | 2008 | β |
| Innate differences in the expression of brain-derived neurotrophic factor in the regions within the extended amygdala between alcohol preferring and nonpreferring rats. | Prakash A et al. | β | 2008 | β |
| Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample. | Agrawal A et al. | β | 2008 | β |
| Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects. | Uhl GR et al. | β | 2008 | β |
| Molecular genetics of successful smoking cessation: convergent genome-wide association study results. | Uhl GR et al. | β | 2008 | β |
| MPDA: microarray pooled DNA analyzer. | Yang HC et al. | β | 2008 | β |
| Role of accumbens BDNF and TrkB in cocaine-induced psychomotor sensitization, conditioned-place preference, and reinstatement in rats. | Bahi A et al. | β | 2008 | β |
| The genetics of alcohol and other drug dependence. | Dick DM et al. | β | 2008 | β |
| A genome-wide scan for loci influencing adolescent cannabis dependence symptoms: evidence for linkage on chromosomes 3 and 9. | Hopfer CJ et al. | β | 2007 | β |
| Association mapping using pooled DNA. | Yang HC et al. | β | 2007 | β |
| Association of specific haplotypes of neurotrophic tyrosine kinase receptor 2 gene (NTRK2) with vulnerability to nicotine dependence in African-Americans and European-Americans. | Beuten J et al. | β | 2007 | β |
| Association of the met66 allele of brain-derived neurotrophic factor (BDNF) with smoking. | Lang UE et al. | β | 2007 | β |
| Brain-derived neurotrophic factor and its intracellular signaling pathways in cocaine addiction. | Corominas M et al. | β | 2007 | β |
| Brain-derived neurotrophic factor in neuronal survival and behavior-related plasticity. | Lipsky RH et al. | β | 2007 | β |
| Brain-derived neurotrophic factor Val66Met and psychiatric disorders: meta-analysis of case-control studies confirm association to substance-related disorders, eating disorders, and schizophrenia. | GratacΓ²s M et al. | β | 2007 | β |
| Genomic screen for substance dependence and body mass index in southwest California Indians. | Ehlers CL et al. | β | 2007 | β |
| Increased central brain-derived neurotrophic factor activity could be a risk factor for substance abuse: Implications for treatment. | Tsai SJ | β | 2007 | β |
| Increased dopamine D2High receptors in knockouts of the dopamine transporter and the vesicular monoamine transporter may contribute to spontaneous hyperactivity and dopamine supersensitivity. | Seeman P et al. | β | 2007 | β |
| Linkage disequilibrium and association analysis of alpha-synuclein and alcohol and drug dependence in two American Indian populations. | Clarimon J et al. | β | 2007 | β |
| Molecular genetics of nicotine dependence and abstinence: whole genome association using 520,000 SNPs. | Uhl GR et al. | β | 2007 | β |
| Neurexin 3 polymorphisms are associated with alcohol dependence and altered expression of specific isoforms. | Hishimoto A et al. | β | 2007 | β |
| Nucleotide sequence variation within the human tyrosine kinase B neurotrophin receptor gene: association with antisocial alcohol dependence. | Xu K et al. | β | 2007 | β |
| Opioid dependence and addiction during opioid treatment of chronic pain. | Ballantyne JC et al. | β | 2007 | β |
| Phosphatase PTEN in neuronal injury and brain disorders. | Chang N et al. | β | 2007 | β |
| Tobacco smoking and the ADRA2A C-1291G polymorphism. | Prestes AP et al. | β | 2007 | β |
| Variation in a bicarbonate co-transporter gene family member SLC4A7 is associated with propensity to addictions: a study using fine-mapping and three samples. | Ishiguro H et al. | β | 2007 | β |
| Addiction molecular genetics: 639,401 SNP whole genome association identifies many "cell adhesion" genes. | Liu QR et al. | β | 2006 | β |
| A genome-wide study of preferential amplification/hybridization in microarray-based pooled DNA experiments. | Yang HC et al. | β | 2006 | β |
| An overview of the genetics of substance use disorders. | Lachman HM | β | 2006 | β |
| Antagonism of ethanol ataxia by intracerebellar nicotine: possible modulation by mouse cerebellar nitric oxide and cGMP. | Al-Rejaie S et al. | β | 2006 | β |
| Association of the phosphatase and tensin homolog gene (PTEN) with smoking initiation and nicotine dependence. | Zhang L et al. | β | 2006 | β |
| Biological research on drug abuse and addiction in Hispanics: current status and future directions. | Trujillo KA et al. | β | 2006 | β |
| Brain derived neurotrophic factor (BDNF) gene variants and Alzheimer's disease, affective disorders, posttraumatic stress disorder, schizophrenia, and substance dependence. | Zhang H et al. | β | 2006 | β |
| Case-control study in basal cell carcinoma of the skin: single nucleotide polymorphisms in three interleukin promoters pre-analysed in pooled DNA. | Wilkening S et al. | β | 2006 | β |
| Central and medial amygdaloid brain-derived neurotrophic factor signaling plays a critical role in alcohol-drinking and anxiety-like behaviors. | Pandey SC et al. | β | 2006 | β |
| Genomewide linkage scan for opioid dependence and related traits. | Gelernter J et al. | β | 2006 | β |
| Linkage disequilibrium, haplotype and association studies of a chromosome 4 GABA receptor gene cluster: candidate gene variants for addictions. | Drgon T et al. | β | 2006 | β |
| Molecular genetics of addiction vulnerability. | Uhl GR | β | 2006 | β |
| NrCAM in addiction vulnerability: positional cloning, drug-regulation, haplotype-specific expression, and altered drug reward in knockout mice. | Ishiguro H et al. | β | 2006 | β |
| Pooled association genome scanning for alcohol dependence using 104,268 SNPs: validation and use to identify alcoholism vulnerability loci in unrelated individuals from the collaborative study on the genetics of alcoholism. | Johnson C et al. | β | 2006 | β |
| Psychiatric comorbidity and progression in drug use in adult male twins: implications for the design of genetic association studies. | Todorov AA et al. | β | 2006 | β |
| Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine. | Liu QR et al. | β | 2006 | β |
| Structural and functional modifications in glutamateric synapses following prolonged ethanol exposure. | Chandler LJ et al. | β | 2006 | β |
| Subtypes of illicit drug users: a latent class analysis of data from an Australian twin sample. | Lynskey MT et al. | β | 2006 | β |
| The genetic epidemiology of cannabis use, abuse and dependence. | Agrawal A et al. | β | 2006 | β |
| The genetics of alcohol dependence. | Dick DM et al. | β | 2006 | β |
| A central resource for accurate allele frequency estimation from pooled DNA genotyped on DNA microarrays. | Simpson CL et al. | β | 2005 | β |
| Association study between brain-derived neurotrophic factor gene polymorphisms and methamphetamine abusers in Japan. | Itoh K et al. | β | 2005 | β |
| A study of the association of (Val66Met) polymorphism in the brain-derived neurotrophic factor gene with alcohol dependence and extreme violence in Chinese males. | Tsai SJ et al. | β | 2005 | β |
| Brain-derived neurotrophic factor (Val66Met) genetic polymorphism is associated with substance abuse in males. | Cheng CY et al. | β | 2005 | β |
| Combining research approaches to advance our understanding of drug addiction. | van den Bree MB | β | 2005 | β |
| Comorbid alcohol and nicotine dependence: from the biomolecular basis to clinical consequences. | Ait-Daoud N et al. | β | 2005 | β |
| Different expression of brain-derived neurotrophic factor in the nucleus accumbens of alcohol-preferring (P) and -nonpreferring (NP) rats. | Yan QS et al. | β | 2005 | β |
| Genetic determinants of addiction to opioids and cocaine. | Saxon AJ et al. | β | 2005 | β |
| Genetic influences in emotional dysfunction and alcoholism-related brain damage. | Oscar-Berman M et al. | β | 2005 | β |
| Genetic research on nicotine dependence will facilitate public health. | Cubells J | β | 2005 | β |
| Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's Disease. | Liu QR et al. | β | 2005 | β |
| Implications of CYP2A6 genetic variation for smoking behaviors and nicotine dependence. | Malaiyandi V et al. | β | 2005 | β |
| Pharmacogenetics and human molecular genetics of opiate and cocaine addictions and their treatments. | Kreek MJ et al. | β | 2005 | β |
| Pooled association genome scanning: validation and use to identify addiction vulnerability loci in two samples. | Liu QR et al. | β | 2005 | β |
| PPC: an algorithm for accurate estimation of SNP allele frequencies in small equimolar pools of DNA using data from high density microarrays. | Brohede J et al. | β | 2005 | β |
| Significant association of BDNF haplotypes in European-American male smokers but not in European-American female or African-American smokers. | Beuten J et al. | β | 2005 | β |
| The genetics of addictions: uncovering the genes. | Goldman D et al. | β | 2005 | β |
| The "ups and downs" of signaling cascades in addiction. | Ron D et al. | β | 2005 | β |
| The use of race variables in genetic studies of complex traits and the goal of reducing health disparities: a transdisciplinary perspective. | Shields AE et al. | β | 2005 | β |
| Application of pooled genotyping to scan candidate regions for association with HDL cholesterol levels. | Hinds DA et al. | β | 2004 | β |
| Association study of brain-derived neurotrophic factor gene polymorphism and alcoholism. | Matsushita S et al. | β | 2004 | β |
| Candidate genes for nicotine dependence via linkage, epistasis, and bioinformatics. | Sullivan PF et al. | β | 2004 | β |
| Genes associated with addiction: alcoholism, opiate, and cocaine addiction. | Kreek MJ et al. | β | 2004 | β |
| Genetics and drug use as a complex phenotype. | Lessov CN et al. | β | 2004 | β |
| Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse. | Zhang PW et al. | β | 2004 | β |
| Mining microarrays for metabolic meaning: nutritional regulation of hypothalamic gene expression. | Mobbs CV et al. | β | 2004 | β |
| Molecular genetics of substance abuse vulnerability: remarkable recent convergence of genome scan results. | Uhl GR | β | 2004 | β |
| Molecular genetic underpinnings of human substance abuse vulnerability: likely contributions to understanding addiction as a mnemonic process. | Uhl GR | β | 2004 | β |
| Partial deletion of the cAMP response element-binding protein gene promotes alcohol-drinking behaviors. | Pandey SC et al. | β | 2004 | β |
| Results of a genomewide linkage scan: support for chromosomes 9 and 11 loci increasing risk for cigarette smoking. | Gelernter J et al. | β | 2004 | β |
| The gene transcription factor cyclic AMP-responsive element binding protein: role in positive and negative affective states of alcohol addiction. | Pandey SC | β | 2004 | β |
| The human serotonin receptor 2B: coding region polymorphisms and association with vulnerability to illegal drug abuse. | Lin Z et al. | β | 2004 | β |
| A genome-wide search for quantitative trait loci influencing substance dependence vulnerability in adolescence. | Stallings MC et al. | β | 2003 | β |
| Allelic variation at alcohol metabolism genes ( ADH1B, ADH1C, ALDH2) and alcohol dependence in an American Indian population. | Mulligan CJ et al. | β | 2003 | β |
| Anxiety and alcohol abuse disorders: a common role for CREB and its target, the neuropeptide Y gene. | Pandey SC | β | 2003 | β |
| Candidate genes for alcohol dependence: a review of genetic evidence from human studies. | Dick DM et al. | β | 2003 | β |
| Elucidating the role of genetic factors in smoking behavior and nicotine dependence. | Lerman C et al. | β | 2003 | β |
| Experimental gene interaction studies with SERT mutant mice as models for human polygenic and epistatic traits and disorders. | Murphy DL et al. | β | 2003 | β |
| Making connections: the development of mesencephalic dopaminergic neurons. | Riddle R et al. | β | 2003 | β |
| Prolactin and prolactin receptor gene polymorphisms in multiple sclerosis and systemic lupus erythematosus. | Mellai M et al. | β | 2003 | β |
| Reduced behavioral effects of cocaine in heterozygous brain-derived neurotrophic factor (BDNF) knockout mice. | Hall FS et al. | β | 2003 | β |
| Specificity of genetic and environmental risk factors for use and abuse/dependence of cannabis, cocaine, hallucinogens, sedatives, stimulants, and opiates in male twins. | Kendler KS et al. | β | 2003 | β |
| The genetic determinants of smoking. | Batra V et al. | β | 2003 | β |
| The genetics of smoking related behavior: a brief review. | Li MD | β | 2003 | β |
| Animal models for the genetic study of human alcohol phenotypes. | Phillips T | β | 2002 | β |
| A whole genome screen for linkage disequilibrium in multiple sclerosis confirms disease associations with regions previously linked to susceptibility. | Sawcer S et al. | β | 2002 | β |
| DNA Pooling: a tool for large-scale association studies. | Sham P et al. | β | 2002 | β |
| Genotyping of drug targets: a method to predict adverse drug reactions? | GΓΌzey C et al. | β | 2002 | β |
| Identification of single nucleotide variations in the coding and regulatory regions of the myelin-associated glycoprotein gene and study of their association with multiple sclerosis. | D'Alfonso S et al. | β | 2002 | β |
| Substance abuse vulnerability loci: converging genome scanning data. | Uhl GR et al. | β | 2002 | β |
| The genetics of otitis media. | Goodwin JH et al. | β | 2002 | β |
| The genetics of substance abuse. | Hardie TL | β | 2002 | β |
| Trends in reporting of SNP associations. | Bansal A | β | 2001 | β |